JP2007507465A5 - - Google Patents
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- Publication number
- JP2007507465A5 JP2007507465A5 JP2006530262A JP2006530262A JP2007507465A5 JP 2007507465 A5 JP2007507465 A5 JP 2007507465A5 JP 2006530262 A JP2006530262 A JP 2006530262A JP 2006530262 A JP2006530262 A JP 2006530262A JP 2007507465 A5 JP2007507465 A5 JP 2007507465A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- het1
- salts
- oxides
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 21
- -1 benzoimidazolyl Chemical group 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 16
- 150000001204 N-oxides Chemical class 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical group 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 6
- 239000005977 Ethylene Substances 0.000 claims 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 6
- 125000004076 pyridyl group Chemical group 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000001041 indolyl group Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 125000002619 bicyclic group Chemical group 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000002541 furyl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- ZHHLLWPSTIDRGT-UHFFFAOYSA-N 2-[2-(4-methoxypyridin-2-yl)ethyl]-6-pyridin-3-yl-1h-imidazo[4,5-b]pyridine Chemical compound COC1=CC=NC(CCC=2NC3=NC=C(C=C3N=2)C=2C=NC=CC=2)=C1 ZHHLLWPSTIDRGT-UHFFFAOYSA-N 0.000 claims 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 2
- 150000002431 hydrogen Chemical group 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000004174 2-benzimidazolyl group Chemical group [H]N1C(*)=NC2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004244 benzofuran-2-yl group Chemical group [H]C1=C(*)OC2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1
- 125000004532 benzofuran-3-yl group Chemical group O1C=C(C2=C1C=CC=C2)* 0.000 claims 1
- 239000000460 chlorine Chemical group 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 1
- 125000004531 indol-5-yl group Chemical group [H]N1C([H])=C([H])C2=C([H])C(*)=C([H])C([H])=C12 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03022064 | 2003-10-01 | ||
| PCT/EP2004/052376 WO2005030769A1 (en) | 2003-10-01 | 2004-09-30 | Imidazopyridine-derivatives as inducible no-synthase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007507465A JP2007507465A (ja) | 2007-03-29 |
| JP2007507465A5 true JP2007507465A5 (https=) | 2007-11-15 |
Family
ID=34384572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006530262A Withdrawn JP2007507465A (ja) | 2003-10-01 | 2004-09-30 | 誘導性ｎｏシンターゼ阻害剤としてのイミダゾピリジン誘導体 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20080125460A1 (https=) |
| EP (1) | EP1673371B1 (https=) |
| JP (1) | JP2007507465A (https=) |
| KR (1) | KR20060092222A (https=) |
| CN (1) | CN1856494A (https=) |
| AT (1) | ATE403655T1 (https=) |
| AU (1) | AU2004276013A1 (https=) |
| BR (1) | BRPI0414873A (https=) |
| CA (1) | CA2540242A1 (https=) |
| DE (1) | DE602004015628D1 (https=) |
| EA (1) | EA200600609A1 (https=) |
| IL (1) | IL173809A0 (https=) |
| MX (1) | MXPA06003554A (https=) |
| NO (1) | NO20061316L (https=) |
| RS (1) | RS20060195A (https=) |
| WO (1) | WO2005030769A1 (https=) |
| ZA (1) | ZA200601552B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA200600607A1 (ru) | 2003-10-01 | 2006-10-27 | Алтана Фарма Аг | Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы |
| BRPI0414972A (pt) | 2003-10-01 | 2006-11-07 | Altana Pharma Ag | derivados de imidazopiridinas como inibidores de no-sintase induzìvel |
| DE602004014523D1 (de) | 2003-10-01 | 2008-07-31 | Nycomed Gmbh | Imidazoä4,5-büpyridinderivate als inhibitoren der induzierbaren no-synthase |
| RS20060206A (sr) | 2003-10-01 | 2008-08-07 | Altana Pharma Ag., | Derivati aminopiridina kao inhibitori inducibilne no-sintaze |
| WO2009029625A1 (en) * | 2007-08-27 | 2009-03-05 | Kalypsys, Inc. | 4- [heterocyclyl-methyl] -8-fluoro-quinolin-2-ones useful as nitric oxide synthase inhibitors |
| NZ603789A (en) * | 2010-05-26 | 2015-03-27 | Sunovion Pharmaceuticals Inc | Heteroaryl compounds and methods of use thereof |
| CA2889906A1 (en) * | 2012-11-29 | 2014-06-05 | Sunovion Pharmaceuticals Inc. | Triazolo-pyrazine derivatives useful in the treatment of disorders of the central nervous system |
| GB201512635D0 (en) | 2015-07-17 | 2015-08-26 | Ucl Business Plc | Uses of therapeutic compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4045564A (en) * | 1974-02-18 | 1977-08-30 | Ab Hassle | Benzimidazole derivatives useful as gastric acid secretion inhibitors |
| SE418966B (sv) * | 1974-02-18 | 1981-07-06 | Haessle Ab | Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan |
| GB8307865D0 (en) * | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
| AUPP873799A0 (en) * | 1999-02-17 | 1999-03-11 | Fujisawa Pharmaceutical Co., Ltd. | Pyridine compounds |
| NZ535959A (en) * | 2002-03-27 | 2006-05-26 | Altana Pharma Ag | Novel alkoxypyridine-derivatives as selective inhibitors of inducible nitric oxidase synthase NOS |
-
2004
- 2004-09-30 AU AU2004276013A patent/AU2004276013A1/en not_active Abandoned
- 2004-09-30 EA EA200600609A patent/EA200600609A1/ru unknown
- 2004-09-30 MX MXPA06003554A patent/MXPA06003554A/es not_active Application Discontinuation
- 2004-09-30 AT AT04787261T patent/ATE403655T1/de not_active IP Right Cessation
- 2004-09-30 DE DE602004015628T patent/DE602004015628D1/de not_active Expired - Fee Related
- 2004-09-30 WO PCT/EP2004/052376 patent/WO2005030769A1/en not_active Ceased
- 2004-09-30 EP EP04787261A patent/EP1673371B1/en not_active Expired - Lifetime
- 2004-09-30 RS YUP-2006/0195A patent/RS20060195A/sr unknown
- 2004-09-30 CN CNA2004800278191A patent/CN1856494A/zh active Pending
- 2004-09-30 US US10/573,525 patent/US20080125460A1/en not_active Abandoned
- 2004-09-30 KR KR1020067005900A patent/KR20060092222A/ko not_active Withdrawn
- 2004-09-30 CA CA002540242A patent/CA2540242A1/en not_active Abandoned
- 2004-09-30 JP JP2006530262A patent/JP2007507465A/ja not_active Withdrawn
- 2004-09-30 BR BRPI0414873-8A patent/BRPI0414873A/pt not_active IP Right Cessation
-
2006
- 2006-02-19 IL IL173809A patent/IL173809A0/en unknown
- 2006-02-22 ZA ZA200601552A patent/ZA200601552B/en unknown
- 2006-03-23 NO NO20061316A patent/NO20061316L/no not_active Application Discontinuation
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