JP2007269673A - 保存剤 - Google Patents
保存剤 Download PDFInfo
- Publication number
- JP2007269673A JP2007269673A JP2006096132A JP2006096132A JP2007269673A JP 2007269673 A JP2007269673 A JP 2007269673A JP 2006096132 A JP2006096132 A JP 2006096132A JP 2006096132 A JP2006096132 A JP 2006096132A JP 2007269673 A JP2007269673 A JP 2007269673A
- Authority
- JP
- Japan
- Prior art keywords
- preservative
- salt
- acid
- sodium
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003755 preservative agent Substances 0.000 title claims abstract description 65
- 230000002335 preservative effect Effects 0.000 title claims abstract description 56
- 239000000203 mixture Substances 0.000 claims abstract description 51
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims abstract description 36
- 150000003839 salts Chemical class 0.000 claims abstract description 33
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000004327 boric acid Substances 0.000 claims abstract description 21
- 229960001484 edetic acid Drugs 0.000 claims abstract description 19
- DHCDFWKWKRSZHF-UHFFFAOYSA-N sulfurothioic S-acid Chemical compound OS(O)(=O)=S DHCDFWKWKRSZHF-UHFFFAOYSA-N 0.000 claims abstract description 12
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical group [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 claims description 13
- 235000019345 sodium thiosulphate Nutrition 0.000 claims description 13
- 230000001580 bacterial effect Effects 0.000 claims description 10
- 229940009662 edetate Drugs 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 159000000007 calcium salts Chemical class 0.000 claims description 5
- 159000000000 sodium salts Chemical class 0.000 claims description 4
- 206010053759 Growth retardation Diseases 0.000 claims description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
- 159000000003 magnesium salts Chemical class 0.000 claims description 3
- 239000011591 potassium Substances 0.000 claims description 3
- 229910052700 potassium Inorganic materials 0.000 claims description 3
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 3
- 150000003751 zinc Chemical class 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 abstract description 10
- 230000002411 adverse Effects 0.000 abstract description 2
- 230000000266 injurious effect Effects 0.000 abstract 1
- 235000002639 sodium chloride Nutrition 0.000 description 29
- 239000003889 eye drop Substances 0.000 description 13
- 238000003860 storage Methods 0.000 description 10
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 7
- 229940012356 eye drops Drugs 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
- 238000011109 contamination Methods 0.000 description 6
- -1 fatty acid esters Chemical class 0.000 description 6
- 230000000813 microbial effect Effects 0.000 description 6
- 239000012085 test solution Substances 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
- 229960000686 benzalkonium chloride Drugs 0.000 description 5
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000002421 anti-septic effect Effects 0.000 description 4
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 4
- 229960001950 benzethonium chloride Drugs 0.000 description 4
