JP2006513222A - アドレナリン性β受容体およびホスホジエステラーゼに対する抑制活性を有する強心性化合物 - Google Patents
アドレナリン性β受容体およびホスホジエステラーゼに対する抑制活性を有する強心性化合物 Download PDFInfo
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- JP2006513222A JP2006513222A JP2004563978A JP2004563978A JP2006513222A JP 2006513222 A JP2006513222 A JP 2006513222A JP 2004563978 A JP2004563978 A JP 2004563978A JP 2004563978 A JP2004563978 A JP 2004563978A JP 2006513222 A JP2006513222 A JP 2006513222A
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- alkyl
- alkenyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43552402P | 2002-12-23 | 2002-12-23 | |
| PCT/US2003/041031 WO2004058726A2 (en) | 2002-12-23 | 2003-12-23 | CARDIOTONIC COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST β-ADRENERGIC RECEPTORS AND PHOSPHODIESTERASE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006513222A true JP2006513222A (ja) | 2006-04-20 |
| JP2006513222A5 JP2006513222A5 (enExample) | 2007-02-15 |
Family
ID=32682255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004563978A Pending JP2006513222A (ja) | 2002-12-23 | 2003-12-23 | アドレナリン性β受容体およびホスホジエステラーゼに対する抑制活性を有する強心性化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20070117978A1 (enExample) |
| EP (1) | EP1575923A2 (enExample) |
| JP (1) | JP2006513222A (enExample) |
| AU (1) | AU2003300297A1 (enExample) |
| CA (1) | CA2511496A1 (enExample) |
| MX (1) | MXPA05006975A (enExample) |
| WO (1) | WO2004058726A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012509858A (ja) * | 2008-11-25 | 2012-04-26 | ベーリンガー インゲルハイム フェトメディカ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 肥大性心筋症治療用のホスホジエステラーゼタイプＩＩＩ（ＰＤＥＩＩＩ）インヒビターまたはＣａ２＋感作剤 |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070060748A1 (en) * | 2002-11-27 | 2007-03-15 | Hamilton Gregory S | Compounds with mixed pde-inhibitory and beta-adrenergic antagonist or partial agonist activity for treatment of heart failure |
| DE102004011512B4 (de) | 2004-03-08 | 2022-01-13 | Boehringer Ingelheim Vetmedica Gmbh | Pharmazeutische Zubereitung enthaltend Pimobendan |
| EP1579862A1 (en) | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
| US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
| US20080090827A1 (en) * | 2004-11-30 | 2008-04-17 | Artesian Therapeutics, Inc. | Compounds With Mixed Pde-Inhibitory and Beta-Adrenergic Antagonist or Partial Agonist Activity For Treatment of Heart Failure |
| EP1833480A2 (en) * | 2004-11-30 | 2007-09-19 | Artesian Therapeutics, Inc. | Cardiotonic compounds with inhibitory activity against beta-adrenergic receptors and phosphodiesterase |
| WO2007027729A1 (en) | 2005-08-29 | 2007-03-08 | Vertex Pharmaceuticals Incorporated | 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases |
| ATE548363T1 (de) | 2005-08-29 | 2012-03-15 | Vertex Pharma | 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen |
