JP2007505107A - 親水性担体及びシリコーンマトリックスを含む局所用製剤 - Google Patents
親水性担体及びシリコーンマトリックスを含む局所用製剤 Download PDFInfo
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Abstract
【選択図】なし
Description
Claims (36)
- 内相及び外相を含む局所用製剤であって:内相は外相内に分散しており;内相は、少なくとも1つの親水性担体及び壊死組織を除去するために外相から放出可能な少なくとも1つの活性物質を含み;外相はシリコーンマトリックスを含み;皮膚に適用したときに湿潤環境を促進させるために液体に対して密閉されている、前記局所用製剤。
- 少なくとも1つの活性物質が親水性である、請求項1に記載の局所用製剤。
- 内相は外相内に分散している液滴で構成され、液滴の直径は約0.1〜約2000μm、又は約0.1〜約1000μm、又は約0.1〜約500μmである、請求項1に記載の局所用製剤。
- 液滴の直径が約0.1〜約200μm、又は約0.1〜約100μm、又は約0.1〜約50μm、又は約0.1〜約10μm、又は約0.1〜約5μmである、請求項1に記載の局所用製剤。
- 少なくとも1つの親水性担体が、プロピレングリコール、ポリエチレングリコール、ポロキサマー、グリセリン、アルコール、多価アルコール、及び水、並びにそれらの組み合わせから選択される、請求項1に記載の局所用製剤。
- 少なくとも1つの親水性担体がポリプロピレングリコールを含む、請求項1に記載の局所用製剤。
- 少なくとも1つの親水性担体が局所用製剤の約50重量%以下で含まれる、請求項1に記載の局所用製剤。
- 少なくとも1つの活性物質が、ヒドロラーゼ、クチナーゼ、オキシダーゼ、トランスフェラーゼ、レダクターゼ、ヘミセルラーゼ、エステラーゼ、イソメラーゼ、ペクチナーゼ、ラクターゼ、ペルオキシダーゼ、ラッカーゼ、カタラーゼ、ポリペプチド、抗体、ペプチド、ホルモン、サイトカイン、及び成長因子、並びにそれらの組み合わせから選択される少なくとも1つの酵素を含む、請求項1に記載の局所用製剤。
- 少なくとも1つの活性物質が少なくとも1つのヒドロラーゼを含む、請求項1に記載の局所用製剤。
- ヒドロラーゼがリパーゼ及びプロテアーゼから選択される、請求項9に記載の局所用製剤。
- プロテアーゼが、サブチリシンプロテアーゼ、プロテアーゼA、プロテアーゼB、又はLG12から選択される、請求項10に記載の局所用製剤。
- ヒドロラーゼがリパーゼを含み、リパーゼがシリコーンマトリックスの約0.0001〜約0.2重量%で含まれる、請求項9に記載の局所用製剤。
- ヒドロラーゼがプロテアーゼを含み、プロテアーゼ濃度が局所用製剤の約0.1〜約5.0mg/gである、請求項9に記載の局所用製剤。
- 内相が少なくとも1つの親水性成分を更に含む、請求項1に記載の局所用製剤。
- 少なくとも1つの親水性成分が、ポリビニルアルコール及びポリビニルピロリドン並びにそれらの組み合わせから選択される、請求項14に記載の局所用製剤。
- 少なくとも1つの親水性成分が、内相の約50重量%以下、又は約35重量%以下で含まれる、請求項15に記載の局所用製剤。
- 少なくとも1つの親水性成分が、局所用製剤の約5〜約40重量%、又は約10〜約35重量%、又は約15〜約35重量%で含まれる、請求項14に記載の局所用製剤。
- 少なくとも1つの親水性成分が、水性増粘剤を含む、請求項14に記載の局所用製剤。
- シリコーンマトリックスが、高分子量ポリジメチルシロキサン、ゆるく又は軽く架橋したシリコーンエラストマー、充填剤のないエラストマー、細胞性エラストマー、シリコーンゴム、シリコーン系粘着剤、及びそれらの組み合わせから選択される、請求項1に記載の局所用製剤。
- 外相がシリコーン系界面活性剤を更に含む、請求項1に記載の局所用製剤。
- 内相及び外相が、局所用製剤が局所包帯剤を構成するように選択され、局所包帯剤はパッチを構成する、請求項1に記載の局所用製剤。
- パッチの厚さが約25μm以下である、請求項21に記載の局所用製剤。
- 外相がゆるく又は軽く架橋したシリコーンエラストマーを含む、請求項21に記載の局所用製剤。
- 内相がプロピレングリコール及びプロテアーゼを含む、請求項23に記載の局所用製剤。
- 内相が、ポリビニルアルコール及びポリビニルプロピレンから選択される親水性成分を更に含む、請求項24に記載の局所用製剤。
- 内相及び外相が、局所用製剤が局所包帯剤を構成するように選択され、局所包帯剤は塗布剤付きフィルムを構成する、請求項1に記載の局所用製剤。
- 外相がシリコーンゴムを含む、請求項26に記載の局所用製剤。
- 内相及び外相が、局所用製剤が軟膏を構成するように選択される、請求項1に記載の局所用製剤。
- 外相が、少なくとも1つのシリコーンエラストマー及び少なくとも1つのシリコーン系界面活性剤を含む、請求項28に記載の局所用製剤。
- 内相が活性物質及びプロピレングリコールを含む、請求項29に記載の局所用製剤。
- 内相がポリビニルアルコールを更に含む、請求項30に記載の局所用製剤。
- 活性物質を局所的に提供する方法であって:
内相及び外相を含む、液体に対して密閉された局所用製剤を提供し、ここで、内相は外相内に分散しており、内相は少なくとも1つの親水性担体及び壊死組織を除去するために外相から放出可能な少なくとも1つの活性物質を含み、外相はシリコーンマトリックスを含む;
活性物質がシリコーンマトリックスから患者の皮膚に局所的に放出されるように局所用製剤を患者の皮膚に接触させる、
ことを含む、前記方法。 - 内相は親水性成分を更に含み、親水性成分は、活性物質が所望の速度でシリコーンマトリックスから放出されるように選択される、請求項32に記載の方法。
- 局所用製剤は厚みを有するパッチを構成し、パッチの厚さは、活性物質が所望の速度でシリコーンマトリックスから放出されるように選択される、請求項32に記載の方法。
- 液体に対する密閉性は、局所用製剤に覆われた壊死組織の膨潤を可能にする湿潤環境を促進させて、壊死組織が膨潤し;そして、シリコーンマトリックスから放出される活性物質は、膨潤した壊死組織を選択的に除去する、請求項32に記載の方法。
- 内相及び外相を含む第2の局所用製剤を提供し、ここで、内相は外相内に分散しており、内相は少なくとも1つの親水性担体と壊死組織を除去するために選択された活性物質を阻害するように選択された少なくとも1つの第2の活性物質とを含み、外相はシリコーン接着剤を含むシリコーンマトリックスを含む;
