JP2006510606A - 骨髄異形成症候群を治療および管理するための選択的サイトカイン阻害剤の使用方法およびそれを含む組成物 - Google Patents

骨髄異形成症候群を治療および管理するための選択的サイトカイン阻害剤の使用方法およびそれを含む組成物 Download PDF

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JP2006510606A
JP2006510606A JP2004545193A JP2004545193A JP2006510606A JP 2006510606 A JP2006510606 A JP 2006510606A JP 2004545193 A JP2004545193 A JP 2004545193A JP 2004545193 A JP2004545193 A JP 2004545193A JP 2006510606 A JP2006510606 A JP 2006510606A
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Prior art keywords
carbon atoms
alkyl
selective cytokine
active ingredient
phenyl
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JP2004545193A
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JP2006510606A5 (https=
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ゼルディス，ジェローム，ビー．
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Celgene Corp
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Celgene Corp
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pregnancy & Childbirth (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Indole Compounds (AREA)
JP2004545193A 2002-10-15 2003-04-13 骨髄異形成症候群を治療および管理するための選択的サイトカイン阻害剤の使用方法およびそれを含む組成物 Pending JP2006510606A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41847002P 2002-10-15 2002-10-15
PCT/US2003/011324 WO2004034962A2 (en) 2002-10-15 2003-04-13 Selective cytokine inhibitory drugs for treating myelodysplastic syndrome

Publications (2)

Publication Number Publication Date
JP2006510606A true JP2006510606A (ja) 2006-03-30
JP2006510606A5 JP2006510606A5 (https=) 2006-09-14

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JP2004545193A Pending JP2006510606A (ja) 2002-10-15 2003-04-13 骨髄異形成症候群を治療および管理するための選択的サイトカイン阻害剤の使用方法およびそれを含む組成物

Country Status (13)

Country Link
US (1) US7842691B2 (https=)
EP (1) EP1551385A4 (https=)
JP (1) JP2006510606A (https=)
KR (1) KR20050056247A (https=)
CN (1) CN1713905A (https=)
AU (1) AU2003228509B2 (https=)
BR (1) BR0315316A (https=)
CA (1) CA2501936A1 (https=)
IL (1) IL168060A0 (https=)
MX (1) MXPA05003889A (https=)
NZ (1) NZ539534A (https=)
WO (1) WO2004034962A2 (https=)
ZA (1) ZA200503024B (https=)

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US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
KR20120049214A (ko) 2009-06-08 2012-05-16 악셀레론 파마 인코포레이티드 발열성 지방세포를 증가시키는 방법
EP2498753B1 (en) * 2009-11-10 2019-03-06 Celgene Corporation Nanosuspension of a poorly soluble drug made by microfluidization process
US10195249B2 (en) 2012-11-02 2019-02-05 Celgene Corporation Activin-ActRII antagonists and uses for treating bone and other disorders
MA40904A (fr) * 2014-11-03 2017-09-12 Hygeia Tech Inc Compositions d'ester de phorbol et procédés pour traiter ou réduire la durée d'une cytopénie
JP2018501307A (ja) 2014-12-03 2018-01-18 セルジーン コーポレイション アクチビン−ＡｃｔＲＩＩアンタゴニスト及び貧血を治療するための使用
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