| ES2361338T3 (es) | 2005-08-29 | 2011-06-16 | Vertex Pharmaceuticals Incorporated | Pirid-2-onas 3,5-disustituidas útiles como inhibidores de la familia tec de tirosina quinasas no ligadas a receptor. |
| EP1920785A1 (en) | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
| EP2825159B1 (en) | 2012-03-15 | 2022-06-22 | Boehringer Ingelheim Vetmedica GmbH | Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof |
| HUE072591T2 (hu) | 2013-07-19 | 2025-11-28 | Boehringer Ingelheim Vetmedica Gmbh | Tartósított, éterezett ciklodextrinszármazékokat tartalmazó folyékony, vizes gyógyászati készítmény |
| EA201992230A1 (ru) | 2013-12-04 | 2020-02-28 | Бёрингер Ингельхайм Ветмедика Гмбх | Улучшенные фармацевтические композиции пимобендана |
| US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5283382A (en) * | 1975-12-27 | 1977-07-12 | Otsuka Pharmaceut Co Ltd | Synthesis of carbostyril derivatives |
| JPS52108970A (en) * | 1976-03-09 | 1977-09-12 | Boehringer Sohn Ingelheim | Production of novel aminoalkyl heterocyclic compound |
| JPS5368775A (en) * | 1976-10-05 | 1978-06-19 | Boehringer Sohn Ingelheim | 11aryloxyy22mydroxyy33 alkyleneaminopropane |
| JPS5745144A (en) * | 1980-06-23 | 1982-03-13 | Boehringer Mannheim Gmbh | Aryloxypropanol amine, manufacture and treating and portecting medicine containing same for cardiac and circulatory diseases |
| JPS59205364A (ja) * | 1983-04-26 | 1984-11-20 | スミスクライン・ベツクマン・コ−ポレイシヨン | ド−パミン様カルボスチリルおよびその製法 |
| JPS62175458A (ja) * | 1985-11-21 | 1987-08-01 | ビ−チヤム・グル−プ・ピ−エルシ− | 新規化合物、その製法及びそれを含む医薬組成物 |
| JPH0386864A (ja) * | 1988-08-10 | 1991-04-11 | Otsuka Pharmaceut Co Ltd | 強心剤 |
| JPH0386868A (ja) * | 1989-06-19 | 1991-04-11 | Teikoku Hormone Mfg Co Ltd | ピリダジノン化合物 |
| JPH03236378A (ja) * | 1989-06-01 | 1991-10-22 | Dr Karl Thomae Gmbh | ２―ヒドロキシ―ｎ―プロピルアミン類、その製法及びそれを含有する医薬組成物 |
| JPH05279256A (ja) * | 1991-04-03 | 1993-10-26 | Otsuka Pharmaceut Co Ltd | 血小板凝集抑制剤 |
| JP2001500865A (ja) * | 1996-09-13 | 2001-01-23 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | 避妊の非ホルモン法 |
| JP2006509790A (ja) * | 2002-11-27 | 2006-03-23 | アルテシアン セラピューティック，インコーポレイティド | 心不全の治療のための混合されたＰＤＥ阻害およびβアドレナリン拮抗薬活性または部分的作用薬活性を有する化合物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS6193169A (ja) * | 1984-10-12 | 1986-05-12 | Sankyo Co Ltd | ピリダジノン誘導体及びその製法 |
| NZ234087A (en) * | 1989-06-19 | 1991-08-27 | Teikoku Hormone Mfg Co Ltd | 2-(3-aryloxy(2-hydroxy-propylamino))-2-methylpropyl- aminophenyl pyridazine derivatives |
| CA2027863A1 (en) * | 1989-11-20 | 1991-05-21 | George Sachs And Jai Moo Shin Partnership Of Michael E. Garst | Anti-inflammatory furanone compounds |
| JPH05283382A (ja) * | 1992-03-31 | 1993-10-29 | Murata Mfg Co Ltd | 半導体ウェハの裏面加工方法及び裏面加工時における半導体ウェハの表面側構造 |
| US5641783A (en) * | 1993-11-12 | 1997-06-24 | Cell Therapeutics, Inc. | Substituted amino alcohol compounds |
