JP2007513079A5 - - Google Patents
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- Publication number
- JP2007513079A5 JP2007513079A5 JP2006539072A JP2006539072A JP2007513079A5 JP 2007513079 A5 JP2007513079 A5 JP 2007513079A5 JP 2006539072 A JP2006539072 A JP 2006539072A JP 2006539072 A JP2006539072 A JP 2006539072A JP 2007513079 A5 JP2007513079 A5 JP 2007513079A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- copolymer
- iii
- pharmaceutical composition
- neurodegenerative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000015122 neurodegenerative disease Diseases 0.000 claims 10
- 229920001577 copolymer Polymers 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000013543 active substance Substances 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 102000029797 Prion Human genes 0.000 claims 2
- 108091000054 Prion Proteins 0.000 claims 2
- 238000009825 accumulation Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 206010061818 Disease progression Diseases 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000005750 disease progression Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229930195712 glutamate Natural products 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51862703P | 2003-11-12 | 2003-11-12 | |
| US60/518,627 | 2003-11-12 | ||
| US61096604P | 2004-09-20 | 2004-09-20 | |
| US60/610,966 | 2004-09-20 | ||
| PCT/IL2004/001037 WO2005046719A1 (en) | 2003-11-12 | 2004-11-11 | Vaccine and method for treatment of neurodegenerative diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007513079A JP2007513079A (ja) | 2007-05-24 |
| JP2007513079A5 true JP2007513079A5 (enExample) | 2008-01-10 |
| JP5456235B2 JP5456235B2 (ja) | 2014-03-26 |
Family
ID=34594916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006539072A Expired - Fee Related JP5456235B2 (ja) | 2003-11-12 | 2004-11-11 | 神経変性疾患を治療するためのワクチン及び方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20080085269A1 (enExample) |
| EP (2) | EP2301569B1 (enExample) |
| JP (1) | JP5456235B2 (enExample) |
| AU (1) | AU2004288654B2 (enExample) |
| CA (1) | CA2546077C (enExample) |
| IL (2) | IL175535A (enExample) |
| WO (1) | WO2005046719A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2527760T3 (es) * | 1998-07-23 | 2015-01-29 | Yeda Research And Development Co., Ltd. | Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos |
| EP2301569B1 (en) | 2003-11-12 | 2018-05-02 | Yeda Research and Development Co. Ltd. | Vaccine and method for treatment of neurodegenerative diseases |
| PL1701730T3 (pl) * | 2003-12-09 | 2014-04-30 | Yeda Res & Dev | Sposób i szczepionka zawierająca kopolimer 1 do leczenia zaburzeń psychicznych |
| US8193147B2 (en) | 2007-09-24 | 2012-06-05 | Hadasit Medical Research Services & Development Ltd. | Use of copolymer 1 for treatment of muscular dystrophy |
| WO2010019270A1 (en) * | 2008-08-14 | 2010-02-18 | Isis Pharmaceuticals, Inc. | Modulation of prion expression |
| USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| US8759302B2 (en) | 2010-03-16 | 2014-06-24 | Teva Pharmaceutical Industries, Ltd. | Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis |
| ES2602977T3 (es) | 2010-10-11 | 2017-02-23 | Teva Pharmaceutical Industries Ltd. | Biomarcadores de citocinas como biomarcadores predictivos de la respuesta clínica para acetato de glatirámero |
| WO2012143924A1 (en) | 2011-04-21 | 2012-10-26 | Mapi Pharma Ltd. | Random pentapolymer for treatment of autoimmune diseases |
| TW201326399A (zh) | 2011-10-10 | 2013-07-01 | Teva Pharma | 用於預測對格拉替雷（ｇｌａｔｉｒａｍｅｒ）醋酸鹽之臨床反應之單核苷酸多型性之判定 |
| WO2013059322A2 (en) * | 2011-10-17 | 2013-04-25 | Lawrence Steinman | Amyloid beta peptide as a therapy for inflammation |
| WO2015017280A1 (en) | 2013-07-28 | 2015-02-05 | Qantu Therapeutics, Inc. | Vaccine formulations that induce a th2 immune response |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| ES3040431T3 (en) * | 2014-03-12 | 2025-10-31 | Yeda Res & Dev | Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns |
