JP2007536318A5 - - Google Patents
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- Publication number
- JP2007536318A5 JP2007536318A5 JP2007512028A JP2007512028A JP2007536318A5 JP 2007536318 A5 JP2007536318 A5 JP 2007536318A5 JP 2007512028 A JP2007512028 A JP 2007512028A JP 2007512028 A JP2007512028 A JP 2007512028A JP 2007536318 A5 JP2007536318 A5 JP 2007536318A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- formula
- diastereomers
- acid
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000002193 Pain Diseases 0.000 claims description 16
- NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical class OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims 4
- 125000006239 protecting group Chemical group 0.000 claims 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- -1 cation salt Chemical class 0.000 claims 2
- 239000012024 dehydrating agents Substances 0.000 claims 2
- RJABZSMSUYBVAG-UHFFFAOYSA-N methyl 2-[[4-(dimethylamino)-4-phenylcyclohexanecarbonyl]amino]-3-(1h-indol-3-yl)propanoate;hydrochloride Chemical compound Cl.C=1NC2=CC=CC=C2C=1CC(C(=O)OC)NC(=O)C(CC1)CCC1(N(C)C)C1=CC=CC=C1 RJABZSMSUYBVAG-UHFFFAOYSA-N 0.000 claims 2
- 239000007800 oxidant agent Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- KKERFSVKOSUXLE-UHFFFAOYSA-N 4-(dimethylamino)-4-phenyl-n-(3-phenylpropyl)cyclohexane-1-carboxamide;hydrochloride Chemical compound Cl.C1CC(N(C)C)(C=2C=CC=CC=2)CCC1C(=O)NCCCC1=CC=CC=C1 KKERFSVKOSUXLE-UHFFFAOYSA-N 0.000 claims 1
- XKIIHUAHYHZDPS-UHFFFAOYSA-N 4-(dimethylamino)-4-phenylcyclohexane-1-carboxylic acid Chemical compound C=1C=CC=CC=1C1(N(C)C)CCC(C(O)=O)CC1 XKIIHUAHYHZDPS-UHFFFAOYSA-N 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 125000004849 alkoxymethyl group Chemical group 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- DCZFGQYXRKMVFG-UHFFFAOYSA-N cyclohexane-1,4-dione Chemical compound O=C1CCC(=O)CC1 DCZFGQYXRKMVFG-UHFFFAOYSA-N 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000002524 organometallic group Chemical group 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 238000011282 treatment Methods 0.000 description 8
- 208000000094 Chronic Pain Diseases 0.000 description 5
- 108090000137 Opioid Receptors Proteins 0.000 description 3
- 102000003840 Opioid Receptors Human genes 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 2
- 208000005298 acute pain Diseases 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 208000004296 neuralgia Diseases 0.000 description 2
- 230000002981 neuropathic effect Effects 0.000 description 2
- 208000021722 neuropathic pain Diseases 0.000 description 2
- 108010020615 nociceptin receptor Proteins 0.000 description 2
- 229940005483 opioid analgesics Drugs 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 101001122499 Homo sapiens Nociceptin receptor Proteins 0.000 description 1
- 102100028646 Nociceptin receptor Human genes 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 102000051367 mu Opioid Receptors Human genes 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000020341 sensory perception of pain Effects 0.000 description 1
- 108020001612 μ-opioid receptors Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004023632A DE102004023632A1 (de) | 2004-05-10 | 2004-05-10 | Substituierte Cyclohexylcarbonsäure-Derivate |
| DE102004023632.1 | 2004-05-10 | ||
