JP2007507465A - 誘導性ｎｏシンターゼ阻害剤としてのイミダゾピリジン誘導体 - Google Patents
誘導性ｎｏシンターゼ阻害剤としてのイミダゾピリジン誘導体 Download PDFInfo
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- JP2007507465A JP2007507465A JP2006530262A JP2006530262A JP2007507465A JP 2007507465 A JP2007507465 A JP 2007507465A JP 2006530262 A JP2006530262 A JP 2006530262A JP 2006530262 A JP2006530262 A JP 2006530262A JP 2007507465 A JP2007507465 A JP 2007507465A
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- pyridin
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- 101710089543 Nitric oxide synthase, inducible Proteins 0.000 title abstract description 30
- 239000003112 inhibitor Substances 0.000 title abstract description 7
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- 150000001875 compounds Chemical class 0.000 claims abstract description 160
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- 150000003839 salts Chemical class 0.000 claims description 69
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- 229910052736 halogen Inorganic materials 0.000 claims description 41
- 150000002367 halogens Chemical group 0.000 claims description 41
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 36
- 239000001257 hydrogen Substances 0.000 claims description 34
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- 239000005977 Ethylene Substances 0.000 claims description 31
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 31
- 125000004076 pyridyl group Chemical group 0.000 claims description 26
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 24
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 24
- 125000001072 heteroaryl group Chemical group 0.000 claims description 23
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 22
- 239000000460 chlorine Chemical group 0.000 claims description 22
- 229910052801 chlorine Inorganic materials 0.000 claims description 22
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 22
- 125000001041 indolyl group Chemical group 0.000 claims description 21
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- 125000001544 thienyl group Chemical group 0.000 claims description 19
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03022064 | 2003-10-01 | ||
| PCT/EP2004/052376 WO2005030769A1 (en) | 2003-10-01 | 2004-09-30 | Imidazopyridine-derivatives as inducible no-synthase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007507465A true JP2007507465A (ja) | 2007-03-29 |
| JP2007507465A5 JP2007507465A5 (https=) | 2007-11-15 |
Family
ID=34384572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006530262A Withdrawn JP2007507465A (ja) | 2003-10-01 | 2004-09-30 | 誘導性ｎｏシンターゼ阻害剤としてのイミダゾピリジン誘導体 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20080125460A1 (https=) |
| EP (1) | EP1673371B1 (https=) |
| JP (1) | JP2007507465A (https=) |
| KR (1) | KR20060092222A (https=) |
| CN (1) | CN1856494A (https=) |
| AT (1) | ATE403655T1 (https=) |
| AU (1) | AU2004276013A1 (https=) |
| BR (1) | BRPI0414873A (https=) |
| CA (1) | CA2540242A1 (https=) |
| DE (1) | DE602004015628D1 (https=) |
| EA (1) | EA200600609A1 (https=) |
| IL (1) | IL173809A0 (https=) |
| MX (1) | MXPA06003554A (https=) |
| NO (1) | NO20061316L (https=) |
| RS (1) | RS20060195A (https=) |
| WO (1) | WO2005030769A1 (https=) |
| ZA (1) | ZA200601552B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA200600607A1 (ru) | 2003-10-01 | 2006-10-27 | Алтана Фарма Аг | Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы |
