CA2504460A1 - Histone deacetylase inhibitors for the treatment of ocular neovascular or edematous disorders and diseases - Google Patents
Histone deacetylase inhibitors for the treatment of ocular neovascular or edematous disorders and diseases Download PDFInfo
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- CA2504460A1 CA2504460A1 CA002504460A CA2504460A CA2504460A1 CA 2504460 A1 CA2504460 A1 CA 2504460A1 CA 002504460 A CA002504460 A CA 002504460A CA 2504460 A CA2504460 A CA 2504460A CA 2504460 A1 CA2504460 A1 CA 2504460A1
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- Prior art keywords
- retinal
- alkyl
- aryl
- retinopathy
- heteroaryl
- Prior art date
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- AODPIQQILQLWGS-GXBDJPPSSA-N tetrahydrocortisol Chemical compound C1[C@H](O)CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CC[C@@H]21 AODPIQQILQLWGS-GXBDJPPSSA-N 0.000 description 1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Epidemiology (AREA)
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- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US42557402P | 2002-11-12 | 2002-11-12 | |
| US60/425,574 | 2002-11-12 | ||
| PCT/US2003/034617 WO2004043352A2 (en) | 2002-11-12 | 2003-10-30 | Histone deacetylase inhibitors for the treatment of ocular neovascular or edematous disorders and diseases |
Publications (1)
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|---|---|
| CA2504460A1 true CA2504460A1 (en) | 2004-05-27 |
Family
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| CA002504460A Abandoned CA2504460A1 (en) | 2002-11-12 | 2003-10-30 | Histone deacetylase inhibitors for the treatment of ocular neovascular or edematous disorders and diseases |
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| US (3) | US20060074100A1 (enExample) |
| EP (1) | EP1560583A4 (enExample) |
| JP (1) | JP2006512318A (enExample) |
| KR (1) | KR20050086526A (enExample) |
| CN (1) | CN1711087A (enExample) |
| AU (1) | AU2003287349B2 (enExample) |
| BR (1) | BR0316206A (enExample) |
| CA (1) | CA2504460A1 (enExample) |
| MX (1) | MXPA05004485A (enExample) |
| RU (1) | RU2352337C2 (enExample) |
| WO (1) | WO2004043352A2 (enExample) |
| ZA (1) | ZA200503237B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| BR0316206A (pt) * | 2002-11-12 | 2005-09-27 | Alcon Inc | Uso inibidores de histona desacetilase para o tratamento de distúrbios e de doenças oculares neovasculares ou edematosos |
| US7375228B2 (en) | 2003-03-17 | 2008-05-20 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| AU2004228011A1 (en) * | 2003-04-01 | 2004-10-21 | Memorial Sloan-Kettering Cancer Center | Hydroxamic acid compounds and methods of use thereof |
| US20050197336A1 (en) * | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
| US7345043B2 (en) * | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
| CN101001851B (zh) * | 2004-08-09 | 2011-04-20 | 安斯泰来制药有限公司 | 具有作为组蛋白脱乙酰酶(hdac)抑制剂的活性的羟基酰胺化合物 |
| US7642275B2 (en) | 2004-12-16 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP2008530136A (ja) | 2005-02-14 | 2008-08-07 | ミイカナ セラピューティクス インコーポレイテッド | ヒストンデアセチラーゼの阻害剤として有用な縮合複素環化合物 |
| MX2007013257A (es) * | 2005-05-05 | 2008-01-21 | Chroma Therapeutics Ltd | Conjugados de ester de alfa-aminoacido-farmaco hidrolizables por carboxilesterasa. |
