JP2007308497A - 微細な水中油型エマルション - Google Patents
微細な水中油型エマルション Download PDFInfo
- Publication number
- JP2007308497A JP2007308497A JP2007132019A JP2007132019A JP2007308497A JP 2007308497 A JP2007308497 A JP 2007308497A JP 2007132019 A JP2007132019 A JP 2007132019A JP 2007132019 A JP2007132019 A JP 2007132019A JP 2007308497 A JP2007308497 A JP 2007308497A
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- oil
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- monohydric alcohol
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- 239000000839 emulsion Substances 0.000 title abstract description 28
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 55
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 8
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 claims description 6
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
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- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 description 3
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- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 239000002759 woven fabric Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 229940050168 zinc lactate Drugs 0.000 description 1
- 235000000193 zinc lactate Nutrition 0.000 description 1
- 239000011576 zinc lactate Substances 0.000 description 1
- 229940100142 zinc pidolate Drugs 0.000 description 1
- OWVLYQRCCIEOPF-QHTZZOMLSA-L zinc;(2s)-5-oxopyrrolidine-2-carboxylate Chemical compound [Zn+2].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]1CCC(=O)N1 OWVLYQRCCIEOPF-QHTZZOMLSA-L 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
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Abstract
【解決手段】本発明は、(1)分子量が10000以上の少なくとも1つのシリコーン界面活性剤、少なくとも1つの非イオン性共界面活性剤、及び少なくとも1つのアニオン性共界面活性剤を含む乳化システム、並びに(2)2から6個の炭素原子を含む少なくとも1つの一価アルコールを含み、油性相の油が前記一価アルコールに可溶性であることを特徴とする、水中油型エマルションの形態をとる局所的適用のための組成物に関する。
【選択図】なし
Description
−例えば、EP-A-728460、EP-A-780114、EP-A-1010413、EP-A-1010414、EP-A-1010415、EP-A-1010416、EP-A-1013338、EP-A-1016453、EP-A-1018363、EP-A-1020219、EP-A-1025898、及びEP-A-1172077の文献に記載されているようなナノエマルション。この技術の欠点は、機械的エネルギー及び特に高圧攪拌機を使用する必要がある点であり、これにより工程が複雑になる。
