JP2006525368A - 脂質白金錯体およびその使用方法 - Google Patents
脂質白金錯体およびその使用方法 Download PDFInfo
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- JP2006525368A JP2006525368A JP2006514250A JP2006514250A JP2006525368A JP 2006525368 A JP2006525368 A JP 2006525368A JP 2006514250 A JP2006514250 A JP 2006514250A JP 2006514250 A JP2006514250 A JP 2006514250A JP 2006525368 A JP2006525368 A JP 2006525368A
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- Prior art keywords
- platinum complex
- lipid
- lipid platinum
- cancer
- liposomal
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- 238000000034 method Methods 0.000 title claims abstract description 63
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 title claims description 369
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- 201000011510 cancer Diseases 0.000 claims abstract description 95
- -1 lipid platinum complexes Chemical class 0.000 claims abstract description 92
- 150000001875 compounds Chemical class 0.000 claims abstract description 81
- 239000000203 mixture Substances 0.000 claims abstract description 78
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 39
- 239000002552 dosage form Substances 0.000 claims abstract description 11
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- 239000002246 antineoplastic agent Substances 0.000 claims description 46
- 150000003904 phospholipids Chemical class 0.000 claims description 40
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- 239000000243 solution Substances 0.000 claims description 26
- 150000004985 diamines Chemical class 0.000 claims description 22
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 20
- 229960002949 fluorouracil Drugs 0.000 claims description 20
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 claims description 19
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- BPHQZTVXXXJVHI-AJQTZOPKSA-N ditetradecanoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCC BPHQZTVXXXJVHI-AJQTZOPKSA-N 0.000 claims description 15
- 229960005277 gemcitabine Drugs 0.000 claims description 15
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims description 14
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- 125000000753 cycloalkyl group Chemical group 0.000 claims description 14
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims description 13
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 13
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- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims description 10
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- SSJXIUAHEKJCMH-OLQVQODUSA-N (1s,2r)-cyclohexane-1,2-diamine Chemical compound N[C@H]1CCCC[C@H]1N SSJXIUAHEKJCMH-OLQVQODUSA-N 0.000 claims description 6
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- SLKDGVPOSSLUAI-PGUFJCEWSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine zwitterion Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCCCCCCCCCCCCCC SLKDGVPOSSLUAI-PGUFJCEWSA-N 0.000 claims description 3
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- BIABMEZBCHDPBV-MPQUPPDSSA-N 1,2-palmitoyl-sn-glycero-3-phospho-(1'-sn-glycerol) Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-MPQUPPDSSA-N 0.000 claims description 3
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 claims description 3
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- NEZDNQCXEZDCBI-UHFFFAOYSA-N 2-azaniumylethyl 2,3-di(tetradecanoyloxy)propyl phosphate Chemical compound CCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCCCCCCCC NEZDNQCXEZDCBI-UHFFFAOYSA-N 0.000 claims description 3
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- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 3
