JP2014520885A5 - - Google Patents

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Publication number
JP2014520885A5
JP2014520885A5 JP2014521703A JP2014521703A JP2014520885A5 JP 2014520885 A5 JP2014520885 A5 JP 2014520885A5 JP 2014521703 A JP2014521703 A JP 2014521703A JP 2014521703 A JP2014521703 A JP 2014521703A JP 2014520885 A5 JP2014520885 A5 JP 2014520885A5
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JP
Japan
Prior art keywords
methyloxy
membered
pyrrolidin
oxo
acceptable salt
Prior art date
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JP2014521703A
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English (en)
Japanese (ja)
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JP2014520885A (ja
JP5987220B2 (ja
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Priority claimed from PCT/US2012/047024 external-priority patent/WO2013012844A1/en
Publication of JP2014520885A publication Critical patent/JP2014520885A/ja
Publication of JP2014520885A5 publication Critical patent/JP2014520885A5/ja
Application granted granted Critical
Publication of JP5987220B2 publication Critical patent/JP5987220B2/ja
Active legal-status Critical Current
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JP2014521703A 2011-07-19 2012-07-17 ロイコトリエンａ４ヒドロラーゼの阻害剤としてのアリールピラゾールエーテル Active JP5987220B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161509155P 2011-07-19 2011-07-19
US61/509,155 2011-07-19
PCT/US2012/047024 WO2013012844A1 (en) 2011-07-19 2012-07-17 Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase

Publications (3)

Publication Number Publication Date
JP2014520885A JP2014520885A (ja) 2014-08-25
JP2014520885A5 true JP2014520885A5 (https=) 2015-09-03
JP5987220B2 JP5987220B2 (ja) 2016-09-07

Family

ID=46551949

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014521703A Active JP5987220B2 (ja) 2011-07-19 2012-07-17 ロイコトリエンａ４ヒドロラーゼの阻害剤としてのアリールピラゾールエーテル

Country Status (4)

Country Link
US (1) US9139567B2 (https=)
EP (1) EP2734516B1 (https=)
JP (1) JP5987220B2 (https=)
WO (1) WO2013012844A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2835617C (en) 2011-03-14 2020-07-21 Boehringer Ingelheim International Gmbh Benzodioxane inhibitors of leukotriene production
EP2734516B1 (en) 2011-07-19 2015-06-17 Boehringer Ingelheim International GmbH Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase
NZ628587A (en) 2012-03-06 2016-07-29 Boehringer Ingelheim Int Benzodioxanes in combination with other actives for inhibiting leukotriene production
TW201350474A (zh) 2012-03-06 2013-12-16 Boehringer Ingelheim Int 白三烯素生成之苯并二噁烷抑制劑
US9233089B2 (en) 2012-03-23 2016-01-12 The Board Of Trustees Of The Leland Stanford Junior University Treatment of pulmonary hypertension with leukotriene inhibitors
US9403830B2 (en) 2012-07-17 2016-08-02 Boehringer Ingelheim International Gmbh Inhibitors of leukotriene production
JP2016523982A (ja) * 2013-07-15 2016-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成の阻害剤
JP6353899B2 (ja) * 2013-07-15 2018-07-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成の阻害剤
US11098026B2 (en) * 2017-03-13 2021-08-24 Impetis Biosciences Limited Fused bicyclic compounds, compositions and applications thereof
GB201815018D0 (en) * 2018-09-14 2018-10-31 Univ Oxford Innovation Ltd Enantiomeric compounds
US20220117949A1 (en) * 2019-01-11 2022-04-21 Novartis Ag Lta4h inhibitors for the treatment of hidradenitis suppurativa
MX2023001725A (es) 2020-08-14 2023-02-22 Novartis Ag Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmaceuticos de los mismos.
AU2022376563A1 (en) 2021-11-01 2023-12-07 Alkahest, Inc. Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
US4918092A (en) 1983-12-21 1990-04-17 Merck Frosst Canada, Inc. Leukotriene antagonists
US5120758A (en) 1991-02-08 1992-06-09 Ciba-Geigy Corporation Certain benzodioxole, benzodioxane and benzodioxepin derivatives useful as 5-lipoxygenase inhibitors
US5585492A (en) 1994-10-11 1996-12-17 G. D. Searle & Co. LTA4 Hydrolase inhibitors
US6506876B1 (en) 1994-10-11 2003-01-14 G.D. Searle & Co. LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
DE19821003A1 (de) 1998-05-11 1999-11-18 Dresden Arzneimittel Neue 1,2,5-trisubstituierte 1,2-dihydro-indazol-3-one mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
HUP0302337A3 (en) 2000-10-26 2004-01-28 Pfizer Prod Inc Pyrimidine-2,4,6-trione metalloproteinase inhibitors, pharmaceutical compositions containing them and their use
US20060019269A1 (en) 2002-10-17 2006-01-26 Decode Genetics, Inc. Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
EP2133340B1 (en) 2002-12-20 2013-01-16 Glaxo Group Limited Novel benzazepine derivatives
US7098222B2 (en) 2004-05-12 2006-08-29 Abbott Laboratories Bicyclic-substituted amines having cyclic-substituted monocyclic substituents
UA86283C2 (uk) 2005-01-07 2009-04-10 Пфайзер Продактс Инк. Гетероароматичні сполуки хіноліну і їх застосування як інгібіторів pde10
US20060223792A1 (en) 2005-03-31 2006-10-05 Butler Christopher R Phenyl and pyridyl LTA4H modulators
US20070078263A1 (en) 2005-09-21 2007-04-05 Decode Chemistry, Inc. Biaryl substituted heterocycle inhibitors of lta4h for treating inflammation
AU2006327245A1 (en) * 2005-12-21 2007-06-28 Decode Genetics Ehf Biaryl substituted nitrogen containing heterocycle inhibitors of LTA4H for treating inflammation
US7750012B2 (en) 2005-12-21 2010-07-06 Decode Genetics Ehf Biaryl nitrogen-heterocycle inhibitors of LTA4H for treating inflammation
CA2634699A1 (en) 2005-12-21 2007-06-28 Decode Genetics Ehf N-linked aryl heteroaryl inhibitors of lta4h for treating inflammation
GB2494787B (en) 2010-03-18 2018-10-17 Univ Hong Kong Sci & Tech Neuro-protective effects of adelostemma gracillimum and its isolated compounds
CA2835617C (en) 2011-03-14 2020-07-21 Boehringer Ingelheim International Gmbh Benzodioxane inhibitors of leukotriene production
EP2734516B1 (en) 2011-07-19 2015-06-17 Boehringer Ingelheim International GmbH Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase
NZ628587A (en) 2012-03-06 2016-07-29 Boehringer Ingelheim Int Benzodioxanes in combination with other actives for inhibiting leukotriene production
TW201350474A (zh) 2012-03-06 2013-12-16 Boehringer Ingelheim Int 白三烯素生成之苯并二噁烷抑制劑
US9403830B2 (en) 2012-07-17 2016-08-02 Boehringer Ingelheim International Gmbh Inhibitors of leukotriene production

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