JP2006528697A5 - - Google Patents
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- Publication number
- JP2006528697A5 JP2006528697A5 JP2006533117A JP2006533117A JP2006528697A5 JP 2006528697 A5 JP2006528697 A5 JP 2006528697A5 JP 2006533117 A JP2006533117 A JP 2006533117A JP 2006533117 A JP2006533117 A JP 2006533117A JP 2006528697 A5 JP2006528697 A5 JP 2006528697A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pharmaceutical formulation
- linker
- hydrogen bond
- immunomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47124703P | 2003-05-16 | 2003-05-16 | |
| PCT/US2004/015313 WO2004103301A2 (en) | 2003-05-16 | 2004-05-14 | Synergistic treatment of cancer using immunomers in conjunction with chemotherapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006528697A JP2006528697A (ja) | 2006-12-21 |
| JP2006528697A5 true JP2006528697A5 (https=) | 2007-06-28 |
Family
ID=33476820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533117A Withdrawn JP2006528697A (ja) | 2003-05-16 | 2004-05-14 | イムノマーを化学療法剤と組み合わせて用いる、癌の相乗的処置 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7569554B2 (https=) |
| EP (1) | EP1628531A4 (https=) |
| JP (1) | JP2006528697A (https=) |
| KR (1) | KR20060012622A (https=) |
| AU (1) | AU2004241093B2 (https=) |
| CA (1) | CA2526212C (https=) |
| MX (1) | MXPA05012421A (https=) |
| WO (1) | WO2004103301A2 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| KR100917101B1 (ko) * | 2000-08-04 | 2009-09-15 | 도요 보세키 가부시키가이샤 | 플렉시블 금속적층체 및 그 제조방법 |
| AU2001294750C1 (en) * | 2000-09-26 | 2008-09-18 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes |
| EP2423335B1 (en) * | 2001-06-21 | 2014-05-14 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same |
| US7785610B2 (en) | 2001-06-21 | 2010-08-31 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same—III |
| US7276489B2 (en) * | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| AR040996A1 (es) * | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
| US10100316B2 (en) * | 2002-11-21 | 2018-10-16 | Archemix Llc | Aptamers comprising CPG motifs |
| US8853376B2 (en) | 2002-11-21 | 2014-10-07 | Archemix Llc | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| US7354907B2 (en) * | 2003-02-07 | 2008-04-08 | Idera Pharmaceuticals, Inc. | Short immunomodulatory oligonucleotides |
| MXPA06000619A (es) * | 2003-07-15 | 2006-04-11 | Hybridon Inc | Estimulacion sinergistica del sistema inmune usando oligonucleotidos inmunoestimuladores y/o compuestos inmunomeros en conjunto con citocinas y/o agentes quimioterapeuticos o terapia de radiacion. |
| ATE439135T1 (de) | 2005-07-01 | 2009-08-15 | Index Pharmaceuticals Ab | Modulierung der reaktion auf steroide |
| AU2006266503B2 (en) | 2005-07-01 | 2011-12-08 | Index Pharmaceuticals Ab | Immunostimulatory method |
| US20070048325A1 (en) * | 2005-08-24 | 2007-03-01 | Dennis Van Epps | Combination therapies for inhibiting integrin-extracellular matrix interactions |
| EP2982679A1 (en) * | 2005-10-12 | 2016-02-10 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| AU2006306805A1 (en) | 2005-10-28 | 2007-05-03 | Index Pharmaceuticals Ab | Composition and method for the prevention, treatment and/or alleviation of an inflammatory disease |
| US7470674B2 (en) * | 2005-11-07 | 2008-12-30 | Idera Pharmaceuticals, Inc. | Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides |
| GB0523041D0 (en) * | 2005-11-11 | 2005-12-21 | Cyclacel Ltd | Combination |
| PT2078080E (pt) | 2006-09-27 | 2015-09-18 | Coley Pharm Gmbh | Análogos dos oligonucleotídeos cpg que contêm análogos t hidrofóbicos com atividade imunoestimulante potenciada |
| DK2596801T3 (en) * | 2006-10-06 | 2018-08-13 | Bavarian Nordic As | RECOMBINANT MODIFIED VACCINIA ANKARA VIRUS CODING A HER-2 ANTIGEN FOR USING CANCER TREATMENT |
| GB0625283D0 (en) | 2006-12-19 | 2007-01-24 | Cyclacel Ltd | Combination |
| AU2009259136B2 (en) * | 2008-06-09 | 2014-09-25 | Cyclacel Limited | Combinations of sapacitabine or CNDAC with DNA methyltransferase inhibitors such as decitabine and procaine |
| TWI409079B (zh) * | 2009-08-14 | 2013-09-21 | Roche Glycart Ag | 非典型岩藻醣化cd20抗體與苯達莫斯汀(bendamustine)之組合療法 |
| CA2769595A1 (en) * | 2009-08-14 | 2011-02-17 | Roche Glycart Ag | Combination therapy of an afucosylated cd20 antibody with fludarabine and/or mitoxantrone |
| EP2425830A1 (en) * | 2010-09-03 | 2012-03-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Synergistic drug combination for the treatment of cancer |
| CN102172359A (zh) * | 2011-03-02 | 2011-09-07 | 张始状 | 腺苷与核苷组合在制备治疗肿瘤药物中的应用 |
| PL2696878T3 (pl) | 2011-04-14 | 2020-01-31 | Cyclacel Limited | Schemat dawkowania dla sapacytabiny i decytabiny w kombinacji do leczenia ostrej białaczki szpikowej |
| FR2975600B1 (fr) | 2011-05-24 | 2013-07-05 | Assist Publ Hopitaux De Paris | Agents pour le traitement de tumeurs |
| JP2014516075A (ja) | 2011-06-06 | 2014-07-07 | シェブロン フィリップス ケミカル カンパニー エルピー | 癌治療のためのメタロセン化合物の使用 |
