JP2007509057A5 - - Google Patents
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- Publication number
- JP2007509057A5 JP2007509057A5 JP2006535366A JP2006535366A JP2007509057A5 JP 2007509057 A5 JP2007509057 A5 JP 2007509057A5 JP 2006535366 A JP2006535366 A JP 2006535366A JP 2006535366 A JP2006535366 A JP 2006535366A JP 2007509057 A5 JP2007509057 A5 JP 2007509057A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- composition
- optionally substituted
- halogen
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 96
- 125000000217 alkyl group Chemical group 0.000 claims 89
- 229910052736 halogen Inorganic materials 0.000 claims 53
- 125000003710 aryl alkyl group Chemical group 0.000 claims 52
- 150000002367 halogens Chemical class 0.000 claims 46
- 125000003118 aryl group Chemical group 0.000 claims 42
- 125000003545 alkoxy group Chemical group 0.000 claims 41
- 150000001875 compounds Chemical class 0.000 claims 41
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 34
- -1 carbamoylamino, carbamoyloxy Chemical group 0.000 claims 28
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 19
- 125000005843 halogen group Chemical group 0.000 claims 18
- 125000004663 dialkyl amino group Chemical group 0.000 claims 16
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 15
- 125000001424 substituent group Chemical group 0.000 claims 12
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 11
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 10
- 239000004202 carbamide Substances 0.000 claims 10
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 10
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 claims 9
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000003884 phenylalkyl group Chemical group 0.000 claims 8
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 7
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 7
- UJOBWOGCFQCDNV-UHFFFAOYSA-N Carbazole Natural products C1=CC=C2C3=CC=CC=C3NC2=C1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 6
- 208000024891 symptom Diseases 0.000 claims 6
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 5
- 208000036142 Viral infection Diseases 0.000 claims 5
- 125000003282 alkyl amino group Chemical group 0.000 claims 5
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 230000009385 viral infection Effects 0.000 claims 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 4
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 4
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 4
- 125000004962 sulfoxyl group Chemical group 0.000 claims 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- CTSOVTHONJJNSW-UHFFFAOYSA-N 8-amino-9h-carbazole-3-carboxamide Chemical compound C1=CC=C2C3=CC(C(=O)N)=CC=C3NC2=C1N CTSOVTHONJJNSW-UHFFFAOYSA-N 0.000 claims 2
- DAQVEWBELJFYBE-UHFFFAOYSA-N 9h-carbazole-3-carboxamide Chemical compound C1=CC=C2C3=CC(C(=O)N)=CC=C3NC2=C1 DAQVEWBELJFYBE-UHFFFAOYSA-N 0.000 claims 2
- 125000005084 alkoxyalkylaminoalkyl group Chemical group 0.000 claims 2
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 2
- 125000002877 alkyl aryl group Chemical group 0.000 claims 2
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 2
- 125000003368 amide group Chemical group 0.000 claims 2
- 125000005140 aralkylsulfonyl group Chemical group 0.000 claims 2
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 2
- 125000001769 aryl amino group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 150000001540 azides Chemical group 0.000 claims 2
