JP2007244388A5 - - Google Patents
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- Publication number
- JP2007244388A5 JP2007244388A5 JP2007106593A JP2007106593A JP2007244388A5 JP 2007244388 A5 JP2007244388 A5 JP 2007244388A5 JP 2007106593 A JP2007106593 A JP 2007106593A JP 2007106593 A JP2007106593 A JP 2007106593A JP 2007244388 A5 JP2007244388 A5 JP 2007244388A5
- Authority
- JP
- Japan
- Prior art keywords
- vegf2
- polypeptide
- cells
- sequence
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/465,968 US6608182B1 (en) | 1994-03-08 | 1995-06-06 | Human vascular endothelial growth factor 2 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9501427A Division JPH11513883A (ja) | 1995-06-06 | 1996-06-06 | ヒト血管内皮増殖因子２ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007244388A JP2007244388A (ja) | 2007-09-27 |
| JP2007244388A5 true JP2007244388A5 (enExample) | 2008-04-03 |
Family
ID=23849909
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9501427A Withdrawn JPH11513883A (ja) | 1995-06-06 | 1996-06-06 | ヒト血管内皮増殖因子２ |
| JP11147333A Withdrawn JP2000069982A (ja) | 1995-06-06 | 1999-05-26 | ヒト血管内皮増殖因子２ |
| JP2007106593A Pending JP2007244388A (ja) | 1995-06-06 | 2007-04-13 | ヒト血管内皮増殖因子２ |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9501427A Withdrawn JPH11513883A (ja) | 1995-06-06 | 1996-06-06 | ヒト血管内皮増殖因子２ |
| JP11147333A Withdrawn JP2000069982A (ja) | 1995-06-06 | 1999-05-26 | ヒト血管内皮増殖因子２ |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6608182B1 (enExample) |
| EP (1) | EP0837934B1 (enExample) |
| JP (3) | JPH11513883A (enExample) |
| KR (1) | KR100511692B1 (enExample) |
| CN (2) | CN1552855A (enExample) |
| AT (1) | ATE347595T1 (enExample) |
| AU (1) | AU714484B2 (enExample) |
| CA (1) | CA2224093C (enExample) |
| DE (1) | DE69636752T2 (enExample) |
| WO (1) | WO1996039515A1 (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6824777B1 (en) | 1992-10-09 | 2004-11-30 | Licentia Ltd. | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
| US6734285B2 (en) | 1994-03-08 | 2004-05-11 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 proteins and compositions |
| US6608182B1 (en) * | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
| US7186688B1 (en) | 1994-03-08 | 2007-03-06 | Human Genome Sciences, Inc. | Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2 |
| US6040157A (en) * | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| US7153827B1 (en) | 1994-03-08 | 2006-12-26 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 and methods of use |
| US7109308B1 (en) | 1994-03-08 | 2006-09-19 | Human Genome Sciences, Inc. | Antibodies to human vascular endothelial growth factor 2 |
| US5932540A (en) | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| EP0751992B1 (en) | 1994-03-08 | 2005-11-09 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| US7597886B2 (en) | 1994-11-07 | 2009-10-06 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
| WO1998033917A1 (en) * | 1994-11-14 | 1998-08-06 | The Ludwig Institute For Cancer Research | Vascular endothelial growth factor c (vegf-c) protein and gene, mutants thereof, and uses thereof |
| US6245530B1 (en) | 1995-08-01 | 2001-06-12 | Ludwig Institute For Cancer Research | Receptor ligand |
| US6818220B1 (en) | 1994-11-14 | 2004-11-16 | Licentia Ltd. | Vascular endothelial growth factor C (VEGF-C) protein and gene mutants thereof, and uses thereof |
| US6645933B1 (en) | 1995-08-01 | 2003-11-11 | Helsinki University Licensing Ltd. Oy | Receptor ligand VEGF-C |
| US6403088B1 (en) | 1995-08-01 | 2002-06-11 | Helsinki University Licensing, Ltd. | Antibodies reactive with VEGF-C, a ligand for the Flt4 receptor tyrosine kinase (VEGFR-3) |
