JP2006510711A5 - - Google Patents
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- JP2006510711A5 JP2006510711A5 JP2004562109A JP2004562109A JP2006510711A5 JP 2006510711 A5 JP2006510711 A5 JP 2006510711A5 JP 2004562109 A JP2004562109 A JP 2004562109A JP 2004562109 A JP2004562109 A JP 2004562109A JP 2006510711 A5 JP2006510711 A5 JP 2006510711A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- leucine
- weight
- composition according
- proteinaceous material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 32
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 19
- 239000000463 material Substances 0.000 claims description 11
- 150000001413 amino acids Chemical class 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 4
- 229960000310 ISOLEUCINE Drugs 0.000 claims description 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 3
- 229960004295 valine Drugs 0.000 claims description 3
- 230000001195 anabolic Effects 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 150000002632 lipids Chemical class 0.000 claims description 2
- 229960003136 leucine Drugs 0.000 claims 16
- 235000001014 amino acid Nutrition 0.000 claims 7
- 229940024606 Amino Acids Drugs 0.000 claims 6
- 229940021015 I.V. solution additive Amino Acids Drugs 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 235000018102 proteins Nutrition 0.000 claims 5
- 150000002016 disaccharides Chemical class 0.000 claims 3
- 235000013305 food Nutrition 0.000 claims 3
- 150000002772 monosaccharides Chemical class 0.000 claims 3
- 235000019749 Dry matter Nutrition 0.000 claims 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 2
- 229930003270 Vitamin B Natural products 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000004474 valine Substances 0.000 claims 2
- 235000019156 vitamin B Nutrition 0.000 claims 2
- 239000011720 vitamin B Substances 0.000 claims 2
- 229940019746 Antifibrinolytic amino acids Drugs 0.000 claims 1
- 206010007733 Catabolic state Diseases 0.000 claims 1
- 229960000304 Folic Acid Drugs 0.000 claims 1
- 235000019766 L-Lysine Nutrition 0.000 claims 1
- 235000019454 L-leucine Nutrition 0.000 claims 1
- 239000004395 L-leucine Substances 0.000 claims 1
- 125000003440 L-leucyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C(C([H])([H])[H])([H])C([H])([H])[H] 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 229960004452 Methionine Drugs 0.000 claims 1
- 210000003205 Muscles Anatomy 0.000 claims 1
- 210000003491 Skin Anatomy 0.000 claims 1
- 229960004799 Tryptophan Drugs 0.000 claims 1
- 229940088594 Vitamin Drugs 0.000 claims 1
- RMRCNWBMXRMIRW-WYVZQNDMSA-L Vitamin B12 Chemical compound N([C@@H]([C@@]1(C)[C@@](C)(CC(N)=O)[C@H](CCC(N)=O)\C(N1[Co+]C#N)=C(/C)\C1=N\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NCC(C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO RMRCNWBMXRMIRW-WYVZQNDMSA-L 0.000 claims 1
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 235000020776 essential amino acid Nutrition 0.000 claims 1
- 239000003797 essential amino acid Substances 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims 1
- 235000019136 lipoic acid Nutrition 0.000 claims 1
- 229960003646 lysine Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000004078 physical exercise Effects 0.000 claims 1
