JP2006512318A - 眼の血管新生もしくは水腫状の疾患および障害を処置するためのヒストンデアセチラーゼインヒビター - Google Patents
眼の血管新生もしくは水腫状の疾患および障害を処置するためのヒストンデアセチラーゼインヒビター Download PDFInfo
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- AODPIQQILQLWGS-GXBDJPPSSA-N tetrahydrocortisol Chemical compound C1[C@H](O)CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CC[C@@H]21 AODPIQQILQLWGS-GXBDJPPSSA-N 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
- 125000005958 tetrahydrothienyl group Chemical group 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229930192474 thiophene Chemical group 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- YTZALCGQUPRCGW-ZSFNYQMMSA-N verteporfin Chemical compound N1C(C=C2C(=C(CCC(O)=O)C(C=C3C(CCC(=O)OC)=C(C)C(N3)=C3)=N2)C)=C(C=C)C(C)=C1C=C1C2=CC=C(C(=O)OC)[C@@H](C(=O)OC)[C@@]2(C)C3=N1 YTZALCGQUPRCGW-ZSFNYQMMSA-N 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
- 229940061392 visudyne Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42557402P | 2002-11-12 | 2002-11-12 | |
| PCT/US2003/034617 WO2004043352A2 (en) | 2002-11-12 | 2003-10-30 | Histone deacetylase inhibitors for the treatment of ocular neovascular or edematous disorders and diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006512318A true JP2006512318A (ja) | 2006-04-13 |
| JP2006512318A5 JP2006512318A5 (enExample) | 2006-07-13 |
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| Application Number | Title | Priority Date | Filing Date |
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Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20060074100A1 (enExample) |
| EP (1) | EP1560583A4 (enExample) |
| JP (1) | JP2006512318A (enExample) |
| KR (1) | KR20050086526A (enExample) |
| CN (1) | CN1711087A (enExample) |
| AU (1) | AU2003287349B2 (enExample) |
| BR (1) | BR0316206A (enExample) |
| CA (1) | CA2504460A1 (enExample) |
| MX (1) | MXPA05004485A (enExample) |
| RU (1) | RU2352337C2 (enExample) |
| WO (1) | WO2004043352A2 (enExample) |
| ZA (1) | ZA200503237B (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006523693A (ja) * | 2003-04-01 | 2006-10-19 | メモリアル スローン−ケタリング キャンサー センター | ヒドロキサム酸化合物およびその使用方法 |
| WO2008117861A1 (ja) * | 2007-03-28 | 2008-10-02 | Santen Pharmaceutical Co., Ltd. | フェニレンジアミン誘導体を有効成分とする眼圧下降剤 |
| JP2019531296A (ja) * | 2016-09-29 | 2019-10-31 | 彦臣生技藥品股▲ふん▼有限公司ＮａｔｕｒｅＷｉｓｅ Ｂｉｏｔｅｃｈ＆ Ｍｅｄｉｃａｌｓ Ｃｏｒｐｏｒａｔｉｏｎ | 眼疾患の処置方法 |
| JP2021514366A (ja) * | 2018-02-20 | 2021-06-10 | チョン クン ダン ファーマシューティカル コーポレーション | ブドウ膜炎の予防または治療のための組成物 |
| US11571426B2 (en) | 2017-11-24 | 2023-02-07 | Chong Kun Dang Pharmaceutical Corp. | Compositions for preventing or treating lupus |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP2006512318A (ja) * | 2002-11-12 | 2006-04-13 | アルコン，インコーポレイテッド | 眼の血管新生もしくは水腫状の疾患および障害を処置するためのヒストンデアセチラーゼインヒビター |
| CA2518318A1 (en) | 2003-03-17 | 2004-09-30 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20050197336A1 (en) * | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
| US7345043B2 (en) * | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
| WO2006016680A1 (en) * | 2004-08-09 | 2006-02-16 | Astellas Pharma Inc. | Hydroxyamide compounds having activity as inhibitors of histone deacetylase (hdac) |
| EP1824831A2 (en) | 2004-12-16 | 2007-08-29 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| CA2596015A1 (en) | 2005-02-14 | 2006-08-24 | Sampath K. Anandan | Fused heterocyclic compounds useful as inhibitors of histone deacetylase |
