JP2007513131A5 - - Google Patents

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Publication number

JP2007513131A5

JP2007513131A5 JP2006542009A JP2006542009A JP2007513131A5 JP 2007513131 A5 JP2007513131 A5 JP 2007513131A5 JP 2006542009 A JP2006542009 A JP 2006542009A JP 2006542009 A JP2006542009 A JP 2006542009A JP 2007513131 A5 JP2007513131 A5 JP 2007513131A5

Authority

JP

Japan

Prior art keywords

alkyl

formula

substituted

optionally

compound

Prior art date

2004-12-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

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• 125000000217 alkyl group Chemical group 0.000 claims description 12
• 239000001257 hydrogen Substances 0.000 claims description 8
• 229910052739 hydrogen Inorganic materials 0.000 claims description 8
• 150000001875 compounds Chemical class 0.000 claims description 7
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
• 125000001424 substituent group Chemical group 0.000 claims 9
• 125000005843 halogen group Chemical group 0.000 claims 8
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
• 238000000034 method Methods 0.000 claims 6
• 150000003839 salts Chemical class 0.000 claims 6
• 239000012453 solvate Substances 0.000 claims 6
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 3
• JRTCCNKNXFGGJT-UHFFFAOYSA-N 5-[(2,3-difluorophenyl)methylsulfanyl]-7-[(1,3-dihydroxy-2-methylpropan-2-yl)amino]-3h-[1,3]thiazolo[4,5-d]pyrimidin-2-one Chemical compound N=1C=2NC(=O)SC=2C(NC(CO)(CO)C)=NC=1SCC1=CC=CC(F)=C1F JRTCCNKNXFGGJT-UHFFFAOYSA-N 0.000 claims 2
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
• 125000003118 aryl group Chemical group 0.000 claims 2
• 125000004093 cyano group Chemical group *C#N 0.000 claims 2
• 125000001072 heteroaryl group Chemical group 0.000 claims 2
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
• 229910052760 oxygen Inorganic materials 0.000 claims 2
• XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 2
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
• SRHSMXLXWORYJK-SSDOTTSWSA-N 5-[(2,3-difluorophenyl)methylsulfanyl]-7-[[(2r)-1-hydroxypropan-2-yl]amino]-3h-[1,3]thiazolo[4,5-d]pyrimidin-2-one Chemical compound N=1C=2NC(=O)SC=2C(N[C@@H](CO)C)=NC=1SCC1=CC=CC(F)=C1F SRHSMXLXWORYJK-SSDOTTSWSA-N 0.000 claims 1
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
• MBKZGLGIFLDKOD-UHFFFAOYSA-N [N].C1=CSC=N1 Chemical group [N].C1=CSC=N1 MBKZGLGIFLDKOD-UHFFFAOYSA-N 0.000 claims 1
• 150000001412 amines Chemical class 0.000 claims 1
• 125000004429 atom Chemical group 0.000 claims 1
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
• 239000003153 chemical reaction reagent Substances 0.000 claims 1
• 239000000460 chlorine Substances 0.000 claims 1
• 229910052801 chlorine Inorganic materials 0.000 claims 1
• 125000004122 cyclic group Chemical group 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 229910052736 halogen Inorganic materials 0.000 claims 1
• 150000002367 halogens Chemical class 0.000 claims 1
• 125000005842 heteroatom Chemical group 0.000 claims 1
• 125000000623 heterocyclic group Chemical group 0.000 claims 1
• 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 229910052757 nitrogen Inorganic materials 0.000 claims 1
• 239000001301 oxygen Substances 0.000 claims 1
• 125000004430 oxygen atom Chemical group O* 0.000 claims 1
• 125000006239 protecting group Chemical group 0.000 claims 1
• 159000000000 sodium salts Chemical class 0.000 claims 1
• 229910052717 sulfur Inorganic materials 0.000 claims 1
• 0 CC(*)(*)Nc(nc(nc1N2)SCc(cccc3F)c3F)c1SC2=O Chemical compound CC(*)(*)Nc(nc(nc1N2)SCc(cccc3F)c3F)c1SC2=O 0.000 description 2
• 150000002431 hydrogen Chemical group 0.000 description 1