第2の局所用製剤を、患者の皮膚にある創傷周辺の皮膚におき;そして
局所用製剤を第2の局所用製剤に接触させることによって局所用製剤を創傷に接着させ、創傷周辺の患者の皮膚は、壊死組織を除去するために選択された活性物質から保護される、
ことを更に含む、請求項35に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US10/660,101 | 2003-09-10 | ||
US10/660,101 US7223386B2 (en) | 2002-03-11 | 2003-09-10 | Preparations for topical skin use and treatment |
PCT/US2004/026218 WO2005025548A1 (en) | 2003-09-10 | 2004-08-13 | Topical preparations comprising a hydrophilic carrier and a silicone matrix |
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JP2007505107A true JP2007505107A (ja) | 2007-03-08 |
JP4993184B2 JP4993184B2 (ja) | 2012-08-08 |
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JP2006526089A Expired - Fee Related JP4993184B2 (ja) | 2003-09-10 | 2004-08-13 | 親水性担体及びシリコーンマトリックスを含む局所用製剤 |
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US (3) | US7223386B2 (ja) |
EP (1) | EP1663177B1 (ja) |
JP (1) | JP4993184B2 (ja) |
KR (1) | KR101121461B1 (ja) |
CN (1) | CN1849114B (ja) |
AT (1) | ATE460929T1 (ja) |
CA (1) | CA2537250C (ja) |
DE (1) | DE602004026080D1 (ja) |
WO (1) | WO2005025548A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006111630A (ja) * | 2004-10-18 | 2006-04-27 | Amorepacific Corp | 皮膚保湿用化粧料組成物 |
JP2013512965A (ja) * | 2009-12-08 | 2013-04-18 | ヘルスポイント リミテッド | 増幅された酵素活性の酵素創傷壊死組織除去組成物 |
JP2017530165A (ja) * | 2014-10-10 | 2017-10-12 | ロチャル インダストリーズ,エルエルシー | 酵素による創傷清拭のための組成物とキット、およびそれを用いた方法 |
JP2017530164A (ja) * | 2014-10-10 | 2017-10-12 | ロチャル インダストリーズ,エルエルシー | 掻痒治療用の組成物とキット及びそれらの使用方法 |
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Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1677762A1 (en) * | 2003-10-27 | 2006-07-12 | Dow Corning Corporation | A controlled-release composition for topical application and a method of delivering an active agent to a substrate |
US20070218115A1 (en) * | 2003-10-27 | 2007-09-20 | Bott Richard R | Preparation for Topical Application and Methods of Delivering an Active Agent to a Substrate |
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US8034323B2 (en) * | 2005-12-21 | 2011-10-11 | Avon Products, Inc. | Cosmetic compositions having in-situ silicone condensation cross-linking |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000103735A (ja) * | 1998-09-29 | 2000-04-11 | L'oreal Sa | アスコルビン酸を安定化するためのシリコ―ンゴムの使用およびこれらの成分を含有する新規組成物 |
JP2000319515A (ja) * | 1999-04-28 | 2000-11-21 | Dow Corning Corp | エラストマーシリコーンターポリマー組成物 |
JP2001278738A (ja) * | 2000-03-30 | 2001-10-10 | Kose Corp | 油中水型乳化化粧料 |
JP2005528425A (ja) * | 2002-03-11 | 2005-09-22 | ダウ・コーニング・コーポレーション | 局所皮膚使用及び治療用製剤 |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2736721A (en) * | 1952-10-08 | 1956-02-28 | Optionally | |
US2814601A (en) * | 1954-04-29 | 1957-11-26 | Dow Corning | Organopolysiloxane adhesive and pressure-sensitive adhesive tape containing same |
