DE10360793A1 - Spirocyclische Cyclohexan-Derivate - Google Patents

Spirocyclische Cyclohexan-Derivate Download PDF

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Publication number
DE10360793A1
DE10360793A1 DE10360793A DE10360793A DE10360793A1 DE 10360793 A1 DE10360793 A1 DE 10360793A1 DE 10360793 A DE10360793 A DE 10360793A DE 10360793 A DE10360793 A DE 10360793A DE 10360793 A1 DE10360793 A1 DE 10360793A1
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DE
Germany
Prior art keywords
unsubstituted
polysubstituted
monosubstituted
alkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10360793A
Other languages
German (de)
English (en)
Inventor
Claudia Dr. Hinze
Bernd Dr. Sundermann
Hans Prof. Dr. Schick
Birgitta Dr. Henkel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Priority to DE10360793A priority Critical patent/DE10360793A1/de
Priority to PL04804137T priority patent/PL1697379T3/pl
Priority to DE502004009243T priority patent/DE502004009243D1/de
Priority to AT04804137T priority patent/ATE426604T1/de
Priority to ES04804137T priority patent/ES2324788T3/es
Priority to EP04804137A priority patent/EP1697379B1/de
Priority to JP2006546041A priority patent/JP4791374B2/ja
Priority to CA2550892A priority patent/CA2550892C/en
Priority to DK04804137T priority patent/DK1697379T3/da
Priority to SI200431139T priority patent/SI1697379T1/sl
Priority to PT04804137T priority patent/PT1697379E/pt
Priority to PCT/EP2004/014540 priority patent/WO2005063769A1/de
Priority to ARP040104858A priority patent/AR046794A1/es
Priority to US11/019,416 priority patent/US7288560B2/en
Priority to PE2005000021A priority patent/PE20050680A1/es
Publication of DE10360793A1 publication Critical patent/DE10360793A1/de
Priority to CY20091100629T priority patent/CY1109142T1/el
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nutrition Science (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
DE10360793A 2003-12-23 2003-12-23 Spirocyclische Cyclohexan-Derivate Withdrawn DE10360793A1 (de)

Priority Applications (16)

Application Number Priority Date Filing Date Title
DE10360793A DE10360793A1 (de) 2003-12-23 2003-12-23 Spirocyclische Cyclohexan-Derivate
CA2550892A CA2550892C (en) 2003-12-23 2004-12-21 Spirocyclic cyclohexane derivatives
PT04804137T PT1697379E (pt) 2003-12-23 2004-12-21 Derivados de ciclo-hexano espirocíclicos
AT04804137T ATE426604T1 (de) 2003-12-23 2004-12-21 Spirocyclische cyclohexan-derivate
ES04804137T ES2324788T3 (es) 2003-12-23 2004-12-21 Derivados de ciclohexano espirociclicos.
EP04804137A EP1697379B1 (de) 2003-12-23 2004-12-21 Spirocyclische cyclohexan-derivate
JP2006546041A JP4791374B2 (ja) 2003-12-23 2004-12-21 スピロ環状シクロヘキサン誘導体
PL04804137T PL1697379T3 (pl) 2003-12-23 2004-12-21 Spirocykliczne pochodne cykloheksanu
DK04804137T DK1697379T3 (da) 2003-12-23 2004-12-21 Spirocykliske cyklohexan-derivater
SI200431139T SI1697379T1 (sl) 2003-12-23 2004-12-21 Spirociklični cikloheksanski derivati
DE502004009243T DE502004009243D1 (en) 2003-12-23 2004-12-21 Spirocyclische cyclohexan-derivate
PCT/EP2004/014540 WO2005063769A1 (de) 2003-12-23 2004-12-21 Spirocyclische cyclohexan-derivate
ARP040104858A AR046794A1 (es) 2003-12-23 2004-12-22 Derivados de ciclohexano espirociclicos, un metodo para su preparacion y medicamentos que los contienen como principio activo.
US11/019,416 US7288560B2 (en) 2003-12-23 2004-12-23 Spirocyclic cyclohexane derivatives
PE2005000021A PE20050680A1 (es) 2003-12-23 2005-01-03 Derivados de ciclohexano espirociclicos
CY20091100629T CY1109142T1 (el) 2003-12-23 2009-06-12 Χαρακτηρισμος: σπειροκυκλικα παραγωγα κυκλοεξανιου

