JP2006520399A5 - - Google Patents
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- Publication number
- JP2006520399A5 JP2006520399A5 JP2006508855A JP2006508855A JP2006520399A5 JP 2006520399 A5 JP2006520399 A5 JP 2006520399A5 JP 2006508855 A JP2006508855 A JP 2006508855A JP 2006508855 A JP2006508855 A JP 2006508855A JP 2006520399 A5 JP2006520399 A5 JP 2006520399A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- group
- pharmaceutically acceptable
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZTJAJUDLGKIXIN-UHFFFAOYSA-N CN(CC1)CCC1C1N(CC(Nc2cc(Cl)cc(Cl)c2)O)CCc2cc(-c3cccc(C#N)c3)ccc12 Chemical compound CN(CC1)CCC1C1N(CC(Nc2cc(Cl)cc(Cl)c2)O)CCc2cc(-c3cccc(C#N)c3)ccc12 ZTJAJUDLGKIXIN-UHFFFAOYSA-N 0.000 description 1
- UERFBWQPEHZSPN-UHFFFAOYSA-N N#Cc1cccc(-c2ccc(C(C(CC3)CCN3C3CCCC3)N(CC(Nc3cc(Cl)cc(Cl)c3)=O)CC3)c3c2)c1 Chemical compound N#Cc1cccc(-c2ccc(C(C(CC3)CCN3C3CCCC3)N(CC(Nc3cc(Cl)cc(Cl)c3)=O)CC3)c3c2)c1 UERFBWQPEHZSPN-UHFFFAOYSA-N 0.000 description 1
- XSLYYJWTXUSRQA-UHFFFAOYSA-N O=C(CN(CCc1c2)C(C(CC3)CCN3C3CCCC3)c1ccc2-c1ccncc1)Nc1cc(Cl)cc(Cl)c1 Chemical compound O=C(CN(CCc1c2)C(C(CC3)CCN3C3CCCC3)c1ccc2-c1ccncc1)Nc1cc(Cl)cc(Cl)c1 XSLYYJWTXUSRQA-UHFFFAOYSA-N 0.000 description 1
- RTIVWDSFWBAUKZ-UHFFFAOYSA-N O=C(CN(CCc1c2)C(C(CC3)CCN3C3CCCC3)c1ccc2-c1cnccc1)Nc1cc(Cl)cc(Cl)c1 Chemical compound O=C(CN(CCc1c2)C(C(CC3)CCN3C3CCCC3)c1ccc2-c1cnccc1)Nc1cc(Cl)cc(Cl)c1 RTIVWDSFWBAUKZ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45079903P | 2003-02-28 | 2003-02-28 | |
| PCT/US2004/005780 WO2004078745A1 (en) | 2003-02-28 | 2004-02-26 | Biaryltetrahydroisoquinoline piperidines as selective mch receptor antagonists for the treatment of obesity and related disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006520399A JP2006520399A (ja) | 2006-09-07 |
| JP2006520399A5 true JP2006520399A5 (https=) | 2007-04-12 |
| JP4570165B2 JP4570165B2 (ja) | 2010-10-27 |
Family
ID=32962533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006508855A Expired - Fee Related JP4570165B2 (ja) | 2003-02-28 | 2004-02-26 | 肥満および関連障害の処置のための選択的ｍｃｈレセプターアンタゴニストとしてのビアリールテトラヒドロイソキノリンピペリジン |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7498441B2 (https=) |
| EP (1) | EP1601664B1 (https=) |
| JP (1) | JP4570165B2 (https=) |
| CN (1) | CN1777596A (https=) |
| AR (1) | AR043420A1 (https=) |
| AT (1) | ATE393766T1 (https=) |
| CA (1) | CA2517088A1 (https=) |
| DE (1) | DE602004013427T2 (https=) |
| ES (1) | ES2305735T3 (https=) |
| MX (1) | MXPA05009193A (https=) |
| TW (1) | TW200427679A (https=) |
| WO (1) | WO2004078745A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008210455A1 (en) * | 2007-01-31 | 2008-08-07 | Vertex Pharmaceuticals Incorporated | 2-aminopyridine derivatives useful as kinase inhibitors |
| AU2009274023A1 (en) | 2008-07-23 | 2010-01-28 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| ES2402087T3 (es) | 2008-07-23 | 2013-04-26 | Vertex Pharmaceuticals Incorporated | Inhibidores de la pirazolopiridina quinasa |
