ES2293380T3 - Procedimiento para preparar 5-amino-pirazolo-(4,3-e)-1,2,4-triazolo(1,5-c)pirimidinas sustituidos. - Google Patents

Procedimiento para preparar 5-amino-pirazolo-(4,3-e)-1,2,4-triazolo(1,5-c)pirimidinas sustituidos. Download PDF

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Publication number
ES2293380T3
ES2293380T3 ES04812380T ES04812380T ES2293380T3 ES 2293380 T3 ES2293380 T3 ES 2293380T3 ES 04812380 T ES04812380 T ES 04812380T ES 04812380 T ES04812380 T ES 04812380T ES 2293380 T3 ES2293380 T3 ES 2293380T3
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ES
Spain
Prior art keywords
formula
compound
baselineskip
alkyl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES04812380T
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English (en)
Spanish (es)
Inventor
Shen-Chun Kuo
Loc Thanh Tran
Pengyi Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2293380T3 publication Critical patent/ES2293380T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ES04812380T 2003-12-01 2004-11-29 Procedimiento para preparar 5-amino-pirazolo-(4,3-e)-1,2,4-triazolo(1,5-c)pirimidinas sustituidos. Expired - Lifetime ES2293380T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52592503P 2003-12-01 2003-12-01
US525925P 2003-12-01

Publications (1)

Publication Number Publication Date
ES2293380T3 true ES2293380T3 (es) 2008-03-16

Family

ID=34652398

Family Applications (1)

Application Number Title Priority Date Filing Date
ES04812380T Expired - Lifetime ES2293380T3 (es) 2003-12-01 2004-11-29 Procedimiento para preparar 5-amino-pirazolo-(4,3-e)-1,2,4-triazolo(1,5-c)pirimidinas sustituidos.

Country Status (8)

Country Link
US (3) US7235659B2 (enExample)
EP (1) EP1689749B1 (enExample)
JP (1) JP2007513091A (enExample)
AT (1) ATE377599T1 (enExample)
CA (1) CA2547248A1 (enExample)
DE (1) DE602004009962T2 (enExample)
ES (1) ES2293380T3 (enExample)
WO (1) WO2005054245A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02011625A (es) * 2000-05-26 2003-03-27 Schering Corp Antagonistas receptores de adenosina a2a.
JP4782693B2 (ja) * 2003-10-28 2011-09-28 シェーリング コーポレイション 置換５−アミノ−ピラゾロ−［４，３−ｅ］−１，２，４−トリアゾロ［１，５−ｃ］ピリミジンを調製するためのプロセス
EP2258372B8 (en) 2005-06-07 2012-12-19 Kyowa Hakko Kirin Co., Ltd. A2A antagonists for use in the treatment of motor disorders
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
US8188098B2 (en) 2008-05-19 2012-05-29 Hoffmann-La Roche Inc. GPR119 receptor agonists
WO2010114894A1 (en) 2009-03-31 2010-10-07 Arqule, Inc. Substituted heterocyclic compounds
WO2012127472A1 (en) * 2011-03-22 2012-09-27 Mapi Pharma Ltd. Process and intermediates for the preparation of preladenant and related compounds
WO2012129381A1 (en) 2011-03-22 2012-09-27 Concert Pharmaceuticals Inc. Deuterated preladenant
WO2013024474A1 (en) * 2011-08-18 2013-02-21 Mapi Phrarma Ltd. Polymorphs of preladenant
US11312719B2 (en) 2018-11-30 2022-04-26 Merck Sharp & Dohme Corp. 9-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264901B1 (it) * 1993-06-29 1996-10-17 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
MXPA02011625A (es) * 2000-05-26 2003-03-27 Schering Corp Antagonistas receptores de adenosina a2a.

Also Published As

Publication number Publication date
DE602004009962T2 (de) 2008-08-28
US20090131663A1 (en) 2009-05-21
WO2005054245A3 (en) 2005-08-11
DE602004009962D1 (de) 2007-12-20
US7507822B2 (en) 2009-03-24
WO2005054245A2 (en) 2005-06-16
JP2007513091A (ja) 2007-05-24
ATE377599T1 (de) 2007-11-15
CA2547248A1 (en) 2005-06-16
US20070238874A1 (en) 2007-10-11
US7235659B2 (en) 2007-06-26
US20060149060A1 (en) 2006-07-06
EP1689749B1 (en) 2007-11-07
EP1689749A2 (en) 2006-08-16

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