|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4275149A
(en)
|
1978-11-24 |
1981-06-23 |
Syva Company |
Macromolecular environment control in specific receptor assays
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
ZA811368B
(en)
|
1980-03-24 |
1982-04-28 |
Genentech Inc |
Bacterial polypedtide expression employing tryptophan promoter-operator
|
|
US4376110A
(en)
|
1980-08-04 |
1983-03-08 |
Hybritech, Incorporated |
Immunometric assays using monoclonal antibodies
|
|
US4873191A
(en)
|
1981-06-12 |
1989-10-10 |
Ohio University |
Genetic transformation of zygotes
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4943529A
(en)
|
1982-05-19 |
1990-07-24 |
Gist-Brocades Nv |
Kluyveromyces as a host strain
|
|
US4713339A
(en)
|
1983-01-19 |
1987-12-15 |
Genentech, Inc. |
Polycistronic expression vector construction
|
|
AU2353384A
(en)
|
1983-01-19 |
1984-07-26 |
Genentech Inc. |
Amplification in eukaryotic host cells
|
|
NZ207394A
(en)
|
1983-03-08 |
1987-03-06 |
Commw Serum Lab Commission |
Detecting or determining sequence of amino acids
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4675187A
(en)
|
1983-05-16 |
1987-06-23 |
Bristol-Myers Company |
BBM-1675, a new antibiotic complex
|
|
DD266710A3
(de)
|
1983-06-06 |
1989-04-12 |
Ve Forschungszentrum Biotechnologie |
Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
AU3145184A
(en)
|
1983-08-16 |
1985-02-21 |
Zymogenetics Inc. |
High expression of foreign genes in schizosaccharomyces pombe
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US4736866B1
(en)
|
1984-06-22 |
1988-04-12 |
|
Transgenic non-human mammals
|
|
US4879231A
(en)
|
1984-10-30 |
1989-11-07 |
Phillips Petroleum Company |
Transformation of yeasts of the genus pichia
|
|
DE3675588D1
(de)
|
1985-06-19 |
1990-12-20 |
Ajinomoto Kk |
Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
AU597574B2
(en)
|
1986-03-07 |
1990-06-07 |
Massachusetts Institute Of Technology |
Method for enhancing glycoprotein stability
|
|
GB8610600D0
(en)
|
1986-04-30 |
1986-06-04 |
Novo Industri As |
Transformation of trichoderma
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US4946783A
(en)
|
1987-01-30 |
1990-08-07 |
President And Fellows Of Harvard College |
Periplasmic protease mutants of Escherichia coli
|
|
US5010182A
(en)
|
1987-07-28 |
1991-04-23 |
Chiron Corporation |
DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides
|
|
IL87737A
(en)
|
1987-09-11 |
1993-08-18 |
Genentech Inc |
Method for culturing polypeptide factor dependent vertebrate recombinant cells
|
|
GB8724885D0
(en)
|
1987-10-23 |
1987-11-25 |
Binns M M |
Fowlpox virus promotors
|
|
ATE105585T1
(de)
|
1987-12-21 |
1994-05-15 |
Univ Toledo |
Transformation von keimenden pflanzensamen mit hilfe von agrobacterium.
|
|
AU4005289A
(en)
|
1988-08-25 |
1990-03-01 |
Smithkline Beecham Corporation |
Recombinant saccharomyces
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5225538A
(en)
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
|
ATE144281T1
(de)
|
1989-04-28 |
1996-11-15 |
Rhein Biotech Proz & Prod Gmbh |
Hefezellen der gattung-schwanniomyces
|
|
FR2646437B1
(fr)
|
1989-04-28 |
1991-08-30 |
Transgene Sa |
Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
|
|
EP0402226A1
(en)
|
1989-06-06 |
1990-12-12 |
Institut National De La Recherche Agronomique |
Transformation vectors for yeast yarrowia
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
ES2096590T3
(es)
|
1989-06-29 |
1997-03-16 |
Medarex Inc |
Reactivos biespecificos para la terapia del sida.
|
|
FR2649120B1
(fr)
|
1989-06-30 |
1994-01-28 |
Cayla |
Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
ATE300615T1
(de)
|
1990-08-29 |
2005-08-15 |
Genpharm Int |
Transgene mäuse fähig zur produktion heterologer antikörper
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
US5206161A
(en)
*
|
1991-02-01 |
1993-04-27 |
Genentech, Inc. |
Human plasma carboxypeptidase B
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
DE69232137T2
(de)
|
1991-11-25 |
2002-05-29 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
|
MD1367C2
(ro)
|
1992-11-13 |
2000-11-30 |
Idec Pharmaceuticals Corporation |
Metode de tratament al limfomului celulelor B, anticorpi anti-CD20, hibridom.
