JP2007513888A5 - - Google Patents
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- Publication number
- JP2007513888A5 JP2007513888A5 JP2006541427A JP2006541427A JP2007513888A5 JP 2007513888 A5 JP2007513888 A5 JP 2007513888A5 JP 2006541427 A JP2006541427 A JP 2006541427A JP 2006541427 A JP2006541427 A JP 2006541427A JP 2007513888 A5 JP2007513888 A5 JP 2007513888A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- aryl
- alkyl
- bis
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003118 aryl group Chemical group 0.000 claims 56
- 125000000217 alkyl group Chemical group 0.000 claims 52
- 229910052739 hydrogen Inorganic materials 0.000 claims 39
- 150000001875 compounds Chemical class 0.000 claims 24
- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 125000003545 alkoxy group Chemical group 0.000 claims 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 12
- -1 (N'-methyl) guanidino-9H-fluorene Chemical compound 0.000 claims 11
- 125000004423 acyloxy group Chemical group 0.000 claims 10
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 10
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 10
- 125000004103 aminoalkyl group Chemical group 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 125000005350 hydroxycycloalkyl group Chemical group 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- PZSWFMXMIRAYBT-UHFFFAOYSA-N 2-(9h-fluoren-1-yl)guanidine Chemical compound C12=CC=CC=C2CC2=C1C=CC=C2N=C(N)N PZSWFMXMIRAYBT-UHFFFAOYSA-N 0.000 claims 2
- VSMIKQGMYDVOEY-UHFFFAOYSA-N 2-[6-(diaminomethylideneamino)acridin-3-yl]guanidine Chemical compound C1=CC(NC(N)=N)=CC2=NC3=CC(NC(=N)N)=CC=C3C=C21 VSMIKQGMYDVOEY-UHFFFAOYSA-N 0.000 claims 2
- ODSIVZAFRQZAQI-UHFFFAOYSA-N 2-[7-(diaminomethylideneamino)-9,10-dioxoanthracen-2-yl]guanidine Chemical compound C1=C(NC(N)=N)C=C2C(=O)C3=CC(NC(=N)N)=CC=C3C(=O)C2=C1 ODSIVZAFRQZAQI-UHFFFAOYSA-N 0.000 claims 2
- OMTZWWSZJUFYDB-UHFFFAOYSA-N 2-[7-(diaminomethylideneamino)-9-oxofluoren-2-yl]guanidine Chemical compound C1=C(NC(N)=N)C=C2C(=O)C3=CC(NC(=N)N)=CC=C3C2=C1 OMTZWWSZJUFYDB-UHFFFAOYSA-N 0.000 claims 2
- WPXDFZVGOJKZMG-UHFFFAOYSA-N 2-[7-(diaminomethylideneamino)-9h-fluoren-2-yl]guanidine Chemical compound NC(=N)NC1=CC=C2C3=CC=C(NC(=N)N)C=C3CC2=C1 WPXDFZVGOJKZMG-UHFFFAOYSA-N 0.000 claims 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- PQVUKLNZANQMSV-UHFFFAOYSA-N phenyl-(7-phenyldiazenyl-9h-fluoren-2-yl)diazene Chemical compound C1=C2CC3=CC(N=NC=4C=CC=CC=4)=CC=C3C2=CC=C1N=NC1=CC=CC=C1 PQVUKLNZANQMSV-UHFFFAOYSA-N 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- CYSPWCARDHRYJX-UHFFFAOYSA-N 9h-fluoren-1-amine Chemical compound C12=CC=CC=C2CC2=C1C=CC=C2N CYSPWCARDHRYJX-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- FEWIOGITFAILBH-UHFFFAOYSA-N pyridin-2-yl-[7-(pyridin-2-yldiazenyl)-9h-fluoren-2-yl]diazene Chemical compound C1=C2CC3=CC(N=NC=4N=CC=CC=4)=CC=C3C2=CC=C1N=NC1=CC=CC=N1 FEWIOGITFAILBH-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52501803P | 2003-11-24 | 2003-11-24 | |
| PCT/US2004/038896 WO2005051296A2 (en) | 2003-11-24 | 2004-11-18 | Fused ring dicationic anti-protozoan agents and their prodrugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007513888A JP2007513888A (ja) | 2007-05-31 |
| JP2007513888A5 true JP2007513888A5 (enExample) | 2007-12-06 |
Family
ID=34632950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006541427A Pending JP2007513888A (ja) | 2003-11-24 | 2004-11-18 | 縮合環ジカチオン性抗原虫剤及びそれらのプロドラッグ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7825279B2 (enExample) |
| EP (1) | EP1689705A4 (enExample) |
| JP (1) | JP2007513888A (enExample) |
| CN (1) | CN1886367A (enExample) |
| AU (1) | AU2004292992A1 (enExample) |
| CA (1) | CA2547972A1 (enExample) |
| WO (1) | WO2005051296A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2687964A1 (en) | 2007-06-01 | 2009-02-19 | The Trustees Of Princeton University | Treatment of viral infections by modulation of host cell metabolic pathways |
