JP2007070271A - Skin care preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin care preparation having excellent moisturizing effect and roughened skin ameliorating effect. <P>SOLUTION: The skin care preparation having excellent moisturizing effect and roughened skin ameliorating effect can be produced by compounding a skin care preparation with an extract of Ayamurasaki (a variety of sweet potato). <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to an external preparation for skin which is excellent in moisture retention and exhibits an excellent effect in preventing and improving rough skin.

  Skin dryness resulting from low humidity conditions due to external environments such as skin barrier function, moisture retention function, and cooling and heating due to aging and diseases is an important factor that causes rough skin. Rough skin caused by dry skin not only causes skin symptoms such as fine wrinkles and reduced skin texture, but also causes skin diseases such as itching and eczema. For this reason, moisturizers that prevent skin dryness and prevent or improve rough skin are considered to be very useful. So far, in the field of topical skin preparations, various moisturizers have been searched and formulated. .

  As conventional humectants, glycerin, sorbitol, maltitol, hydroxyproline, chitosan, sodium pyrrolidonecarboxylate (see Non-Patent Document 1) are known. In recent years, the effects of moisturizing the extracts of plants including medicinal plants have also been examined, and the extraction of orchidaceae plants (see Patent Document 1), agave extracts (see Patent Document 2), and peanut seed coats Extract (see Patent Document 3), psyllium extract (see Patent Document 4), longan seed extract (see Patent Document 5), psyllium extract (see Patent Document 6), extract of the Asteraceae genus Pseudomonas Reference 7), various plant extracts extracted from plants consisting of cherry, violet, yarrow, itlan, italian, genus and ginkgo (see patent document 8), etc. Has been.

  The use of Ayamurasaki according to the present invention includes a food containing an aqueous solvent extract of purple sweet potato as a blood circulation improving agent (see Patent Document 9), a health food containing Ayamurasaki (see Patent Document 10), and the like. Has been.

JP 2002-205933 A JP 2002-193820 A JP 2002-145757 A JP 2002-145756 A JP 2002-145732 A JP 2002-145731 A JP 2002-20262 A JP 2002-20225 A Japan Patent Office "Knowledge and Conventional Techniques" (Cosmetics and similar products), August 21, 1984, p22-25 JP 2001-145471 A JP 2001-245630 A

  Conventionally known external preparations for skin containing the above-mentioned active ingredients are not necessarily sufficient in moisturizing effect and skin roughening effect, and development of more effective active ingredients has been demanded. Therefore, this invention is made | formed in view of the said situation, The subject is providing the skin external preparation excellent in the moisturizing effect and the rough skin improvement effect.

  In order to solve the above-mentioned problems, the present inventors have conducted intensive research to obtain a component excellent in a moisturizing effect and a rough skin improvement effect. As a result, the extract of Ayamurasaki is excellent in a moisturizing effect and a rough skin improving effect. As a result, the present invention has been completed.

  That is, this invention relates to the skin external preparation characterized by containing the extract of Ayamurasaki.

  ADVANTAGE OF THE INVENTION According to this invention, the skin external preparation excellent in the moisturizing effect and the rough skin improvement effect can be provided.

  An embodiment of the present invention will be described.

  Ayamurasaki used in the present invention is a cultivar obtained by crossing the Chiryu lineage with the native Yamakawa purple, selecting Kyushu No. 109, and crossing Kyushu No. 109 with Satsuma Hikari with low sugar content and high yield. Agricultural forest was registered as agricultural forestry No. 47 in 1995 (Makoto Yoshimoto, Osamu Yamakawa, Ikuo Suda: Food and Development. 33 (8): 15-17, 1998).

  The extract of Ayamurasaki can be prepared by a conventional extraction method using an appropriate solvent. In the extraction, it may be used as it is, but considering the extraction efficiency, it is preferable to perform the extraction after performing processing such as shredding, drying, and pulverization. The extraction can be performed by immersing in an extraction solvent or by an extraction method using a supercritical fluid or a subcritical fluid. In order to increase the extraction efficiency, homogenization may be performed in stirring or an extraction solvent. The extraction temperature is suitably about 5 ° C. to the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but it is appropriate to set it to about 1 hour to 14 days.