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 150000001716 carbazoles Chemical class 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 150000002170 ethers Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 125000005309 thioalkoxy group Chemical group 0.000 claims 2
- 150000003573 thiols Chemical class 0.000 claims 2
- QQHZPRXFNKGPRL-UHFFFAOYSA-N 2-cyano-n-(6-methyl-2,3,4,9-tetrahydro-1h-carbazol-1-yl)benzamide Chemical compound C1CCC=2C3=CC(C)=CC=C3NC=2C1NC(=O)C1=CC=CC=C1C#N QQHZPRXFNKGPRL-UHFFFAOYSA-N 0.000 claims 1
- XFOLGWDGOBRIFV-UHFFFAOYSA-N 3-fluoro-n-(6-methyl-2,3,4,9-tetrahydro-1h-carbazol-1-yl)benzamide Chemical compound C1CCC=2C3=CC(C)=CC=C3NC=2C1NC(=O)C1=CC=CC(F)=C1 XFOLGWDGOBRIFV-UHFFFAOYSA-N 0.000 claims 1
- RZSABRBSOXDHFP-UHFFFAOYSA-N 6-bromo-n-cyclohexyl-2,3,4,9-tetrahydro-1h-carbazol-1-amine Chemical compound C1CCC=2C3=CC(Br)=CC=C3NC=2C1NC1CCCCC1 RZSABRBSOXDHFP-UHFFFAOYSA-N 0.000 claims 1
- JQXFZHDNOXNLDF-UHFFFAOYSA-N 6-chloro-n-[(4-fluorophenyl)methyl]-2,3,4,9-tetrahydro-1h-carbazol-1-amine Chemical compound C1=CC(F)=CC=C1CNC1C(NC=2C3=CC(Cl)=CC=2)=C3CCC1 JQXFZHDNOXNLDF-UHFFFAOYSA-N 0.000 claims 1
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- VXWKNFYNAXLMPP-UHFFFAOYSA-N n-(3-bicyclo[2.2.1]heptanyl)-6-nitro-2,3,4,9-tetrahydro-1h-carbazol-1-amine Chemical compound C1C(C2)CCC2C1NC1CCCC2=C1NC1=CC=C([N+](=O)[O-])C=C12 VXWKNFYNAXLMPP-UHFFFAOYSA-N 0.000 claims 1
- BEFYBAVDNIRHSD-UHFFFAOYSA-N n-(6-methyl-2,3,4,9-tetrahydro-1h-carbazol-1-yl)-3-(trifluoromethyl)benzamide Chemical compound C1CCC=2C3=CC(C)=CC=C3NC=2C1NC(=O)C1=CC=CC(C(F)(F)F)=C1 BEFYBAVDNIRHSD-UHFFFAOYSA-N 0.000 claims 1
- JFKCRXOEDSALMK-UHFFFAOYSA-N n-[(4-methoxyphenyl)methyl]-6-methyl-2,3,4,9-tetrahydro-1h-carbazol-1-amine Chemical compound C1=CC(OC)=CC=C1CNC1C(NC=2C3=CC(C)=CC=2)=C3CCC1 JFKCRXOEDSALMK-UHFFFAOYSA-N 0.000 claims 1
- 125000005359 phenoxyalkyl group Chemical group 0.000 claims 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51176903P | 2003-10-15 | 2003-10-15 | |
| PCT/US2004/034169 WO2005037791A1 (en) | 2003-10-15 | 2004-10-15 | Compositions and methods for viral inhibition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007509057A JP2007509057A (ja) | 2007-04-12 |
| JP2007509057A5 true JP2007509057A5 (enExample) | 2007-11-22 |
Family
ID=34465275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006535366A Pending JP2007509057A (ja) | 2003-10-15 | 2004-10-15 | ウイルス阻害のための組成物および方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20070276009A1 (enExample) |
| EP (1) | EP1678137A1 (enExample) |
| JP (1) | JP2007509057A (enExample) |
| WO (1) | WO2005037791A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1980672B (zh) | 2004-03-15 | 2011-05-04 | Ptc医疗公司 | 用于抑制血管生成的咔啉衍生物 |
| US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
| US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
| US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
| WO2006012310A2 (en) * | 2004-06-25 | 2006-02-02 | Genzyme Corporation | Carbazole derivatives for treating polycystic kidney disease |
| US20090156621A1 (en) * | 2004-11-22 | 2009-06-18 | Kristian Gudmundsson | Hcv inhibitors |
| US20090170906A1 (en) * | 2004-11-22 | 2009-07-02 | Kristjan Gudmundsson | Hcv inhibitors |
| US20090170923A1 (en) * | 2004-11-22 | 2009-07-02 | Kristjan Gudmundsson | Hcv inhibitors |
| CA2588607A1 (en) | 2004-11-23 | 2006-06-01 | Ptc Therapeutics, Inc. | Carbazole, carboline and indole derivatives useful in the inhibition of vegf production |
| JPWO2006085685A1 (ja) * | 2005-02-09 | 2008-06-26 | 武田薬品工業株式会社 | ピラゾール化合物 |