| GB0509225D0 (en) * | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Inhibitors of enzymatic activity |
| JP2008540574A (ja) | 2005-05-11 | 2008-11-20 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| CA2615105A1 (en) | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| CN101267779A (zh) * | 2005-07-27 | 2008-09-17 | 福罗里达大学研究基金会有限公司 | 使用热休克治疗眼睛疾病 |
| CN101379059A (zh) | 2006-02-07 | 2009-03-04 | 安斯泰来制药有限公司 | N-羟基丙烯酰胺化合物 |
| WO2007113644A2 (en) * | 2006-04-05 | 2007-10-11 | Orchid Research Laboratories Limited | New hdac inhibitors |
| CA2668070A1 (en) * | 2006-10-30 | 2008-05-08 | Chroma Therapeutics Ltd. | Hydroxamates as inhibitors of histone deacetylase |
| JP2010513223A (ja) * | 2006-12-15 | 2010-04-30 | アステラス製薬株式会社 | Ｎ−ヒドロキシアクリルアミド化合物 |
| CN101239929B (zh) * | 2007-02-09 | 2013-04-17 | 中国科学院上海药物研究所 | 曲古抑菌素a衍生物及其制备方法和用途 |
| WO2008117861A1 (ja) * | 2007-03-28 | 2008-10-02 | Santen Pharmaceutical Co., Ltd. | フェニレンジアミン誘導体を有効成分とする眼圧下降剤 |
| CA3038845C (en) * | 2016-09-29 | 2022-04-19 | Naturewise Biotech & Medicals Corporation | Methods for treating ocular diseases |
| US11253480B2 (en) * | 2017-10-30 | 2022-02-22 | University of Pittsburgh—of the Commonwealth System of Higher Education | Treatment of ocular conditions utilizing a histone/protein deacetylase inhibitor |
| KR102236356B1 (ko) | 2017-11-24 | 2021-04-05 | 주식회사 종근당 | 루푸스의 예방 또는 치료를 위한 조성물 |
| KR20190099952A (ko) * | 2018-02-20 | 2019-08-28 | 주식회사 종근당 | 포도막염의 예방 또는 치료를 위한 조성물 |
| WO2019246509A1 (en) * | 2018-06-22 | 2019-12-26 | Mohan Rajiv R | Methods and compositions for promoting wound healing with decreased scar formation after glaucoma filtration surgery |
| US20220008365A1 (en) * | 2018-11-14 | 2022-01-13 | Vanderbilt University | Treating Intraocular Retinoblastoma with Inhibitors of Histone Modification |
| RU2769320C1 (ru) * | 2020-12-28 | 2022-03-30 | Федеральное государственное бюджетное учреждение науки Институт проблем химической физики Российской академии наук (ИПХФ РАН) | Способ получения производных N-гидроксибутанамида |
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| US4975537A (en) * | 1985-10-23 | 1990-12-04 | The Upjohn Company | Δ9(11) -angiostatic steroids |
| US4771042A (en) * | 1985-11-25 | 1988-09-13 | The Upjohn Company | Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments |
| US5629327A (en) * | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
| GB9804504D0 (en) * | 1998-03-03 | 1998-04-29 | Leo Pharm Prod Ltd | Matrix metalloproteinase inhibitors |
| AUPP505798A0 (en) * | 1998-08-04 | 1998-08-27 | Fujisawa Pharmaceutical Co., Ltd. | Novel compound fr225497 substance |
| WO2000021979A2 (en) * | 1998-10-13 | 2000-04-20 | Fujisawa Pharmaceutical Co., Ltd. | Cyclic tetrapeptide and their use as histone deacetylase inhibitor |
| US6953783B1 (en) * | 1998-10-19 | 2005-10-11 | Methylgene, Inc. | Modulation of gene expression by combination therapy |
| WO2000059865A1 (en) * | 1999-04-06 | 2000-10-12 | Ono Pharmaceutical Co., Ltd. | 4-aminobutanoic acid derivatives and drugs containing these derivatives as the active ingredient |
| BR0014254A (pt) * | 1999-09-08 | 2002-08-27 | Sloan Kettering Inst Cancer | Nova classe de agentes de citodiferenciação e inibidores de desacetilase de histona, e métodos de uso dos mesmos |