| PCT/EP2005/004908 WO2005110977A1 (de) | 2004-05-10 | 2005-05-06 | Substituierte cyclohexylcarbonsäure-derivate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007536318A JP2007536318A (ja) | 2007-12-13 |
| JP2007536318A5 true JP2007536318A5 (enExample) | 2011-06-23 |
| JP4874237B2 JP4874237B2 (ja) | 2012-02-15 |
Family
ID=34968746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007512028A Expired - Fee Related JP4874237B2 (ja) | 2004-05-10 | 2005-05-06 | 置換されたシクロヘキシルカルボン酸誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7241802B2 (enExample) |
| EP (1) | EP1751095B1 (enExample) |
| JP (1) | JP4874237B2 (enExample) |
| CA (1) | CA2562539C (enExample) |
| DE (1) | DE102004023632A1 (enExample) |
| ES (1) | ES2482109T3 (enExample) |
| PL (1) | PL1751095T3 (enExample) |
| WO (1) | WO2005110977A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103183630A (zh) | 2008-03-27 | 2013-07-03 | 格吕伦塔尔有限公司 | 取代的4-氨基环己烷衍生物 |
| WO2009118163A1 (de) | 2008-03-27 | 2009-10-01 | Grünenthal GmbH | (hetero-)aryl-cyclohexan-derivate |
| PL2271613T3 (pl) * | 2008-03-27 | 2014-09-30 | Gruenenthal Gmbh | Hydroksymetylocykloheksyloaminy |
| JP5597188B2 (ja) | 2008-03-27 | 2014-10-01 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 置換されたスピロ環状シクロヘキサン誘導体 |
| AU2009228643B2 (en) | 2008-03-27 | 2013-07-11 | Grunenthal Gmbh | Spiro(5.5)undecane derivatives |
| US8357705B2 (en) | 2008-03-27 | 2013-01-22 | Gruenenthal Gmbh | Substituted cyclohexyldiamines |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5599898A (en) * | 1996-12-12 | 1998-07-03 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone |
| CA2373855A1 (en) * | 1999-05-12 | 2000-11-23 | Solvay Pharmaceuticals B.V. | Method of treating psychotic disorders |
| GB0012240D0 (en) | 2000-05-19 | 2000-07-12 | Merck Sharp & Dohme | Therapeutic agents |
| AU2001294196B2 (en) | 2000-10-06 | 2005-11-17 | Tanabe Seiyaku Co., Ltd. | Nitrogenous five-membered ring compounds |
| JP4329291B2 (ja) * | 2000-10-06 | 2009-09-09 | 田辺三菱製薬株式会社 | 含窒素五員環化合物 |
| JP4329290B2 (ja) * | 2000-10-06 | 2009-09-09 | 田辺三菱製薬株式会社 | 脂肪族含窒素五員環化合物 |
| ES2188344B1 (es) * | 2000-11-29 | 2004-09-16 | Laboratorios Vita, S.A. | Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos. |
| DE10123163A1 (de) * | 2001-05-09 | 2003-01-16 | Gruenenthal Gmbh | Substituierte Cyclohexan-1,4-diaminderivate |
| CA2467337A1 (en) * | 2001-12-21 | 2003-07-10 | H. Lundbeck A/S | Aminoindane derivatives as serotonin and norepinephrine uptake inhibitors |
| DE10252665A1 (de) * | 2002-11-11 | 2004-06-03 | Grünenthal GmbH | 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate |
| DE10252666A1 (de) * | 2002-11-11 | 2004-08-05 | Grünenthal GmbH | N-Piperidyl-cyclohexan-Derivate |
| DE10252650A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Cyclohexyl-Harnstoff-Derivate |
-
2004
- 2004-05-10 DE DE102004023632A patent/DE102004023632A1/de not_active Withdrawn
-
2005
- 2005-05-06 WO PCT/EP2005/004908 patent/WO2005110977A1/de not_active Ceased
- 2005-05-06 US US11/594,935 patent/US7241802B2/en not_active Expired - Fee Related
- 2005-05-06 CA CA2562539A patent/CA2562539C/en not_active Expired - Fee Related
- 2005-05-06 ES ES05745589.1T patent/ES2482109T3/es not_active Expired - Lifetime
- 2005-05-06 PL PL05745589T patent/PL1751095T3/pl unknown
- 2005-05-06 JP JP2007512028A patent/JP4874237B2/ja not_active Expired - Fee Related
- 2005-05-06 EP EP05745589.1A patent/EP1751095B1/de not_active Expired - Lifetime
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