CN1856494A - 作为诱导型no－合酶抑制剂的咪唑并吡啶类衍生物 - Google Patents

作为诱导型no－合酶抑制剂的咪唑并吡啶类衍生物 Download PDF

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Publication number
CN1856494A
CN1856494A CNA2004800278191A CN200480027819A CN1856494A CN 1856494 A CN1856494 A CN 1856494A CN A2004800278191 A CNA2004800278191 A CN A2004800278191A CN 200480027819 A CN200480027819 A CN 200480027819A CN 1856494 A CN1856494 A CN 1856494A
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CN
China
Prior art keywords
het1
alkyl
compound
pyridin
salt
Prior art date
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Pending
Application number
CNA2004800278191A
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English (en)
Chinese (zh)
Inventor
T·福赫斯
T·马丁
R·贝尔
A·斯特拉布
M·埃尔策
M·勒纳
D·马克斯
W·-R·乌尔里希
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Takeda GmbH
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Altana Pharma AG
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Filing date
Publication date
Application filed by Altana Pharma AG filed Critical Altana Pharma AG
Publication of CN1856494A publication Critical patent/CN1856494A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
CNA2004800278191A 2003-10-01 2004-09-30 作为诱导型no－合酶抑制剂的咪唑并吡啶类衍生物 Pending CN1856494A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03022064.4 2003-10-01
EP03022064 2003-10-01

Publications (1)

Publication Number Publication Date
CN1856494A true CN1856494A (zh) 2006-11-01

Family

ID=34384572

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800278191A Pending CN1856494A (zh) 2003-10-01 2004-09-30 作为诱导型no－合酶抑制剂的咪唑并吡啶类衍生物

Country Status (17)

Country Link
US (1) US20080125460A1 (https=)
EP (1) EP1673371B1 (https=)
JP (1) JP2007507465A (https=)
KR (1) KR20060092222A (https=)
CN (1) CN1856494A (https=)
AT (1) ATE403655T1 (https=)
AU (1) AU2004276013A1 (https=)
BR (1) BRPI0414873A (https=)
CA (1) CA2540242A1 (https=)
DE (1) DE602004015628D1 (https=)
EA (1) EA200600609A1 (https=)
IL (1) IL173809A0 (https=)
MX (1) MXPA06003554A (https=)
NO (1) NO20061316L (https=)
RS (1) RS20060195A (https=)
WO (1) WO2005030769A1 (https=)
ZA (1) ZA200601552B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200600607A1 (ru) 2003-10-01 2006-10-27 Алтана Фарма Аг Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы
BRPI0414972A (pt) 2003-10-01 2006-11-07 Altana Pharma Ag derivados de imidazopiridinas como inibidores de no-sintase induzìvel
DE602004014523D1 (de) 2003-10-01 2008-07-31 Nycomed Gmbh Imidazoä4,5-büpyridinderivate als inhibitoren der induzierbaren no-synthase
RS20060206A (sr) 2003-10-01 2008-08-07 Altana Pharma Ag., Derivati aminopiridina kao inhibitori inducibilne no-sintaze
WO2009029625A1 (en) * 2007-08-27 2009-03-05 Kalypsys, Inc. 4- [heterocyclyl-methyl] -8-fluoro-quinolin-2-ones useful as nitric oxide synthase inhibitors
NZ603789A (en) * 2010-05-26 2015-03-27 Sunovion Pharmaceuticals Inc Heteroaryl compounds and methods of use thereof
CA2889906A1 (en) * 2012-11-29 2014-06-05 Sunovion Pharmaceuticals Inc. Triazolo-pyrazine derivatives useful in the treatment of disorders of the central nervous system
GB201512635D0 (en) 2015-07-17 2015-08-26 Ucl Business Plc Uses of therapeutic compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4045564A (en) * 1974-02-18 1977-08-30 Ab Hassle Benzimidazole derivatives useful as gastric acid secretion inhibitors
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
AUPP873799A0 (en) * 1999-02-17 1999-03-11 Fujisawa Pharmaceutical Co., Ltd. Pyridine compounds
NZ535959A (en) * 2002-03-27 2006-05-26 Altana Pharma Ag Novel alkoxypyridine-derivatives as selective inhibitors of inducible nitric oxidase synthase NOS

Also Published As

Publication number Publication date
EP1673371A1 (en) 2006-06-28
US20080125460A1 (en) 2008-05-29
MXPA06003554A (es) 2006-06-05
BRPI0414873A (pt) 2006-12-12
JP2007507465A (ja) 2007-03-29
DE602004015628D1 (de) 2008-09-18
EA200600609A1 (ru) 2006-10-27
AU2004276013A1 (en) 2005-04-07
ATE403655T1 (de) 2008-08-15
IL173809A0 (en) 2006-07-05
CA2540242A1 (en) 2005-04-07
NO20061316L (no) 2006-03-23
WO2005030769A1 (en) 2005-04-07
RS20060195A (sr) 2008-08-07
KR20060092222A (ko) 2006-08-22
ZA200601552B (en) 2007-04-25
EP1673371B1 (en) 2008-08-06

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