| US6544957B2 (en) * | 2000-01-04 | 2003-04-08 | The Johns Hopkins University | Methods and reagents for facilitating transcription |
| AR030345A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes relacionados con angiogenesis |
| GB0023983D0 (en) * | 2000-09-29 | 2000-11-15 | Prolifix Ltd | Therapeutic compounds |
| RU2177801C1 (ru) * | 2001-01-25 | 2002-01-10 | Санкт-Петербургская Общественная Организация "Санкт-Петербургский Институт Биорегуляции И Геронтологии Сзо Рамн" | Средство, ингибирующее ангиогенез при заболеваниях органа зрения |
| WO2002074298A1 (en) * | 2001-03-21 | 2002-09-26 | Ono Pharmaceutical Co., Ltd. | Il-6 production inhibitors |
| US6905669B2 (en) * | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
| EP1443928B1 (en) * | 2001-10-16 | 2011-07-27 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases and cancer of the brain |
| US7154002B1 (en) * | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20080004311A1 (en) * | 2002-11-12 | 2008-01-03 | Alcon, Inc. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
| BR0316206A (pt) * | 2002-11-12 | 2005-09-27 | Alcon Inc | Uso inibidores de histona desacetilase para o tratamento de distúrbios e de doenças oculares neovasculares ou edematosos |
| US20040092431A1 (en) * | 2002-11-12 | 2004-05-13 | Hellberg Peggy E. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
-
2003
- 2003-10-30 BR BR0316206-0A patent/BR0316206A/pt not_active Application Discontinuation
- 2003-10-30 CN CNA2003801030038A patent/CN1711087A/zh active Pending
- 2003-10-30 CA CA002504460A patent/CA2504460A1/en not_active Abandoned
- 2003-10-30 JP JP2004551638A patent/JP2006512318A/ja active Pending
- 2003-10-30 MX MXPA05004485A patent/MXPA05004485A/es active IP Right Grant
- 2003-10-30 EP EP03781581A patent/EP1560583A4/en not_active Withdrawn
- 2003-10-30 AU AU2003287349A patent/AU2003287349B2/en not_active Ceased
- 2003-10-30 RU RU2005118107/14A patent/RU2352337C2/ru not_active IP Right Cessation
- 2003-10-30 US US10/531,754 patent/US20060074100A1/en not_active Abandoned
- 2003-10-30 US US10/697,135 patent/US20040092558A1/en not_active Abandoned
- 2003-10-30 KR KR1020057008413A patent/KR20050086526A/ko not_active Ceased
- 2003-10-30 WO PCT/US2003/034617 patent/WO2004043352A2/en not_active Ceased
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2005
- 2005-04-21 ZA ZA200503237A patent/ZA200503237B/en unknown
-
2009
- 2009-10-30 US US12/609,873 patent/US20100048608A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR0316206A (pt) | 2005-09-27 |
| US20040092558A1 (en) | 2004-05-13 |
| ZA200503237B (en) | 2006-06-28 |
| JP2006512318A (ja) | 2006-04-13 |
| EP1560583A4 (en) | 2010-09-22 |
| AU2003287349B2 (en) | 2009-04-23 |
| US20100048608A1 (en) | 2010-02-25 |
| WO2004043352A3 (en) | 2004-07-15 |
| WO2004043352A8 (en) | 2005-06-30 |
| RU2352337C2 (ru) | 2009-04-20 |
| CN1711087A (zh) | 2005-12-21 |
| AU2003287349A1 (en) | 2004-06-03 |
| KR20050086526A (ko) | 2005-08-30 |
| US20060074100A1 (en) | 2006-04-06 |
| MXPA05004485A (es) | 2005-11-23 |
| EP1560583A2 (en) | 2005-08-10 |
| RU2005118107A (ru) | 2006-01-20 |
| WO2004043352A2 (en) | 2004-05-27 |
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| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20121001 |