JP2006513166A5 - - Google Patents
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- JP2006513166A5 JP2006513166A5 JP2004552204A JP2004552204A JP2006513166A5 JP 2006513166 A5 JP2006513166 A5 JP 2006513166A5 JP 2004552204 A JP2004552204 A JP 2004552204A JP 2004552204 A JP2004552204 A JP 2004552204A JP 2006513166 A5 JP2006513166 A5 JP 2006513166A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- polysaccharide
- isolated
- subject
- daltons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000004676 glycans Chemical class 0.000 claims 110
- 239000005017 polysaccharide Substances 0.000 claims 110
- 229920001282 polysaccharide Polymers 0.000 claims 110
- 239000000203 mixture Substances 0.000 claims 95
- 241000191940 Staphylococcus Species 0.000 claims 42
- 238000002360 preparation method Methods 0.000 claims 28
- 208000015181 infectious disease Diseases 0.000 claims 26
- 238000000034 method Methods 0.000 claims 24
- 230000001580 bacterial effect Effects 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 20
- 239000002671 adjuvant Substances 0.000 claims 16
- 239000011230 binding agent Substances 0.000 claims 16
- 230000028993 immune response Effects 0.000 claims 16
- 241000283984 Rodentia Species 0.000 claims 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 10
- 238000004519 manufacturing process Methods 0.000 claims 10
- 239000000523 sample Substances 0.000 claims 9
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 8
- 229960002442 glucosamine Drugs 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 6
- 238000006467 substitution reaction Methods 0.000 claims 6
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 5
- 208000035143 Bacterial infection Diseases 0.000 claims 5
- 208000022362 bacterial infectious disease Diseases 0.000 claims 5
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 4
- 210000000628 antibody-producing cell Anatomy 0.000 claims 4
- 239000002585 base Substances 0.000 claims 4
- 230000000850 deacetylating effect Effects 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 230000003472 neutralizing effect Effects 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 210000004989 spleen cell Anatomy 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 3
- 239000003899 bactericide agent Substances 0.000 claims 3
- 210000005056 cell body Anatomy 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- 230000004936 stimulating effect Effects 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 108010067770 Endopeptidase K Proteins 0.000 claims 2
- 108090000988 Lysostaphin Proteins 0.000 claims 2
- 102000016943 Muramidase Human genes 0.000 claims 2
- 108010014251 Muramidase Proteins 0.000 claims 2
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 2
- 101710163270 Nuclease Proteins 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010041925 Staphylococcal infections Diseases 0.000 claims 2
- 241000191967 Staphylococcus aureus Species 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 230000000844 anti-bacterial effect Effects 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 229960000274 lysozyme Drugs 0.000 claims 2
- 239000004325 lysozyme Substances 0.000 claims 2
- 235000010335 lysozyme Nutrition 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 230000001376 precipitating effect Effects 0.000 claims 2
- 238000004513 sizing Methods 0.000 claims 2
- 238000012360 testing method Methods 0.000 claims 2
- 108090001008 Avidin Proteins 0.000 claims 1
- 241000283690 Bos taurus Species 0.000 claims 1
- 241000282472 Canis lupus familiaris Species 0.000 claims 1
- 241000283707 Capra Species 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 241000283086 Equidae Species 0.000 claims 1
- 241000282326 Felis catus Species 0.000 claims 1
- 125000003047 N-acetyl group Chemical group 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 241000288906 Primates Species 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 241000282887 Suidae Species 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000003637 basic solution Substances 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 230000000855 fungicidal effect Effects 0.000 claims 1
- 239000000417 fungicide Substances 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 210000004915 pus Anatomy 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 208000015339 staphylococcus aureus infection Diseases 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42542502P | 2002-11-12 | 2002-11-12 | |