DE1017883B (de) * | 1954-07-08 | 1957-10-17 | Fellows Gear Shaper Co | Schalt- und Vorschubeinrichtung fuer Zahnradherstellungsmaschinen |
US3528940A (en) * | 1966-12-15 | 1970-09-15 | Gen Electric | Silicone pressure-sensitive adhesive of improved strength |
GB1372034A (en) | 1970-12-31 | 1974-10-30 | Unilever Ltd | Detergent compositions |
US4053580A (en) | 1975-01-01 | 1977-10-11 | G. D. Searle & Co. | Microsealed pharmaceutical delivery device |
JPS59501908A (ja) * | 1982-10-25 | 1984-11-15 | ヘルグレン・ラルス・グスタ−ヴ・インゲ | クリーニング用酵素組成物 |
US4760025A (en) * | 1984-05-29 | 1988-07-26 | Genencor, Inc. | Modified enzymes and methods for making same |
US5763257A (en) * | 1984-05-29 | 1998-06-09 | Genencor International, Inc. | Modified subtilisins having amino acid alterations |
US5972682A (en) * | 1984-05-29 | 1999-10-26 | Genencor International, Inc. | Enzymatically active modified subtilisins |
EP0218272B1 (en) * | 1985-08-09 | 1992-03-18 | Gist-Brocades N.V. | Novel lipolytic enzymes and their use in detergent compositions |
US5389536A (en) * | 1986-11-19 | 1995-02-14 | Genencor, Inc. | Lipase from Pseudomonas mendocina having cutinase activity |
GB8704755D0 (en) | 1987-02-28 | 1987-04-01 | Dow Corning Ltd | Pharmaceutical delivery device |
FR2618337B1 (fr) * | 1987-07-22 | 1989-12-15 | Dow Corning Sa | Pansement chirurgical et procede pour le fabriquer |
FR2653438B1 (fr) * | 1989-10-23 | 1993-06-11 | Dow Corning Sa | Composition de silicone expansible et son utilisation. |
US5145937A (en) * | 1989-11-09 | 1992-09-08 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Polyimides with carbonyl and ether connecting groups between the aromatic rings |
CA2046802C (en) * | 1990-08-15 | 2007-05-22 | Donald Zane Fortney | Compositions containing protease produced by vibrio and method of use in debridement and wound healing |
FR2673948B1 (fr) | 1991-03-13 | 1995-03-10 | Dow Corning Sa | Compositions de silicone expansibles utiles a la realisation de pansements medicaux. |
FR2681246B1 (fr) * | 1991-04-05 | 1995-02-10 | Oreal | Composition cosmetique sous forme d'emulsion triple. |
US5232702A (en) * | 1991-07-22 | 1993-08-03 | Dow Corning Corporation | Silicone pressure sensitive adhesive compositons for transdermal drug delivery devices and related medical devices |
FR2686510A1 (fr) | 1992-01-27 | 1993-07-30 | Oreal | Emulsion eau-dans-huile stable au cours du temps a haute teneur en silicone. |
WO1994006915A1 (en) * | 1992-09-24 | 1994-03-31 | Genencor International, Inc. | Cleaning compositions containing novel alkaline proteases |
GB9316323D0 (en) | 1993-08-06 | 1993-09-22 | Procter & Gamble | Cosmetic compositions |
FR2715563B1 (fr) * | 1994-01-31 | 1996-03-15 | Oreal | Emulsion stabilisée, destinée à hydrater la peau et son utilisation. |
FR2725366B1 (fr) * | 1994-10-10 | 1996-11-22 | Oreal | Composition cosmetique comprenant des huiles siliconees |