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10360793A DE10360793A1 (de) 2003-12-23 2003-12-23 Spirocyclische Cyclohexan-Derivate

Publications (1)

Publication Number Publication Date
DE10360793A1 true DE10360793A1 (de) 2005-07-28

Family

ID=34706498

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10360793A Withdrawn DE10360793A1 (de) 2003-12-23 2003-12-23 Spirocyclische Cyclohexan-Derivate
DE502004009243T Expired - Lifetime DE502004009243D1 (en) 2003-12-23 2004-12-21 Spirocyclische cyclohexan-derivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE502004009243T Expired - Lifetime DE502004009243D1 (en) 2003-12-23 2004-12-21 Spirocyclische cyclohexan-derivate

Country Status (15)

Country Link
US (1) US7288560B2 (enExample)
EP (1) EP1697379B1 (enExample)
JP (1) JP4791374B2 (enExample)
AR (1) AR046794A1 (enExample)
AT (1) ATE426604T1 (enExample)
CA (1) CA2550892C (enExample)
CY (1) CY1109142T1 (enExample)
DE (2) DE10360793A1 (enExample)
DK (1) DK1697379T3 (enExample)
ES (1) ES2324788T3 (enExample)
PE (1) PE20050680A1 (enExample)
PL (1) PL1697379T3 (enExample)
PT (1) PT1697379E (enExample)
SI (1) SI1697379T1 (enExample)
WO (1) WO2005063769A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102006019597A1 (de) 2006-04-27 2007-10-31 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102006033114A1 (de) 2006-07-18 2008-01-24 Grünenthal GmbH Spirocyclische Azaindol-Derivate
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
DE102007009235A1 (de) * 2007-02-22 2008-09-18 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
MX2010010446A (es) 2008-03-27 2010-11-05 Gruenenthal Gmbh Derivados de (hetero)arilo ciclohexano.
JP5674635B2 (ja) 2008-03-27 2015-02-25 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換された４−アミノシクロヘキサン誘導体
US8293758B2 (en) 2008-03-27 2012-10-23 Grunenthal Gmbh Substituted spirocyclic cyclohexane derivatives
PL2257526T3 (pl) 2008-03-27 2012-05-31 Gruenenthal Gmbh Pochodne spiro (5.5) undekanu
AR071067A1 (es) 2008-03-27 2010-05-26 Gruenenthal Chemie Ciclohexildiaminas sustituidas
EP2271613B1 (de) 2008-03-27 2014-06-18 Grünenthal GmbH Hydroxymethylcyclohexylamine
NZ590416A (en) 2008-07-21 2012-10-26 Purdue Pharma Lp Substituted-quinoxaline-type bridged-piperidine compounds and the uses thereof
NZ767139A (en) * 2009-12-04 2022-08-26 Sunovion Pharmaceuticals Inc Multicyclic compounds and methods of use thereof
TWI582092B (zh) * 2010-07-28 2017-05-11 歌林達股份有限公司 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物
RU2638818C2 (ru) 2010-08-04 2017-12-15 Грюненталь Гмбх Лекарственная дозированная форма, которая содержит 6'-фтор-(n-метил-или n, n-диметил)-4-фенил-4', 9'-дигидро-3'н-спиро[циклогексан-1, 1'-пирано[3, 4, в]индол]-4-амин для лечения невропатической боли
EA201391486A1 (ru) * 2011-04-07 2014-09-30 Ариад Фармасьютикалз, Инк. Способы и композиции для лечения болезни паркинсона
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
US10214520B2 (en) 2014-07-15 2019-02-26 Gruenenthal Gmbh Substituted azaspiro(4.5)decane derivatives
CN116514761A (zh) 2016-07-29 2023-08-01 赛诺维信制药公司 化合物、组合物及其用途
EA201990399A1 (ru) 2016-07-29 2019-07-31 Суновион Фармасьютикалз, Инк. Соединения, композиции и их применение
EP3582815A1 (en) 2017-02-16 2019-12-25 Sunovion Pharmaceuticals Inc. Methods of treating schizophrenia
CN111183138A (zh) 2017-08-02 2020-05-19 赛诺维信制药公司 异色满化合物以及用途
MX2020008537A (es) 2018-02-16 2021-01-08 Sunovion Pharmaceuticals Inc Sales, formas cristalinas y metodos de produccion de las mismas.
JP7703449B2 (ja) 2019-03-14 2025-07-07 スミトモ・ファーマ・アメリカ・インコーポレイテッド イソクロマニル化合物の塩およびその結晶体、ならびにそれらの製造方法、治療用途および医薬組成物
CN119241381A (zh) 2019-12-26 2025-01-03 吉尔伽美什制药公司 芳基环己基胺衍生物及其在精神障碍的治疗中的用途
BR112022016382A2 (pt) 2020-02-18 2022-10-25 Gilgamesh Pharmaceuticals Inc Triptaminas específicas para o uso no tratamento de doenças do humor
IL297248A (en) 2020-04-14 2022-12-01 Sunovion Pharmaceuticals Inc (s)-(5,4-dihydro-7h-thiano[3,2-c]pyran-7-yl)-n-methylmethanamine for the treatment of neurological and psychiatric disorders
US12129234B1 (en) 2023-08-03 2024-10-29 Gilgamesh Pharmaceuticals, Inc. Crystalline salts of N-ethyl-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine
US12157722B1 (en) 2023-08-03 2024-12-03 Gilgamesh Pharmaceuticals, Inc. Crystalline hydrochloride salts of N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine

Citations (2)

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Publication number Priority date Publication date Assignee Title
DE10044649A1 (de) * 2000-09-08 2002-07-04 Gruenenthal Gmbh Substituierte 4-Phenyl-1-(1-phenyl-cyclohexyl)-1,2,3,6-tetrahydropyridine
WO2002090330A1 (de) * 2001-05-09 2002-11-14 Grünenthal GmbH Substituierte 2-pyridin-cyclohexan-1,4-diaminderivate

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NZ508765A (en) * 1998-06-12 2003-10-31 Sod Conseils Rech Applic Beta-carboline derivatives and pharmaceuticals thereof that selectively bind somatostatin receptor subtypes
EP1142587A1 (en) * 1998-12-24 2001-10-10 Meiji Seika Kaisha Ltd. Remedies for pain
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10044649A1 (de) * 2000-09-08 2002-07-04 Gruenenthal Gmbh Substituierte 4-Phenyl-1-(1-phenyl-cyclohexyl)-1,2,3,6-tetrahydropyridine
WO2002090330A1 (de) * 2001-05-09 2002-11-14 Grünenthal GmbH Substituierte 2-pyridin-cyclohexan-1,4-diaminderivate

Also Published As

Publication number Publication date
PL1697379T3 (pl) 2009-08-31
US20050187281A1 (en) 2005-08-25
CA2550892A1 (en) 2005-07-14
AR046794A1 (es) 2005-12-21
DE502004009243D1 (en) 2009-05-07
PT1697379E (pt) 2009-06-08
JP4791374B2 (ja) 2011-10-12
US7288560B2 (en) 2007-10-30
ES2324788T3 (es) 2009-08-14
JP2007515447A (ja) 2007-06-14
PE20050680A1 (es) 2005-09-27
ATE426604T1 (de) 2009-04-15
SI1697379T1 (sl) 2009-08-31
CA2550892C (en) 2012-03-06
WO2005063769A1 (de) 2005-07-14
EP1697379A1 (de) 2006-09-06
EP1697379B1 (de) 2009-03-25
DK1697379T3 (da) 2009-07-20
CY1109142T1 (el) 2014-07-02

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