- 229910021538 borax Inorganic materials 0.000 description 4
- 229960004926 chlorobutanol Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 235000010339 sodium tetraborate Nutrition 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical group [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- ACYGYJFTZSAZKR-UHFFFAOYSA-J dicalcium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Ca+2].[Ca+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O ACYGYJFTZSAZKR-UHFFFAOYSA-J 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 230000009422 growth inhibiting effect Effects 0.000 description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 description 3
- 235000017550 sodium carbonate Nutrition 0.000 description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 229940042585 tocopherol acetate Drugs 0.000 description 3
- 229910001868 water Inorganic materials 0.000 description 3
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
- 229920002971 Heparan sulfate Polymers 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 102000016943 Muramidase Human genes 0.000 description 2
- 108010014251 Muramidase Proteins 0.000 description 2
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 2
- DJDFFEBSKJCGHC-UHFFFAOYSA-N Naphazoline Chemical compound Cl.C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 DJDFFEBSKJCGHC-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 229920002413 Polyhexanide Polymers 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- 235000011054 acetic acid Nutrition 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 150000008064 anhydrides Chemical class 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 235000011148 calcium chloride Nutrition 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 2
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000002826 coolant Substances 0.000 description 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 235000019800 disodium phosphate Nutrition 0.000 description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 description 2
- IFQUWYZCAGRUJN-UHFFFAOYSA-N ethylenediaminediacetic acid Chemical compound OC(=O)CNCCNCC(O)=O IFQUWYZCAGRUJN-UHFFFAOYSA-N 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 150000004677 hydrates Chemical class 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000003589 local anesthetic agent Substances 0.000 description 2
- 239000004325 lysozyme Substances 0.000 description 2
- 235000010335 lysozyme Nutrition 0.000 description 2
- 229960000274 lysozyme Drugs 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 235000011007 phosphoric acid Nutrition 0.000 description 2
- 229920000137 polyphosphoric acid Polymers 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
- 235000011164 potassium chloride Nutrition 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 235000010199 sorbic acid Nutrition 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- BJORNXNYWNIWEY-UHFFFAOYSA-N tetrahydrozoline hydrochloride Chemical compound Cl.N1CCN=C1C1C2=CC=CC=C2CCC1 BJORNXNYWNIWEY-UHFFFAOYSA-N 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- NYEPHMYJRNWPLA-UHFFFAOYSA-N (6-amino-2-ethoxyacridin-9-yl)azanium;2-hydroxypropanoate;hydrate Chemical compound O.CC(O)C([O-])=O.C1=C(N)C=CC2=C(N)C3=CC(OCC)=CC=C3[NH+]=C21 NYEPHMYJRNWPLA-UHFFFAOYSA-N 0.000 description 1