UA48973C2 (uk) * | 1995-06-07 | 2002-09-16 | Орто-Макнейл Фармасьютікалз Інк. | Трансдермальний пластир на основі 17-деацетилноргестимату для попередження овуляції |
GB9519094D0 (en) * | 1995-09-19 | 1995-11-22 | Warwick Int Group | Granulated active with controlled release |
US5976682A (en) * | 1996-03-12 | 1999-11-02 | Tenneco Packaging | Stretch wrap films |
US6060546A (en) * | 1996-09-05 | 2000-05-09 | General Electric Company | Non-aqueous silicone emulsions |
MA25044A1 (fr) * | 1997-10-23 | 2000-10-01 | Procter & Gamble | Compositions de lavage contenant des variants de proteases multisubstituees. |
BR9904799A (pt) * | 1998-01-08 | 2001-07-31 | Dsm Nv | Aplicação tópica de enzimas usando um filme descamável |
EP0955347B1 (en) | 1998-05-06 | 2011-08-31 | Dow Corning France S.A. | Method for adhering substrates using adhesive devices containing silicone gels |
EP0966972B1 (en) | 1998-06-18 | 2003-09-24 | Dow Corning France S.A. | Topical composition containing silicon gum |
FR2780645B1 (fr) | 1998-07-06 | 2000-08-11 | Oreal | Produit pour application topique contenant une lipase, un precurseur de vitamine et un alcool gras |
US6207717B1 (en) * | 1999-01-12 | 2001-03-27 | Dow Corning Corporation | Entrapment of vitamins with an elastomeric silicone polyether |
US6337086B1 (en) * | 1999-02-06 | 2002-01-08 | Dow Corning Corporation | Pressure sensitive adhesive compositions for transdermal drug delivery devices |
US6168782B1 (en) * | 1999-05-24 | 2001-01-02 | Dow Corning Corporation | Elastomeric silicone containing an active ingredient |
US6238657B1 (en) * | 1999-07-12 | 2001-05-29 | Dow Corning Corporation | Oil-in-oil and three-phase emulsions |
MXPA02002897A (es) | 1999-09-16 | 2003-10-14 | Durminster Ltd | Metodo y composicion para el control de artropodos. |
GB0007140D0 (en) | 1999-09-27 | 2000-05-17 | Dow Corning Sa | Scar treatment composition |
US6080394A (en) * | 1999-11-08 | 2000-06-27 | Dow Corning Corporation | Polar solvent-in-oil emulsions and multiple emulsions |
DE10107628A1 (de) | 2001-02-15 | 2002-08-22 | Beiersdorf Ag | Kosmetische und dermatologische Zubereitungen in Form von W/O-Emulsionen mit einem Gehalt an Siliconölen und Talkum |
US7235249B2 (en) | 2002-03-28 | 2007-06-26 | The Procter & Gamble Company | Methods for regulating the condition of mammalian keratinous tissue via topical application of vitamin B6 compositions |
-
2003
- 2003-09-10 US US10/660,101 patent/US7223386B2/en not_active Expired - Lifetime
-
2004
- 2004-08-13 CN CN2004800260840A patent/CN1849114B/zh not_active Expired - Fee Related
- 2004-08-13 CA CA2537250A patent/CA2537250C/en not_active Expired - Fee Related
- 2004-08-13 WO PCT/US2004/026218 patent/WO2005025548A1/en active Application Filing
- 2004-08-13 EP EP04780975A patent/EP1663177B1/en not_active Not-in-force