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 229960002663 thioctic acid Drugs 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 229930003231 vitamins Natural products 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000005862 Whey Substances 0.000 description 2
- 229960002743 Glutamine Drugs 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000002708 enhancing Effects 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/325,711 US7288570B2 (en) | 2002-12-20 | 2002-12-20 | Stimulation of in vivo production of proteins |
| PCT/NL2003/000892 WO2004056208A1 (en) | 2002-12-20 | 2003-12-15 | Stimulation of in vivo production of proteins with formulation comprising leucine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006510711A JP2006510711A (ja) | 2006-03-30 |
| JP2006510711A5 true JP2006510711A5 (ru) | 2011-01-20 |
Family
ID=32593858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004562109A Pending JP2006510711A (ja) | 2002-12-20 | 2003-12-15 | ロイシンを含む組成物でタンパク質のインビボ生産を刺激する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7288570B2 (ru) |
| EP (1) | EP1455603B1 (ru) |
| JP (1) | JP2006510711A (ru) |
| CN (1) | CN100353866C (ru) |
| AT (1) | ATE341226T1 (ru) |
| AU (1) | AU2003290447B2 (ru) |
| CA (1) | CA2510760C (ru) |
| DE (1) | DE60308810T2 (ru) |
| DK (1) | DK1455603T3 (ru) |
| ES (1) | ES2274299T3 (ru) |
| HK (1) | HK1065447A1 (ru) |
| WO (1) | WO2004056208A1 (ru) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4970694B2 (ja) * | 2002-12-02 | 2012-07-11 | 株式会社明治 | 持続性筋肉疲労改善剤 |
| US7288570B2 (en) * | 2002-12-20 | 2007-10-30 | Nutricia N.V. | Stimulation of in vivo production of proteins |
| BRPI0606687A2 (pt) * | 2005-01-18 | 2009-07-14 | Dsm Ip Assets Bv | composições nutracêuticas |
| EP1774973A1 (en) * | 2005-10-12 | 2007-04-18 | Nutricia N.V. | Leucine rich composition |
| JP5155870B2 (ja) * | 2005-10-26 | 2013-03-06 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 除脂肪筋量を増加させ、および／または脂肪増加を低下させるための組成物および方法 |
| ES2302463B1 (es) * | 2006-12-29 | 2009-06-05 | Madaus, S.A. | "composicion a base de fibra de cacao". |
| ES2345461T3 (es) | 2007-02-23 | 2010-09-23 | Hill's Pet Nutrition, Inc. | Composiciones y metodos para controlar el peso de animales. |
| EP2098124A1 (en) * | 2008-03-03 | 2009-09-09 | Nestec S.A. | Carbohydrate gel |
| EP2098125B1 (en) * | 2008-03-03 | 2011-10-05 | Nestec S.A. | A gelled food product with high carbohydrate intake efficiency |
| EP2098126A1 (en) * | 2008-03-03 | 2009-09-09 | Nestec S.A. | Carbohydrate Bar |
| WO2010002242A1 (en) * | 2008-07-02 | 2010-01-07 | N.V. Nutricia | Nutritional composition for improving muscle function and daily activity |
| US20110052729A1 (en) | 2009-08-26 | 2011-03-03 | Golini Jeffrey M | Pharmaceutical or nutraceutical composition |
| EP2327316B1 (en) * | 2009-11-29 | 2016-11-16 | Premier Nutrition Corporation | Method of enhancing muscle protein synthesis |
| ES2441365T3 (es) * | 2009-11-29 | 2014-02-04 | Nestec S.A. | Protocolos de dosificación para incrementar la síntesis de proteínas en un individuo activo |
| WO2011078654A1 (en) * | 2009-12-24 | 2011-06-30 | N.V. Nutricia | Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis |
| JP2013519869A (ja) | 2010-02-10 | 2013-05-30 | ノバルティス アーゲー | 筋肉成長のための方法および化合物 |
| ES2681849T3 (es) * | 2010-03-12 | 2018-09-17 | Nestec S.A. | Composiciones para enmascarar el sabor de la leucina y métodos para producirlas |