| US5827893A (en) * | 1996-03-29 | 1998-10-27 | Lurie; Keith G. | Mechanical and pharmacological therapies to treat cardiac arrest |
| KR20030031907A (ko) * | 2000-06-05 | 2003-04-23 | 알타나 파마 아게 | β-2-아드레날린 수용체 작동물질로서 뿐만 아니라ＰＤＥ4-억제제로서 효과적인 화합물 |
| EP1326861A1 (en) * | 2000-10-20 | 2003-07-16 | Pfizer Products Inc. | Alpha-aryl ethanolamines and their use as beta-3 adrenergic receptor agonists |
-
2003
- 2003-12-23 EP EP03814338A patent/EP1575923A2/en not_active Withdrawn
- 2003-12-23 JP JP2004563978A patent/JP2006513222A/ja active Pending
- 2003-12-23 WO PCT/US2003/041031 patent/WO2004058726A2/en not_active Ceased
- 2003-12-23 CA CA002511496A patent/CA2511496A1/en not_active Abandoned
- 2003-12-23 MX MXPA05006975A patent/MXPA05006975A/es unknown
- 2003-12-23 AU AU2003300297A patent/AU2003300297A1/en not_active Abandoned
- 2003-12-23 US US10/547,930 patent/US20070117978A1/en not_active Abandoned
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5283382A (en) * | 1975-12-27 | 1977-07-12 | Otsuka Pharmaceut Co Ltd | Synthesis of carbostyril derivatives |
| JPS52108970A (en) * | 1976-03-09 | 1977-09-12 | Boehringer Sohn Ingelheim | Production of novel aminoalkyl heterocyclic compound |
| JPS5368775A (en) * | 1976-10-05 | 1978-06-19 | Boehringer Sohn Ingelheim | 11aryloxyy22mydroxyy33 alkyleneaminopropane |
| JPS5745144A (en) * | 1980-06-23 | 1982-03-13 | Boehringer Mannheim Gmbh | Aryloxypropanol amine, manufacture and treating and portecting medicine containing same for cardiac and circulatory diseases |
| JPS59205364A (ja) * | 1983-04-26 | 1984-11-20 | スミスクライン・ベツクマン・コ−ポレイシヨン | ド−パミン様カルボスチリルおよびその製法 |
| JPS62175458A (ja) * | 1985-11-21 | 1987-08-01 | ビ−チヤム・グル−プ・ピ−エルシ− | 新規化合物、その製法及びそれを含む医薬組成物 |
| JPH0386864A (ja) * | 1988-08-10 | 1991-04-11 | Otsuka Pharmaceut Co Ltd | 強心剤 |
| JPH03236378A (ja) * | 1989-06-01 | 1991-10-22 | Dr Karl Thomae Gmbh | ２―ヒドロキシ―ｎ―プロピルアミン類、その製法及びそれを含有する医薬組成物 |
| JPH0386868A (ja) * | 1989-06-19 | 1991-04-11 | Teikoku Hormone Mfg Co Ltd | ピリダジノン化合物 |
| JPH05279256A (ja) * | 1991-04-03 | 1993-10-26 | Otsuka Pharmaceut Co Ltd | 血小板凝集抑制剤 |
| JP2001500865A (ja) * | 1996-09-13 | 2001-01-23 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | 避妊の非ホルモン法 |
| JP2006509790A (ja) * | 2002-11-27 | 2006-03-23 | アルテシアン セラピューティック，インコーポレイティド | 心不全の治療のための混合されたＰＤＥ阻害およびβアドレナリン拮抗薬活性または部分的作用薬活性を有する化合物 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012509858A (ja) * | 2008-11-25 | 2012-04-26 | ベーリンガー インゲルハイム フェトメディカ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 肥大性心筋症治療用のホスホジエステラーゼタイプＩＩＩ（ＰＤＥＩＩＩ）インヒビターまたはＣａ２＋感作剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2511496A1 (en) | 2004-07-15 |
| WO2004058726A3 (en) | 2004-10-28 |
| WO2004058726A2 (en) | 2004-07-15 |
| AU2003300297A1 (en) | 2004-07-22 |
| MXPA05006975A (es) | 2005-12-14 |
| US20070117978A1 (en) | 2007-05-24 |
| EP1575923A2 (en) | 2005-09-21 |
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