- 150000007942 carboxylates Chemical class 0.000 claims description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical group P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46756703P | 2003-05-02 | 2003-05-02 | |
| PCT/US2004/013727 WO2004098524A2 (en) | 2003-05-02 | 2004-05-03 | Lipid platinum complexes and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006525368A true JP2006525368A (ja) | 2006-11-09 |
| JP2006525368A5 JP2006525368A5 (enExample) | 2007-06-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006514250A Pending JP2006525368A (ja) | 2003-05-02 | 2004-05-03 | 脂質白金錯体およびその使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070160656A1 (enExample) |
| EP (1) | EP1622585A4 (enExample) |
| JP (1) | JP2006525368A (enExample) |
| AU (1) | AU2004235781A1 (enExample) |
| CA (1) | CA2524478A1 (enExample) |
| WO (1) | WO2004098524A2 (enExample) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009528340A (ja) * | 2006-03-03 | 2009-08-06 | ブリカス，パルテニオス | 癌治療 |
| JP2011521913A (ja) * | 2008-05-23 | 2011-07-28 | リプラサム ファーマ エーピーエス | 薬剤送達のためのリポソームおよびその調製方法 |
| JP2013529219A (ja) * | 2010-06-04 | 2013-07-18 | オハイオ ユニバーシティー | ホスファプラチン、及び癌治療のためのそれらの使用 |
| JP2015193629A (ja) * | 2009-06-03 | 2015-11-05 | マヨ、ジョン、チャールズ | 深部組織の痛みを治療するための製剤 |
| US9555051B2 (en) | 2012-03-29 | 2017-01-31 | Sequessome Technology Holdings Limited | Vesicular formulations |
| US10744090B2 (en) | 2015-06-30 | 2020-08-18 | Sequessome Technology Holdings Limited | Multiphasic compositions |
| JP2022506612A (ja) * | 2018-11-02 | 2022-01-17 | テソリックス ファーマ， エルエルシー | リポソーム強化された腹腔内化学療法 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080050425A1 (en) * | 2003-05-20 | 2008-02-28 | Jonathan Lewis | Combination Chemotherapy Comprising 5-Fluorouracil or a Derivative Thereof and a Liposomal Platinum Complex |
| WO2004105747A1 (en) * | 2003-05-20 | 2004-12-09 | Aronex Pharmaceuticals, Inc | Combination chemotherapy comprising capecitabine and a liposomal platinum complex |
| AU2005228410A1 (en) | 2004-03-29 | 2005-10-13 | University Of South Florida | Effective treatment of tumors and cancer with triciribine and related compounds |
| US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
| US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
| WO2008070136A1 (en) * | 2006-12-06 | 2008-06-12 | University Of South Florida | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
| CN103665050B (zh) * | 2013-08-29 | 2016-04-27 | 西北工业大学 | 一种苯基咪唑邻菲罗啉竹红菌素铂配合物及其制备方法 |
| CN105481902B (zh) * | 2015-12-03 | 2017-12-05 | 昆明贵金属研究所 | 以磷酸二氢根为轴向配体的铂(iv)抗癌化合物 |
| WO2021043402A1 (en) * | 2019-09-05 | 2021-03-11 | Vuab Pharma A.S. | New platinum iv complexes with substantially increased antitumor efficacy |
| ES2998498T3 (en) * | 2020-03-10 | 2025-02-20 | Univ Chung Yuan Christian | Liposome composition and preparation method thereof |
| WO2021216849A1 (en) * | 2020-04-22 | 2021-10-28 | Oncovolution, Llc | Peptide platinum complexes and methods of use thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002013817A1 (en) * | 2000-08-11 | 2002-02-21 | Sumitomo Pharmaceuticals Co., Ltd. | Remedies for cisplatin-tolerant cancer |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5829957B2 (ja) * | 1977-09-12 | 1983-06-25 | 喜徳 喜谷 | 新規な白金錯体 |
| JPS5622724A (en) * | 1979-08-02 | 1981-03-03 | Asahi Chem Ind Co Ltd | Pharmaceutical preparation of n4-acylcytosine arabinoside |
| EP0113508A1 (en) * | 1982-11-04 | 1984-07-18 | Inco Research & Development Center, Inc. | Hydrophobic platinum compounds and their preparation |