| FR2920775B1 (fr) * | 2007-09-07 | 2009-11-06 | Pharma Hydro Dev P H D Soc Par | Nouveaux composes diaminophenothiazine, leur procede de preparation et leurs utilisations. |
| US8277026B2 (en) * | 2008-01-16 | 2012-10-02 | Zamtec Limited | Printhead cartridge insertion protocol |
| CA2934523A1 (en) | 2013-12-24 | 2015-07-02 | University Of Florida Research Foundation, Inc. | Phenazine derivatives as antimicrobial agents |
| WO2017011730A2 (en) * | 2015-07-15 | 2017-01-19 | University Of Florida Research Foundation, Incorporated | Phenazine derivatives as antimicrobial agents |
| WO2018152436A1 (en) | 2017-02-17 | 2018-08-23 | University Of Research Foundation, Incorporated | Phenazine derivatives as antimicrobial agents |
| US12060334B2 (en) | 2021-03-12 | 2024-08-13 | University Of Florida Research Foundation, Incorporated | 3-substituted phenazine derivatives as antimicrobial agents |
| ES2950283B2 (es) | 2022-03-04 | 2024-02-12 | Consejo Superior Investigacion | Compuestos derivados de 4-amino-n-(4-aminofenil)benzamida y analogos y uso de los mismos |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1374695A (en) * | 1919-11-21 | 1921-04-12 | Barrett Co | Catalytic oxidation of fluorene |
| DE1014518B (de) * | 1956-03-09 | 1957-08-29 | Bayer Ag | Verfahren zum Faerben und Bedrucken von Polymerisaten und Mischpolymerisaten des Acrylnitrils bzw. Dicyanaethylens |
| US4141992A (en) * | 1975-08-22 | 1979-02-27 | American Cyanamid Company | Cycloalkylcarboxyamidines and halobenzamidines as anti-amebic agents |
| US5521190A (en) * | 1993-05-27 | 1996-05-28 | Fmc Corporation | Insecticidal pterdines and 8-deazapteridines |
| US5521189A (en) * | 1994-05-06 | 1996-05-28 | The University Of Nc At Ch | Methods of treating pneumocystis carinii pneumonia |
| US5677349A (en) * | 1995-04-27 | 1997-10-14 | Gilad; Gad M. | Agmatine for the treatment of neurotrauma and neurodegenerative diseases |
| US5668167A (en) * | 1995-06-07 | 1997-09-16 | Duke University | Methods of treating microbial infections |
| WO1996040138A1 (en) | 1995-06-07 | 1996-12-19 | The Administrators Of The Tulane Educational Fund | Chloroquine analogs and methods of preventing and treating plasmodial disease |
| US5628984A (en) * | 1995-07-31 | 1997-05-13 | University Of North Carolina At Chapel Hill | Method of detecting lung disease |
| WO2000010990A2 (en) * | 1998-08-20 | 2000-03-02 | University Of North Carolina At Chapel Hill | Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof |
| CA2361734A1 (en) * | 1999-01-26 | 2000-10-12 | Andre Rosowsky | Pharmaceutically active compounds and methods of use thereof |
| FR2796642B1 (fr) * | 1999-07-21 | 2001-10-19 | Centre Nat Rech Scient | Precurseurs de sels de bis-ammonium quaternaire et leurs applications comme prodrogues ayant une activite anti-parasitaire |
| JP2002097133A (ja) * | 2000-07-17 | 2002-04-02 | Shionogi & Co Ltd | トリアゼン化合物を含有する抗マラリア剤および殺線虫剤 |
| EP1545544A2 (en) * | 2002-07-11 | 2005-06-29 | Combinatorx, Incorporated | Combinations of drugs for the treatment of neoplasms |
| US20050054708A1 (en) * | 2003-07-28 | 2005-03-10 | Nichols Matthew James | Combinations of drugs for the treatment of neoplasms |
| ITMI20031754A1 (it) | 2003-09-12 | 2005-03-13 | Fabrizio Marcucci | Composizione microbicida. |
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2004
- 2004-11-18 JP JP2006541427A patent/JP2007513888A/ja active Pending
- 2004-11-18 US US10/992,607 patent/US7825279B2/en not_active Expired - Fee Related
- 2004-11-18 WO PCT/US2004/038896 patent/WO2005051296A2/en not_active Ceased
- 2004-11-18 CN CNA2004800347505A patent/CN1886367A/zh active Pending
- 2004-11-18 EP EP04811591A patent/EP1689705A4/en not_active Withdrawn
- 2004-11-18 AU AU2004292992A patent/AU2004292992A1/en not_active Abandoned
- 2004-11-18 CA CA002547972A patent/CA2547972A1/en not_active Abandoned