|
|
PT616812E
(pt)
|
1993-03-24 |
2000-04-28 |
Berlex Biosciences |
Combinacao de compostos anti-hormonais e moleculas de ligacao no tratamento do cancro
|
|
US5989811A
(en)
*
|
1994-09-29 |
1999-11-23 |
Urocor, Inc. |
Sextant core biopsy predictive mechanism for non-organ confined disease status
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5750345A
(en)
*
|
1995-10-31 |
1998-05-12 |
Evanston Hospital Corporation |
Detection of human α-thalassemia mutations and their use as predictors of blood-related disorders
|
|
AU2582897A
(en)
|
1996-03-15 |
1997-10-01 |
Millennium Pharmaceuticals, Inc. |
Compositions and methods for the diagnosis, prevention, and treatment of neoplastic cell growth and proliferation
|
|
WO1998023761A1
(en)
|
1996-11-27 |
1998-06-04 |
Genentech, Inc. |
HUMANIZED ANTI-CD11a ANTIBODIES
|
|
WO1999063063A1
(en)
|
1998-06-03 |
1999-12-09 |
Northwestern University |
Cellular proteins which mediate herpesvirus entry
|
|
US6518033B1
(en)
|
1998-08-05 |
2003-02-11 |
The Research Foundation Of State University Of New York |
Method of detecting the presence of CD155 for diagnosis of cancer and to determine treatment
|
|
CA2362427A1
(en)
*
|
1999-03-08 |
2000-09-14 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
WO2000058334A1
(en)
*
|
1999-03-26 |
2000-10-05 |
Human Genome Sciences, Inc. |
50 human secreted proteins
|
|
US7282570B2
(en)
*
|
1999-04-20 |
2007-10-16 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
AU4011300A
(en)
*
|
1999-07-20 |
2001-02-05 |
Genentech Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
US20080050809A1
(en)
*
|
1999-09-28 |
2008-02-28 |
Alejandro Abuin |
Novel human kinases and polynucleotides encoding the same
|
|
WO2001029221A2
(en)
|
1999-10-20 |
2001-04-26 |
Zymogenetics, Inc. |
Proteins and polynucleotides encoding them
|
|
US20040219521A1
(en)
*
|
2000-01-21 |
2004-11-04 |
Tang Y. Tom |
Novel nucleic acids and polypeptides
|
|
WO2001075166A2
(en)
|
2000-03-31 |
2001-10-11 |
Genentech, Inc. |
Compositions and methods for detecting and quantifying gene expression
|
|
US6569668B2
(en)
|
2000-04-04 |
2003-05-27 |
Schering Corporation |
Isolated nucleic acids from Micromonospora rosaria plasmid pMR2 and vectors made therefrom
|
|
CA2412377A1
(en)
|
2000-06-06 |
2001-12-13 |
Bristol-Myers Squibb Company |
B7-related nucleic acids and polypeptides and their uses for immunomodulation
|
|
US7713705B2
(en)
*
|
2002-12-24 |
2010-05-11 |
Biosite, Inc. |
Markers for differential diagnosis and methods of use thereof
|
|
US20040101876A1
(en)
|
2002-05-31 |
2004-05-27 |
Liat Mintz |
Methods and systems for annotating biomolecular sequences
|
|
EP1504099A4
(en)
|
2001-12-10 |
2006-05-10 |
Nuvelo Inc |
NEW NUCLEIC ACIDS AND POLYPEPTIDES
|
|
WO2003068943A2
(en)
*
|
2002-02-13 |
2003-08-21 |
Incyte Corporation |
Secreted proteins
|
|
EP2388265A1
(en)
|
2002-02-22 |
2011-11-23 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
US7193069B2
(en)
|
2002-03-22 |
2007-03-20 |
Research Association For Biotechnology |
Full-length cDNA
|
|
ES2350687T3
(es)
|
2002-07-03 |
2011-01-26 |
Ono Pharmaceutical Co., Ltd. |
Composiciones de inmunopotenciación.