| US5041581A (en) * | 1985-10-18 | 1991-08-20 | The University Of Texas System Board Of Regents | Hydrophobic cis-platinum complexes efficiently incorporated into liposomes |
| US5384127A (en) * | 1985-10-18 | 1995-01-24 | Board Of Regents, The University Of Texas System | Stable liposomal formulations of lipophilic platinum compounds |
| US5117022A (en) * | 1985-10-18 | 1992-05-26 | The Board Of Regents, The University Of Texas System | Hydrophobic cis-platinum complexes efficiently incorporated into liposomes |
| US5698155A (en) * | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| US5902604A (en) * | 1995-06-06 | 1999-05-11 | Board Of Regents, The University Of Texas System | Submicron liposome suspensions obtained from preliposome lyophilizates |
| WO1998024424A1 (en) * | 1996-12-03 | 1998-06-11 | Rijksuniversiteit Utrecht | Cisplatinum comprising pharmaceutical |
| US5843475A (en) * | 1996-12-06 | 1998-12-01 | Board Of Regents, The University Of Texas System | Delivery and activation through liposome incorporation of diaminocyclohexane platinum (II) complexes |
| CN1191067C (zh) * | 1997-02-05 | 2005-03-02 | 法玛西雅厄普约翰美国公司 | 高不溶性铂配合物的脂质复合物和脂质体 |
| AU2003258075A1 (en) * | 2002-08-06 | 2004-02-23 | Lyotropic Therapeutics, Inc. | Lipid-drug complexes in reversed liquid and liquid crystalline phases |
-
2004
- 2004-05-03 JP JP2006514250A patent/JP2006525368A/ja active Pending
- 2004-05-03 EP EP04751216A patent/EP1622585A4/en not_active Withdrawn
- 2004-05-03 US US10/555,495 patent/US20070160656A1/en not_active Abandoned
- 2004-05-03 CA CA002524478A patent/CA2524478A1/en not_active Abandoned
- 2004-05-03 WO PCT/US2004/013727 patent/WO2004098524A2/en not_active Ceased
- 2004-05-03 AU AU2004235781A patent/AU2004235781A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002013817A1 (en) * | 2000-08-11 | 2002-02-21 | Sumitomo Pharmaceuticals Co., Ltd. | Remedies for cisplatin-tolerant cancer |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009528340A (ja) * | 2006-03-03 | 2009-08-06 | ブリカス，パルテニオス | 癌治療 |
| JP2011521913A (ja) * | 2008-05-23 | 2011-07-28 | リプラサム ファーマ エーピーエス | 薬剤送達のためのリポソームおよびその調製方法 |
| JP2015193629A (ja) * | 2009-06-03 | 2015-11-05 | マヨ、ジョン、チャールズ | 深部組織の痛みを治療するための製剤 |
| JP2013529219A (ja) * | 2010-06-04 | 2013-07-18 | オハイオ ユニバーシティー | ホスファプラチン、及び癌治療のためのそれらの使用 |
| US9688709B2 (en) | 2010-06-04 | 2017-06-27 | Ohio University | Phosphaplatins and their use for treatment of cancers |
| US10364264B2 (en) | 2010-06-04 | 2019-07-30 | Ohio University | Proliferative disease treatment methods with phosphaplatin complexes |
| US10385083B2 (en) | 2010-06-04 | 2019-08-20 | Ohio University | Phosphaplatin complexes and methods for treatment of proliferative diseases using the phosphaplatin complexes |
| US10759820B2 (en) | 2010-06-04 | 2020-09-01 | Ohio University | Proliferative disease treatment methods with phosphaplatin complexes |
| US9555051B2 (en) | 2012-03-29 | 2017-01-31 | Sequessome Technology Holdings Limited | Vesicular formulations |
| US10744090B2 (en) | 2015-06-30 | 2020-08-18 | Sequessome Technology Holdings Limited | Multiphasic compositions |
| US11547665B2 (en) | 2015-06-30 | 2023-01-10 | Sequessome Technology Holdings Limited | Multiphasic compositions |
| JP2022506612A (ja) * | 2018-11-02 | 2022-01-17 | テソリックス ファーマ， エルエルシー | リポソーム強化された腹腔内化学療法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004235781A1 (en) | 2004-11-18 |
| WO2004098524A2 (en) | 2004-11-18 |
| WO2004098524A3 (en) | 2005-05-26 |
| CA2524478A1 (en) | 2004-11-18 |
| EP1622585A2 (en) | 2006-02-08 |
| EP1622585A4 (en) | 2009-07-01 |
| US20070160656A1 (en) | 2007-07-12 |
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