−例えば、EP-A-1297824の文献に記載されているようなPITエマルション。この技術は、相転位の範囲内の温度で機械的エネルギーを必要としない。この方法は、組成物のタイプが制限されるという欠点があり、従って、例えば、相転位の温度の変更につながるため、ポリオールとアルコールの量を変更することが困難である。この技術の別の欠点は、油性相を5%未満に低減させることができない点である。現在、ローションとトニックの場合には、大量の水と5%未満のオイル重量とを含むO/W型エマルションを有することが所望されて良い。
本発明に係る組成物は、分子量が10000以上の少なくとも1つのシリコーン界面活性剤、少なくとも1つの非イオン性共界面活性剤、及び少なくとも1つのアニオン性共界面活性剤を含む乳化システムを含む。
用語「シリコーン界面活性剤」とは、少なくとも1つのオキシアルキレン化炭素鎖、特に少なくとも1つのオキシエチレン化(-OCH2CH2-)、及び/またはオキシプロピレン化(-OCH2CH2CH2-)炭素鎖を含むシリコーン化合物を意味することを意図する。
本発明に係る組成物は、好ましくは15以下のHLBを有する非イオン性界面活性剤から選択される、少なくとも1つの非イオン性共界面活性剤を含む。
H-(O-CH2-CH2)a-(O-CH(CH3)-CH2)b-(O-CH2-CH2)a-OH
を有し、式中のaは2から150、bは1から100に及び、好ましくはaは10から130、bは20から80の範囲にある。
本発明に関連して用いることができるアニオン性共界面活性剤は、好ましくは中和されたアニオン性脂質を含む群から選択される。それらは、特にリポアミノ酸、及びその塩、例えば、アシルグルタミン酸一ナトリウム及びアシルグルタミン酸二ナトリウム等(例えば、味の素社製のアシルグルタミン酸HS21PまたはアミソフトHS21Pという名称で販売されるN-ステアロイルL-グルタミン酸の二ナトリウム塩、味の素社製のアシルグルタミン酸LS11またはアミソフトLS11という名称で販売されるN-ラウロイルL-グルタミン酸の一ナトリウム塩)から選択することができる。
本発明に係る組成物は、2から6個の炭素原子を含む少なくとも1つの一価アルコールを含む。一価アルコールとは、ただ1つのOH官能基を含む第一級アルコールのことである。
前記一価アルコールに加えて、当該組成物は1つ以上のポリオール(例えばグリセロール、ポリグリセロールまたはソルビトール)、並びにグリコール(イソプレングリコール、1,3-ブチレングリコール、プロピレングリコール、ジプロピレングリコール、及びヘキシレングリコール等)、並びにそれらの混合物を含んで良い。
前記油性相は、本発明の組成物中に存在する油とすべての親油性成分とからなる。
(1)「Prediction of Organic Compounds by a Conceptional Diagram」A. FUJITA Pharm. Bull 2, pp.163-173(1954);
(2)「Organic Analysis」Fujita(1930), published by Kaniya Shoten;
(3)「Prediction of Organic Compounds and Organic Conceptional Diagram」A. Fujita(Kagaku-no-Ryoiki 11-10), pp.719-725(1957);
(4)「Systematic Organic Qualitative Analysis(Book of Purified Substances)」Fujita and Akatsuka, p.487(1970), published by Kazama Shoten;
(5)「Organic Conceptional Diagram, Its Fundamentals and Applications」Koda, p.227(1984), published by Sankyo Shuppan;
(6)「Design of Emulsion Formulation by Use of Organic Conceptional Diagram」Yaguchi, p98(1985), published by Nippon Emulsion K.K.;
(7)R. H. Ewell, J. M. Harrison, L. Berg.: Ind. Eng. Chem. 36, 871(1944)
(8)EP-A-985404
−化学式R1COOR2の油等の脂肪酸エステル、ここで、R1は8から29個の炭素原子を含む脂肪酸残基を表し、またR2は3から30個の炭素原子を含む分枝または枝なし炭化水素に基づく測鎖を表す。例えば、イソノニルイソノナノエート(分子量=284)、パルミチン酸イソプロピル(分子量=298)、パルミチン酸2-エチルヘキシル(分子量=368;IOB=0.128)、イソステアリン酸イソプロピル(分子量=326;IOB=0.15)、カプリル酸/カプリン酸トリグリセリド(分子量=494;IOB=0.314)、及びテトラオクタン酸ペンタエリスリチル(INCI名:テトラエチルヘキサン酸ペンタエリスリチル)(分子量=640;IOB=0.353)、ジ(2-エチルヘキシル)アジピン酸(分子量=640;IOB=0.353)またはC12-C15安息香酸アルキル(分子量=309;IOB=0.184)(Finsolv TN)等のペンタエリスリトールエステル;
−8から26個の炭素原子を含む脂肪族アルコール、特にオクチルドデカノール(分子量=300);