| US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| MX2011001319A (es) * | 2008-08-06 | 2011-04-05 | Vertex Pharma | Inhibidores de aminopiridina cinasa. |
| CA2760705A1 (en) | 2009-05-06 | 2010-11-11 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridines |
| MX2012008643A (es) | 2010-01-27 | 2013-02-26 | Vertex Pharma | Inhibidores de cinasas de pirazolopiridinas. |
| EP2528917B1 (en) | 2010-01-27 | 2016-10-19 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridines useful for the treatment of autoimmune, inflammatory or (hyper)proliferative diseases |
| WO2011094288A1 (en) | 2010-01-27 | 2011-08-04 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrazine kinase inhibitors |
| MX2018007844A (es) * | 2015-12-22 | 2019-01-21 | Jiangsu Hengrui Medicine Co | Derivado de benzopiperidina, metodo de preparacion del mismo y su uso medico del mismo. |
| CN117343011A (zh) * | 2023-09-28 | 2024-01-05 | 晨伫(杭州)生物科技有限责任公司 | 基于吡唑基-磺酰基-苯基骨架结构的化合物及其制备方法和应用、药物组合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5908830A (en) | 1996-10-31 | 1999-06-01 | Merck & Co., Inc. | Combination therapy for the treatment of diabetes and obesity |
| CA2289574C (en) * | 1997-05-30 | 2007-04-24 | Neurosearch A/S | 8-azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ach receptors |
| EP1113007A1 (en) * | 1999-12-24 | 2001-07-04 | Pfizer Inc. | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists |
| EP1299362A4 (en) * | 2000-07-05 | 2004-11-03 | Synaptic Pharma Corp | SELECTIVE RECEPTOR ANTAGONISTS OF MELANINE CONCENTRATING HORMON-1 (MCH1) AND THEIR USE |
| PE20021081A1 (es) | 2001-04-12 | 2002-12-18 | Pharmacopeia Drug Discovery | Aril y biaril piperidinas con actividad moduladora mch |
| CA2490531C (en) * | 2002-06-27 | 2011-03-22 | Schering Corporation | Spirosubstituted piperidines as selective melanin concentrating hormone receptor antagonists for the treatment of obesity |
-
2004
- 2004-02-26 ES ES04715072T patent/ES2305735T3/es not_active Expired - Lifetime
- 2004-02-26 MX MXPA05009193A patent/MXPA05009193A/es active IP Right Grant
- 2004-02-26 DE DE602004013427T patent/DE602004013427T2/de not_active Expired - Lifetime
- 2004-02-26 JP JP2006508855A patent/JP4570165B2/ja not_active Expired - Fee Related
- 2004-02-26 CA CA002517088A patent/CA2517088A1/en not_active Abandoned
- 2004-02-26 AT AT04715072T patent/ATE393766T1/de not_active IP Right Cessation
- 2004-02-26 US US10/788,109 patent/US7498441B2/en not_active Expired - Fee Related
- 2004-02-26 TW TW093104942A patent/TW200427679A/zh unknown
- 2004-02-26 CN CNA2004800109047A patent/CN1777596A/zh active Pending
- 2004-02-26 WO PCT/US2004/005780 patent/WO2004078745A1/en not_active Ceased
- 2004-02-26 EP EP04715072A patent/EP1601664B1/en not_active Expired - Lifetime
- 2004-02-27 AR ARP040100622A patent/AR043420A1/es not_active Application Discontinuation
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