JP2006516622A5 - - Google Patents

Download PDF

Info

Publication number
JP2006516622A5
JP2006516622A5 JP2006502975A JP2006502975A JP2006516622A5 JP 2006516622 A5 JP2006516622 A5 JP 2006516622A5 JP 2006502975 A JP2006502975 A JP 2006502975A JP 2006502975 A JP2006502975 A JP 2006502975A JP 2006516622 A5 JP2006516622 A5 JP 2006516622A5
Authority
JP
Japan
Prior art keywords
group
groups
alkyl
optionally substituted
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2006502975A
Other languages
English (en)
Japanese (ja)
Other versions
JP4560035B2 (ja
JP2006516622A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2004/001927 external-priority patent/WO2004069158A2/en
Publication of JP2006516622A publication Critical patent/JP2006516622A/ja
Publication of JP2006516622A5 publication Critical patent/JP2006516622A5/ja
Application granted granted Critical
Publication of JP4560035B2 publication Critical patent/JP4560035B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2006502975A 2003-01-27 2004-01-23 置換ピラゾール、このような化合物を含有する組成物及び使用方法 Expired - Fee Related JP4560035B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44282803P 2003-01-27 2003-01-27
PCT/US2004/001927 WO2004069158A2 (en) 2003-01-27 2004-01-23 Substituted pyrazoles, compositions containing such compounds and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010027448A Division JP5260569B2 (ja) 2003-01-27 2010-02-10 置換ピラゾール、このような化合物を含有する組成物及び使用方法

Publications (3)

Publication Number Publication Date
JP2006516622A JP2006516622A (ja) 2006-07-06
JP2006516622A5 true JP2006516622A5 (OSRAM) 2007-11-01
JP4560035B2 JP4560035B2 (ja) 2010-10-13

Family

ID=32850762

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006502975A Expired - Fee Related JP4560035B2 (ja) 2003-01-27 2004-01-23 置換ピラゾール、このような化合物を含有する組成物及び使用方法
JP2010027448A Expired - Fee Related JP5260569B2 (ja) 2003-01-27 2010-02-10 置換ピラゾール、このような化合物を含有する組成物及び使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010027448A Expired - Fee Related JP5260569B2 (ja) 2003-01-27 2010-02-10 置換ピラゾール、このような化合物を含有する組成物及び使用方法

Country Status (8)