| GB0509225D0 (en) * | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Inhibitors of enzymatic activity |
| AU2006243000B2 (en) * | 2005-05-05 | 2011-05-26 | Macrophage Pharma Limited | Alpha aminoacid ester-drug conjugates hydrolysable by carboxylesterase |
| JP2008540574A (ja) | 2005-05-11 | 2008-11-20 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| CN101263121A (zh) | 2005-07-14 | 2008-09-10 | 塔克达圣地亚哥公司 | 组蛋白脱乙酰基酶抑制剂 |
| EP1909812A4 (en) * | 2005-07-27 | 2009-11-25 | Univ Florida | SMALL CONNECTIONS FOR THE CORRECTION OF PROTEIN MISFAIRINGS AND USES THEREOF |
| ATE554084T1 (de) | 2006-02-07 | 2012-05-15 | Astellas Pharma Inc | N-hydroxyacrylamidverbindungen |
| WO2007113644A2 (en) * | 2006-04-05 | 2007-10-11 | Orchid Research Laboratories Limited | New hdac inhibitors |
| US8962825B2 (en) * | 2006-10-30 | 2015-02-24 | Glaxosmithkline Intellectual Property Development Limited | Hydroxamates as inhibitors of histone deacetylase |
| CA2671993A1 (en) * | 2006-12-15 | 2008-06-26 | Astellas Pharma Inc. | N-hydroxyacrylamide compounds |
| CN101239929B (zh) * | 2007-02-09 | 2013-04-17 | 中国科学院上海药物研究所 | 曲古抑菌素a衍生物及其制备方法和用途 |
| US11253480B2 (en) * | 2017-10-30 | 2022-02-22 | University of Pittsburgh—of the Commonwealth System of Higher Education | Treatment of ocular conditions utilizing a histone/protein deacetylase inhibitor |
| WO2019246509A1 (en) * | 2018-06-22 | 2019-12-26 | Mohan Rajiv R | Methods and compositions for promoting wound healing with decreased scar formation after glaucoma filtration surgery |
| US20220008365A1 (en) * | 2018-11-14 | 2022-01-13 | Vanderbilt University | Treating Intraocular Retinoblastoma with Inhibitors of Histone Modification |
| RU2769320C1 (ru) * | 2020-12-28 | 2022-03-30 | Федеральное государственное бюджетное учреждение науки Институт проблем химической физики Российской академии наук (ИПХФ РАН) | Способ получения производных N-гидроксибутанамида |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4975537A (en) * | 1985-10-23 | 1990-12-04 | The Upjohn Company | Δ9(11) -angiostatic steroids |
| US4771042A (en) * | 1985-11-25 | 1988-09-13 | The Upjohn Company | Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments |
| US5629327A (en) * | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
| GB9804504D0 (en) * | 1998-03-03 | 1998-04-29 | Leo Pharm Prod Ltd | Matrix metalloproteinase inhibitors |
| AUPP505798A0 (en) * | 1998-08-04 | 1998-08-27 | Fujisawa Pharmaceutical Co., Ltd. | Novel compound fr225497 substance |
| JP2002527449A (ja) * | 1998-10-13 | 2002-08-27 | 藤沢薬品工業株式会社 | 環状テトラペプチド化合物およびその用途 |
| US6953783B1 (en) * | 1998-10-19 | 2005-10-11 | Methylgene, Inc. | Modulation of gene expression by combination therapy |
| EP1167346A4 (en) * | 1999-04-06 | 2003-07-23 | Ono Pharmaceutical Co | DERIVATIVES OF 4-AMINOBUTANIC ACID AND MEDICINES THAT CONTAIN THESE DERIVATIVES AS ACTIVE ACTIVE SUBSTANCES |
| US6511990B1 (en) * | 1999-09-08 | 2003-01-28 | Sloan-Kettering Institute For Cancer Research | Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof |
| US6544957B2 (en) * | 2000-01-04 | 2003-04-08 | The Johns Hopkins University | Methods and reagents for facilitating transcription |
| AR030345A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes relacionados con angiogenesis |
| GB0023983D0 (en) * | 2000-09-29 | 2000-11-15 | Prolifix Ltd | Therapeutic compounds |
