JP2007238481A - 歯垢形成抑制剤 - Google Patents
歯垢形成抑制剤 Download PDFInfo
- Publication number
- JP2007238481A JP2007238481A JP2006060909A JP2006060909A JP2007238481A JP 2007238481 A JP2007238481 A JP 2007238481A JP 2006060909 A JP2006060909 A JP 2006060909A JP 2006060909 A JP2006060909 A JP 2006060909A JP 2007238481 A JP2007238481 A JP 2007238481A
- Authority
- JP
- Japan
- Prior art keywords
- water
- insoluble fraction
- plaque formation
- tragacanth gum
- plaque
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000007505 plaque formation Effects 0.000 title claims abstract description 32
- 239000003112 inhibitor Substances 0.000 title claims abstract description 18
- 208000002064 Dental Plaque Diseases 0.000 title abstract description 7
- 229920001615 Tragacanth Polymers 0.000 claims abstract description 41
- 239000000305 astragalus gummifer gum Substances 0.000 claims abstract description 37
- 235000013305 food Nutrition 0.000 claims abstract description 17
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- 239000004480 active ingredient Substances 0.000 claims abstract description 6
- 230000000694 effects Effects 0.000 claims description 15
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- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 16
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- 230000015572 biosynthetic process Effects 0.000 description 8
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- 239000001103 potassium chloride Substances 0.000 description 8
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Abstract
【解決手段】トラガントガム水不溶性画分を有効成分とする歯垢形成抑制剤。
【選択図】なし
Description
得られた水不溶性画分は、そのまま又は乾燥や溶液後、目的物に応じて希釈若しくは濃縮等してから用いることができる。
本発明の歯垢形成抑制剤や口腔剤組成物は、口腔内細菌が定着していない乳幼児等に投与すれば、口腔内への細菌感染を予防する効果を有する。
0.1%濃度になるように市販粗トラガントガム水溶液を調製した後、遠心分離し(1800×g、10分、室温)、不溶性画分(沈殿画分)と水溶性画分(上清画分)に分画した。各画分を凍結乾燥し乾燥物を獲得した。
その結果、乾燥物の質量比は、不溶性画分:水溶性画分=7:3であった。
次法により被験物質の細菌吸着阻害効果を測定した。
ヒト口腔内より単離したS.mutans 保存菌体を10μCi/mLメチル化[3H]−チミジン0.2重量%グルコース含有ブレインハートインフュージョン培地(DIFCO社)10mLに接種し、37℃で24時間嫌気培養した。緩衝KCl溶液(50mM塩化カリウム、1mM塩化マグネシウム、0.1mM 塩化マグネシウム含有1mMリン酸緩衝液)で3回洗浄後、5mg/mLウシ血清アルブミン含有緩衝塩化カリウム溶液に1×109CFU/mLの濃度で分散させ、3H標識S.mutans液とした。
吸着数をAとする。また該水溶液の代わりに蒸留水1mL、耳下腺唾液の代わりに緩衝塩化カリウム溶液0.5mLを用いて同様の処理を行ったときの、細菌吸着数をBとする。
細菌吸着阻害率I(%)=〔(A−X)/(A−B)〕×100
上記トラガント不溶画分を用い下記実施例3〜8の口腔剤組成物及び食品を調製した。実施例3〜8の本発明の口腔剤組成物及び飲料・食品は、いずれも優れた歯垢形成抑制効果が認められた。
トラガントガム水不溶性画分 0.1質量%
シリカ 30
ソルビトール 30
ラウリル硫酸ナトリウム 1.0
カルボキシメチルセルロース 1.0
サッカリン 0.1
香料 適量
水 全100
トラガントガム水不溶性画分 0.1質量%
エタノール 20
ピロリン酸ナトリウム 2.0
サッカリン 0.1
香料 適量
水 全100
トラガントガム水不溶性画分 0.1質量%
ガムベース 20
ブドウ糖 20
ソルビトール 20
キシリトール 10
香料 適量
水飴 全100
トラガントガム水不溶性画分 0.1質量%
水飴 40
ソルビトール 25
アスパルテーム 0.5
香料 適量
還元マルチトール 全100
