JP2007513888A - 縮合環ジカチオン性抗原虫剤及びそれらのプロドラッグ - Google Patents

縮合環ジカチオン性抗原虫剤及びそれらのプロドラッグ Download PDF

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Publication number
JP2007513888A
JP2007513888A JP2006541427A JP2006541427A JP2007513888A JP 2007513888 A JP2007513888 A JP 2007513888A JP 2006541427 A JP2006541427 A JP 2006541427A JP 2006541427 A JP2006541427 A JP 2006541427A JP 2007513888 A JP2007513888 A JP 2007513888A
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aryl
alkyl
bis
formula
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Japanese (ja)
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JP2007513888A5 (enExample
Inventor
ダブリュー． ボイキン ダビド
アール． チドウェル リカルド
ダブリュー． ウィルソン ダビド
ブルン レト
ケー． アラファ レエム
イー． ステプヘンス チャド
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Georgia State University Research Foundation Inc
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Georgia State University Research Foundation Inc
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Publication of JP2007513888A publication Critical patent/JP2007513888A/ja
Publication of JP2007513888A5 publication Critical patent/JP2007513888A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2006541427A 2003-11-24 2004-11-18 縮合環ジカチオン性抗原虫剤及びそれらのプロドラッグ Pending JP2007513888A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52501803P 2003-11-24 2003-11-24
PCT/US2004/038896 WO2005051296A2 (en) 2003-11-24 2004-11-18 Fused ring dicationic anti-protozoan agents and their prodrugs

Publications (2)

Publication Number Publication Date
JP2007513888A true JP2007513888A (ja) 2007-05-31
JP2007513888A5 JP2007513888A5 (enExample) 2007-12-06

Family

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JP2006541427A Pending JP2007513888A (ja) 2003-11-24 2004-11-18 縮合環ジカチオン性抗原虫剤及びそれらのプロドラッグ

Country Status (7)

Country Link
US (1) US7825279B2 (enExample)
EP (1) EP1689705A4 (enExample)
JP (1) JP2007513888A (enExample)
CN (1) CN1886367A (enExample)
AU (1) AU2004292992A1 (enExample)
CA (1) CA2547972A1 (enExample)
WO (1) WO2005051296A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010538051A (ja) * 2007-09-07 2010-12-09 ファルマ イドロ デヴロプマン ペ．アッシュ．デ． 新規なジアミノフェノチアジン化合物、その製造方法、およびその使用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2687964A1 (en) 2007-06-01 2009-02-19 The Trustees Of Princeton University Treatment of viral infections by modulation of host cell metabolic pathways
US8277026B2 (en) * 2008-01-16 2012-10-02 Zamtec Limited Printhead cartridge insertion protocol
CA2934523A1 (en) 2013-12-24 2015-07-02 University Of Florida Research Foundation, Inc. Phenazine derivatives as antimicrobial agents
WO2017011730A2 (en) * 2015-07-15 2017-01-19 University Of Florida Research Foundation, Incorporated Phenazine derivatives as antimicrobial agents
WO2018152436A1 (en) 2017-02-17 2018-08-23 University Of Research Foundation, Incorporated Phenazine derivatives as antimicrobial agents
US12060334B2 (en) 2021-03-12 2024-08-13 University Of Florida Research Foundation, Incorporated 3-substituted phenazine derivatives as antimicrobial agents
ES2950283B2 (es) 2022-03-04 2024-02-12 Consejo Superior Investigacion Compuestos derivados de 4-amino-n-(4-aminofenil)benzamida y analogos y uso de los mismos