−イソヘキサデカン(分子量=226)、イソドデカン(分子量=170);
−シリコーン油、例えば、シクロヘキサシロキサン及びシクロペンタシロキサン(分子量=370;IOB=0.4)等のシクロポリジメチルシロキサン(シクロメチコーン)等の特に揮発性シリコーン油、または例えばフェニルトリメチコーン(分子量=372;IOB=0.212)等のフェニルシリコーン;
−それらの混合物。
一般に、溶剤である水性相は、水、及びいずれかの水に可溶性または水に分散性のアジュバントを含む。
当該組成物は1つ以上の親水性ポリマーを含むこともできる。
本発明に係る組成物は、化粧用または皮膚科学用組成物に通常用いられるいずれかのアジュバントを含むことができる。
−加湿剤、例えば、乳酸ナトリウム;ポリオール、及び特にグリセロール若しくはソルビトール、ポリエチレングリコール;マンニトール;アミノ酸;ヒアルロン酸;ラノリン;尿素及びNMF(天然加湿因子)等の尿素を含む混合物;液体石油ゼリー;N-ラウロイルピロリドンカルボン酸、及びその塩;必須脂肪酸;精油;並びにそれらの混合物;
−アンチエイジング活性剤及び角質溶解性因子(角質除去因子)、例えば、α-ヒドロキシ酸、及び特にフルーツ由来の酸(例えば、グリコール酸、乳酸、リンゴ酸、クエン酸、酒石酸若しくはマンデル酸)、それらの誘導体、及びそれらの混合物;β-ヒドロキシ酸(例えば、サリチル酸、及びその誘導体(5-n-オクタノイルサリチル酸または5-n-ドデカノイルサリチル酸等));α-ケト酸(アスコルビン酸またはビタミンC、及びその塩等のそれらの誘導体(例えば、アスコルビン酸ナトリウム、アスコルビン酸リン酸マグネシウム若しくはアスコルビン酸リン酸ナトリウム));そのエステル(例えば、アスコルビルアセテート、アスコルビルパルミテート及びアスコルビルプロピオネート、または例えばグリコシル化アスコルビン酸等のアスコルビン酸の糖類、並びにそれらの混合物);β-ケト酸;レチノール(ビタミンA)とそのエステル等のレチノイド、レチナール、レチノイン酸、及びその誘導体、及びFR-A-2570377、EP-A-199636、EP-A-325540とEP-A-402072の文献に記載されるレチノイド;アダパレン;カロテノイド;並びにそれらの混合物;
−ビタミン、例えば、前記のビタミンA及びビタミンC、並びにビタミンE(トコフェロール)、及びその誘導体等;ビタミンB3(またはビタミンPP若しくはナイアシンアミド)、及びその誘導体;ビタミンB5(または様々な形態のパンテノール:D-パンテノール、DL-パンテノール)、及びその誘導体と類似体(パントテン酸カルシウム、パンテチン、パンテテイン、パントテニルエチルエーテル、パンガミン酸、ピリドキシン、パントイルラクトース、及び同様のものを含む天然化合物(ロイヤルゼリー等)等);ビタミンD、及び例えばWO-A-00/26167の文献に記載等のその類似体;ビタミンFまたはその類似体(例えば、少なくとも1つの二重結合を有する不飽和酸の混合物、及び特にリノール酸の混合物、リノール酸及びアラキドン酸、または同様のものを含む化合物等);
−抗菌性及び抗脂漏性因子、例えば、サリチル酸、2,4,4’-トリクロロ-2’-ヒドロキシジフェニルエーテル(またはトリクロサン)、3,4,4’-トリクロロバニリド(またはトリクロカルバン)、アゼライン酸、過酸化ベンゾイル、及び亜鉛塩(乳酸亜鉛、グルコン酸亜鉛、ピドール酸亜鉛、カルボン酸亜鉛、サリチル酸亜鉛、及び/または亜鉛システエート)。
−室温で、油、親油性活性剤、シリコーン界面活性剤、及び一価アルコールを混合する工程;
−低速攪拌で油性相を水性相中に注入する工程;
を含む。
これらの実施例において、以下の手順を用いて前記工程を実施する。
<A相>: A相の化合物を、解凝タービンを備えたRayneriミキサーを用いて室温で攪拌し、水に溶解した。
《A相》
水 81.55%
フェノニップ(保存剤の混合物) 0.5%
グリセロール 5%
ジプロピレングリコール 3%
ラウロイルグルタミン酸ナトリウム 0.03%
ステアロイルグルタミン酸二ナトリウム 0.02%
ポロキサマー184 0.1%
エタノール 8%
BIS-PEG/PPG-16/16 PEG/PPG-16/16 ジメチコーン
(及び)カプリル酸/カプリン酸トリグリセリド
(Abil Care 85) 0.4%
テトラエチルヘキサン酸ペンタエリスリチル 1.6%
Claims (15)
- (1)分子量が10000以上の少なくとも1つのシリコーン界面活性剤、少なくとも1つの非イオン性共界面活性剤、及び少なくとも1つのアニオン性共界面活性剤を含む乳化システム、並びに(2)2から6個の炭素原子を含む少なくとも1つの一価アルコールを含み、油性相の油が前記一価アルコールに可溶性であることを特徴とする、水性相中に分散した油性相を含む、水中油型エマルションの形態をとる組成物。
- 前記シリコーン界面活性剤が、オキシエチレン化基及びオキシプロピレン化基を含むポリジメチルシロキサンから選択されることを特徴とする、請求項1に記載の組成物。
- シリコーン界面活性剤の量が、当該組成物の総重量に対して、0.05重量%から4重量%の範囲にあることを特徴とする、請求項1または2に記載の組成物。
