JP2006508124A5 - - Google Patents
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- Publication number
- JP2006508124A5 JP2006508124A5 JP2004551738A JP2004551738A JP2006508124A5 JP 2006508124 A5 JP2006508124 A5 JP 2006508124A5 JP 2004551738 A JP2004551738 A JP 2004551738A JP 2004551738 A JP2004551738 A JP 2004551738A JP 2006508124 A5 JP2006508124 A5 JP 2006508124A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- inhibiting
- chemical formula
- following chemical
- diluent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- 230000002401 inhibitory effect Effects 0.000 claims 8
- 239000000126 substance Substances 0.000 claims 7
- 239000003085 diluting agent Substances 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 230000005764 inhibitory process Effects 0.000 claims 4
- 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 claims 3
- 108050009527 Hypoxia-inducible factor-1 alpha Proteins 0.000 claims 3
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 3
- 230000002491 angiogenic effect Effects 0.000 claims 3
- 230000005740 tumor formation Effects 0.000 claims 2
- 208000005623 Carcinogenesis Diseases 0.000 claims 1
- 230000036952 cancer formation Effects 0.000 claims 1
- 231100000504 carcinogenesis Toxicity 0.000 claims 1
- 0 C*c(cc1)ccc1[N+](CCCl)(CCCl)O Chemical compound C*c(cc1)ccc1[N+](CCCl)(CCCl)O 0.000 description 1
- XILCGVGBGARDAY-UHFFFAOYSA-N CP1(OCCCN1)=O Chemical compound CP1(OCCCN1)=O XILCGVGBGARDAY-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/288,888 US20040087556A1 (en) | 2002-11-06 | 2002-11-06 | N-oxides and derivatives of melphalan for treating diseased states associated with hypoxia inducible factor |
| PCT/US2003/035226 WO2004043359A2 (en) | 2002-11-06 | 2003-11-03 | N-oxides and derivatives of melphalan for treating diseased states associated with hypoxia inducible factor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006508124A JP2006508124A (ja) | 2006-03-09 |
| JP2006508124A5 true JP2006508124A5 (enExample) | 2006-12-14 |
Family
ID=32175991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004551738A Pending JP2006508124A (ja) | 2002-11-06 | 2003-11-03 | 低酸素誘導性因子に関連した病状を治療するためのメルファレンのｎ−オキシドと誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20040087556A1 (enExample) |
| EP (1) | EP1567476A4 (enExample) |
| JP (1) | JP2006508124A (enExample) |
| AU (1) | AU2003291282B2 (enExample) |
| CA (1) | CA2504496C (enExample) |
| MX (1) | MXPA05004845A (enExample) |
| WO (1) | WO2004043359A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005007828A2 (en) * | 2003-07-14 | 2005-01-27 | Prolx Pharmaceuticals, Inc. | Regulation of hif protein levels via deubiquitination pathways |
| US20110092595A1 (en) * | 2008-02-15 | 2011-04-21 | Garth Powis | Compositions and Methods for Treating Lung Cancer |
| WO2012058325A1 (en) * | 2010-10-29 | 2012-05-03 | Oncothyreon Inc. | Compounds and methods useful for treatment of diseases mediated by hif-1 |
| WO2012082765A2 (en) | 2010-12-16 | 2012-06-21 | The United State Of America. As Represented By The Secretary Department Of Health And Human Services | Methods for decreasing body weight and treating diabetes |
| NZ723940A (en) | 2014-02-03 | 2017-12-22 | Quadriga Biosciences Inc | Beta-substituted beta-amino acids and analogs as chemotherapeutic agents |
| US9394236B2 (en) | 2014-02-03 | 2016-07-19 | Quadriga Biosciences, Inc. | β-substituted γ-amino acids and analogs as chemotherapeutic agents |
| US10349839B2 (en) * | 2015-02-27 | 2019-07-16 | Biotronik Se & Co. | Implantable pressure sensor device |
| KR20180035894A (ko) | 2015-08-03 | 2018-04-06 | 콰드리가 바이오사이언시스 인코포레이티드 | 화학치료제로서의 베타-치환된 베타-아미노산 및 유사체 및 이들의 용도 |
| WO2017027810A2 (en) | 2015-08-12 | 2017-02-16 | The General Hospital Corporation | Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders |
| WO2018160772A1 (en) | 2017-02-28 | 2018-09-07 | The United State Of America, As Represented By The Secretary, Department Of Health & Human Services | Method of treating obesity, insulin resistance, non-alcoholic fatty liver disease including non-alcoholic steatohepatitis |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602278A (en) * | 1994-10-20 | 1997-02-11 | Kirkpatrick; Lynn | N-oxides and derivatives of chlorambucil for treating hypoxic tumor cells |
-
2002
- 2002-11-06 US US10/288,888 patent/US20040087556A1/en not_active Abandoned
-
2003
- 2003-11-03 JP JP2004551738A patent/JP2006508124A/ja active Pending
- 2003-11-03 WO PCT/US2003/035226 patent/WO2004043359A2/en not_active Ceased
- 2003-11-03 CA CA2504496A patent/CA2504496C/en not_active Expired - Fee Related
- 2003-11-03 EP EP03768672A patent/EP1567476A4/en not_active Withdrawn
- 2003-11-03 MX MXPA05004845A patent/MXPA05004845A/es active IP Right Grant
- 2003-11-03 AU AU2003291282A patent/AU2003291282B2/en not_active Ceased
-
2004
- 2004-08-30 US US10/929,156 patent/US7399785B2/en not_active Expired - Fee Related
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