JP2007515447A5 - - Google Patents
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- Publication number
- JP2007515447A5 JP2007515447A5 JP2006546041A JP2006546041A JP2007515447A5 JP 2007515447 A5 JP2007515447 A5 JP 2007515447A5 JP 2006546041 A JP2006546041 A JP 2006546041A JP 2006546041 A JP2006546041 A JP 2006546041A JP 2007515447 A5 JP2007515447 A5 JP 2007515447A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclohexane
- dimethyl
- spiro
- phenyl
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000002193 Pain Diseases 0.000 claims description 16
- 125000000113 cyclohexyl group Chemical class [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- -1 cation salts Chemical class 0.000 claims 3
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical group 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 239000007858 starting material Substances 0.000 claims 2
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- ADTWVXGAUOMTIE-UHFFFAOYSA-N [1'-(3-fluorophenyl)spiro[4,5-dihydro-3h-pyrano[4,3-b]indole-1,4'-cyclohexane]-1'-yl]-dimethylazanium;trifluoromethanesulfonate Chemical compound [O-]S(=O)(=O)C(F)(F)F.C1CC2(C=3C4=CC=CC=C4NC=3CCO2)CCC1([NH+](C)C)C1=CC=CC(F)=C1 ADTWVXGAUOMTIE-UHFFFAOYSA-N 0.000 claims 1
- INBNCBAGQQSESL-UHFFFAOYSA-N [1'-(4-fluorophenyl)spiro[4,5-dihydro-3h-pyrano[4,3-b]indole-1,4'-cyclohexane]-1'-yl]-dimethylazanium;trifluoromethanesulfonate Chemical compound [O-]S(=O)(=O)C(F)(F)F.C1CC2(C=3C4=CC=CC=C4NC=3CCO2)CCC1([NH+](C)C)C1=CC=C(F)C=C1 INBNCBAGQQSESL-UHFFFAOYSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229940098779 methanesulfonic acid Drugs 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 description 5
- 102000051367 mu Opioid Receptors Human genes 0.000 description 3
- 108020001612 μ-opioid receptors Proteins 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 2
- 208000005298 acute pain Diseases 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 208000004296 neuralgia Diseases 0.000 description 2
- 230000002981 neuropathic effect Effects 0.000 description 2
- 208000021722 neuropathic pain Diseases 0.000 description 2
- 229940005483 opioid analgesics Drugs 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 1
- 102000003840 Opioid Receptors Human genes 0.000 description 1
- 108090000137 Opioid Receptors Proteins 0.000 description 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 1
- 206010038678 Respiratory depression Diseases 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 230000020341 sensory perception of pain Effects 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 208000009935 visceral pain Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10360793.5 | 2003-12-23 | ||
| DE10360793A DE10360793A1 (de) | 2003-12-23 | 2003-12-23 | Spirocyclische Cyclohexan-Derivate |
| PCT/EP2004/014540 WO2005063769A1 (de) | 2003-12-23 | 2004-12-21 | Spirocyclische cyclohexan-derivate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007515447A JP2007515447A (ja) | 2007-06-14 |
| JP2007515447A5 true JP2007515447A5 (enExample) | 2011-06-02 |
| JP4791374B2 JP4791374B2 (ja) | 2011-10-12 |
Family
ID=34706498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006546041A Expired - Fee Related JP4791374B2 (ja) | 2003-12-23 | 2004-12-21 | スピロ環状シクロヘキサン誘導体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7288560B2 (enExample) |
| EP (1) | EP1697379B1 (enExample) |
| JP (1) | JP4791374B2 (enExample) |
| AR (1) | AR046794A1 (enExample) |
| AT (1) | ATE426604T1 (enExample) |
| CA (1) | CA2550892C (enExample) |
| CY (1) | CY1109142T1 (enExample) |
| DE (2) | DE10360793A1 (enExample) |
| DK (1) | DK1697379T3 (enExample) |
| ES (1) | ES2324788T3 (enExample) |
| PE (1) | PE20050680A1 (enExample) |
| PL (1) | PL1697379T3 (enExample) |
| PT (1) | PT1697379E (enExample) |
| SI (1) | SI1697379T1 (enExample) |
| WO (1) | WO2005063769A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10360792A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102005016460A1 (de) * | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
| DE102006019597A1 (de) | 2006-04-27 | 2007-10-31 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102006033114A1 (de) * | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
| DE102006033109A1 (de) * | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
| DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
| DE102007009235A1 (de) * | 2007-02-22 | 2008-09-18 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| PE20091823A1 (es) | 2008-03-27 | 2009-12-10 | Gruenenthal Chemie | Ciclohexildiaminas sustituidas |
| MX2010010407A (es) | 2008-03-27 | 2010-10-25 | Gruenenthal Gmbh | Derivados de 4-aminociclohexanos sustituidos. |
| WO2009118163A1 (de) | 2008-03-27 | 2009-10-01 | Grünenthal GmbH | (hetero-)aryl-cyclohexan-derivate |
