JP2007505033A - 呼吸器合胞体得ウイルス感染に対するサブユニットワクチン - Google Patents
呼吸器合胞体得ウイルス感染に対するサブユニットワクチン Download PDFInfo
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- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
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| US56758604P | 2004-05-03 | 2004-05-03 | |
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| PCT/CA2004/001007 WO2005007189A1 (en) | 2003-07-15 | 2004-07-14 | Subunit vaccine against respiratory syncytial virus infection |
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| JP2007505033A true JP2007505033A (ja) | 2007-03-08 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2014518620A (ja) * | 2011-04-26 | 2014-08-07 | モレキュラー エクスプレス，インコーポレイテッド | リポソーム製剤 |
| JP2020536934A (ja) * | 2017-10-13 | 2020-12-17 | トレリス バイオサイエンス リミテッド ライアビリティー カンパニー | 呼吸器合胞体ウイルスｇタンパク質中央保存領域の立体構造エピトープ |
| US12246063B2 (en) | 2018-08-08 | 2025-03-11 | Trellis Bioscience, Inc. | Immunogen providing an extended protective lifetime against respiratory syncytial virus (RSV) and vaccines thereof |
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| AU2002245636B2 (en) * | 2001-03-09 | 2004-10-14 | Id Biomedical Corporation Of Quebec | A novel proteosome-liposaccharide vaccine adjuvant |
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| US7368537B2 (en) * | 2003-07-15 | 2008-05-06 | Id Biomedical Corporation Of Quebec | Subunit vaccine against respiratory syncytial virus infection |
| CA2543080C (en) | 2003-10-22 | 2019-01-08 | Id Biomedical Corporation Of Quebec | Compositions and methods for activating innate and allergic immunity |
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| SI2590676T1 (sl) * | 2010-07-06 | 2016-11-30 | Glaxosmithkline Biologicals, S.A. | Virionu podobni delci za dajanje za samorepliciranje RNA molekul |
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| SI3970742T1 (sl) * | 2010-08-31 | 2022-08-31 | Glaxosmithkline Biologicals S.A. | Pegilirani liposomi za dostavo RNA, ki kodira imunogen |
| WO2012030901A1 (en) * | 2010-08-31 | 2012-03-08 | Novartis Ag | Small liposomes for delivery of immunogen-encoding rna |
| BR112013008700B8 (pt) | 2010-10-11 | 2022-10-04 | Novartis Ag | Molécula de rna auto-replicante, partícula de replicon de alfavírus, composição, molécula de dna recombinante, uso da molécula de rna auto-replicante |
| KR20120068647A (ko) * | 2010-12-18 | 2012-06-27 | 아이진 주식회사 | 개선된 면역반응을 유도하는 백신 |
| CN103501811B (zh) | 2011-01-13 | 2016-03-30 | 变异生物技术公司 | 用于治疗病毒感染的组合物和方法 |
| AU2012205315B2 (en) * | 2011-01-13 | 2017-05-04 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| RU2456020C1 (ru) * | 2011-03-30 | 2012-07-20 | Государственное образовательное учреждение дополнительного профессионального образования Российская медицинская академия последипломного образования Федерального агентства по здравоохранению и социальному развитию (ГОУ ДПО РМАПО Росздрава) | Способ профилактики гриппа и острых респираторных инфекций у детей с бронхиальной астмой |
| LT2707385T (lt) | 2011-05-13 | 2017-12-11 | Glaxosmithkline Biologicals Sa | Iš anksto sulieti rsv f antigenai |
| US11896636B2 (en) | 2011-07-06 | 2024-02-13 | Glaxosmithkline Biologicals Sa | Immunogenic combination compositions and uses thereof |
| EP2802353A4 (en) | 2012-01-12 | 2015-12-02 | Variation Biotechnologies Inc | COMPOSITIONS AND METHOD FOR THE TREATMENT OF VIRUS INFECTIONS |
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| CA2879915C (en) | 2012-08-01 | 2022-07-05 | Bavarian Nordic A/S | Recombinant modified vaccinia virus ankara (mva) respiratory syncytial virus (rsv) vaccine |
| US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
| SG11201500573RA (en) | 2012-08-06 | 2015-02-27 | Glaxosmithkline Biolog Sa | Method for eliciting in infants an immune response against rsv and b. pertussis |
| BR112016002354A2 (pt) | 2013-08-05 | 2017-09-12 | Glaxosmithkline Biologicals Sa | composição imunogênica, métodos para proteger um bebê contra infecção ou doença e para evocar uma resposta imune, regime de vacinação, e, kit |
| US9415101B2 (en) * | 2013-09-25 | 2016-08-16 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| KR101695518B1 (ko) * | 2014-09-30 | 2017-01-12 | 이화여자대학교 산학협력단 | 호흡기 신시치아 바이러스 범용 백신 |