  Extraction solvents include water, lower alcohols such as methanol, ethanol, propanol, and isopropanol, polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol, and glycerin, and ethers such as ethyl ether and propyl ether. And solvents such as esters such as butyl acetate and ethyl acetate, and ketones such as acetone and ethyl methyl ketone can be used, and one or more of these can be selected and used. Further, physiological saline, phosphate buffer, phosphate buffered saline, or the like may be used. Furthermore, you may use 1 type, or 2 or more types of supercritical liquids and subcritical liquids, such as water, a carbon dioxide, ethylene, propylene, ethanol, methanol, ammonia.

  The extract of Ayamurasaki using the above solvent can be used as it is, but the concentrated and dried product can be dissolved again in water or a polar solvent, or decolorized, deodorized and deodorized as long as these physiological functions are not impaired. You may use, after refine | purifying a salt etc. or performing the fractionation process by column chromatography etc. The said extract of plant, its processed material, and a fraction can also be lyophilized | freeze-dried after each process and fractionation, and can also be used after melt | dissolving in a solvent at the time of use. It can also be used by encapsulating in vesicles such as liposomes or microcapsules.

  In the present invention, by adding the extract of Ayamurasaki to the external preparation for skin, it is possible to obtain an external preparation for skin that is excellent in moisture retention and exhibits excellent effects in preventing and improving rough skin.

  The blending amount of the extract of Ayamurasaki in the present invention can be adjusted according to the type and purpose of the external preparation for skin, but is preferably 0.0001 to 10.0% by weight based on the total amount of the external preparation for skin. Preferably, it is 0.001 to 5.0 weight%.

  The external preparation for skin according to the present invention can be provided in various dosage forms such as lotion, emulsion, gel, cream, ointment, powder, granule and the like.

  In addition, the external preparation for skin according to the present invention includes, in addition to the plant extract of the present invention, an oily component, a moisturizing agent, and the like, which are usually blended in pharmaceuticals, quasi drugs, skin cosmetics, hair cosmetics and cleaning agents. Agents, powders, pigments, emulsifiers, solubilizers, detergents, ultraviolet absorbers, thickeners, drugs, fragrances, resins, antibacterial agents, antioxidants, alcohols, and the like can be appropriately blended. Moreover, in the range which does not impair the effect of this invention, combined use with another plant extract is also possible.

  Further, the features of the present invention will be described in detail by way of examples. First, the preparation method of the extract of Ayamurasaki of this invention is shown.

[Preparation Method 1]
10 kg of a 50 wt% aqueous ethanol solution was added to 1 kg of dried pulverized roots of Ayamurasaki and immersed for 7 days at room temperature. The extract was collected by filtration, and after removing the solvent, an extract of Ayamurasaki was obtained.

[Preparation Method 2]
Nine liters of water was added to 1 kg of dried pulverized roots of Ayamurasaki, and the mixture was extracted by refluxing at 90 ° C. for 6 hours. The extract was collected by filtration, and after removing the solvent, an extract of Ayamurasaki was obtained.

[Preparation Method 3]
Nine liters of methanol was added to 1 kg of dried ground millet of Ayamurasaki and immersed for 7 days at room temperature. The extract was collected by filtration, and after removing the solvent, an extract of Ayamurasaki was obtained.

[Preparation Method 4]
A tuber of Ayamurasaki was put into a supercritical extraction apparatus, and extracted using a supercritical fluid of carbon dioxide at 40 ° C. under an atmospheric pressure of 15 Mpa. The extract was recovered to obtain an extract of Ayamurasaki.

  Subsequently, a prescription for an external preparation for skin containing an extract of Ayamurasaki will be shown. In the formulations of Examples 1 to 4, the extract of Ayamurasaki of the present invention shown in Table 1 was blended, and in the formulations of Examples 5 to 7, an extract of Ayamurasaki was blended in each formulation.

[Examples 1 to 4] Lotion (1) Ethanol 15.0 (wt%)
(2) Polyoxyethylene (40E.O.) hydrogenated castor oil 0.3
(3) Fragrance 0.1
(4) Ayamurasaki extract shown in Table 1.0
(5) Purified water 83.38
(6) Citric acid 0.02
(7) Sodium citrate 0.1
(8) Hydroxyethyl cellulose 0.1
Production method: (2) to (4) are dissolved in (1). After dissolution, (5) to (7) are sequentially added, and then sufficiently stirred, (8) is added and mixed uniformly.