| EP3024936B1 (en) | 2013-07-25 | 2019-09-04 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| TR201908550T4 (tr) | 2014-06-04 | 2019-07-22 | Exicure Inc | Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi. |
| US11213593B2 (en) | 2014-11-21 | 2022-01-04 | Northwestern University | Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5149797A (en) | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
| US5652355A (en) | 1992-07-23 | 1997-07-29 | Worcester Foundation For Experimental Biology | Hybrid oligonucleotide phosphorothioates |
| US6346614B1 (en) | 1992-07-23 | 2002-02-12 | Hybridon, Inc. | Hybrid oligonucleotide phosphorothioates |
| TW244371B (https=) | 1992-07-23 | 1995-04-01 | Tri Clover Inc | |
| WO1997032604A1 (en) * | 1996-03-07 | 1997-09-12 | Novartis Ag | Antiproliferative combinations, containing raf-targeted oligonucleotides and chemotherapeutic compounds |
| US5912332A (en) | 1996-07-26 | 1999-06-15 | Hybridon, Inc. | Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| US6426334B1 (en) | 1997-04-30 | 2002-07-30 | Hybridon, Inc. | Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal |
| US20010034330A1 (en) * | 1998-08-10 | 2001-10-25 | Charlotte Kensil | Innate immunity-stimulating compositions of CpG and saponin and methods thereof |
| US6581606B2 (en) * | 1999-07-06 | 2003-06-24 | The Rx Files Corporation | Method, apparatus and system for use in treating patient with a drug having an antineoplastic effect to optimize therapy and prevent an adverse drug response |
| EP2314693A3 (en) | 1999-08-13 | 2012-11-28 | Idera Pharmaceuticals, Inc. | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides |
| EP1867718B1 (en) * | 1999-12-13 | 2010-01-20 | Bioniche Life Sciences Inc. | Therapeutically useful synthetic oligonucleotides |
| US20010044416A1 (en) * | 2000-01-20 | 2001-11-22 | Mccluskie Michael J. | Immunostimulatory nucleic acids for inducing a Th2 immune response |
| CA2398432C (en) | 2000-01-26 | 2012-06-19 | Hybridon, Inc. | Modulation of oligonucleotide cpg-mediated immune stimulation by positional modification of nucleosides |
| US20020156033A1 (en) * | 2000-03-03 | 2002-10-24 | Bratzler Robert L. | Immunostimulatory nucleic acids and cancer medicament combination therapy for the treatment of cancer |
| AU5736601A (en) | 2000-05-01 | 2001-11-12 | Hybridon Inc | Modulation of oligonucleotide cpg-mediated immune stimulation by positional modification of nucleosides |
| EP1296714B1 (en) * | 2000-06-22 | 2009-08-26 | University Of Iowa Research Foundation | Combination of CpG and antibodies directed against CD19,CD20, CD22 or CD40 for the treatment or prevention of cancer. |
| AU2001294750C1 (en) * | 2000-09-26 | 2008-09-18 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes |
| ES2307568T3 (es) * | 2000-12-08 | 2008-12-01 | Coley Pharmaceutical Gmbh | Acidos nucleicos de tipo cpg y metodos de uso de los mismos. |
| EP2423335B1 (en) | 2001-06-21 | 2014-05-14 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same |
| CA2456193A1 (en) * | 2001-08-03 | 2003-03-27 | Medarex, Inc. | Compositions comprising immunostimulatory oligonucleotides and uses thereof to enhance fc receptor-mediated immunotherapies |
| US7276489B2 (en) * | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| WO2003035836A2 (en) * | 2001-10-24 | 2003-05-01 | Hybridon Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends |
| AR040996A1 (es) * | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
| CA2512484A1 (en) * | 2003-01-16 | 2004-05-08 | Hybridon, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides |
| MXPA06000619A (es) * | 2003-07-15 | 2006-04-11 | Hybridon Inc | Estimulacion sinergistica del sistema inmune usando oligonucleotidos inmunoestimuladores y/o compuestos inmunomeros en conjunto con citocinas y/o agentes quimioterapeuticos o terapia de radiacion. |
| JP4942646B2 (ja) * | 2004-06-15 | 2012-05-30 | イデラ ファーマシューティカルズ インコーポレイテッド | 免疫賦活オリゴヌクレオチドマルチマー |
| US7498425B2 (en) * | 2004-06-15 | 2009-03-03 | Idera Pharmaceuticals, Inc. | Immunostimulatory oligonucleotide multimers |
-
2004
- 2004-05-14 MX MXPA05012421A patent/MXPA05012421A/es active IP Right Grant
- 2004-05-14 KR KR1020057021896A patent/KR20060012622A/ko not_active Abandoned
- 2004-05-14 US US10/846,167 patent/US7569554B2/en active Active
- 2004-05-14 JP JP2006533117A patent/JP2006528697A/ja not_active Withdrawn
- 2004-05-14 WO PCT/US2004/015313 patent/WO2004103301A2/en not_active Ceased
- 2004-05-14 AU AU2004241093A patent/AU2004241093B2/en not_active Ceased
- 2004-05-14 EP EP04752345A patent/EP1628531A4/en not_active Withdrawn
- 2004-05-14 CA CA2526212A patent/CA2526212C/en not_active Expired - Lifetime
-
2008
- 2008-01-28 US US12/020,694 patent/US7875594B2/en not_active Expired - Lifetime
-
2011
- 2011-01-14 US US13/006,860 patent/US20120107303A1/en not_active Abandoned
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