|
|
EP2116551A1
(en)
|
2002-09-11 |
2009-11-11 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
US20040121370A1
(en)
|
2002-09-11 |
2004-06-24 |
Genentech, Inc. |
Novel composition and methods for the treatment of immune related diseases
|
|
EP1481993A1
(en)
|
2003-05-28 |
2004-12-01 |
Xerion Pharmaceuticals AG |
Modulation of the poliovirus receptor function
|
|
PE20050928A1
(es)
|
2003-11-21 |
2005-11-08 |
Schering Corp |
Combinaciones terapeuticas de anticuerpo anti-igfr1
|
|
KR20060120161A
(ko)
|
2003-11-28 |
2006-11-24 |
아스트라제네카 아베 |
항체
|
|
CN101035807A
(zh)
|
2004-06-09 |
2007-09-12 |
泰勒公司 |
Siglec-6相关疾病的诊断和治疗
|
|
GT200500283A
(es)
|
2004-10-08 |
2006-05-08 |
|
Inmunoterapia de desordenes autoinmunes
|
|
RU2494107C2
(ru)
|
2005-05-09 |
2013-09-27 |
Оно Фармасьютикал Ко., Лтд. |
Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами
|
|
EP3214095B1
(en)
|
2005-05-12 |
2019-12-11 |
ZymoGenetics, Inc. |
Compositions and methods for modulating immune responses
|
|
US20100075377A1
(en)
|
2006-04-13 |
2010-03-25 |
West James W |
Tetramerizing polypeptides and methods of use
|
|
US20070243584A1
(en)
|
2006-04-13 |
2007-10-18 |
West James W |
Tetramerizing polypeptides and methods of use
|
|
EP2004682A2
(en)
|
2006-04-13 |
2008-12-24 |
Zymogenetics, Inc. |
Tetramerizing polypeptides and methods of use
|
|
WO2007124383A2
(en)
|
2006-04-19 |
2007-11-01 |
Oregon Health & Science University |
1,1'-binaphthyl-based inhibitors of nad+-dependent deacetylase activity and sir2-family members
|
|
EP3208612B1
(en)
|
2008-04-09 |
2019-09-18 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
AU2009333580B2
(en)
|
2008-12-09 |
2016-07-07 |
Genentech, Inc. |
Anti-PD-L1 antibodies and their use to enhance T-cell function
|
|
WO2011066342A2
(en)
|
2009-11-24 |
2011-06-03 |
Amplimmune, Inc. |
Simultaneous inhibition of pd-l1/pd-l2
|
|
US8822642B2
(en)
|
2010-06-09 |
2014-09-02 |
Zymogenetics, Inc. |
Dimeric fusion proteins and related compositions and methods
|
|
JP6238459B2
(ja)
|
2011-08-01 |
2017-11-29 |
ジェネンテック, インコーポレイテッド |
Pd−1軸結合アンタゴニストとmek阻害剤を使用する癌の治療方法
|
|
AU2012369202A1
(en)
|
2012-02-06 |
2014-09-25 |
Providence Health & Services - Oregon |
Cancer treatment and monitoring methods using OX40 agonists
|
|
CN104968364A
(zh)
|
2012-12-03 |
2015-10-07 |
百时美施贵宝公司 |
强化免疫调变性Fc融合蛋白的抗癌活性
|
|
HK1210964A1
(en)
|
2012-12-04 |
2016-05-13 |
Oncomed Pharmaceuticals, Inc. |
Immunotherapy with binding agents
|
|
EP2948475A2
(en)
|
2013-01-23 |
2015-12-02 |
AbbVie Inc. |
Methods and compositions for modulating an immune response
|
|
CA2916681A1
(en)
|
2013-07-16 |
2015-01-22 |
Genentech, Inc. |
Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors
|
|
RU2016142476A
(ru)
|
2014-03-31 |
2018-05-07 |
Дженентек, Инк. |
Комбинированная терапия, включающая антиангиогенезные агенты и агонисты, связывающие ох40
|
|
EP3126394B1
(en)
|
2014-03-31 |
2019-10-30 |
F.Hoffmann-La Roche Ag |
Anti-ox40 antibodies and methods of use
|
|
SG11201700258VA
(en)
|
2014-07-16 |
2017-02-27 |
Genentech Inc |
Methods of treating cancer using tigit inhibitors and anti-cancer agents
|
|
KR20170072343A
(ko)
|
2014-11-06 |
2017-06-26 |
제넨테크, 인크. |
Ox40 결합 효능제 및 tigit 억제제를 포함하는 병용 요법
|
|
CA2994858C
(en)
|
2015-09-25 |
2024-01-23 |
Genentech, Inc. |
Anti-tigit antibodies and methods of use
|