JP2007176830A5 - - Google Patents
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- JP2007176830A5 JP2007176830A5 JP2005375094A JP2005375094A JP2007176830A5 JP 2007176830 A5 JP2007176830 A5 JP 2007176830A5 JP 2005375094 A JP2005375094 A JP 2005375094A JP 2005375094 A JP2005375094 A JP 2005375094A JP 2007176830 A5 JP2007176830 A5 JP 2007176830A5
- Authority
- JP
- Japan
- Prior art keywords
- skin
- extract
- external preparation
- producing
- purified product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000003491 skin Anatomy 0.000 claims description 64
- 239000000284 extract Substances 0.000 claims description 53
- 238000002360 preparation method Methods 0.000 claims description 43
- 239000012264 purified product Substances 0.000 claims description 26
- 210000005175 epidermal keratinocyte Anatomy 0.000 claims description 19
- 238000004519 manufacturing process Methods 0.000 claims description 19
- 239000012528 membrane Substances 0.000 claims description 19
- 230000008591 skin barrier function Effects 0.000 claims description 19
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 239000002798 polar solvent Substances 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 12
- 241000218201 Ranunculaceae Species 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 10
- 229910001424 calcium ion Inorganic materials 0.000 claims description 10
- 238000012258 culturing Methods 0.000 claims description 9
- QUCQEUCGKKTEBI-UHFFFAOYSA-N palmatine Chemical compound COC1=CC=C2C=C(C3=C(C=C(C(=C3)OC)OC)CC3)[N+]3=CC2=C1OC QUCQEUCGKKTEBI-UHFFFAOYSA-N 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 8
- 230000002401 inhibitory effect Effects 0.000 claims description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 6
- 230000035699 permeability Effects 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 2
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- 230000006872 improvement Effects 0.000 claims 1
- 238000000622 liquid--liquid extraction Methods 0.000 claims 1
- 230000008569 process Effects 0.000 claims 1
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- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 2
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 2
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- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
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- 239000004386 Erythritol Substances 0.000 description 2
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- 239000002253 acid Substances 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
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- 239000012298 atmosphere Substances 0.000 description 2
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| JP2020164486A (ja) | 2019-03-29 | 2020-10-08 | 丸善製薬株式会社 | 抗老化剤、抗酸化剤、抗炎症剤、及び美白剤、並びに、化粧料 |
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| JP4880816B2 (ja) * | 2000-12-15 | 2012-02-22 | 株式会社ヤクルト本社 | 皮膚老化防止剤 |
| JP2003171310A (ja) * | 2002-05-02 | 2003-06-20 | Noevir Co Ltd | 皮膚バリア機能強化剤 |
| JP2003342122A (ja) * | 2002-05-30 | 2003-12-03 | Noevir Co Ltd | 皮膚外用剤 |
| JP2006111560A (ja) * | 2004-10-14 | 2006-04-27 | Nippon Menaade Keshohin Kk | セラミド合成促進剤 |
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