| BRPI0414972A (pt) | 2003-10-01 | 2006-11-07 | Altana Pharma Ag | derivados de imidazopiridinas como inibidores de no-sintase induzìvel |
| DE602004014523D1 (de) | 2003-10-01 | 2008-07-31 | Nycomed Gmbh | Imidazoä4,5-büpyridinderivate als inhibitoren der induzierbaren no-synthase |
| RS20060206A (sr) | 2003-10-01 | 2008-08-07 | Altana Pharma Ag., | Derivati aminopiridina kao inhibitori inducibilne no-sintaze |
| WO2009029625A1 (en) * | 2007-08-27 | 2009-03-05 | Kalypsys, Inc. | 4- [heterocyclyl-methyl] -8-fluoro-quinolin-2-ones useful as nitric oxide synthase inhibitors |
| NZ603789A (en) * | 2010-05-26 | 2015-03-27 | Sunovion Pharmaceuticals Inc | Heteroaryl compounds and methods of use thereof |
| CA2889906A1 (en) * | 2012-11-29 | 2014-06-05 | Sunovion Pharmaceuticals Inc. | Triazolo-pyrazine derivatives useful in the treatment of disorders of the central nervous system |
| GB201512635D0 (en) | 2015-07-17 | 2015-08-26 | Ucl Business Plc | Uses of therapeutic compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4045564A (en) * | 1974-02-18 | 1977-08-30 | Ab Hassle | Benzimidazole derivatives useful as gastric acid secretion inhibitors |
| SE418966B (sv) * | 1974-02-18 | 1981-07-06 | Haessle Ab | Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan |
| GB8307865D0 (en) * | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
| AUPP873799A0 (en) * | 1999-02-17 | 1999-03-11 | Fujisawa Pharmaceutical Co., Ltd. | Pyridine compounds |
| NZ535959A (en) * | 2002-03-27 | 2006-05-26 | Altana Pharma Ag | Novel alkoxypyridine-derivatives as selective inhibitors of inducible nitric oxidase synthase NOS |
-
2004
- 2004-09-30 AU AU2004276013A patent/AU2004276013A1/en not_active Abandoned
- 2004-09-30 EA EA200600609A patent/EA200600609A1/ru unknown
- 2004-09-30 MX MXPA06003554A patent/MXPA06003554A/es not_active Application Discontinuation
- 2004-09-30 AT AT04787261T patent/ATE403655T1/de not_active IP Right Cessation
- 2004-09-30 DE DE602004015628T patent/DE602004015628D1/de not_active Expired - Fee Related
- 2004-09-30 WO PCT/EP2004/052376 patent/WO2005030769A1/en not_active Ceased
- 2004-09-30 EP EP04787261A patent/EP1673371B1/en not_active Expired - Lifetime
- 2004-09-30 RS YUP-2006/0195A patent/RS20060195A/sr unknown
- 2004-09-30 CN CNA2004800278191A patent/CN1856494A/zh active Pending
- 2004-09-30 US US10/573,525 patent/US20080125460A1/en not_active Abandoned
- 2004-09-30 KR KR1020067005900A patent/KR20060092222A/ko not_active Withdrawn
- 2004-09-30 CA CA002540242A patent/CA2540242A1/en not_active Abandoned
- 2004-09-30 JP JP2006530262A patent/JP2007507465A/ja not_active Withdrawn
- 2004-09-30 BR BRPI0414873-8A patent/BRPI0414873A/pt not_active IP Right Cessation
-
2006
- 2006-02-19 IL IL173809A patent/IL173809A0/en unknown
- 2006-02-22 ZA ZA200601552A patent/ZA200601552B/en unknown
- 2006-03-23 NO NO20061316A patent/NO20061316L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1673371A1 (en) | 2006-06-28 |
| US20080125460A1 (en) | 2008-05-29 |
| MXPA06003554A (es) | 2006-06-05 |
| CN1856494A (zh) | 2006-11-01 |
| BRPI0414873A (pt) | 2006-12-12 |
| DE602004015628D1 (de) | 2008-09-18 |
| EA200600609A1 (ru) | 2006-10-27 |
| AU2004276013A1 (en) | 2005-04-07 |
| ATE403655T1 (de) | 2008-08-15 |
| IL173809A0 (en) | 2006-07-05 |
| CA2540242A1 (en) | 2005-04-07 |
| NO20061316L (no) | 2006-03-23 |
| WO2005030769A1 (en) | 2005-04-07 |
| RS20060195A (sr) | 2008-08-07 |
| KR20060092222A (ko) | 2006-08-22 |
| ZA200601552B (en) | 2007-04-25 |
| EP1673371B1 (en) | 2008-08-06 |
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