| US6221839B1 (en) | 1994-11-14 | 2001-04-24 | Helsinki University Licensing Ltd. Oy | FIt4 ligand and methods of use |
| US6130071A (en) * | 1997-02-05 | 2000-10-10 | Helsinki University Licensing, Ltd. | Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof |
| US7429646B1 (en) | 1995-06-05 | 2008-09-30 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like 2 |
| US7423125B2 (en) | 1995-08-01 | 2008-09-09 | Vegenics Limited | Antibodies to VEGF-C |
| AU755708B2 (en) * | 1995-08-01 | 2002-12-19 | Vegenics Limited | Receptor ligand VEGF-C |
| US6361946B1 (en) | 1997-02-05 | 2002-03-26 | Licentia Ltd | Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
| AU2003201371B2 (en) * | 1995-08-01 | 2007-03-01 | Helsinki University Licensing Ltd. Oy | Receptor Ligand VEGF-C |
| ES2202469T5 (es) * | 1995-09-08 | 2011-06-06 | Genentech, Inc. | Proteína relacionada con el vegf. |
| US6994989B1 (en) | 1995-11-08 | 2006-02-07 | Immunex Corp. | FLK-1 binding proteins |
| AU1116297A (en) | 1995-11-08 | 1997-05-29 | Immunex Corporation | Flk-1 binding protein |
| US6713061B1 (en) | 1996-03-12 | 2004-03-30 | Human Genome Sciences, Inc. | Death domain containing receptors |
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| WO1997033904A1 (en) | 1996-03-12 | 1997-09-18 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US7964190B2 (en) | 1996-03-22 | 2011-06-21 | Human Genome Sciences, Inc. | Methods and compositions for decreasing T-cell activity |
| US6635743B1 (en) | 1996-03-22 | 2003-10-21 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II and methods of use |
| US20060171907A1 (en) * | 1996-11-21 | 2006-08-03 | The Procter & Gamble Company | Oral care compositions providing enhanced whitening and stain prevention |
| US7125714B2 (en) | 1997-02-05 | 2006-10-24 | Licentia Ltd. | Progenitor cell materials and methods |
| WO1998039035A1 (en) * | 1997-03-07 | 1998-09-11 | The Wistar Institute Of Anatomy & Biology | Method and compositions for healing tissue defects and inducing hypervascularity in mammalian tissue |
| US6676937B1 (en) | 1998-03-09 | 2004-01-13 | Caritas St. Elizabeth's Medical Center Of Boston Inc. | Compositions and methods for modulating vascularization |
| CA2322748A1 (en) * | 1998-03-13 | 1999-09-16 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| ATE489108T1 (de) | 1998-10-09 | 2010-12-15 | Vegenics Ltd | Flt4 (vegfr-3) als ziel für tumornachweis (imaging) und antitumortherapie |
| US6958147B1 (en) | 1998-10-26 | 2005-10-25 | Licentia Ltd | Use of VEGF-C to prevent restenosis |
| US6783953B1 (en) | 1998-12-22 | 2004-08-31 | Janssen Pharmaceutica N.V. | Vascular endothelial growth factor-X |
| US7223724B1 (en) | 1999-02-08 | 2007-05-29 | Human Genome Sciences, Inc. | Use of vascular endothelial growth factor to treat photoreceptor cells |
| EP2357192A1 (en) | 1999-02-26 | 2011-08-17 | Human Genome Sciences, Inc. | Human endokine alpha and methods of use |
| US6764820B2 (en) * | 1999-03-26 | 2004-07-20 | Ludwig Institute For Cancer Research | Screening for lymphatic disorders involving the FLT4 receptor tyrosine kinase (VEGFR-3) |
| WO2000058511A1 (en) | 1999-03-26 | 2000-10-05 | Ludwig Institute For Cancer Research | Screening and therapy for lymphatic disorders involving the flt4 receptor tyrosine kinase (vegfr-3) |
| AU2001239884B2 (en) * | 2000-02-25 | 2006-08-10 | Vegenics Limited | Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins and screening methods for modulators |
| US7291597B2 (en) * | 2000-04-06 | 2007-11-06 | Franco Wayne P | Growth factor therapy mobilization of stem cells into the peripheral blood |