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
- A61L2/186—Peroxide solutions
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/14—Boron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
【解決手段】(A)チオ硫酸塩、(B)エデト酸及び/又はその塩及び(C)ホウ酸及び/又はその塩を有効成分とする、保存剤。
【選択図】なし
Description
項1.(A)チオ硫酸塩、(B)エデト酸及び/又はその塩、ならびに(C)ホウ酸及び/又はその塩を含有する、保存剤。
項2.チオ硫酸塩が、チオ硫酸ナトリウムである、項1に記載の保存剤。
項3.エデト酸塩が、エデト酸のナトリウム塩、カリウム塩及びカルシウム塩からなる群より選択される少なくとも1種である、項1に記載の保存剤。
項4.エデト酸塩が、エデト酸二ナトリウム又はエデト酸カルシウムである、項1に記載の保存剤。
項5.ホウ酸塩が、ホウ酸のナトリウム塩、カリウム塩、カルシウム塩、マグネシウム塩及び亜鉛塩からなる群より選択される少なくとも1種である、項1に記載の保存剤。
項6.ホウ酸塩が、ホウ酸ナトリウムである項1に記載の保存剤。
項7.チオ硫酸ナトリウム、エデト酸二ナトリウム及びホウ酸を含有する保存剤。
項8.項1〜7のいずれかに記載の保存剤を含有する、水系組成物。
項9.項1〜7のいずれかに記載の保存剤を含有する、眼科用組成物。
項10.(A)チオ硫酸ナトリウム、(B)エデト酸及び/又はその塩、ならびに(C)ホウ酸及び/又はその塩を水系組成物に配合することを特徴とする、細菌増殖抑制方法。
本発明の保存剤は、(A)チオ硫酸塩、(B)エデト酸及び/又はその塩、ならびに(C)ホウ酸及び/又はその塩を有効成分とする。
(A)チオ硫酸塩
本発明において使用されるチオ硫酸塩としては、薬学的に許容される塩であれば特に限定されないが、例えば、チオ硫酸ナトリウム、チオ硫酸カリウム、チオ硫酸アンモニウム等が挙げられる。本発明において使用されるチオ硫酸塩は、無水塩の形態であってもよく、また、例えば五水和物といった水和物の形態で用いてもよい。これらの塩を1種単独で使用することもでき、2種以上を組み合わせて用いてもよい。本発明においては、チオ硫酸ナトリウムを用いることが好ましい。
本発明においては、エデト酸(エチレンジアミン四酢酸)を有効成分の1つとして使用する。エデト酸は、塩の状態であってもよく、エデト酸とエデト酸塩の混合物であってもよい。また、エデト酸塩は、無水物の形態でもよく、水和物の形態であってもよい。エデト酸塩としては、薬学的に許容される塩であれば特に限定されず、例えば、エデト酸のナトリウム塩、カリウム塩、カルシウム塩等を使用することができる。このような塩としては、例えば、エデト酸二ナトリウム、エデト酸三ナトリウム、エデト酸四ナトリウム、エデト酸カルシウム、エデト酸カルシウム二ナトリウム、エデト酸二カリウム、エデト酸三カリウム、これらの水和物等が挙げられる。これらの塩を1種単独で使用することもでき、2種以上を組み合わせて用いてもよい。本発明においては、エデト酸のナトリウム塩(より好ましくはエデト酸二ナトリウム)、エデト酸カルシウムであることが好ましい。
本発明においては、ホウ酸を有効成分の1つとして使用する。ホウ酸は、塩の状態であってもよく、ホウ酸とホウ酸塩の混合物でもよい。また、ホウ酸塩は、無水物の形態でもよく、水和物の形態であってもよい。本発明において使用されるホウ酸塩としては、薬学的に許容される塩であれば特に限定されず、例えば、ホウ酸のナトリウム塩、カリウム塩、カルシウム塩、マグネシウム塩、亜鉛塩等を使用することができる。このような塩としては、例えば、ホウ酸ナトリウム、ホウ酸カルシウム、ホウ酸マグネシウム、ホウ酸カリウム、ホウ酸亜鉛、これらの水和物等が挙げられる。これらの塩を1種単独で使用することもでき、2種以上を組み合わせてもよい。本発明においては、ホウ酸、ホウ砂(ホウ酸ナトリウム)であることが好ましい。
上記(1)に記載する本発明の保存剤を眼科用組成物に配合することにより、該眼科用組成物の使用過程における微生物汚染等による腐敗を防止することができる。さらに、本発明の保存剤は、コンタクトレンズに吸着することがなく、コンタクトレンズの変質を引き起こすこともないため、コンタクトレンズ用の眼科用組成物にも適用することができる。ここで、コンタクトレンズ用の眼科用組成物とは、コンタクトレンズ装着時に使用される点眼剤を含み、後述のコンタクトレンズ用剤等も含むものである。
上記成分(A)、(B)及び(C)を前述の水系組成物に配合することによって、該水系組成物の保存性を高めることができる。成分(A)〜(C)の配合量及び配合比率は、上記(1)に記載される範囲に従って、適宜調整され得る。
(1)試験例1:保存効力試験
下記表1の処方に従い、各成分を精製水に溶解させて全量を100mLとして試験液を調製し、これを滅菌濾過した。これらの試験液について、第14改正日本薬局方の保存効力試験方法を参考に、保存効力を評価した。具体的には、Escherichia coli(表中E.C.)及びPseudomonas aeruginosa(表中P.A.)の菌液をそれぞれ調製し、各菌液を、105〜106CFU/mLになるように試験液に接種し、25℃で保管した。その後、7、14、21及び28日目に寒天平板混釈法によって生菌数を測定し、細菌増殖抑制効果の有無を判定した。結果を表1の判定の欄に示す。
判定基準は以下の通りである。
<判定基準>
○:14日までに生菌数が接種した菌数の0.1%以下になった
×:14日までの生菌数が接種した菌数の0.1%より多い
下記表2の処方に従って、試験例1と同様の方法により試験液を調製した後、保存効力を評価した。ただし、菌液はEscherichia coliのみを用いた。結果を表2の判定の欄に示す。
眼科用組成物の一般的なpH範囲(pH5〜8)における保存効力を評価した。下記表3の処方に従って、試験例1と同様の方法に従って試験液を調製した後、保存効力を評価した。ただし、菌液はEscherichia coliのみを用いた。結果を表3の判定の欄に示す。
本発明の保存剤と、防腐剤として配合されることが公知の化合物について保存効力を評価した。下記表4の処方に従って、試験例1と同様の方法に従って試験液を調製した後、保存効力を評価した。ただし、菌液として、Escherichia coli(表中EC)及びPseudomonas aeruginosa(表中PA)の他に、試験例1に示される方法で調製されたAspergillus niger(表中AN)を用いた。結果を表4の判定の欄に示す。
Claims (7)
- (A)チオ硫酸塩、(B)エデト酸及び/又はその塩、ならびに(C)ホウ酸及び/又はその塩を含有する、保存剤。
- チオ硫酸塩が、チオ硫酸ナトリウムである、請求項1に記載の保存剤。
- エデト酸塩が、エデト酸のナトリウム塩、カリウム塩及びカルシウム塩からなる群より選択される少なくとも1種である、請求項1に記載の保存剤。
