JP2007513091A - 置換された５−アミノ−ピラゾロ−［４，３−ｅ］−１，２，４−トリアゾロ［１，５−ｃ］ピリミジンを調製するための方法 - Google Patents
置換された５−アミノ−ピラゾロ−［４，３−ｅ］−１，２，４−トリアゾロ［１，５−ｃ］ピリミジンを調製するための方法 Download PDFInfo
- Publication number
- JP2007513091A JP2007513091A JP2006541481A JP2006541481A JP2007513091A JP 2007513091 A JP2007513091 A JP 2007513091A JP 2006541481 A JP2006541481 A JP 2006541481A JP 2006541481 A JP2006541481 A JP 2006541481A JP 2007513091 A JP2007513091 A JP 2007513091A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- alkyl
- alkoxy
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 C[n]1ncc2c1nc(N)nc2NNC(*)=O Chemical compound C[n]1ncc2c1nc(N)nc2NNC(*)=O 0.000 description 1
- SKTSVWWOAIAIKI-UHFFFAOYSA-N NNC(c1ccc[o]1)=O Chemical compound NNC(c1ccc[o]1)=O SKTSVWWOAIAIKI-UHFFFAOYSA-N 0.000 description 1
- IIEAJFVQJSLSPU-UHFFFAOYSA-N Nc1nc(Cl)c(C=O)c(NNC(c2ccc[o]2)=O)n1 Chemical compound Nc1nc(Cl)c(C=O)c(NNC(c2ccc[o]2)=O)n1 IIEAJFVQJSLSPU-UHFFFAOYSA-N 0.000 description 1
- CESLYADTBJIPJO-UHFFFAOYSA-N Nc1nc(NNC(c2ccc[o]2)=O)c(cn[n]2CCO)c2n1 Chemical compound Nc1nc(NNC(c2ccc[o]2)=O)c(cn[n]2CCO)c2n1 CESLYADTBJIPJO-UHFFFAOYSA-N 0.000 description 1
- AUFJTVGCSJNQIF-UHFFFAOYSA-N Nc1nc(O)cc(O)n1 Chemical compound Nc1nc(O)cc(O)n1 AUFJTVGCSJNQIF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52592503P | 2003-12-01 | 2003-12-01 | |
| PCT/US2004/039847 WO2005054245A2 (en) | 2003-12-01 | 2004-11-29 | Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007513091A true JP2007513091A (ja) | 2007-05-24 |
| JP2007513091A5 JP2007513091A5 (enExample) | 2007-12-20 |
Family
ID=34652398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006541481A Withdrawn JP2007513091A (ja) | 2003-12-01 | 2004-11-29 | 置換された５−アミノ−ピラゾロ−［４，３−ｅ］−１，２，４−トリアゾロ［１，５−ｃ］ピリミジンを調製するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7235659B2 (enExample) |
| EP (1) | EP1689749B1 (enExample) |
| JP (1) | JP2007513091A (enExample) |
| AT (1) | ATE377599T1 (enExample) |
| CA (1) | CA2547248A1 (enExample) |
| DE (1) | DE602004009962T2 (enExample) |
| ES (1) | ES2293380T3 (enExample) |
| WO (1) | WO2005054245A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI288137B (en) * | 2000-05-26 | 2007-10-11 | Schering Corp | Adenosine A2a receptor antagonists |
| HRP20070063T3 (hr) * | 2003-10-28 | 2007-04-30 | Schering Corporation | POSTUPAK DOBIVANJA SUPSTITUIRANIH 5-AMINOPIRAZOLO[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PIRIMIDINA |
| JPWO2006132275A1 (ja) | 2005-06-07 | 2009-01-08 | 協和醗酵工業株式会社 | 運動障害の予防および／または治療剤 |
| ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
| US8188098B2 (en) | 2008-05-19 | 2012-05-29 | Hoffmann-La Roche Inc. | GPR119 receptor agonists |
| CA2756871A1 (en) | 2009-03-31 | 2010-10-07 | Arqule, Inc. | Substituted heterocyclic compounds |
| WO2012127472A1 (en) * | 2011-03-22 | 2012-09-27 | Mapi Pharma Ltd. | Process and intermediates for the preparation of preladenant and related compounds |
| WO2012129381A1 (en) | 2011-03-22 | 2012-09-27 | Concert Pharmaceuticals Inc. | Deuterated preladenant |
| WO2013024474A1 (en) * | 2011-08-18 | 2013-02-21 | Mapi Phrarma Ltd. | Polymorphs of preladenant |
| AU2019385905B2 (en) | 2018-11-30 | 2023-01-12 | Merck Sharp & Dohme Llc | 9-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1264901B1 (it) | 1993-06-29 | 1996-10-17 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina |
| TWI288137B (en) * | 2000-05-26 | 2007-10-11 | Schering Corp | Adenosine A2a receptor antagonists |
-
2004
- 2004-11-29 AT AT04812380T patent/ATE377599T1/de not_active IP Right Cessation
- 2004-11-29 WO PCT/US2004/039847 patent/WO2005054245A2/en not_active Ceased
- 2004-11-29 EP EP04812380A patent/EP1689749B1/en not_active Expired - Lifetime
- 2004-11-29 DE DE602004009962T patent/DE602004009962T2/de not_active Expired - Lifetime
- 2004-11-29 ES ES04812380T patent/ES2293380T3/es not_active Expired - Lifetime
- 2004-11-29 CA CA002547248A patent/CA2547248A1/en not_active Abandoned
- 2004-11-29 JP JP2006541481A patent/JP2007513091A/ja not_active Withdrawn
- 2004-11-29 US US10/999,048 patent/US7235659B2/en not_active Expired - Fee Related
-
2007
- 2007-05-17 US US11/804,162 patent/US7507822B2/en not_active Expired - Fee Related
-
2009
- 2009-01-27 US US12/360,570 patent/US20090131663A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7507822B2 (en) | 2009-03-24 |
| WO2005054245A3 (en) | 2005-08-11 |
| EP1689749B1 (en) | 2007-11-07 |
| CA2547248A1 (en) | 2005-06-16 |
| ES2293380T3 (es) | 2008-03-16 |
| ATE377599T1 (de) | 2007-11-15 |
| US20060149060A1 (en) | 2006-07-06 |
| US20090131663A1 (en) | 2009-05-21 |
| US20070238874A1 (en) | 2007-10-11 |
| DE602004009962D1 (de) | 2007-12-20 |
| WO2005054245A2 (en) | 2005-06-16 |
| DE602004009962T2 (de) | 2008-08-28 |
| US7235659B2 (en) | 2007-06-26 |
| EP1689749A2 (en) | 2006-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20071105 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20071105 |
|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20101008 |