- 前記アニオン性共界面活性剤が、エチレンオキシド及びプロピレンオキシドの重縮合体から選択されることを特徴とする、請求項1から3のいずれか一項に記載の組成物。
- アニオン性共界面活性剤の量が、当該組成物の総重量に対して、0.01重量%から0.5重量%の範囲にあることを特徴とする、請求項1から4のいずれか一項に記載の組成物。
- 前記アニオン性共界面活性剤が、リポアミノ酸及びその塩から選択されることを特徴とする、請求項1から5のいずれか一項に記載の組成物。
- アニオン性共界面活性剤の量が、当該組成物の総重量に対して、0.01重量%から0.5重量%の範囲にあることを特徴とする、請求項1から6のいずれか一項に記載の組成物。
- 前記一価アルコールがエタノールであることを特徴とする、請求項1から7のいずれか一項に記載の組成物。
- 一価アルコールの量が、当該組成物の総重量に対して、0.1重量%から60重量%の範囲にあることを特徴とする、請求項1から8のいずれか一項に記載の組成物。
- シリコーン界面活性剤の量に対する油の量の重量比が0.5から20の範囲にあることを特徴とする、請求項1から9のいずれか一項に記載の組成物。
- 一価アルコールの量に対するシリコーン界面活性剤と油の量の重量比が0.01から1の範囲にあることを特徴とする、請求項1から10のいずれか一項に記載の組成物。
- 水の量に対する一価アルコールの量の重量比が0.01から0.2の範囲にあることを特徴とする、請求項1から11のいずれか一項に記載の組成物。
- 前記油が、フェニルトリメチコーン、ペンタエリスリトールエステル、オクチルドデカノール、イソヘキサデカン、イソドデカン、シクロポリジメチルシロキサン、及びそれらの混合物から選択されることを特徴とする、請求項1から12のいずれか一項に記載の組成物。
- 油性相の量が、当該組成物の総重量に対して、0.5重量%から10重量%の範囲にあることを特徴とする、請求項1から13のいずれか一項に記載の組成物。
- −室温で、水、非イオン性共界面活性剤、アニオン性共界面活性剤、及び一価アルコールを除く親水性化合物を混合する工程;
−室温で、油、親油性活性剤、シリコーン界面活性剤、及び一価アルコールを混合する工程;
−低速攪拌で油性相を水性相中に注入する工程;
を含む、請求項1から14のいずれか一項に記載の組成物の調製方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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FR0604406A FR2901124B1 (fr) | 2006-05-17 | 2006-05-17 | Emulsion huile dans eau fine |
FR0604406 | 2006-05-17 |
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JP2007308497A true JP2007308497A (ja) | 2007-11-29 |
JP5855324B2 JP5855324B2 (ja) | 2016-02-09 |
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US (1) | US20070269390A1 (ja) |
EP (1) | EP1857095A1 (ja) |
JP (1) | JP5855324B2 (ja) |
CN (1) | CN101073537B (ja) |
FR (1) | FR2901124B1 (ja) |
Cited By (2)
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JP2011046709A (ja) * | 2009-08-28 | 2011-03-10 | L'oreal Sa | ヒドロキシル化ジフェニルメタン誘導体を含む化粧品組成物 |
WO2021085534A1 (ja) * | 2019-10-31 | 2021-05-06 | 株式会社カネカ | ポリヒドロキシアルカン酸の製造方法およびその利用 |
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ES2535047T3 (es) | 2004-12-17 | 2015-05-04 | Ventana Medical Systems, Inc. | Método para la desparafinación de una muestra tisular a base de una microemulsión |
CA2636912A1 (en) * | 2006-01-13 | 2007-07-26 | Ventana Medical Systems, Inc. | Biological sample processing composition and method |
FR2928540B1 (fr) * | 2008-03-11 | 2011-07-29 | Oreal | Composition cosmetique comprenant un compose d'acide ascorbique |