| US60/425,425 | 2002-11-12 | ||
| PCT/US2003/036358 WO2004043405A2 (en) | 2002-11-12 | 2003-11-12 | Polysaccharide vaccine for staphylococcal infections |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012222333A Division JP2013010789A (ja) | 2002-11-12 | 2012-10-04 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
| JP2014231224A Division JP6335102B2 (ja) | 2002-11-12 | 2014-11-14 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006513166A JP2006513166A (ja) | 2006-04-20 |
| JP2006513166A5 true JP2006513166A5 (https=) | 2006-12-07 |
| JP5814494B2 JP5814494B2 (ja) | 2015-11-17 |
Family
ID=32312989
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004552204A Expired - Fee Related JP5814494B2 (ja) | 2002-11-12 | 2003-11-12 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
| JP2012222333A Pending JP2013010789A (ja) | 2002-11-12 | 2012-10-04 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
| JP2014231224A Expired - Fee Related JP6335102B2 (ja) | 2002-11-12 | 2014-11-14 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
| JP2016171443A Pending JP2016204388A (ja) | 2002-11-12 | 2016-09-02 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
| JP2019035315A Pending JP2019089845A (ja) | 2002-11-12 | 2019-02-28 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012222333A Pending JP2013010789A (ja) | 2002-11-12 | 2012-10-04 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
| JP2014231224A Expired - Fee Related JP6335102B2 (ja) | 2002-11-12 | 2014-11-14 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
| JP2016171443A Pending JP2016204388A (ja) | 2002-11-12 | 2016-09-02 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
| JP2019035315A Pending JP2019089845A (ja) | 2002-11-12 | 2019-02-28 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10919956B2 (https=) |
| EP (1) | EP1565478B1 (https=) |
| JP (5) | JP5814494B2 (https=) |
| KR (1) | KR101062525B1 (https=) |
| CN (1) | CN100351260C (https=) |
| AU (1) | AU2003295520B8 (https=) |
| BR (1) | BRPI0316018B8 (https=) |
| CA (1) | CA2501077C (https=) |
| DK (1) | DK1565478T3 (https=) |
| ES (1) | ES2648046T3 (https=) |
| IL (3) | IL167532A (https=) |
| MX (1) | MXPA05005045A (https=) |
| NO (1) | NO341730B1 (https=) |
| NZ (1) | NZ539153A (https=) |
| PL (1) | PL229487B1 (https=) |
| PT (1) | PT1565478T (https=) |
| WO (1) | WO2004043405A2 (https=) |
| ZA (1) | ZA200502607B (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69227127T2 (de) | 1992-12-28 | 1999-04-29 | Yoshiki Industrial Co. Ltd., Yonezawa, Yamagata | Hebelmechanismus mit festem drehpunkt, drehendem krafteinleitungspunkt und drehendem kraftangriffspunkt und eine einrichtung mit einem derartigen hebel. |
| US7252828B2 (en) | 1998-07-15 | 2007-08-07 | The Brigham And Women's Hospital, Inc. | Polysaccharide vaccine for staphylococcal infections |
| PL229487B1 (pl) | 2002-11-12 | 2018-07-31 | Brigham & Womens Hospital Inc | Kompozycja zawierająca polimer β-1,6-glukozaminy, kompozycja zawierająca przeciwciało, kompozycja farmaceutyczna, sposób wytwarzania wyodrębnionego polisacharydu, sposób identyfikacji obecności deacetylowanej poli-N-acetyloglukozaminy (dPNAG) i/ lub poli-N-acetyloglukozaminy (PNAG), wyodrębniony polisacharyd do zastosowania w leczeniu lub profilaktyce zakażenia, wyodrębniony polisacharyd do zastosowania do wytwarzania przeciwciał, w tym przeciwciał monoklonalnych, wyodrębniony polisacharyd do zastosowania w identyfikacji przeciwciała monoklonalnego |
| AU2003290867A1 (en) * | 2002-11-12 | 2004-06-03 | The Brigham And Women's Hospital, Inc. | Methods and products for treating staphylococcal infections |
| ES2415358T3 (es) * | 2004-04-21 | 2013-07-25 | The Brigham And Women's Hospital, Inc. | Péptidos de fijación a la poli-N-acetil glucosamina (PNAG/DPNAG) y procedimientos para el uso de los mismos |
| NZ553776A (en) | 2004-09-22 | 2010-05-28 | Glaxosmithkline Biolog Sa | Immunogenic composition comprising staphylococcal PNAG and Type 5 and/or 8 Capsular polysaccharide or oligosaccharide. |
| EP2298341A3 (en) * | 2004-10-21 | 2011-07-13 | Wyeth LLC | Immunogenic compositions of staphylococcus epidermidis polypeptide and polynucleotide antigens |
| AR060187A1 (es) | 2006-03-30 | 2008-05-28 | Glaxosmithkline Biolog Sa | Composicion inmunogenica |
| EP2476433A1 (en) | 2006-03-30 | 2012-07-18 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