| US7288521B2 (en) * | 2000-04-06 | 2007-10-30 | Franco Wayne P | Growth factor therapy mobilization of stem cells into the peripheral blood |
| EP1274720A4 (en) | 2000-04-12 | 2004-08-18 | Human Genome Sciences Inc | FUSION PROTEINS CONTAINING ALBUMIN |
| US7273751B2 (en) | 2000-08-04 | 2007-09-25 | Human Genome Science, Inc. | Vascular endothelial growth factor-2 |
| US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| AU2884102A (en) | 2000-12-07 | 2002-06-18 | Sangamo Biosciences Inc | Regulation of angiogenesis with zinc finger proteins |
| US7611711B2 (en) * | 2001-01-17 | 2009-11-03 | Vegenics Limited | VEGFR-3 inhibitor materials and methods |
| CA2435503C (en) | 2001-01-19 | 2011-02-22 | Ludwig Institute For Cancer Research | Flt4(vegfr-3) as a target for tumor imaging and anti-tumor therapy |
| AU2002252631A1 (en) * | 2001-04-13 | 2002-10-28 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| US20050232921A1 (en) * | 2001-04-13 | 2005-10-20 | Rosen Craig A | Vascular endothelial growth factor 2 |
| DE60236646D1 (de) | 2001-04-13 | 2010-07-22 | Human Genome Sciences Inc | Anti-VEGF-2 Antikörper |
| US7402312B2 (en) | 2001-04-13 | 2008-07-22 | Human Genome Sciences, Inc. | Antibodies to vascular endothelial growth factor 2 (VEGF-2) |
| CN1555488A (zh) * | 2001-07-12 | 2004-12-15 | 路德维格癌症研究院 | 淋巴管内皮细胞物质及方法 |
| WO2003018752A2 (en) | 2001-08-23 | 2003-03-06 | The Wistar Institute Of Anatomy And Biology | An organotypic intestinal culture and methods of use thereof |
| US20040214766A1 (en) * | 2001-10-01 | 2004-10-28 | Kari Alitalo | VEGF-C or VEGF-D materials and methods for treatment of neuropathologies |
| US20030113324A1 (en) * | 2001-10-01 | 2003-06-19 | Kari Alitalo | Neuropilin/VEGF-C/VEGFR-3 materials and methods |
| PT1463751E (pt) | 2001-12-21 | 2013-08-26 | Human Genome Sciences Inc | Proteínas de fusão de albumina |
| WO2003104428A2 (en) | 2002-01-21 | 2003-12-18 | Vaccinex, Inc. | Gene differentially expressed in breast and bladder cancer and encoded polypeptides |
| US20040120950A1 (en) * | 2002-12-20 | 2004-06-24 | Kari Alitalo | Modulation of VEGF-C/VEGFR-3 interactions in the treatment of rheumatoid arthritis |
| EP1594527A2 (en) * | 2003-02-04 | 2005-11-16 | Ludwig Institute For Cancer Research | Vegf-b and pdgf modulation of stem cells |
| EP1635860A2 (en) * | 2003-06-12 | 2006-03-22 | Ludwig Institute For Cancer Research | Use of vegf-c or vegf-d in reconstructive surgery |
| WO2005016963A2 (en) * | 2003-06-12 | 2005-02-24 | Ludwig Institute For Cancer Research | Heparin binding veger-3 ligands |
| US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
| EP1869075B1 (en) | 2005-02-28 | 2012-04-11 | Sangamo BioSciences, Inc. | Anti-angiogenic methods and compositions |
| CN101257861B (zh) * | 2005-06-21 | 2012-12-05 | 渗透治疗有限公司 | 用于增强血管通路的方法和组合物 |
| JP5690593B2 (ja) | 2007-12-26 | 2015-03-25 | ヴァクシネックス， インコーポレイテッド | 抗ｃ３５抗体併用療法および方法 |
| WO2010005850A1 (en) | 2008-07-08 | 2010-01-14 | The J. David Gladstone Institutes | Methods and compositions for modulating angiogenesis |
| MY199344A (en) | 2013-02-18 | 2023-10-24 | Vegenics Pty Ltd | Ligand binding molecules and uses thereof |
| CN108339154A (zh) * | 2017-01-25 | 2018-07-31 | 中国科学院遗传与发育生物学研究所 | 一种诱导颅脑损伤组织再生的功能生物材料及其应用 |
| CN111303271B (zh) * | 2020-02-19 | 2022-02-01 | 西安交通大学医学院第一附属医院 | 一种用于治疗肺纤维化的血小板源性生长因子重组疫苗及其应用 |
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| EP0186084B1 (en) | 1984-12-24 | 1991-09-04 | Merck & Co. Inc. | Brain-derived growth factor |
| US5073492A (en) * | 1987-01-09 | 1991-12-17 | The Johns Hopkins University | Synergistic composition for endothelial cell growth |