| WO2012005568A1 (en) * | 2010-07-07 | 2012-01-12 | N.V. Nutricia | Nutritional composition for the stimulation of muscle protein synthesis |
| CA2841748C (en) | 2011-07-15 | 2021-06-15 | Nusirt Sciences, Inc. | Compositions and methods for modulating metabolic pathways |
| US9198454B2 (en) * | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
| EP2831100A4 (en) | 2012-03-26 | 2016-02-10 | Pronutria Inc | NUTRIENT PROTEINS AND METHODS |
| CN104364259A (zh) * | 2012-03-26 | 2015-02-18 | 普罗努塔利亚公司 | 营养性片段、蛋白质和方法 |
| SG11201405842PA (en) | 2012-03-26 | 2014-10-30 | Pronutria Inc | Charged nutritive proteins and methods |
| CA2868469A1 (en) | 2012-03-26 | 2013-10-03 | Pronutria, Inc. | Nutritive fragments, proteins and methods |
| MX2015006023A (es) | 2012-11-13 | 2016-03-31 | Nusirt Sciences Inc | Composiciones y metodos para incrementar el metabolismo energetico. |
| CA2902879C (en) | 2013-03-15 | 2023-09-26 | Nusirt Sciences, Inc. | Leucine and nicotinic acid reduces lipid levels |
| US9597367B2 (en) * | 2013-04-19 | 2017-03-21 | Bioventures, Llc | Methods for improving muscle and heart function |
| ES2636479T3 (es) * | 2013-06-10 | 2017-10-05 | N.V. Nutricia | Conservación muscular en el adulto con sobrepeso u obesidad durante un programa de pérdida de peso |
| AU2014324901A1 (en) | 2013-09-25 | 2016-05-19 | Axcella Health Inc. | Compositions and formulations for prevention and treatment of diabetes and obesity, and methods of production and use thereof in glucose and caloric control |
| US9724319B2 (en) | 2014-02-27 | 2017-08-08 | Nusirt Sciences, Inc. | Compositions and methods for the reduction or prevention of hepatic steatosis |
| WO2016031839A1 (ja) | 2014-08-29 | 2016-03-03 | 株式会社プロジェクトＰｍ | ピリドキサミン化合物及びチアミン化合物を組み合わせてなる医薬組成物 |
| US10188135B2 (en) * | 2015-11-04 | 2019-01-29 | Stokley-Van Camp, Inc. | Method for inducing satiety |
| RU2601406C1 (ru) * | 2015-11-17 | 2016-11-10 | Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Саратовский Государственный Медицинский Университет Имени В.И. Разумовского" Министерства Здравоохранения Российской Федерации | Средство, обладающее антикахексическим, противоопухолевым свойствами и снижающее уровень эндогенной интоксикации |
| JP6105111B1 (ja) | 2016-03-02 | 2017-03-29 | 国立大学法人東北大学 | 自閉スペクトラム症改善用組成物 |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| US10682325B2 (en) | 2017-08-14 | 2020-06-16 | Axcella Health Inc. | Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting |
| CH714189A1 (de) * | 2017-09-25 | 2019-03-29 | Omanda Ag | Verfahren zur Herstellung von L-Leucin und Molkenprotein L-Leucin zur Nahrungsanreicherung und dessen Anwendung. |
| WO2019090061A1 (en) | 2017-11-02 | 2019-05-09 | Bioventures, Llc | Use of amino acid supplementation for improved muscle protein synthesis |
| EP3810123A1 (en) | 2018-06-20 | 2021-04-28 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
| CH715997A1 (de) * | 2019-03-25 | 2020-09-30 | Omanda Ag | Proteingetränk und Darreichungseinheit zur Verabreichung von mit L-Leucin-angereicherten Molkenproteinkomponenten als Nahrungsanreicherung und dessen Herstellung. |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3928445A (en) * | 1973-12-26 | 1975-12-23 | Allied Chem | Synthesis of 2-halo-5-cyano alkyl valerate |
| JPS6049764A (ja) * | 1983-08-29 | 1985-03-19 | Ajinomoto Co Inc | 食品組成物 |