| RU2514192C2 (ru) | 2008-03-27 | 2014-04-27 | Грюненталь Гмбх | Гидроксиметилциклогексиламины |
| PL2260042T3 (pl) | 2008-03-27 | 2012-02-29 | Gruenenthal Gmbh | Podstawione spirocykliczne pochodne cykloheksanu |
| DK2257526T3 (da) | 2008-03-27 | 2012-02-06 | Gruenenthal Gmbh | Spiro(5,5)undecan-derivater |
| ES2393849T7 (es) | 2008-07-21 | 2015-01-28 | Purdue Pharma Lp | Compuestos de piperidina puenteada, de tipo quinoxalina sustituida, y usos de los mismos |
| CA2781716A1 (en) | 2009-12-04 | 2011-06-09 | Sunovion Pharmaceuticals Inc. | Multicyclic thieno compounds and use thereof for the treatment of a neurological disorder |
| TWI582092B (zh) * | 2010-07-28 | 2017-05-11 | 歌林達股份有限公司 | 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物 |
| SI2600851T1 (en) | 2010-08-04 | 2018-07-31 | Gruenenthal Gmbh | PHARMACEUTICAL FORM OF DOSAGE COVERING 6'-FLUORO- (N-METHYLLINE N, N-DIMETHYL-4-PHENYL-4 ', 9'-DIHYDRO-3'H-SPIRO- (CYCLOHEXANE-1,1'- PIRANO (3,4, B) INDOL) -4-AMIN, FOR NON-PROPHETIC DISEASE TREATMENT |
| BR112013024169A2 (pt) * | 2011-04-07 | 2016-12-06 | Ariad Pharma Inc | método para o tratamento e prevenção da doença de parkinson |
| TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
| ES2686326T3 (es) | 2014-07-15 | 2018-10-17 | Grünenthal GmbH | Derivados de azaspiro(4,5)decano sustituidos |
| SG10202100751YA (en) | 2016-07-29 | 2021-03-30 | Sunovion Pharmaceuticals Inc | Compounds and compositions and uses thereof |
| AU2017301769B2 (en) | 2016-07-29 | 2022-07-28 | Pgi Drug Discovery Llc | Compounds and compositions and uses thereof |
| AU2018220509B2 (en) | 2017-02-16 | 2022-04-28 | Sumitomo Pharma America, Inc. | Methods of treating schizophrenia |
| SG11202000669VA (en) | 2017-08-02 | 2020-02-27 | Sunovion Pharmaceuticals Inc | Isochroman compounds and uses thereof |
| CA3091292A1 (en) | 2018-02-16 | 2019-08-22 | Sunovion Pharmaceuticals Inc. | Salts, crystal forms, and production methods thereof |
| JP7703449B2 (ja) | 2019-03-14 | 2025-07-07 | スミトモ・ファーマ・アメリカ・インコーポレイテッド | イソクロマニル化合物の塩およびその結晶体、ならびにそれらの製造方法、治療用途および医薬組成物 |
| JP7644122B2 (ja) | 2019-12-26 | 2025-03-11 | ギルガメッシュ・ファーマシューティカルズ・インコーポレイテッド | アリールシクロヘキシルアミン誘導体及び精神障害の処置におけるそれらの使用 |
| PL4084791T3 (pl) | 2020-02-18 | 2025-04-22 | Gilgamesh Pharmaceuticals, Inc. | Specyficzne tryptaminy do zastosowania w leczeniu zaburzeń nastroju |
| CN115734785A (zh) | 2020-04-14 | 2023-03-03 | 桑诺维恩药品公司 | (S)-(4,5-二氢-7H-噻吩并[2,3-c]吡喃-7-基)-N-甲基甲胺用于治疗神经和精神方面的病症 |
| US12180158B1 (en) | 2023-08-03 | 2024-12-31 | Gilgamesh Pharmaceuticals, Inc. | Crystalline fumarate salts of n-ethyl-2-(5-fluoro-1H-indol-3-yl)-n-methylethan-1-amine |
| US12129234B1 (en) | 2023-08-03 | 2024-10-29 | Gilgamesh Pharmaceuticals, Inc. | Crystalline salts of N-ethyl-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2663935A1 (fr) * | 1990-06-27 | 1992-01-03 | Adir | Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| HUP0302962A2 (hu) * | 1998-06-12 | 2003-12-29 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Béta-karbolinszármazékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények és a vegyületek alkalmazása |
| AU1691500A (en) * | 1998-12-24 | 2000-07-31 | Meiji Seika Kaisha Ltd. | Remedies for pain |
| DE10044649A1 (de) * | 2000-09-08 | 2002-07-04 | Gruenenthal Gmbh | Substituierte 4-Phenyl-1-(1-phenyl-cyclohexyl)-1,2,3,6-tetrahydropyridine |
| DE10123163A1 (de) * | 2001-05-09 | 2003-01-16 | Gruenenthal Gmbh | Substituierte Cyclohexan-1,4-diaminderivate |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10360792A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
-
2003
- 2003-12-23 DE DE10360793A patent/DE10360793A1/de not_active Withdrawn
-
2004
- 2004-12-21 ES ES04804137T patent/ES2324788T3/es not_active Expired - Lifetime
- 2004-12-21 PL PL04804137T patent/PL1697379T3/pl unknown
- 2004-12-21 AT AT04804137T patent/ATE426604T1/de active
- 2004-12-21 DE DE502004009243T patent/DE502004009243D1/de not_active Expired - Lifetime
- 2004-12-21 CA CA2550892A patent/CA2550892C/en not_active Expired - Fee Related
- 2004-12-21 EP EP04804137A patent/EP1697379B1/de not_active Expired - Lifetime
- 2004-12-21 WO PCT/EP2004/014540 patent/WO2005063769A1/de not_active Ceased
- 2004-12-21 PT PT04804137T patent/PT1697379E/pt unknown
- 2004-12-21 DK DK04804137T patent/DK1697379T3/da active
- 2004-12-21 SI SI200431139T patent/SI1697379T1/sl unknown
- 2004-12-21 JP JP2006546041A patent/JP4791374B2/ja not_active Expired - Fee Related
- 2004-12-22 AR ARP040104858A patent/AR046794A1/es unknown
- 2004-12-23 US US11/019,416 patent/US7288560B2/en not_active Expired - Fee Related
-
2005
- 2005-01-03 PE PE2005000021A patent/PE20050680A1/es not_active Application Discontinuation
-
2009
- 2009-06-12 CY CY20091100629T patent/CY1109142T1/el unknown
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