| JPS6438100A (en) | 1987-07-31 | 1989-02-08 | Toray Industries | Vascular endothelial cell growth factor |
| JPH02117698A (ja) | 1988-10-27 | 1990-05-02 | Toray Ind Inc | 血管内皮細胞成長因子 |
| US5240848A (en) | 1988-11-21 | 1993-08-31 | Monsanto Company | Dna sequences encoding human vascular permeability factor having 189 amino acids |
| US5693622A (en) | 1989-03-21 | 1997-12-02 | Vical Incorporated | Expression of exogenous polynucleotide sequences cardiac muscle of a mammal |
| EP0399816B1 (en) | 1989-05-24 | 1995-12-20 | Merck & Co. Inc. | Purification and characterization of a glioma-derived growth factor |
| US5219739A (en) | 1989-07-27 | 1993-06-15 | Scios Nova Inc. | DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121 |
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| US6245530B1 (en) * | 1995-08-01 | 2001-06-12 | Ludwig Institute For Cancer Research | Receptor ligand |
| WO1998033917A1 (en) | 1994-11-14 | 1998-08-06 | The Ludwig Institute For Cancer Research | Vascular endothelial growth factor c (vegf-c) protein and gene, mutants thereof, and uses thereof |
| US6130071A (en) * | 1997-02-05 | 2000-10-10 | Helsinki University Licensing, Ltd. | Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof |
| US6645933B1 (en) | 1995-08-01 | 2003-11-11 | Helsinki University Licensing Ltd. Oy | Receptor ligand VEGF-C |
| US6221839B1 (en) * | 1994-11-14 | 2001-04-24 | Helsinki University Licensing Ltd. Oy | FIt4 ligand and methods of use |
| US5792453A (en) | 1995-02-28 | 1998-08-11 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
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| ATE219517T1 (de) | 1995-08-18 | 2002-07-15 | Morphosys Ag | Protein-/(poly)peptidbibliotheken |
| ES2202469T5 (es) | 1995-09-08 | 2011-06-06 | Genentech, Inc. | Proteína relacionada con el vegf. |
| US6121246A (en) | 1995-10-20 | 2000-09-19 | St. Elizabeth's Medical Center Of Boston, Inc. | Method for treating ischemic tissue |
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| DE60236646D1 (de) | 2001-04-13 | 2010-07-22 | Human Genome Sciences Inc | Anti-VEGF-2 Antikörper |
| WO2002083850A2 (en) | 2001-04-13 | 2002-10-24 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| AU2002252631A1 (en) | 2001-04-13 | 2002-10-28 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| WO2003097660A1 (en) | 2002-04-12 | 2003-11-27 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
-
1995
- 1995-06-06 US US08/465,968 patent/US6608182B1/en not_active Expired - Fee Related
-
1996
- 1996-06-06 EP EP96918130A patent/EP0837934B1/en not_active Revoked
- 1996-06-06 KR KR1019970709003A patent/KR100511692B1/ko not_active Expired - Fee Related
- 1996-06-06 CN CNA2004100022261A patent/CN1552855A/zh active Pending
- 1996-06-06 WO PCT/US1996/009001 patent/WO1996039515A1/en not_active Ceased
- 1996-06-06 CN CN96194405A patent/CN1186518A/zh active Pending
- 1996-06-06 DE DE69636752T patent/DE69636752T2/de not_active Revoked
- 1996-06-06 AU AU60467/96A patent/AU714484B2/en not_active Withdrawn - After Issue
- 1996-06-06 CA CA002224093A patent/CA2224093C/en not_active Expired - Fee Related
- 1996-06-06 JP JP9501427A patent/JPH11513883A/ja not_active Withdrawn
- 1996-06-06 AT AT96918130T patent/ATE347595T1/de not_active IP Right Cessation
-
1999
- 1999-05-26 JP JP11147333A patent/JP2000069982A/ja not_active Withdrawn
-
2002
- 2002-04-23 US US10/127,551 patent/US7115392B2/en not_active Expired - Fee Related
-
2007
- 2007-04-13 JP JP2007106593A patent/JP2007244388A/ja active Pending
-
2008
- 2008-10-24 US US12/258,109 patent/US20100143360A1/en not_active Abandoned
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