| US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| WO2017201539A1 (en) * | 2016-05-20 | 2017-11-23 | Cedars-Sinai Medical Center | Methods of treating or preventing alzheimer's disease and associated conditions |
| US12097292B2 (en) | 2016-08-28 | 2024-09-24 | Mapi Pharma Ltd. | Process for preparing microparticles containing glatiramer acetate |
| HRP20250396T1 (hr) | 2016-08-31 | 2025-05-23 | Mapi Pharma Ltd. | Depo sustavi koji sadrže glatiramer acetat |
| AU2018242998B2 (en) | 2017-03-26 | 2023-11-02 | Mapi Pharma Ltd. | Glatiramer depot systems for treating progressive forms of multiple sclerosis |
| MY205095A (en) | 2018-11-21 | 2024-10-01 | Ionis Pharmaceuticals Inc | Compounds and methods for reducing prion expression |
| EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL36670A (en) | 1971-04-21 | 1974-09-10 | Sela M | Therapeutic basic copolymers of amino acids |
| US6071970A (en) | 1993-02-08 | 2000-06-06 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US5800808A (en) | 1994-05-24 | 1998-09-01 | Veda Research And Development Co., Ltd. | Copolymer-1 improvements in compositions of copolymers |
| US6717031B2 (en) | 1995-06-07 | 2004-04-06 | Kate Dora Games | Method for selecting a transgenic mouse model of alzheimer's disease |
| US6794414B1 (en) | 1998-06-17 | 2004-09-21 | Yeda Research And Development Co. Ltd. | Method and compositions for treating diseases mediated by transglutaminase activity |
| WO2000005250A1 (en) | 1998-07-23 | 2000-02-03 | Yeda Research And Development Co., Ltd | Treatment of autoimmune conditions with copolymer 1 and related copolymers and peptides |
| JP2003521448A (ja) | 1998-07-23 | 2003-07-15 | ザ・プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ | 合成ペプチドおよび自己免疫疾患治療のための使用方法 |
| DK1248643T3 (da) * | 2000-01-20 | 2005-11-07 | Yeda Res & Dev | Anvendelse af copolymer 1 og beslægtede peptider og polypeptider og T-celler behandlet dermed til neurobeskyttende terapi |
| US20020037848A1 (en) * | 2000-06-07 | 2002-03-28 | Michal Eisenbach-Schwartz | Use of copolymer 1 and related peptides and polypeptides and T cells treated therewith for neuroprotective therapy |
| IL148202A0 (en) * | 2000-06-20 | 2002-09-12 | Caprion Pharmaceuticals Inc | Copolymers and methods of treating prion-related diseases |
| WO2002092122A2 (en) | 2001-05-17 | 2002-11-21 | Applied Research Systems Ars Holding N.V. | Use of osteopontin for the treatment and/or prevention of neurologic diseases |
| US7718699B1 (en) | 2005-03-04 | 2010-05-18 | Broyles Robert H | Abscissic acid and derivatives thereof for the treatment of diseases |
| PL205469B1 (pl) | 2001-12-06 | 2010-04-30 | Yeda Res & Dev | Zastosowanie Cop 1 |
| EP2301569B1 (en) | 2003-11-12 | 2018-05-02 | Yeda Research and Development Co. Ltd. | Vaccine and method for treatment of neurodegenerative diseases |
| US7220729B2 (en) | 2004-05-10 | 2007-05-22 | Academia Sinica | Huntington's Disease Treatment |
-
2004
- 2004-11-11 EP EP10012062.5A patent/EP2301569B1/en not_active Expired - Lifetime
- 2004-11-11 JP JP2006539072A patent/JP5456235B2/ja not_active Expired - Fee Related
- 2004-11-11 EP EP04799345A patent/EP1684797A1/en not_active Withdrawn
- 2004-11-11 AU AU2004288654A patent/AU2004288654B2/en not_active Ceased
- 2004-11-11 US US10/578,899 patent/US20080085269A1/en not_active Abandoned
- 2004-11-11 CA CA2546077A patent/CA2546077C/en not_active Expired - Fee Related
- 2004-11-11 WO PCT/IL2004/001037 patent/WO2005046719A1/en not_active Ceased
-
2006
- 2006-05-10 IL IL175535A patent/IL175535A/en active IP Right Grant
-
2011
- 2011-04-29 US US13/097,427 patent/US8828404B2/en not_active Expired - Fee Related
-
2013
- 2013-01-24 IL IL224393A patent/IL224393B/en active IP Right Grant
-
2014
- 2014-01-23 US US14/162,482 patent/US9517256B2/en not_active Expired - Fee Related
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