| JPS60186261A (ja) * | 1984-03-06 | 1985-09-21 | Ajinomoto Co Inc | 固体状食品組成物 |
| US4687782A (en) | 1984-12-10 | 1987-08-18 | Nutri-Fuels Systems, Inc. | Nutritional composition for enhancing skeletal muscle adaptation to exercise training |
| US5639731A (en) * | 1987-05-22 | 1997-06-17 | Pripps Bryggerier Ab | Amino acids for the preparation of a beverage |
| FI892006A (fi) * | 1988-04-29 | 1989-10-30 | Phil Gold | Lactalbumin saosom tillaeggsaemne i mat. |
| US5242697A (en) | 1990-10-26 | 1993-09-07 | Maurizio Luca | Method of preparing nutrified food products |
| JP3622271B2 (ja) | 1995-07-11 | 2005-02-23 | 味の素株式会社 | 馬用栄養組成物 |
| US5817329A (en) * | 1997-02-28 | 1998-10-06 | Gardiner; Paul T. | Nutritional supplement for increased muscle size and strength for body builders |
| IT1291127B1 (it) | 1997-04-01 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica |
| DE29707308U1 (de) | 1997-04-23 | 1997-06-26 | Kunz, Armin, 66450 Bexbach | Präparat zur Muskelerhaltung bzw. zur Förderung des Muskelaufbaus |
| US6051236A (en) * | 1998-11-12 | 2000-04-18 | Pacifichealth Laboratories, Inc. | Composition for optimizing muscle performance during exercise |
| US6221418B1 (en) * | 1999-03-25 | 2001-04-24 | Focused Foods, Inc. | High protein edible composition and method of preparing the same |
| US6241996B1 (en) * | 1999-04-09 | 2001-06-05 | Novartis Nutrition Ag | Liquid soy nutritional products |
| ATE320724T1 (de) | 1999-12-30 | 2006-04-15 | Kerry Group Services Ltd | Aufbaupräparat, das kohlenhydrat- und peptidmaterial enthält und sein gebrauch als energieergänzung nach oder während körperlicher übung oder als metabolischer nährstoff für die orale verabreichung |
| US6521591B1 (en) * | 2000-02-10 | 2003-02-18 | N.V. Nutricia | Pharmaceutical composition for muscular anabolism |
| US6420342B1 (en) * | 2000-05-08 | 2002-07-16 | N.V. Nutricia | Nutritional preparation comprising ribose and medical use thereof |
| US6706295B2 (en) * | 2000-09-29 | 2004-03-16 | The Procter & Gamble Co. | Compositions comprising arabinogalactan and a defined protein component |
| GB0110288D0 (en) | 2001-04-26 | 2001-06-20 | Novartis Nutrition Ag | Composition and treatment method |
| US7288570B2 (en) * | 2002-12-20 | 2007-10-30 | Nutricia N.V. | Stimulation of in vivo production of proteins |
-
2002
- 2002-12-20 US US10/325,711 patent/US7288570B2/en not_active Expired - Lifetime
-
2003
- 2003-12-15 CN CNB2003801098651A patent/CN100353866C/zh not_active Expired - Lifetime
- 2003-12-15 DK DK03782981T patent/DK1455603T3/da active
- 2003-12-15 DE DE60308810T patent/DE60308810T2/de not_active Expired - Lifetime
- 2003-12-15 WO PCT/NL2003/000892 patent/WO2004056208A1/en active IP Right Grant
- 2003-12-15 ES ES03782981T patent/ES2274299T3/es not_active Expired - Lifetime
- 2003-12-15 JP JP2004562109A patent/JP2006510711A/ja active Pending
- 2003-12-15 AT AT03782981T patent/ATE341226T1/de active
- 2003-12-15 AU AU2003290447A patent/AU2003290447B2/en not_active Ceased
- 2003-12-15 EP EP03782981A patent/EP1455603B1/en not_active Expired - Lifetime
- 2003-12-15 CA CA2510760A patent/CA2510760C/en not_active Expired - Fee Related
-
2004
- 2004-10-27 HK HK04108425A patent/HK1065447A1/xx not_active IP Right Cessation
-
2007
- 2007-10-16 US US11/872,804 patent/US20080161398A1/en not_active Abandoned
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