Country Link
US (2) US7572922B2 (OSRAM)
EP (1) EP1590336B1 (OSRAM)
JP (2) JP4560035B2 (OSRAM)
AT (1) ATE490244T1 (OSRAM)
AU (2) AU2004210127B2 (OSRAM)
CA (1) CA2513102C (OSRAM)
DE (1) DE602004030318D1 (OSRAM)
WO (1) WO2004069158A2 (OSRAM)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004069158A2 (en) * 2003-01-27 2004-08-19 Merck & Co., Inc. Substituted pyrazoles, compositions containing such compounds and methods of use
WO2004092140A1 (en) 2003-04-03 2004-10-28 Merck & Co., Inc. Biaryl substituted pyrazoles as sodium channel blockers
CN1964947A (zh) * 2004-06-04 2007-05-16 默克公司 吡唑衍生物、包含其的组合物及其用法
CN1980665A (zh) 2004-07-07 2007-06-13 默克公司 吡唑酰胺衍生物，包含这些化合物的组合物和使用方法
JP2008507528A (ja) * 2004-07-22 2008-03-13 メルク　エンド　カムパニー　インコーポレーテッド 置換ピラゾール、このような化合物を含有する組成物及び使用方法
US7642275B2 (en) 2004-12-16 2010-01-05 Takeda San Diego, Inc. Histone deacetylase inhibitors
US8318760B2 (en) 2005-03-21 2012-11-27 Merck Sharp & Dohme Corp. Substituted aryl and heteroaryl derivatives, compositions containing such compounds and methods of use
US7642253B2 (en) 2005-05-11 2010-01-05 Takeda San Diego, Inc. Histone deacetylase inhibitors
NZ564916A (en) 2005-06-27 2011-03-31 Exelixis Inc Imidazole based LXR modulators
US7709658B2 (en) * 2005-07-26 2010-05-04 Merck Sharp & Dohme Corp. Process for synthesizing a substituted pyrazole
TW200745031A (en) 2005-10-13 2007-12-16 Merck & Co Inc Acyl indoles, compositions containing such compounds and methods of use
AR056574A1 (es) * 2005-10-19 2007-10-10 Merck & Co Inc Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso
AU2007229850A1 (en) 2006-03-23 2007-10-04 Merck & Co., Inc. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
SI2402317T1 (sl) 2006-03-31 2013-10-30 Novartis Ag DGAT inhibitor
EP2019585A2 (en) 2006-05-16 2009-02-04 Merck & Co., Inc. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
KR20090094125A (ko) * 2006-12-08 2009-09-03 엑셀리시스, 인코포레이티드 Ｌｘｒ 및 ｆｘｒ 조절자
EP2128138A1 (en) 2007-01-29 2009-12-02 Takeda Pharmaceutical Company Limited Pyrazole compound
DK2129654T3 (da) 2007-02-09 2014-08-25 Metabasis Therapeutics Inc Antagonister af glucagonreceptoren
ES2380165T3 (es) * 2007-08-02 2012-05-09 Recordati Ireland Limited Nuevos compuestos heterocíclicos como antagonistas mGlu5
US8232413B2 (en) * 2007-09-12 2012-07-31 Merck Sharp & Dohme Corp. Process for the production of a crystalline glucagon receptor antagonist compound
AR066169A1 (es) 2007-09-28 2009-07-29 Novartis Ag Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat
JP5450083B2 (ja) * 2007-11-01 2014-03-26 武田薬品工業株式会社 複素環化合物
WO2009082761A1 (en) 2007-12-26 2009-07-02 Elster Electricity, Llc. Optimized data collection in a wireless fixed network metering system
JP5465658B2 (ja) * 2008-03-05 2014-04-09 武田薬品工業株式会社 複素環化合物
JP2011520897A (ja) 2008-05-16 2011-07-21 シェーリング コーポレイション グルカゴン受容体アンタゴニスト、組成物およびそれらの使用方法
RU2477281C2 (ru) * 2008-07-17 2013-03-10 Асахи Касеи Фарма Корпорейшн Азотсодержащие гетероциклические соединения
PL2799428T3 (pl) 2008-08-13 2017-05-31 Metabasis Therapeutics, Inc. Antagoniści glukagonu
EP2346830B1 (en) * 2008-09-15 2015-05-13 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
JP2012504630A (ja) * 2008-10-03 2012-02-23 シェーリング コーポレイション グルカゴン受容体アンタゴニストとしてのスピロイミダゾロン誘導体
EA201100620A1 (ru) * 2008-10-10 2011-12-30 Лонца Лтд Способ получения 2-алкил-3-ароил-5-нитробензофуранов
US8324384B2 (en) 2009-02-12 2012-12-04 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
WO2010098994A1 (en) 2009-02-25 2010-09-02 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
US8470773B2 (en) 2009-06-12 2013-06-25 Merck Sharp & Dohme Corp. Thiophenes as glucagon receptor antagonists, compositions, and methods for their use
EP2480077B1 (en) 2009-09-22 2015-02-18 Merck Sharp & Dohme Corp. Pyrrolidines as glucagon receptor antagonists, compositions, and methods for their use
EP2568812B1 (en) * 2010-05-11 2016-10-26 Merck Sharp & Dohme Corp. Novel prolylcarboxypeptidase inhibitors
US8748442B2 (en) * 2010-06-30 2014-06-10 Ironwood Pharmaceuticals, Inc. sGC stimulators
RU2582679C2 (ru) 2010-11-09 2016-04-27 Айронвуд Фармасьютикалз, Инк. СТИМУЛЯТОРЫ sGC
CA2822017C (en) 2010-12-23 2015-04-07 Pfizer Inc. Glucagon receptor modulators
GEP20156351B (en) 2011-02-08 2015-08-25 Pfizer Glucagon receptor modulator
CN103732578B (zh) 2011-07-22 2015-08-12 辉瑞大药厂 喹啉基胰高血糖素受体调节剂
US9139564B2 (en) 2011-12-27 2015-09-22 Ironwood Pharmaceuticals, Inc. 2-benzyl, 3-(pyrimidin-2-yl) substituted pyrazoles useful as sGC stimulators
EP3065736B1 (en) 2013-11-04 2018-11-14 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions thereof, and methods of use
JP2017519000A (ja) 2014-06-12 2017-07-13 リガンド・ファーマシューティカルズ・インコーポレイテッド グルカゴンアンタゴニスト
TWI757332B (zh) * 2016-09-06 2022-03-11 比利時商健生藥品公司 使用作為升糖素受體拮抗劑之吲唑衍生物
TW201811752A (zh) * 2016-09-06 2018-04-01 比利時商健生藥品公司 用作升糖素受體拮抗劑之吲唑衍生物
WO2019160940A1 (en) 2018-02-13 2019-08-22 Ligand Pharmaceuticals Incorporated Glucagon receptor antagonists
US12030866B2 (en) * 2021-12-23 2024-07-09 Springworks Therapeutics, Inc. 2-pyrazole anilines and related analogs for inhibiting YAP/TAZ-TEAD
WO2025034531A1 (en) * 2023-08-04 2025-02-13 The University Of Vermont And State Agricultural College Small molecule allosteric modulator to pac1 receptor and uses thereof