[Example 5] Emulsion (1) Squalane 10.0 (wt%)
(2) Methylphenylpolysiloxane 4.0
(3) Hydrogenated palm kernel oil 0.5
(4) Hydrogenated soybean phospholipid 0.1
(5) Polystearic acid polyoxyethylene sorbitan (20EO) 1.3
(6) Sorbitan monostearate 1.0
(7) Glycerin 10.0
(8) Methyl paraoxybenzoate 0.1
(9) Carboxymethyl polymer 0.15
(10) Purified water 50.85
(11) Arginine (1 wt% aqueous solution) 20.0
(12) Ayamuraki extract (Preparation method 1) 2.0
Production method: The oil phase components (1) to (6) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (7) to (10) are dissolved by heating at 80 ° C. The oil phase component is added to this while stirring and uniformly emulsified with a homogenizer. After the emulsification, cooling is started, and (11) and (12) are sequentially added and mixed uniformly.

[Example 6] Cream (1) Squalane 10.0 (% by weight)
(2) Stearic acid 2.0
(3) Hydrogenated palm kernel oil 0.5
(4) Hydrogenated soybean phospholipid 0.1
(5) Cetanol 3.6
(6) Lipophilic glyceryl monostearate 2.0
(7) Glycerin 10.0
(8) Methyl paraoxybenzoate 0.1
(9) Arginine (20% by weight aqueous solution) 15.0
(10) Purified water 40.7
(11) Carboxyvinyl polymer (1% by weight aqueous solution) 15.0
(12) Ayamurasaki extract (Preparation method 2) 1.0
Production method: The oil phase components (1) to (6) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (7) to (11) are dissolved by heating at 80 ° C. The oil phase component is added to this while stirring and uniformly emulsified with a homogenizer. After emulsification, cooling is started, and (12) is added at 40 ° C. and mixed uniformly.

[Example 7] Aqueous gel (1) Carboxyvinyl polymer 0.5 (% by weight)
(2) Purified water 86.6
(3) Sodium hydroxide (10% by weight aqueous solution) 0.5
(4) Ethanol 10.0
(5) Methyl paraoxybenzoate 0.1
(6) Fragrance 0.1
(7) Polyoxyethylene (60E.O.) hydrogenated castor oil 0.1
(8) Glycerin 2.0
(9) Ayamurasaki extract (Preparation method 3) 0.1
Manufacturing method: (1) is added to (2), and after stirring uniformly, (3) is added. After uniformly dissolving, (5) previously dissolved in (4) is added. After stirring uniformly, the previously mixed (6) to (7) are added. After stirring uniformly, (8) to (9) are sequentially added and mixed uniformly.

  The use test was done about Examples 1-4 of this invention, and the moisture retention of the extract of Ayamurasaki was evaluated. At that time, the extract of Ayamurasaki blended in Example 1 was replaced with sorbitol, and a use test was simultaneously conducted as Comparative Example 1.

  A group of 15 male and female panelists used each sample blindly, and the moisturizing properties of Examples 1 to 4 were compared to Comparative Example 1 in three stages: “feel”, “cannot say”, and “do not feel” Table 3 shows the number of panelists that obtained each evaluation.

  From Table 3, it was found that 60% or more of panelists felt a clear moisturizing property in the example use group in which the extract of Ayamurasaki of the present invention was blended. From this, it was revealed that the extract of Ayamurasaki of the present invention has excellent moisture retention.

  Next, a usage test was performed on Examples 1 to 4 of the present invention, and the improvement effect of these symptoms was evaluated for rough skin, skin texture, and skin transparency. At that time, in Example 1, the blended extract of Ayamurasaki was replaced with maltitol, and a use test was simultaneously conducted as Comparative Example 2.

  For each sample, a group of 20 male and female panelists in their 20s to 50s who are worried about rough skin, skin texture, and skin transparency, and used blindly for 1 month to observe changes in skin condition before and after use. And evaluated. As an index of skin condition, rough skin, skin texture, and skin transparency were evaluated in three stages: “Improved”, “Slightly improved”, and “No change”. Table 4 shows the number of panelists that obtained each evaluation. Indicated. The rough skin and the transparency of the skin were evaluated visually, and the texture of the skin was observed using a microscope.

  From Table 4, in the use group of Comparative Example 2 which does not contain the extract of Ayamurasaki of the present invention with respect to rough skin, skin texture, and skin transparency, improvement was not recognized in more than half of the panelists. In the example use group in which the extract of Ayamurasaki was blended, a clear improvement was recognized in more than 60% of the panelists.

As mentioned above, in the Example of this invention, it had the effect excellent in improvement of skin symptoms, such as rough skin, the texture of skin, and the transparency of the skin, compared with the conventional comparative example.

Claims (1)

An external preparation for skin containing an extract of Ayamurasaki.