JP2014520885A5 - - Google Patents

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Publication number
JP2014520885A5
JP2014520885A5 JP2014521703A JP2014521703A JP2014520885A5 JP 2014520885 A5 JP2014520885 A5 JP 2014520885A5 JP 2014521703 A JP2014521703 A JP 2014521703A JP 2014521703 A JP2014521703 A JP 2014521703A JP 2014520885 A5 JP2014520885 A5 JP 2014520885A5
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JP
Japan
Prior art keywords
methyloxy
membered
pyrrolidin
oxo
acceptable salt
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JP2014521703A
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English (en)
Japanese (ja)
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JP5987220B2 (ja
JP2014520885A (ja
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Priority claimed from PCT/US2012/047024 external-priority patent/WO2013012844A1/en
Publication of JP2014520885A publication Critical patent/JP2014520885A/ja
Publication of JP2014520885A5 publication Critical patent/JP2014520885A5/ja
Application granted granted Critical
Publication of JP5987220B2 publication Critical patent/JP5987220B2/ja
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JP2014521703A 2011-07-19 2012-07-17 ロイコトリエンａ４ヒドロラーゼの阻害剤としてのアリールピラゾールエーテル Active JP5987220B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161509155P 2011-07-19 2011-07-19
US61/509,155 2011-07-19
PCT/US2012/047024 WO2013012844A1 (en) 2011-07-19 2012-07-17 Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase

Publications (3)

Publication Number Publication Date
JP2014520885A JP2014520885A (ja) 2014-08-25
JP2014520885A5 true JP2014520885A5 (https=) 2015-09-03
JP5987220B2 JP5987220B2 (ja) 2016-09-07

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ID=46551949

Family Applications (1)

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JP2014521703A Active JP5987220B2 (ja) 2011-07-19 2012-07-17 ロイコトリエンａ４ヒドロラーゼの阻害剤としてのアリールピラゾールエーテル

Country Status (4)

Country Link
US (1) US9139567B2 (https=)
EP (1) EP2734516B1 (https=)
JP (1) JP5987220B2 (https=)
WO (1) WO2013012844A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103415513B (zh) 2011-03-14 2016-01-20 勃林格殷格翰国际有限公司 白三烯产物的苯并二氧杂环己烷抑制剂
WO2013012844A1 (en) 2011-07-19 2013-01-24 Boehringer Ingelheim International Gmbh Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase
JP6080227B2 (ja) 2012-03-06 2017-02-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成を阻害するためのベンゾジオキサン
US9662339B2 (en) 2012-03-06 2017-05-30 Boehringer Ingelheim International Gmbh Benzodioxane inhibitors of leukotriene production for combination therapy
WO2013142369A1 (en) 2012-03-23 2013-09-26 The Board Of Trustees Of The Leland Stanford Junior University Treatment of pulmonary hypertension with leukotriene inhibitors
AR091786A1 (es) * 2012-07-17 2015-02-25 Boehringer Ingelheim Int Inhibidores de la produccion de leucotrienos
WO2015009611A1 (en) * 2013-07-15 2015-01-22 Boehringer Ingelheim International Gmbh Inhibitors of leukotriene production
WO2015009609A1 (en) * 2013-07-15 2015-01-22 Boehringer Ingelheim International Gmbh Inhibitors of leukotriene production
US11098026B2 (en) * 2017-03-13 2021-08-24 Impetis Biosciences Limited Fused bicyclic compounds, compositions and applications thereof
GB201815018D0 (en) * 2018-09-14 2018-10-31 Univ Oxford Innovation Ltd Enantiomeric compounds
TWI828839B (zh) * 2019-01-11 2024-01-11 瑞士商諾華公司 使用lta4h抑制劑治療化膿性汗腺炎之方法
JP7545570B2 (ja) 2020-08-14 2024-09-04 ノバルティス アーゲー ヘテロアリール置換スピロピペリジニル誘導体及びその薬学的使用
AU2022376563A1 (en) 2021-11-01 2023-12-07 Alkahest, Inc. Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases

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US4918092A (en) 1983-12-21 1990-04-17 Merck Frosst Canada, Inc. Leukotriene antagonists
US5120758A (en) 1991-02-08 1992-06-09 Ciba-Geigy Corporation Certain benzodioxole, benzodioxane and benzodioxepin derivatives useful as 5-lipoxygenase inhibitors
US6506876B1 (en) 1994-10-11 2003-01-14 G.D. Searle & Co. LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
US5585492A (en) 1994-10-11 1996-12-17 G. D. Searle & Co. LTA4 Hydrolase inhibitors
DE19821003A1 (de) 1998-05-11 1999-11-18 Dresden Arzneimittel Neue 1,2,5-trisubstituierte 1,2-dihydro-indazol-3-one mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
IL154946A0 (en) * 2000-10-26 2003-10-31 Pfizer Prod Inc Pyrimidine-2,4,6-trione metalloproteinase inhibitors
US20060019269A1 (en) 2002-10-17 2006-01-26 Decode Genetics, Inc. Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
KR100897642B1 (ko) 2002-12-20 2009-05-14 글락소 그룹 리미티드 신경 장애 치료용 벤즈아제핀 유도체
US7098222B2 (en) 2004-05-12 2006-08-29 Abbott Laboratories Bicyclic-substituted amines having cyclic-substituted monocyclic substituents
KR100896380B1 (ko) 2005-01-07 2009-05-08 화이자 프로덕츠 인코포레이티드 헤테로방향족 퀴놀린 화합물 및 ｐｄｅ10 저해제로서의그의 용도
CA2603122A1 (en) 2005-03-31 2006-10-05 Janssen Pharmaceutica N.V. Phenyl and pyridyl lta4h modulators
JP5133889B2 (ja) * 2005-09-21 2013-01-30 デコード ジェネティクス イーエイチエフ 炎症治療のためのビアリール基置換複素環ｌｔａ４ｈ阻害剤
CA2634699A1 (en) 2005-12-21 2007-06-28 Decode Genetics Ehf N-linked aryl heteroaryl inhibitors of lta4h for treating inflammation
CA2636929A1 (en) 2005-12-21 2007-07-12 Decode Genetics, Ehf Biaryl nitrogen heterocycle inhibitors of lta4h for treating inflammation
EP1963261A1 (en) * 2005-12-21 2008-09-03 Decode Genetics EHF Biaryl substituted nitrogen containing heterocycle inhibitors of lta4h for treating inflammation
CN102946877B (zh) 2010-03-18 2019-07-05 香港科技大学 乳突果及其分离的化合物在制备用于治疗神经疾病的药物中的用途
CN103415513B (zh) 2011-03-14 2016-01-20 勃林格殷格翰国际有限公司 白三烯产物的苯并二氧杂环己烷抑制剂
WO2013012844A1 (en) 2011-07-19 2013-01-24 Boehringer Ingelheim International Gmbh Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase
JP6080227B2 (ja) 2012-03-06 2017-02-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成を阻害するためのベンゾジオキサン
US9662339B2 (en) 2012-03-06 2017-05-30 Boehringer Ingelheim International Gmbh Benzodioxane inhibitors of leukotriene production for combination therapy
AR091786A1 (es) 2012-07-17 2015-02-25 Boehringer Ingelheim Int Inhibidores de la produccion de leucotrienos

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