- 2004-08-13 JP JP2006526089A patent/JP4993184B2/ja not_active Expired - Fee Related
- 2004-08-13 AT AT04780975T patent/ATE460929T1/de not_active IP Right Cessation
- 2004-08-13 DE DE602004026080T patent/DE602004026080D1/de active Active
- 2004-08-13 KR KR1020067004845A patent/KR101121461B1/ko active IP Right Grant
-
2007
- 2007-02-20 US US11/676,668 patent/US20070190152A1/en not_active Abandoned
- 2007-02-20 US US11/676,660 patent/US20070148199A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000103735A (ja) * | 1998-09-29 | 2000-04-11 | L'oreal Sa | アスコルビン酸を安定化するためのシリコ―ンゴムの使用およびこれらの成分を含有する新規組成物 |
JP2000319515A (ja) * | 1999-04-28 | 2000-11-21 | Dow Corning Corp | エラストマーシリコーンターポリマー組成物 |
JP2001278738A (ja) * | 2000-03-30 | 2001-10-10 | Kose Corp | 油中水型乳化化粧料 |
JP2005528425A (ja) * | 2002-03-11 | 2005-09-22 | ダウ・コーニング・コーポレーション | 局所皮膚使用及び治療用製剤 |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006111630A (ja) * | 2004-10-18 | 2006-04-27 | Amorepacific Corp | 皮膚保湿用化粧料組成物 |
JP2013512965A (ja) * | 2009-12-08 | 2013-04-18 | ヘルスポイント リミテッド | 増幅された酵素活性の酵素創傷壊死組織除去組成物 |
JP2015057420A (ja) * | 2009-12-08 | 2015-03-26 | スミス アンド ネフュー オーソペディックス アーゲーSmith & Nephew Orthopaedics AG | 増幅された酵素活性の酵素創傷壊死組織除去組成物 |
JP2016185994A (ja) * | 2009-12-08 | 2016-10-27 | スミス アンド ネフュー オーソペディックス アーゲーSmith & Nephew Orthopaedics AG | 増幅された酵素活性の酵素創傷壊死組織除去組成物 |
US9694100B2 (en) | 2009-12-08 | 2017-07-04 | Smith & Nephew, Inc. | Enzymatic wound debriding compositions with enhanced enzymatic activity |
US10155061B2 (en) | 2009-12-08 | 2018-12-18 | Smith & Nephew, Inc. | Enzymatic wound debriding compositions with enhanced enzymatic activity |
US10556037B2 (en) | 2009-12-08 | 2020-02-11 | Smith & Nephew, Inc. | Enzymatic wound debriding compositions with enhanced enzymatic activity |
JP2017530165A (ja) * | 2014-10-10 | 2017-10-12 | ロチャル インダストリーズ,エルエルシー | 酵素による創傷清拭のための組成物とキット、およびそれを用いた方法 |
JP2017530164A (ja) * | 2014-10-10 | 2017-10-12 | ロチャル インダストリーズ,エルエルシー | 掻痒治療用の組成物とキット及びそれらの使用方法 |
JP2020532558A (ja) * | 2017-09-04 | 2020-11-12 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 乳化剤を含む経皮送達システム |
JP7212676B2 (ja) | 2017-09-04 | 2023-01-25 | エルテーエス ローマン テラピー-ジステーメ アーゲー | 乳化剤を含む経皮送達システム |
Also Published As
Publication number | Publication date |
---|---|
ATE460929T1 (de) | 2010-04-15 |
JP4993184B2 (ja) | 2012-08-08 |
CN1849114B (zh) | 2011-02-02 |
CA2537250C (en) | 2013-01-22 |
EP1663177A1 (en) | 2006-06-07 |
KR20060119946A (ko) | 2006-11-24 |
DE602004026080D1 (de) | 2010-04-29 |
CA2537250A1 (en) | 2005-03-24 |
US20070190152A1 (en) | 2007-08-16 |
WO2005025548A1 (en) | 2005-03-24 |
US20070148199A1 (en) | 2007-06-28 |
US20040105874A1 (en) | 2004-06-03 |
US7223386B2 (en) | 2007-05-29 |
EP1663177B1 (en) | 2010-03-17 |
CN1849114A (zh) | 2006-10-18 |
KR101121461B1 (ko) | 2012-03-16 |
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