トラガントガム水不溶性画分 0.1質量%
直打用微粒No.209*(富士化学社製) 45
結晶セルロース 40
CMCカルシウム 8
香料 適量
ステアリン酸マグネシウム 全100
*直打用微粒No.209(メタケイ酸アルミン酸マグネシウム 20質量%、トウモロコシデンプン 30質量%、乳糖 50質量%)
トラガントガム水不溶性画分 0.1質量%
エリスリトール 0.8
アスパルテーム 0.5
グレープフルーツ果汁 0.1
香料 適量
水 全100
Claims (5)
- トラガントガム水不溶性画分を有効成分とする歯垢形成抑制剤。
- トラガントガム水不溶性画分を含有する口腔剤組成物。
- トラガントガム水不溶性画分を含有する食品又は飲料。
- 歯垢形成を抑制する効果を有することを特徴とし、歯垢形成を抑制するために用いるものである旨の表示をした、請求項3記載の食品又は飲料。
- トラガントガム水不溶性画分を含有する食品又は飲料の添加用組成物。
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JP2006060909A JP4602922B2 (ja) | 2006-03-07 | 2006-03-07 | 歯垢形成抑制剤 |
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JP4602922B2 JP4602922B2 (ja) | 2010-12-22 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104547856A (zh) * | 2014-12-18 | 2015-04-29 | 苏敏华 | 一种治疗牙周炎的中药组合物、凝胶制剂及其制备方法 |
CN104721249A (zh) * | 2015-03-25 | 2015-06-24 | 江琴 | 一种治疗急性牙周脓肿的外用制剂 |
CN104784484A (zh) * | 2015-04-16 | 2015-07-22 | 江琴 | 一种治疗儿童乳牙根尖周炎的药物组合物及其应用 |
Citations (7)
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JPH01213222A (ja) * | 1988-01-14 | 1989-08-28 | Warner Lambert Co | 歯垢の抑制 |
JPH04217613A (ja) * | 1990-12-19 | 1992-08-07 | Lion Corp | 口腔用組成物 |
JPH05139979A (ja) * | 1991-11-16 | 1993-06-08 | Lotte Co Ltd | 虫歯菌歯牙付着阻害及び脱離のための口腔用組成物 |
JPH09175968A (ja) * | 1995-12-26 | 1997-07-08 | Lion Corp | 口腔用組成物 |
JPH11255612A (ja) * | 1998-03-12 | 1999-09-21 | Noevir Co Ltd | 抗菌剤及び抗菌性組成物 |
JP2002515911A (ja) * | 1997-06-17 | 2002-05-28 | ノボザイムス アクティーゼルスカブ | バチルス・プルラナーゼ及びデキストラナーゼを含んで成るオーラルケア組成物 |
JP2003183148A (ja) * | 2001-12-20 | 2003-07-03 | Kao Corp | 皮膚外用剤組成物 |
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2006
- 2006-03-07 JP JP2006060909A patent/JP4602922B2/ja not_active Expired - Fee Related
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH01213222A (ja) * | 1988-01-14 | 1989-08-28 | Warner Lambert Co | 歯垢の抑制 |
JPH04217613A (ja) * | 1990-12-19 | 1992-08-07 | Lion Corp | 口腔用組成物 |
JPH05139979A (ja) * | 1991-11-16 | 1993-06-08 | Lotte Co Ltd | 虫歯菌歯牙付着阻害及び脱離のための口腔用組成物 |
JPH09175968A (ja) * | 1995-12-26 | 1997-07-08 | Lion Corp | 口腔用組成物 |
JP2002515911A (ja) * | 1997-06-17 | 2002-05-28 | ノボザイムス アクティーゼルスカブ | バチルス・プルラナーゼ及びデキストラナーゼを含んで成るオーラルケア組成物 |
JPH11255612A (ja) * | 1998-03-12 | 1999-09-21 | Noevir Co Ltd | 抗菌剤及び抗菌性組成物 |
JP2003183148A (ja) * | 2001-12-20 | 2003-07-03 | Kao Corp | 皮膚外用剤組成物 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104547856A (zh) * | 2014-12-18 | 2015-04-29 | 苏敏华 | 一种治疗牙周炎的中药组合物、凝胶制剂及其制备方法 |
CN104721249A (zh) * | 2015-03-25 | 2015-06-24 | 江琴 | 一种治疗急性牙周脓肿的外用制剂 |
CN104784484A (zh) * | 2015-04-16 | 2015-07-22 | 江琴 | 一种治疗儿童乳牙根尖周炎的药物组合物及其应用 |
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