JP2007513888A5 - - Google Patents

Info

Publication number

JP2007513888A5

JP2007513888A5 JP2006541427A JP2006541427A JP2007513888A5 JP 2007513888 A5 JP2007513888 A5 JP 2007513888A5 JP 2006541427 A JP2006541427 A JP 2006541427A JP 2006541427 A JP2006541427 A JP 2006541427A JP 2007513888 A5 JP2007513888 A5 JP 2007513888A5

Authority

JP

Japan

Prior art keywords

group

aryl

alkyl

bis

independently

Prior art date

2004-11-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

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• 125000003118 aryl group Chemical group 0.000 claims 56
• 125000000217 alkyl group Chemical group 0.000 claims 52
• 229910052739 hydrogen Inorganic materials 0.000 claims 39
• 150000001875 compounds Chemical class 0.000 claims 24
• 239000008194 pharmaceutical composition Substances 0.000 claims 22
• 125000003545 alkoxy group Chemical group 0.000 claims 14
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 12
• -1 (N'-methyl) guanidino-9H-fluorene Chemical compound 0.000 claims 11
• 125000004423 acyloxy group Chemical group 0.000 claims 10
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 10
• 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 10
• 125000004103 aminoalkyl group Chemical group 0.000 claims 10
• 125000003710 aryl alkyl group Chemical group 0.000 claims 10
• 125000000753 cycloalkyl group Chemical group 0.000 claims 10
• 125000005350 hydroxycycloalkyl group Chemical group 0.000 claims 10
• 229910052760 oxygen Inorganic materials 0.000 claims 6
• 229910052757 nitrogen Inorganic materials 0.000 claims 4
• 125000004104 aryloxy group Chemical group 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• PZSWFMXMIRAYBT-UHFFFAOYSA-N 2-(9h-fluoren-1-yl)guanidine Chemical compound C12=CC=CC=C2CC2=C1C=CC=C2N=C(N)N PZSWFMXMIRAYBT-UHFFFAOYSA-N 0.000 claims 2
• VSMIKQGMYDVOEY-UHFFFAOYSA-N 2-[6-(diaminomethylideneamino)acridin-3-yl]guanidine Chemical compound C1=CC(NC(N)=N)=CC2=NC3=CC(NC(=N)N)=CC=C3C=C21 VSMIKQGMYDVOEY-UHFFFAOYSA-N 0.000 claims 2
• ODSIVZAFRQZAQI-UHFFFAOYSA-N 2-[7-(diaminomethylideneamino)-9,10-dioxoanthracen-2-yl]guanidine Chemical compound C1=C(NC(N)=N)C=C2C(=O)C3=CC(NC(=N)N)=CC=C3C(=O)C2=C1 ODSIVZAFRQZAQI-UHFFFAOYSA-N 0.000 claims 2
• OMTZWWSZJUFYDB-UHFFFAOYSA-N 2-[7-(diaminomethylideneamino)-9-oxofluoren-2-yl]guanidine Chemical compound C1=C(NC(N)=N)C=C2C(=O)C3=CC(NC(=N)N)=CC=C3C2=C1 OMTZWWSZJUFYDB-UHFFFAOYSA-N 0.000 claims 2
• WPXDFZVGOJKZMG-UHFFFAOYSA-N 2-[7-(diaminomethylideneamino)-9h-fluoren-2-yl]guanidine Chemical compound NC(=N)NC1=CC=C2C3=CC=C(NC(=N)N)C=C3CC2=C1 WPXDFZVGOJKZMG-UHFFFAOYSA-N 0.000 claims 2
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
• 125000002947 alkylene group Chemical group 0.000 claims 2
• 125000002102 aryl alkyloxo group Chemical group 0.000 claims 2
• 229910052799 carbon Inorganic materials 0.000 claims 2
• 125000001475 halogen functional group Chemical group 0.000 claims 2
• 239000001257 hydrogen Substances 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• PQVUKLNZANQMSV-UHFFFAOYSA-N phenyl-(7-phenyldiazenyl-9h-fluoren-2-yl)diazene Chemical compound C1=C2CC3=CC(N=NC=4C=CC=CC=4)=CC=C3C2=CC=C1N=NC1=CC=CC=C1 PQVUKLNZANQMSV-UHFFFAOYSA-N 0.000 claims 2
• 229910052717 sulfur Inorganic materials 0.000 claims 2
• QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
• CYSPWCARDHRYJX-UHFFFAOYSA-N 9h-fluoren-1-amine Chemical compound C12=CC=CC=C2CC2=C1C=CC=C2N CYSPWCARDHRYJX-UHFFFAOYSA-N 0.000 claims 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 150000002431 hydrogen Chemical class 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 230000000813 microbial effect Effects 0.000 claims 1
• FEWIOGITFAILBH-UHFFFAOYSA-N pyridin-2-yl-[7-(pyridin-2-yldiazenyl)-9h-fluoren-2-yl]diazene Chemical compound C1=C2CC3=CC(N=NC=4N=CC=CC=4)=CC=C3C2=CC=C1N=NC1=CC=CC=N1 FEWIOGITFAILBH-UHFFFAOYSA-N 0.000 claims 1