| US7601856B2 (en) | 2006-07-27 | 2009-10-13 | Wyeth | Benzofurans as potassium ion channel modulators |
| JP5526339B2 (ja) * | 2007-10-26 | 2014-06-18 | 国立大学法人 鹿児島大学 | 複素芳香族化合物を有効成分とする抗ウイルス剤 |
| WO2009103022A1 (en) * | 2008-02-13 | 2009-08-20 | Itherx Pharmaceuticals, Inc. | Derivatives of substituted fused ring cycloindoles and methods of their use |
| WO2009114725A2 (en) | 2008-03-12 | 2009-09-17 | Children's Hospital Medical Center | Mobilization of hematopoietic stem cells |
| RU2436786C1 (ru) * | 2010-07-23 | 2011-12-20 | Александр Васильевич Иващенко | Замещенные индолы, противовирусный активный компонент, способ получения и применения |
| CA2873898A1 (en) * | 2011-08-24 | 2013-02-28 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor compounds |
| WO2013139929A1 (en) * | 2012-03-22 | 2013-09-26 | Ludwig-Maximilians-Universität München | Novel means and methods for treating diseases of the central nervous system, metabolic and cardiac diseases and aging |
| US10028503B2 (en) | 2014-06-18 | 2018-07-24 | Children's Hospital Medical Center | Platelet storage methods and compositions for same |
| US11529354B2 (en) | 2017-09-05 | 2022-12-20 | President And Fellows Of Harvard College | Methods and compositions for the treatment of tuberculosis |
| US10882821B1 (en) | 2017-09-26 | 2021-01-05 | The Board Of Trustees Of The Leland Stanford Junior University | Enantiomeric compound for the reduction of the deleterious activity of extended nucleotide repeat containing genes |
| JP2022516030A (ja) * | 2018-12-18 | 2022-02-24 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 遺伝子を含む伸長ヌクレオチドリピートの有害活性を低下させるための化合物 |
| CN112094223B (zh) * | 2019-06-18 | 2023-09-15 | 华东师范大学 | 一类脲基四氢咔唑类小分子有机化合物及用途 |
| US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
| US20240285598A1 (en) * | 2021-05-28 | 2024-08-29 | Arun K. Ghosh | Compounds for the treatment of sars |
| CN117281120A (zh) * | 2023-10-12 | 2023-12-26 | 兰州大学 | 一种四氢咔唑衍生物在防治农业细菌病害上的用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994027607A1 (fr) * | 1993-05-28 | 1994-12-08 | Seikagaku Corporation | Agent antiviral |
| JPH07188017A (ja) * | 1993-09-30 | 1995-07-25 | Souyaku Gijutsu Kenkyusho:Kk | チアジアゾール誘導体を含有する抗ウイルス剤 |
| JPH07126282A (ja) * | 1993-11-01 | 1995-05-16 | Nippon Kayaku Co Ltd | 新規なチオヌクレオシド誘導体 |
| US6037348A (en) * | 1996-02-09 | 2000-03-14 | Eli Lilly And Company | Inhibition of viral replication |
| DE60001218D1 (de) * | 1999-02-22 | 2003-02-20 | Shire Biochem Inc | [1,8]-naphthyridinderivate derivate mit antiviraler wirkung |
| AU4599601A (en) * | 2000-01-07 | 2001-07-16 | Eli Lilly And Company | Substituted tricyclics |
| EP1248777A2 (en) * | 2000-01-07 | 2002-10-16 | Warner-Lambert Company | Tricyclic compounds with antiviral activity |
| US20020107262A1 (en) * | 2000-12-08 | 2002-08-08 | 3M Innovative Properties Company | Substituted imidazopyridines |
| WO2005005386A1 (en) * | 2003-06-12 | 2005-01-20 | Smithkline Beecham Corporation | Tetrahydrocarbazole derivatives and their pharmaceutical use |
| EP1658068B1 (en) * | 2003-08-26 | 2009-02-18 | Smithkline Beecham Corporation | Novel cycloalkyl[b] condensed indoles |
-
2004
- 2004-10-15 US US10/576,045 patent/US20070276009A1/en not_active Abandoned
- 2004-10-15 JP JP2006535366A patent/JP2007509057A/ja active Pending
- 2004-10-15 WO PCT/US2004/034169 patent/WO2005037791A1/en not_active Ceased
- 2004-10-15 EP EP04795347A patent/EP1678137A1/en not_active Withdrawn
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