- ホウ酸塩が、ホウ酸のナトリウム塩、カリウム塩、カルシウム塩、マグネシウム塩及び亜鉛塩からなる群より選択される少なくとも1種である、請求項1に記載の保存剤。
- チオ硫酸ナトリウム、エデト酸二ナトリウム及びホウ酸を含有する保存剤。
- 請求項1〜5のいずれかに記載の保存剤を含有する、眼科用組成物。
- (A)チオ硫酸ナトリウム、(B)エデト酸及び/又はその塩、ならびに(C)ホウ酸及び/又はその塩を水系組成物に配合することを特徴とする、細菌増殖抑制方法。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006096132A JP2007269673A (ja) | 2006-03-30 | 2006-03-30 | 保存剤 |
PCT/JP2007/056978 WO2007114300A1 (ja) | 2006-03-30 | 2007-03-29 | 保存剤 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006096132A JP2007269673A (ja) | 2006-03-30 | 2006-03-30 | 保存剤 |
Publications (1)
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JP2007269673A true JP2007269673A (ja) | 2007-10-18 |
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Family Applications (1)
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JP2006096132A Withdrawn JP2007269673A (ja) | 2006-03-30 | 2006-03-30 | 保存剤 |
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JP (1) | JP2007269673A (ja) |
WO (1) | WO2007114300A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE202011003029U1 (de) | 2010-02-23 | 2011-08-01 | Ahlstrom Corp. | Träger auf Cellulosefaser-Basis, der eine modifizierte PVA-Schicht enthält |
JP2019059718A (ja) * | 2017-09-22 | 2019-04-18 | ロート製薬株式会社 | コンタクトレンズ用眼科組成物 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP5369346B2 (ja) * | 2008-12-25 | 2013-12-18 | 株式会社メニコンネクト | コンタクトレンズ用の装着・保存・点眼用の組成物 |
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US4880601A (en) * | 1985-09-27 | 1989-11-14 | Laboratoires, P.O.S. | Hydrogen peroxide disinfecting system for contact lenses |
JPH04242649A (ja) * | 1990-12-28 | 1992-08-31 | Tome Sangyo Kk | 含水性カラーコンタクトレンズの消毒方法 |
JPH08133911A (ja) * | 1994-11-04 | 1996-05-28 | Senju Pharmaceut Co Ltd | 抗菌組成物 |
JP2001242427A (ja) * | 1999-12-21 | 2001-09-07 | Tanaka Kagaku Kenkyusho:Kk | コンタクトレンズ用洗浄剤 |
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JP2005002048A (ja) * | 2003-06-12 | 2005-01-06 | Saga Seiyaku Kk | 水溶性アズレン製剤 |
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- 2007-03-29 WO PCT/JP2007/056978 patent/WO2007114300A1/ja active Application Filing
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US4880601A (en) * | 1985-09-27 | 1989-11-14 | Laboratoires, P.O.S. | Hydrogen peroxide disinfecting system for contact lenses |
JPH04242649A (ja) * | 1990-12-28 | 1992-08-31 | Tome Sangyo Kk | 含水性カラーコンタクトレンズの消毒方法 |
JPH08133911A (ja) * | 1994-11-04 | 1996-05-28 | Senju Pharmaceut Co Ltd | 抗菌組成物 |
JP2001242427A (ja) * | 1999-12-21 | 2001-09-07 | Tanaka Kagaku Kenkyusho:Kk | コンタクトレンズ用洗浄剤 |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE202011003029U1 (de) | 2010-02-23 | 2011-08-01 | Ahlstrom Corp. | Träger auf Cellulosefaser-Basis, der eine modifizierte PVA-Schicht enthält |
WO2011104427A1 (en) | 2010-02-23 | 2011-09-01 | Ahlstrom Corporation | Cellulose fibre - based support containing a modified pva layer, and a method its production and use |
JP2019059718A (ja) * | 2017-09-22 | 2019-04-18 | ロート製薬株式会社 | コンタクトレンズ用眼科組成物 |
JP7195838B2 (ja) | 2017-09-22 | 2022-12-26 | ロート製薬株式会社 | コンタクトレンズ用眼科組成物 |
JP7499829B2 (ja) | 2017-09-22 | 2024-06-14 | ロート製薬株式会社 | コンタクトレンズ用眼科組成物 |
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