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9303993D0 (en) 1993-02-26 1993-04-14 Fujisawa Pharmaceutical Co New heterocyclic derivatives
BE1009189A3 (fr) * 1995-03-14 1996-12-03 Solvay Procede pour la fabrication d'un corps creux.
AU702887B2 (en) 1995-10-31 1999-03-11 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
AR008789A1 (es) 1996-07-31 2000-02-23 Bayer Corp Piridinas y bifenilos substituidos
US5776954A (en) 1996-10-30 1998-07-07 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
JP2001504489A (ja) 1996-11-20 2001-04-03 メルク エンド カンパニー インコーポレーテッド トリアリール置換イミダゾール及び使用方法
WO1998021957A1 (en) 1996-11-20 1998-05-28 Merck & Co., Inc. Triaryl substituted imidazoles, compositions containing such compounds and methods of use
WO1998022109A1 (en) 1996-11-20 1998-05-28 Merck & Co., Inc. Triaryl substituted imidazoles as glucagon antagonists
CA2274592C (en) * 1996-12-12 2007-03-13 Banyu Pharmaceutical Co., Ltd. Pyrazole derivatives
HUP0001777A3 (en) 1997-04-18 2001-07-30 G D Searle & Co Chicago Use of cyclooxygenase-2 inhibitors for producing medicaments useful for the prevention of cardiovascular disorders
US6613942B1 (en) * 1997-07-01 2003-09-02 Novo Nordisk A/S Glucagon antagonists/inverse agonists
CN1282319A (zh) * 1997-10-09 2001-01-31 小野药品工业株式会社 氨基丁酸衍生物
PT1042293E (pt) 1997-12-19 2008-04-18 Amgen Inc Compostos de piridazina e piridina substituídos e as suas utilizações farmacêuticas
KR20010079842A (ko) 1998-09-17 2001-08-22 스티븐 비. 데이비스 ａＰ2 억제제 또는 조합을 사용한 아테롬성동맥경화증의치료 방법
US6503949B1 (en) * 1999-05-17 2003-01-07 Noro Nordisk A/S Glucagon antagonists/inverse agonists
ATE307798T1 (de) 1999-05-17 2005-11-15 Novo Nordisk As Glucagon antagonisten/inverse agonisten
JP2003506443A (ja) * 1999-08-10 2003-02-18 バイエルクロップサイエンス株式会社 除草性テトラゾリノン誘導体
EP1457490A1 (en) * 1999-11-10 2004-09-15 Takeda Chemical Industries, Ltd. 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity
US6562807B2 (en) * 2000-06-23 2003-05-13 Novo Nordisk A/S Glucagon antagonists/inverse agonists
IL153181A0 (en) 2000-06-23 2003-06-24 Novo Nordisk As Glucagon antagonists/inverse agonists
DE60128475T2 (de) 2000-07-25 2008-02-07 Merck & Co., Inc. N-substituierte indole mit anwendung in der behandlung von diabetes
US20030203946A1 (en) 2000-11-17 2003-10-30 Carsten Behrens Glucagon antagonists/inverse agonists
WO2002040444A1 (en) 2000-11-17 2002-05-23 Novo Nordisk A/S Glucagon antagonists/inverse agonists
ITMI20010733A1 (it) * 2001-04-05 2002-10-05 Recordati Chem Pharm Uso di inibitori dell'isoenzina cox-2 per il trattamento dell'incontinenza urinaria
JP2005511683A (ja) 2001-12-03 2005-04-28 ノボ　ノルディスク　アクティーゼルスカブ 新規なグルカゴンアンタゴニスト
US6762318B2 (en) * 2001-12-03 2004-07-13 Novo Nordisk A/S Glucagon antagonists
US6881746B2 (en) * 2001-12-03 2005-04-19 Novo Nordick A/S Glucagon antagonists/inverse agonists
AU2002351730A1 (en) 2001-12-19 2003-06-30 Novo Nordisk A/S Glucagon receptor antagonists/inverse agonists
AU2002347022A1 (en) 2001-12-20 2003-07-09 Novo Nordisk A/S Benzimidazols and indols as glucagon receptor antagonists/inverse agonisten
BR0307409A (pt) 2002-02-01 2004-12-28 Dainippon Pharmaceutical Co Compostos de hidrazida de ácido 2-furanocarboxìlico, composições farmacêuticas contendo os mesmos e uso dos mesmos para preparação de um agente preventivo ou terapêutico
WO2004002480A1 (en) 2002-06-27 2004-01-08 Novo Nordisk A/S Novel glucagon antagonists/inverse agonists
JP4890761B2 (ja) 2002-07-19 2012-03-07 バクスター・インターナショナル・インコーポレイテッド 腹膜透析を実施するためのシステムおよび方法
EP1400243A1 (en) 2002-09-19 2004-03-24 Tanabe Seiyaku Co., Ltd. Calcium-activated K channel activator
WO2004050039A2 (en) 2002-12-04 2004-06-17 Merck & Co., Inc. Spirocyclic ureas, compositions containing such compounds and methods of use
WO2004069158A2 (en) 2003-01-27 2004-08-19 Merck & Co., Inc. Substituted pyrazoles, compositions containing such compounds and methods of use
ATE384526T1 (de) 2003-04-14 2008-02-15 Inst For Pharm Discovery Inc N-(((((1,3-thiazol-2- yl)amino)carbonyl)phenyl)sulphonyl)phenylalanin derivate und verwandte verbindungen zur behandlung von diabetes
DE10317108A1 (de) 2003-04-14 2004-11-11 Mutzbauer, Till S., Dr. Dr.med. Transdermal applizierbares Beruhigungs- und Sedierungsmittel
CN1784226A (zh) 2003-05-09 2006-06-07 麦克公司 苯并咪唑化合物、含有苯并咪唑化合物的组合物以及使用方法
CN1964947A (zh) * 2004-06-04 2007-05-16 默克公司 吡唑衍生物、包含其的组合物及其用法
JP2008507528A (ja) * 2004-07-22 2008-03-13 メルク　エンド　カムパニー　インコーポレーテッド 置換ピラゾール、このような化合物を含有する組成物及び使用方法
AR056574A1 (es) * 2005-10-19 2007-10-10 Merck & Co Inc Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso

Similar Documents

Publication Publication Date Title
JP2006516622A5 (OSRAM)
CA2513102A1 (en) Substituted pyrazoles, compositions containing such compounds and methods of use
TWI354666B (en) Heterocyclic aspartyl protease inhibitors
JP2006509015A5 (OSRAM)
JP2013513613A5 (OSRAM)
CA2557538A1 (en) Benzimidazole derivative and use as an angiotensin ii receptor antagonist
KR940701383A (ko) 질소 함유 헤테로사이클릭 화합물의 플루오로알콕시벤질아미노 유도체
JP2013528602A5 (OSRAM)
JP2008513498A5 (OSRAM)
RU2011105422A (ru) Дейтерированные бензилбензольные производные и способы применения
JP2008526724A5 (OSRAM)
AR065276A1 (es) Herbicidas de n-oxidos de piridina sustituidos
RU2009126745A (ru) Производные сульфонилфенил-2н-{1,2,4}оксадиазол-5-она, способы их получения и их применение в качестве фармацевтических средств
JP2002535323A5 (OSRAM)
JP2009535358A5 (OSRAM)
EA200601830A1 (ru) Ортозамещённые арильные или гетероарильные амидные соединения
JP2011520969A5 (OSRAM)
JPWO2020061101A5 (OSRAM)
JP2011511840A5 (OSRAM)
UA103894C2 (ru) Соединения и способ для снижения уровня мочевой кислоты
DE602004030004D1 (de) Verbindungen zur behandlung von stoffwechselstörungen
JP2011503006A5 (OSRAM)
TW202334116A (zh) 一種取代的苯丙酸衍生物及其用途
RU2002107318A (ru) Новые фенилпиперазины
WO2009158257A4 (en) Fungicidal pyridines