WO2009054401A1 - 複素芳香族化合物を有効成分とする抗ウイルス剤 - Google Patents

複素芳香族化合物を有効成分とする抗ウイルス剤 Download PDF

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Publication number
WO2009054401A1
WO2009054401A1 PCT/JP2008/069122 JP2008069122W WO2009054401A1 WO 2009054401 A1 WO2009054401 A1 WO 2009054401A1 JP 2008069122 W JP2008069122 W JP 2008069122W WO 2009054401 A1 WO2009054401 A1 WO 2009054401A1
Authority
WO
WIPO (PCT)
Prior art keywords
atom
nitrogen atom
viral agent
independently represent
active ingredient
Prior art date
Application number
PCT/JP2008/069122
Other languages
English (en)
French (fr)
Inventor
Masanori Baba
Yuichi Hashimoto
Hiroshi Aoyama
Kumiko Sako
Shinichi Sato
Katsuyuki Nagai
Original Assignee
Kagoshima University
Oncolys Biopharma, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kagoshima University, Oncolys Biopharma, Inc. filed Critical Kagoshima University
Priority to JP2009538227A priority Critical patent/JP5526339B2/ja
Priority to US12/739,795 priority patent/US20100256379A1/en
Publication of WO2009054401A1 publication Critical patent/WO2009054401A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

　本発明は、次式(I)： 【化１】 (式中、 Xは、CH、窒素原子、酸素原子又は硫黄原子であり、 Y及びZは、同一又は異なり、窒素原子又はC-R8であって、少なくとも一方は窒素原子であり、 R1～R8は、同一又は異なり、水素原子、直鎖C1-10-炭化水素基、水酸基又は置換若しくは非置換のベンジル基であり、ただし、Xが酸素原子又は硫黄原子の場合には、R5は存在しない)、若しくは 　次式(II)： 【化２】 (式中、 X'は、CH又は窒素原子であり、 Y'及びZ'は、同一又は異なり、窒素原子、N-R9又はC-R8であって、少なくとも一方は窒素原子又はN-R9であり、 R1～R4及びR6～R8は、前記と同一であり、 R9は、水素原子、直鎖C1-10-炭化水素基、水酸基又は置換若しくは非置換のベンジル基であり、 C環は、点線部分に最多二重結合を有する) で示される化合物又はその薬学的に許容される塩を含有する抗ウイルス剤に関する。
PCT/JP2008/069122 2007-10-26 2008-10-22 複素芳香族化合物を有効成分とする抗ウイルス剤 WO2009054401A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009538227A JP5526339B2 (ja) 2007-10-26 2008-10-22 複素芳香族化合物を有効成分とする抗ウイルス剤
US12/739,795 US20100256379A1 (en) 2007-10-26 2008-10-22 Anti-viral agent containing heterocyclic aromatic compound as active ingredient

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-279648 2007-10-26
JP2007279648 2007-10-26
JP2008050771 2008-02-29
JP2008-050771 2008-02-29

Publications (1)

Publication Number Publication Date
WO2009054401A1 true WO2009054401A1 (ja) 2009-04-30

Family

ID=40579505

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/069122 WO2009054401A1 (ja) 2007-10-26 2008-10-22 複素芳香族化合物を有効成分とする抗ウイルス剤

Country Status (3)

Country Link
US (1) US20100256379A1 (ja)
JP (1) JP5526339B2 (ja)
WO (1) WO2009054401A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120178759A1 (en) * 2009-07-28 2012-07-12 Commissariat A L'energie Atomique Et Aux Ene Alt Condensed pyridine derivatives useful as potent inhibitors of the protein kinase ck2
CN110759923A (zh) * 2018-07-26 2020-02-07 上海医药工业研究院 嘧啶并吡咯并哒嗪衍生物、其中间体、制备方法、药物组合物和用途
WO2022194087A1 (en) * 2021-03-16 2022-09-22 Cullgen (Shanghai) , Inc. Modified proteins and protein binders

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037791A1 (en) * 2003-10-15 2005-04-28 Chiron Corporation Compositions and methods for viral inhibition
WO2006118607A2 (en) * 2004-11-22 2006-11-09 Smithkline Beecham Corporation Hcv inhibitors with carbazole structure
WO2006121467A2 (en) * 2004-11-22 2006-11-16 Smithkline Beecham Corporation Tetrahydrocarbazole derivatives for treating flaviridae viruses
WO2006121466A2 (en) * 2004-11-22 2006-11-16 Smithkline Beecham Corporation Hcv inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1268771A (en) * 1968-03-15 1972-03-29 Glaxo Lab Ltd Azacarbazoles
JPS60100576A (ja) * 1983-07-25 1985-06-04 ザ　ボ−ドオブトラステイ−ズ　オブ　ザ　ユニバ−シテイ　オブ　イリノイズ 海洋被嚢類からの抗ビ−ルス性ユ−ジストミン類
BRPI0407052A (pt) * 2003-01-27 2006-01-17 Pfizer Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037791A1 (en) * 2003-10-15 2005-04-28 Chiron Corporation Compositions and methods for viral inhibition
WO2006118607A2 (en) * 2004-11-22 2006-11-09 Smithkline Beecham Corporation Hcv inhibitors with carbazole structure
WO2006121467A2 (en) * 2004-11-22 2006-11-16 Smithkline Beecham Corporation Tetrahydrocarbazole derivatives for treating flaviridae viruses
WO2006121466A2 (en) * 2004-11-22 2006-11-16 Smithkline Beecham Corporation Hcv inhibitors

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120178759A1 (en) * 2009-07-28 2012-07-12 Commissariat A L'energie Atomique Et Aux Ene Alt Condensed pyridine derivatives useful as potent inhibitors of the protein kinase ck2
JP2013500325A (ja) * 2009-07-28 2013-01-07 コミサリア ア レネルジィ アトミーク エ オ ゼネ ルジイ アルテアナティーフ プロテインキナーゼｃｋ２の強力阻害剤として有用な縮合ピリジン誘導体
US8686144B2 (en) * 2009-07-28 2014-04-01 Commissariat a l'Energie Atomique et aux Energie Alternative Condensed pyridine derivatives useful as potent inhibitors of the protein kinase CK2
CN110759923A (zh) * 2018-07-26 2020-02-07 上海医药工业研究院 嘧啶并吡咯并哒嗪衍生物、其中间体、制备方法、药物组合物和用途
CN110759923B (zh) * 2018-07-26 2022-08-30 上海医药工业研究院有限公司 嘧啶并吡咯并哒嗪衍生物、其中间体、制备方法、药物组合物和用途
WO2022194087A1 (en) * 2021-03-16 2022-09-22 Cullgen (Shanghai) , Inc. Modified proteins and protein binders

Also Published As

Publication number Publication date
JPWO2009054401A1 (ja) 2011-03-03
JP5526339B2 (ja) 2014-06-18
US20100256379A1 (en) 2010-10-07

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