EP2100585A1 (fr) * | 2008-03-11 | 2009-09-16 | L'Oréal | Composition cosmétique comprenant un composé d'acide ascorbique ou d'acide salicylique |
FR2928541B1 (fr) * | 2008-03-11 | 2011-07-29 | Oreal | Composition cosmetique comprenant un compose d'acide salicylique |
DE102008015366A1 (de) * | 2008-03-20 | 2009-09-24 | Merck Patent Gmbh | Lyophilisierte Nanoemulsion |
DE102008042381A1 (de) * | 2008-09-26 | 2010-04-01 | Evonik Goldschmidt Gmbh | Emulgator-Systeme für kosmetische und pharmazeutische Öl-in-Wasser-Emulsionen |
EP2406323B1 (en) | 2009-03-10 | 2013-07-24 | Dow Corning Toray Co., Ltd. | Oil-in-water silicone emulsion composition |
CN102959016A (zh) | 2010-07-02 | 2013-03-06 | 道康宁东丽株式会社 | 水包油有机硅乳液组合物 |
EP2811986A1 (en) * | 2012-02-08 | 2014-12-17 | Dow Corning Corporation | Silicone emulsions for delivery of healthcare actives |
DE102014104255A1 (de) | 2014-03-26 | 2015-10-01 | Beiersdorf Ag | Öl in Wasser-Emulsionen mit einem Gehalt an 4-Hydroxyacetophenon und anionischen Emulgatoren |
CN106962352B (zh) * | 2017-03-27 | 2019-07-02 | 中国农业科学院植物保护研究所 | 用于防治水稻稻瘟病的油乳剂 |
WO2024000404A1 (en) * | 2022-06-30 | 2024-01-04 | L'oreal | Composition for caring for and/or making up keratin materials |
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- 2007-05-14 US US11/747,998 patent/US20070269390A1/en not_active Abandoned
- 2007-05-16 CN CN2007101041297A patent/CN101073537B/zh active Active
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JP2000313808A (ja) * | 1999-04-28 | 2000-11-14 | Shiseido Co Ltd | 可溶化組成物 |
JP2005526865A (ja) * | 2002-01-25 | 2005-09-08 | ダウ・コーニング・コーポレイション | 水中シリコーン油型エマルション、塩、アルコール、および溶媒を含有する組成物 |
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WO2021085534A1 (ja) * | 2019-10-31 | 2021-05-06 | 株式会社カネカ | ポリヒドロキシアルカン酸の製造方法およびその利用 |
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Publication number | Publication date |
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CN101073537A (zh) | 2007-11-21 |
FR2901124A1 (fr) | 2007-11-23 |
JP5855324B2 (ja) | 2016-02-09 |
EP1857095A1 (fr) | 2007-11-21 |
US20070269390A1 (en) | 2007-11-22 |
FR2901124B1 (fr) | 2008-06-27 |
CN101073537B (zh) | 2011-11-02 |
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