| EP3373961A4 (en) * | 2015-11-10 | 2019-07-31 | Ohio State Innovation Foundation | METHODS AND COMPOSITIONS ASSOCIATED WITH ACCELERATED HUMORAL AFFINITY |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001060402A2 (en) * | 2000-02-15 | 2001-08-23 | Intellivax International Inc. | Proteosome influenza vaccine |
| JP2001516583A (ja) * | 1997-09-19 | 2001-10-02 | アメリカン・サイアナミド・カンパニー | Ｒｓウイルスの付着（ｇ）タンパク質由来のペプチド |
| WO2002072012A2 (en) * | 2001-03-09 | 2002-09-19 | Id Biomedical Corporation Of Quebec | A novel proteosome-liposaccharide vaccine adjuvant |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4707543A (en) * | 1985-09-17 | 1987-11-17 | The United States Of America As Represented By The Secretary Of The Army | Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines |
| US5726292A (en) * | 1987-06-23 | 1998-03-10 | Lowell; George H. | Immuno-potentiating systems for preparation of immunogenic materials |
| US5576016A (en) * | 1993-05-18 | 1996-11-19 | Pharmos Corporation | Solid fat nanoemulsions as drug delivery vehicles |
| US5961970A (en) * | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
| HUP9901577A3 (en) * | 1995-09-18 | 2000-03-28 | Lowell Georg H Cote St Luc | Improved methods for the production of non-covalently complexed and multivalent proteosome sub-unit vaccines |
| US5848152A (en) | 1995-09-26 | 1998-12-08 | Motorola, Inc. | Communication device having interchangeable faceplates and active keypad cover |
| US6699478B1 (en) * | 1997-09-19 | 2004-03-02 | Wyeth Holdings Corporation | Enhanced immune response to attachment (G) protein of Respiratory Syncytial Virus |
| FR2819810B1 (fr) | 2001-01-23 | 2004-05-28 | Pf Medicament | Peptides non glycosyles derives de la proteine g du vrs et leur utilisation dans un vaccin |
| US7368537B2 (en) * | 2003-07-15 | 2008-05-06 | Id Biomedical Corporation Of Quebec | Subunit vaccine against respiratory syncytial virus infection |
-
2004
- 2004-07-09 US US10/888,805 patent/US7368537B2/en not_active Expired - Fee Related
- 2004-07-14 AU AU2004257363A patent/AU2004257363A1/en not_active Abandoned
- 2004-07-14 ES ES04761567T patent/ES2337901T3/es not_active Expired - Lifetime
- 2004-07-14 DE DE602004024542T patent/DE602004024542D1/de not_active Expired - Lifetime
- 2004-07-14 WO PCT/CA2004/001007 patent/WO2005007189A1/en not_active Ceased
- 2004-07-14 JP JP2006519734A patent/JP2007505033A/ja active Pending
- 2004-07-14 EP EP04761567A patent/EP1651264B1/en not_active Expired - Lifetime
- 2004-07-14 AT AT04761567T patent/ATE451119T1/de not_active IP Right Cessation
- 2004-07-14 CA CA002532164A patent/CA2532164A1/en not_active Abandoned
- 2004-07-14 EP EP09178294A patent/EP2204188A1/en not_active Withdrawn
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2008
- 2008-03-19 US US12/051,397 patent/US20080226673A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001516583A (ja) * | 1997-09-19 | 2001-10-02 | アメリカン・サイアナミド・カンパニー | Ｒｓウイルスの付着（ｇ）タンパク質由来のペプチド |
| WO2001060402A2 (en) * | 2000-02-15 | 2001-08-23 | Intellivax International Inc. | Proteosome influenza vaccine |
| WO2002072012A2 (en) * | 2001-03-09 | 2002-09-19 | Id Biomedical Corporation Of Quebec | A novel proteosome-liposaccharide vaccine adjuvant |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014518620A (ja) * | 2011-04-26 | 2014-08-07 | モレキュラー エクスプレス，インコーポレイテッド | リポソーム製剤 |
| JP2020536934A (ja) * | 2017-10-13 | 2020-12-17 | トレリス バイオサイエンス リミテッド ライアビリティー カンパニー | 呼吸器合胞体ウイルスｇタンパク質中央保存領域の立体構造エピトープ |
| US11773143B2 (en) | 2017-10-13 | 2023-10-03 | Trellis Bioscience, Llc | Conformational epitopes in respiratory syncytial virus G protein central conserved region |
| JP7445895B2 (ja) | 2017-10-13 | 2024-03-08 | トレリス・バイオサイエンス・インコーポレーテッド | 呼吸器合胞体ウイルスｇタンパク質中央保存領域の立体構造エピトープ |
| US12246063B2 (en) | 2018-08-08 | 2025-03-11 | Trellis Bioscience, Inc. | Immunogen providing an extended protective lifetime against respiratory syncytial virus (RSV) and vaccines thereof |
Also Published As
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|---|---|
| AU2004257363A1 (en) | 2005-01-27 |
| EP1651264B1 (en) | 2009-12-09 |
| WO2005007189A1 (en) | 2005-01-27 |
| EP1651264A1 (en) | 2006-05-03 |
| US20080226673A1 (en) | 2008-09-18 |
| ES2337901T3 (es) | 2010-04-30 |
| ATE451119T1 (de) | 2009-12-15 |
| CA2532164A1 (en) | 2005-01-27 |
| EP2204188A1 (en) | 2010-07-07 |
| US7368537B2 (en) | 2008-05-06 |
| DE602004024542D1 (de) | 2010-01-21 |
| US20050042230A1 (en) | 2005-02-24 |
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