JP2007517892A5 - - Google Patents
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- JP2007517892A5 JP2007517892A5 JP2006549451A JP2006549451A JP2007517892A5 JP 2007517892 A5 JP2007517892 A5 JP 2007517892A5 JP 2006549451 A JP2006549451 A JP 2006549451A JP 2006549451 A JP2006549451 A JP 2006549451A JP 2007517892 A5 JP2007517892 A5 JP 2007517892A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- insulin
- administered
- physiological
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 37
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 18
- 102000004877 Insulin Human genes 0.000 claims 9
- 108090001061 Insulin Proteins 0.000 claims 9
- 229940125396 insulin Drugs 0.000 claims 9
- 210000002966 serum Anatomy 0.000 claims 6
- 230000006362 insulin response pathway Effects 0.000 claims 5
- 108010076181 Proinsulin Proteins 0.000 claims 4
- 235000012054 meals Nutrition 0.000 claims 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000008103 glucose Substances 0.000 claims 3
- 102000010752 Plasminogen Inactivators Human genes 0.000 claims 2
- 108010077971 Plasminogen Inactivators Proteins 0.000 claims 2
- 235000005911 diet Nutrition 0.000 claims 2
- 239000011859 microparticle Substances 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 claims 2
- 239000002797 plasminogen activator inhibitor Substances 0.000 claims 2
- 230000002685 pulmonary effect Effects 0.000 claims 2
- BBNKIRVUCQNAQR-FETIZUMASA-N (e)-4-[4-[(2s,5s)-5-[4-[[(e)-3-carboxyprop-2-enoyl]amino]butyl]-3,6-dioxopiperazin-2-yl]butylamino]-4-oxobut-2-enoic acid Chemical group OC(=O)\C=C\C(=O)NCCCC[C@@H]1NC(=O)[C@H](CCCCNC(=O)\C=C\C(O)=O)NC1=O BBNKIRVUCQNAQR-FETIZUMASA-N 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 claims 1
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 claims 1
- 229920002988 biodegradable polymer Polymers 0.000 claims 1
- 239000004621 biodegradable polymer Substances 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000037213 diet Effects 0.000 claims 1
- 230000000378 dietary effect Effects 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000012377 drug delivery Methods 0.000 claims 1
- 229940094417 fumaryl diketopiperazine Drugs 0.000 claims 1
- 230000004110 gluconeogenesis Effects 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53594504P | 2004-01-12 | 2004-01-12 | |
| PCT/US2005/000596 WO2005067964A1 (en) | 2004-01-12 | 2005-01-10 | A method of reducing serum proinsulin levels in type 2 diabetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007517892A JP2007517892A (ja) | 2007-07-05 |
| JP2007517892A5 true JP2007517892A5 (enExample) | 2008-02-14 |
Family
ID=34794375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006549451A Pending JP2007517892A (ja) | 2004-01-12 | 2005-01-10 | ２型糖尿病における血清プロインスリンレベルを低下させる方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20050153874A1 (enExample) |
| EP (1) | EP1708738B1 (enExample) |
| JP (1) | JP2007517892A (enExample) |
| KR (2) | KR20060110353A (enExample) |
| CN (1) | CN101027082A (enExample) |
| AU (2) | AU2005204378B2 (enExample) |
| BR (1) | BRPI0506791A (enExample) |
| ES (1) | ES2584867T3 (enExample) |
| IL (1) | IL176699A (enExample) |
| NZ (1) | NZ548980A (enExample) |
| WO (1) | WO2005067964A1 (enExample) |
Families Citing this family (45)
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| US20070027063A1 (en) * | 2004-01-12 | 2007-02-01 | Mannkind Corporation | Method of preserving the function of insulin-producing cells |
| PL2319500T3 (pl) * | 2004-03-12 | 2013-05-31 | Biodel Inc | Szybko działające kompozycje do dostarczania leku |
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| BR122019022692B1 (pt) | 2004-08-23 | 2023-01-10 | Mannkind Corporation | Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo |
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| ES2439455T3 (es) * | 2005-08-01 | 2014-01-23 | Mannkind Corporation | Procedimiento de preservar la función de las células productoras de insulina |
| KR101384456B1 (ko) * | 2005-09-14 | 2014-04-10 | 맨카인드 코포레이션 | 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법 |
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| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| SI2379100T1 (sl) * | 2009-01-08 | 2015-02-27 | Mannkind Corporation | Zdravljenje hiperglikemije z GLP-1 |
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| US8551528B2 (en) | 2009-06-12 | 2013-10-08 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
| JP5784622B2 (ja) | 2009-11-03 | 2015-09-24 | マンカインド コーポレ−ション | 吸入活動をシミュレートするための装置及び方法 |
| ES2625858T3 (es) | 2011-04-01 | 2017-07-20 | Mannkind Corporation | Paquete de tipo blíster para cartuchos farmacéuticos |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| HK1201475A1 (en) | 2011-10-24 | 2015-09-04 | Mannkind Corporation | Methods and compositions for treating pain |
| CA3098386C (en) | 2012-07-12 | 2022-11-29 | Mannkind Corporation | Dry powder drug delivery systems and methods |
| EP2911690A1 (en) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalable influenza vaccine compositions and methods |
| MX369136B (es) | 2013-03-15 | 2019-10-30 | Mannkind Corp | Composiciones de dicetopiperazina microcristalina y metodos. |
| BR122019026637B1 (pt) | 2013-07-18 | 2023-09-26 | Mannkind Corporation | Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco |
| US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
| WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| CN110187123B (zh) * | 2019-05-06 | 2022-07-22 | 天津医科大学总医院 | 一种糖尿病早期诊断生物标志物及其应用 |
| CN111235036B (zh) * | 2020-01-15 | 2022-03-18 | 西北大学 | 一种冠突散囊菌及从其中分离纯化二酮哌嗪二聚体的方法 |
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| PL2319500T3 (pl) * | 2004-03-12 | 2013-05-31 | Biodel Inc | Szybko działające kompozycje do dostarczania leku |
| WO2007041481A1 (en) * | 2005-09-29 | 2007-04-12 | Biodel, Inc. | Rapid acting and prolonged acting insulin preparations |
-
2005
- 2005-01-10 NZ NZ548980A patent/NZ548980A/en not_active IP Right Cessation
- 2005-01-10 JP JP2006549451A patent/JP2007517892A/ja active Pending
- 2005-01-10 KR KR1020067013980A patent/KR20060110353A/ko not_active Ceased
- 2005-01-10 EP EP05711314.4A patent/EP1708738B1/en not_active Expired - Lifetime
- 2005-01-10 WO PCT/US2005/000596 patent/WO2005067964A1/en not_active Ceased
- 2005-01-10 CN CNA200580002306XA patent/CN101027082A/zh active Pending
- 2005-01-10 AU AU2005204378A patent/AU2005204378B2/en not_active Ceased
- 2005-01-10 ES ES05711314.4T patent/ES2584867T3/es not_active Expired - Lifetime
- 2005-01-10 BR BRPI0506791-0A patent/BRPI0506791A/pt not_active Application Discontinuation
- 2005-01-10 US US11/032,278 patent/US20050153874A1/en not_active Abandoned
- 2005-01-10 KR KR1020097017808A patent/KR100985126B1/ko not_active Expired - Fee Related
-
2006
- 2006-07-04 IL IL176699A patent/IL176699A/en not_active IP Right Cessation
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2009
- 2009-03-06 AU AU2009200894A patent/AU2009200894B2/en not_active Ceased
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