| RU2177801C1 (ru) * | 2001-01-25 | 2002-01-10 | Санкт-Петербургская Общественная Организация "Санкт-Петербургский Институт Биорегуляции И Геронтологии Сзо Рамн" | Средство, ингибирующее ангиогенез при заболеваниях органа зрения |
| US20050119305A1 (en) * | 2001-03-21 | 2005-06-02 | Masao Naka | Il-6 production inhibitors |
| US6905669B2 (en) * | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
| JP4638148B2 (ja) * | 2001-10-16 | 2011-02-23 | スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ | 神経変性疾患および脳の癌の処置 |
| US7154002B1 (en) * | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP2006512318A (ja) * | 2002-11-12 | 2006-04-13 | アルコン，インコーポレイテッド | 眼の血管新生もしくは水腫状の疾患および障害を処置するためのヒストンデアセチラーゼインヒビター |
| US20080004311A1 (en) * | 2002-11-12 | 2008-01-03 | Alcon, Inc. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
| KR20050074547A (ko) * | 2002-11-12 | 2005-07-18 | 알콘, 인코퍼레이티드 | 눈의 퇴행성 질환을 치료하기 위한 히스톤 디아세틸라제저해제 |
-
2003
- 2003-10-30 JP JP2004551638A patent/JP2006512318A/ja active Pending
- 2003-10-30 MX MXPA05004485A patent/MXPA05004485A/es active IP Right Grant
- 2003-10-30 WO PCT/US2003/034617 patent/WO2004043352A2/en not_active Ceased
- 2003-10-30 CN CNA2003801030038A patent/CN1711087A/zh active Pending
- 2003-10-30 KR KR1020057008413A patent/KR20050086526A/ko not_active Ceased
- 2003-10-30 CA CA002504460A patent/CA2504460A1/en not_active Abandoned
- 2003-10-30 US US10/531,754 patent/US20060074100A1/en not_active Abandoned
- 2003-10-30 BR BR0316206-0A patent/BR0316206A/pt not_active Application Discontinuation
- 2003-10-30 US US10/697,135 patent/US20040092558A1/en not_active Abandoned
- 2003-10-30 EP EP03781581A patent/EP1560583A4/en not_active Withdrawn
- 2003-10-30 AU AU2003287349A patent/AU2003287349B2/en not_active Ceased
- 2003-10-30 RU RU2005118107/14A patent/RU2352337C2/ru not_active IP Right Cessation
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2005
- 2005-04-21 ZA ZA200503237A patent/ZA200503237B/en unknown
-
2009
- 2009-10-30 US US12/609,873 patent/US20100048608A1/en not_active Abandoned
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006523693A (ja) * | 2003-04-01 | 2006-10-19 | メモリアル スローン−ケタリング キャンサー センター | ヒドロキサム酸化合物およびその使用方法 |
| WO2008117861A1 (ja) * | 2007-03-28 | 2008-10-02 | Santen Pharmaceutical Co., Ltd. | フェニレンジアミン誘導体を有効成分とする眼圧下降剤 |
| JP2019531296A (ja) * | 2016-09-29 | 2019-10-31 | 彦臣生技藥品股▲ふん▼有限公司ＮａｔｕｒｅＷｉｓｅ Ｂｉｏｔｅｃｈ＆ Ｍｅｄｉｃａｌｓ Ｃｏｒｐｏｒａｔｉｏｎ | 眼疾患の処置方法 |
| US11571426B2 (en) | 2017-11-24 | 2023-02-07 | Chong Kun Dang Pharmaceutical Corp. | Compositions for preventing or treating lupus |
| JP2021514366A (ja) * | 2018-02-20 | 2021-06-10 | チョン クン ダン ファーマシューティカル コーポレーション | ブドウ膜炎の予防または治療のための組成物 |
| JP7058745B2 (ja) | 2018-02-20 | 2022-04-22 | チョン クン ダン ファーマシューティカル コーポレーション | ブドウ膜炎の予防または治療のための組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003287349B2 (en) | 2009-04-23 |
| AU2003287349A1 (en) | 2004-06-03 |
| CA2504460A1 (en) | 2004-05-27 |
| MXPA05004485A (es) | 2005-11-23 |
| US20040092558A1 (en) | 2004-05-13 |
| WO2004043352A3 (en) | 2004-07-15 |
| WO2004043352A8 (en) | 2005-06-30 |
| KR20050086526A (ko) | 2005-08-30 |
| BR0316206A (pt) | 2005-09-27 |
| EP1560583A4 (en) | 2010-09-22 |
| ZA200503237B (en) | 2006-06-28 |
| RU2005118107A (ru) | 2006-01-20 |
| WO2004043352A2 (en) | 2004-05-27 |
| CN1711087A (zh) | 2005-12-21 |
| US20060074100A1 (en) | 2006-04-06 |
| US20100048608A1 (en) | 2010-02-25 |
| EP1560583A2 (en) | 2005-08-10 |
| RU2352337C2 (ru) | 2009-04-20 |
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