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1014518B (de) * 1956-03-09 1957-08-29 Bayer Ag Verfahren zum Faerben und Bedrucken von Polymerisaten und Mischpolymerisaten des Acrylnitrils bzw. Dicyanaethylens
US4141992A (en) * 1975-08-22 1979-02-27 American Cyanamid Company Cycloalkylcarboxyamidines and halobenzamidines as anti-amebic agents
WO2000010990A2 (en) * 1998-08-20 2000-03-02 University Of North Carolina At Chapel Hill Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof
JP2002097133A (ja) * 2000-07-17 2002-04-02 Shionogi & Co Ltd トリアゼン化合物を含有する抗マラリア剤および殺線虫剤
JP2002541144A (ja) * 1999-01-26 2002-12-03 ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド 医薬的に活性のある化合物及びその使用方法
JP2003505357A (ja) * 1999-07-21 2003-02-12 サーントゥル ナシオナル ドゥ ラ ルシェルシュ シャーンティフィク （セ エン エール エス） ビス第４アンモニウム塩の前駆体及び駆虫活性をもつプロドラッグとしてのその応用
JP2005536509A (ja) * 2002-07-11 2005-12-02 コンビナトアールエックス インコーポレーティッド 新生物の治療のための薬物の組み合わせ
JP2007500698A (ja) * 2003-07-28 2007-01-18 コンビナトアールエックス インコーポレーティッド 新生物の治療のための薬物の併用

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US1374695A (en) * 1919-11-21 1921-04-12 Barrett Co Catalytic oxidation of fluorene
US5521190A (en) * 1993-05-27 1996-05-28 Fmc Corporation Insecticidal pterdines and 8-deazapteridines
US5521189A (en) * 1994-05-06 1996-05-28 The University Of Nc At Ch Methods of treating pneumocystis carinii pneumonia
US5677349A (en) * 1995-04-27 1997-10-14 Gilad; Gad M. Agmatine for the treatment of neurotrauma and neurodegenerative diseases
US5668167A (en) * 1995-06-07 1997-09-16 Duke University Methods of treating microbial infections
WO1996040138A1 (en) 1995-06-07 1996-12-19 The Administrators Of The Tulane Educational Fund Chloroquine analogs and methods of preventing and treating plasmodial disease
US5628984A (en) * 1995-07-31 1997-05-13 University Of North Carolina At Chapel Hill Method of detecting lung disease
ITMI20031754A1 (it) 2003-09-12 2005-03-13 Fabrizio Marcucci Composizione microbicida.

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1014518B (de) * 1956-03-09 1957-08-29 Bayer Ag Verfahren zum Faerben und Bedrucken von Polymerisaten und Mischpolymerisaten des Acrylnitrils bzw. Dicyanaethylens
US4141992A (en) * 1975-08-22 1979-02-27 American Cyanamid Company Cycloalkylcarboxyamidines and halobenzamidines as anti-amebic agents
WO2000010990A2 (en) * 1998-08-20 2000-03-02 University Of North Carolina At Chapel Hill Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof
JP2002541144A (ja) * 1999-01-26 2002-12-03 ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド 医薬的に活性のある化合物及びその使用方法
JP2003505357A (ja) * 1999-07-21 2003-02-12 サーントゥル ナシオナル ドゥ ラ ルシェルシュ シャーンティフィク （セ エン エール エス） ビス第４アンモニウム塩の前駆体及び駆虫活性をもつプロドラッグとしてのその応用
JP2002097133A (ja) * 2000-07-17 2002-04-02 Shionogi & Co Ltd トリアゼン化合物を含有する抗マラリア剤および殺線虫剤
JP2005536509A (ja) * 2002-07-11 2005-12-02 コンビナトアールエックス インコーポレーティッド 新生物の治療のための薬物の組み合わせ
JP2007500698A (ja) * 2003-07-28 2007-01-18 コンビナトアールエックス インコーポレーティッド 新生物の治療のための薬物の併用

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JPN6010041102, Ｏｒｇａｎｉｃ Ｐｒｅｐａｒａｔｉｏｎｓ ａｎｄ Ｐｒｏｃｅｄｕｒｅｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ, 2000, ３２（６）, ｐ．５７３−５７７ *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010538051A (ja) * 2007-09-07 2010-12-09 ファルマ イドロ デヴロプマン ペ．アッシュ．デ． 新規なジアミノフェノチアジン化合物、その製造方法、およびその使用

Also Published As

Publication number Publication date
WO2005051296A3 (en) 2005-07-28
EP1689705A2 (en) 2006-08-16
US20050165044A1 (en) 2005-07-28
WO2005051296A2 (en) 2005-06-09
CN1886367A (zh) 2006-12-27
AU2004292992A1 (en) 2005-06-09
US7825279B2 (en) 2010-11-02
CA2547972A1 (en) 2005-06-09
EP1689705A4 (en) 2007-08-29

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