| CA2881717C (en) | 2006-06-06 | 2018-06-12 | Cecilia Anna Wilhelmina Geuijen | Human binding molecules having killing activity against staphylococci and uses thereof |
| MX2008014978A (es) | 2006-06-06 | 2008-12-09 | Crucell Holland Bv | Moleculas de union humanas que tienen actividad exterminadora contra enterococos y staphylococcus aureus y usos de las mismas. |
| WO2009114520A2 (en) * | 2008-03-10 | 2009-09-17 | Pharmain Corporation | Compositions for treatment with metallopeptidases, methods of making and using the same |
| CN102159540B (zh) | 2008-07-21 | 2015-08-12 | 布赖汉姆妇女医院 | 与合成的β-1,6葡糖胺寡糖相关的方法和组合物 |
| EP2341929B1 (en) | 2008-10-06 | 2017-01-25 | University Of Chicago | Compositions and methods related to bacterial emp proteins |
| HUE026855T2 (en) | 2009-04-03 | 2016-07-28 | Univ Chicago | Compositions and methods related to protein a (spa) variants |
| SA110310528B1 (ar) | 2009-06-22 | 2014-07-02 | Wyeth Llc | التركيبات المولدة للمناعة لأنتيجينات ستافيلوكوكس أوريس |
| SG10201406432RA (en) | 2009-06-22 | 2014-11-27 | Wyeth Llc | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
| GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| BR112012009014B8 (pt) | 2009-09-30 | 2022-10-04 | Novartis Ag | Processo para preparar conjugado de polissacarídeo capsular de s. aureus tipo 5 ou tipo 8 e molécula de transporte crm197, conjugado e composição imunogênica |
| HUE034251T2 (en) | 2009-10-30 | 2018-02-28 | Glaxosmithkline Biologicals Sa | Purification of staphylococcus aureus type 5 and type 8 capsular saccharides |
| LT2547361T (lt) | 2010-03-17 | 2020-12-28 | Socpra - Sciences Et Génie, S.E.C. | Staphylococcus aureus bakterinės vakcinos komponentai ir jų naudojimas |
| EP2555794A4 (en) | 2010-04-05 | 2014-01-15 | Univ Chicago | COMPOSITIONS AND METHODS RELATING TO PROTEIN A (SPA) ANTIBODIES AS IMMUNE REACTION AMPLIFIERS |
| US20130116423A1 (en) * | 2010-04-23 | 2013-05-09 | A. Stewart Campbell | Synthetic Oligosaccharides for Staphylococcus Vaccine |
| CA2803298C (en) | 2010-07-02 | 2020-07-14 | The University Of Chicago | Compositions and methods related to protein a (spa) variants |
| EP2614074A1 (en) | 2010-09-09 | 2013-07-17 | The University of Chicago | Methods and compositions involving protective staphylococcal antigens |
| JP6670106B2 (ja) | 2012-04-26 | 2020-03-18 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | ブドウ球菌コアグラーゼ抗原およびその使用方法 |
| WO2013168965A2 (ko) * | 2012-05-07 | 2013-11-14 | 목암생명공학연구소 | 포도상구균 감염 예방용 백신 조성물 |
| RU2019101166A (ru) * | 2012-05-30 | 2020-03-02 | Дзе Брихэм Энд Уимен`З Хоспитал, Инк. | Композиции полисахаридов и способы применения |
| WO2015183041A1 (ko) * | 2014-05-29 | 2015-12-03 | 주식회사 녹십자 | 포도상구균 감염 질환의 예방 또는 치료용 조성물 |
| WO2017010845A1 (ko) * | 2015-07-15 | 2017-01-19 | 재단법인 목암생명과학연구소 | 포도상구균 감염 질환의 예방 또는 치료용 조성물 |
| KR101847051B1 (ko) | 2016-04-26 | 2018-04-09 | 한국외국어대학교 연구산학협력단 | 병원균에 대한 항생활성을 갖는 펩타이드 및 이를 포함하는 항생 펩타이드 조성물 |
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| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| US12397014B2 (en) | 2019-02-05 | 2025-08-26 | The Brigham And Women's Hospital, Inc. | Polysaccharide compositions for use in treating filariasis |
| US20200355139A1 (en) | 2019-05-10 | 2020-11-12 | Mazda Motor Corporation | Engine piston and method for manufacturing the same |
| CA3152520A1 (en) * | 2019-08-27 | 2021-03-04 | OneBioPharma, Inc. | Antimicrobial vaccine compositions |
| US11173199B2 (en) | 2019-11-13 | 2021-11-16 | Alopexx Inc. | Low contaminant compositions |
| US10828360B1 (en) | 2020-02-04 | 2020-11-10 | OneBioPharma, Inc. | Methods for inhibiting biofilm formation |
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-
2003
- 2003-11-12 PL PL377145A patent/PL229487B1/pl unknown
- 2003-11-12 DK DK03786713.2T patent/DK1565478T3/da active
- 2003-11-12 KR KR1020057008332A patent/KR101062525B1/ko not_active Expired - Fee Related
- 2003-11-12 EP EP03786713.2A patent/EP1565478B1/en not_active Expired - Lifetime
- 2003-11-12 WO PCT/US2003/036358 patent/WO2004043405A2/en not_active Ceased
- 2003-11-12 AU AU2003295520A patent/AU2003295520B8/en not_active Ceased
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- 2003-11-12 ES ES03786713.2T patent/ES2648046T3/es not_active Expired - Lifetime
- 2003-11-12 US US10/713,790 patent/US10919956B2/en active Active
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