MXPA05004845A - N-oxidos y derivados de melfalan para el tratamiento de estados de enfermedad asociados a un factor inducible por hipoxia. - Google Patents
N-oxidos y derivados de melfalan para el tratamiento de estados de enfermedad asociados a un factor inducible por hipoxia.Info
- Publication number
- MXPA05004845A MXPA05004845A MXPA05004845A MXPA05004845A MXPA05004845A MX PA05004845 A MXPA05004845 A MX PA05004845A MX PA05004845 A MXPA05004845 A MX PA05004845A MX PA05004845 A MXPA05004845 A MX PA05004845A MX PA05004845 A MXPA05004845 A MX PA05004845A
- Authority
- MX
- Mexico
- Prior art keywords
- derivatives
- oxides
- melphalan
- states associated
- inducible factor
- Prior art date
Links
- 150000001204 N-oxides Chemical class 0.000 title abstract 2
- 206010021143 Hypoxia Diseases 0.000 title 1
- 230000007954 hypoxia Effects 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical class OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/288,888 US20040087556A1 (en) | 2002-11-06 | 2002-11-06 | N-oxides and derivatives of melphalan for treating diseased states associated with hypoxia inducible factor |
| PCT/US2003/035226 WO2004043359A2 (en) | 2002-11-06 | 2003-11-03 | N-oxides and derivatives of melphalan for treating diseased states associated with hypoxia inducible factor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05004845A true MXPA05004845A (es) | 2005-10-05 |
Family
ID=32175991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05004845A MXPA05004845A (es) | 2002-11-06 | 2003-11-03 | N-oxidos y derivados de melfalan para el tratamiento de estados de enfermedad asociados a un factor inducible por hipoxia. |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20040087556A1 (enExample) |
| EP (1) | EP1567476A4 (enExample) |
| JP (1) | JP2006508124A (enExample) |
| AU (1) | AU2003291282B2 (enExample) |
| CA (1) | CA2504496C (enExample) |
| MX (1) | MXPA05004845A (enExample) |
| WO (1) | WO2004043359A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005007828A2 (en) * | 2003-07-14 | 2005-01-27 | Prolx Pharmaceuticals, Inc. | Regulation of hif protein levels via deubiquitination pathways |
| US20110092595A1 (en) * | 2008-02-15 | 2011-04-21 | Garth Powis | Compositions and Methods for Treating Lung Cancer |
| WO2012058325A1 (en) * | 2010-10-29 | 2012-05-03 | Oncothyreon Inc. | Compounds and methods useful for treatment of diseases mediated by hif-1 |
| WO2012082765A2 (en) | 2010-12-16 | 2012-06-21 | The United State Of America. As Represented By The Secretary Department Of Health And Human Services | Methods for decreasing body weight and treating diabetes |
| NZ723940A (en) | 2014-02-03 | 2017-12-22 | Quadriga Biosciences Inc | Beta-substituted beta-amino acids and analogs as chemotherapeutic agents |
| US9394236B2 (en) | 2014-02-03 | 2016-07-19 | Quadriga Biosciences, Inc. | β-substituted γ-amino acids and analogs as chemotherapeutic agents |
| US10349839B2 (en) * | 2015-02-27 | 2019-07-16 | Biotronik Se & Co. | Implantable pressure sensor device |
| KR20180035894A (ko) | 2015-08-03 | 2018-04-06 | 콰드리가 바이오사이언시스 인코포레이티드 | 화학치료제로서의 베타-치환된 베타-아미노산 및 유사체 및 이들의 용도 |
| WO2017027810A2 (en) | 2015-08-12 | 2017-02-16 | The General Hospital Corporation | Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders |
| WO2018160772A1 (en) | 2017-02-28 | 2018-09-07 | The United State Of America, As Represented By The Secretary, Department Of Health & Human Services | Method of treating obesity, insulin resistance, non-alcoholic fatty liver disease including non-alcoholic steatohepatitis |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602278A (en) * | 1994-10-20 | 1997-02-11 | Kirkpatrick; Lynn | N-oxides and derivatives of chlorambucil for treating hypoxic tumor cells |
-
2002
- 2002-11-06 US US10/288,888 patent/US20040087556A1/en not_active Abandoned
-
2003
- 2003-11-03 JP JP2004551738A patent/JP2006508124A/ja active Pending
- 2003-11-03 WO PCT/US2003/035226 patent/WO2004043359A2/en not_active Ceased
- 2003-11-03 CA CA2504496A patent/CA2504496C/en not_active Expired - Fee Related
- 2003-11-03 EP EP03768672A patent/EP1567476A4/en not_active Withdrawn
- 2003-11-03 MX MXPA05004845A patent/MXPA05004845A/es active IP Right Grant
- 2003-11-03 AU AU2003291282A patent/AU2003291282B2/en not_active Ceased
-
2004
- 2004-08-30 US US10/929,156 patent/US7399785B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004043359A3 (en) | 2004-09-10 |
| CA2504496A1 (en) | 2004-05-27 |
| US7399785B2 (en) | 2008-07-15 |
| EP1567476A2 (en) | 2005-08-31 |
| WO2004043359B1 (en) | 2004-10-28 |
| US20050026872A1 (en) | 2005-02-03 |
| EP1567476A4 (en) | 2008-09-24 |
| JP2006508124A (ja) | 2006-03-09 |
| AU2003291282B2 (en) | 2010-11-11 |
| AU2003291282A1 (en) | 2004-06-03 |
| WO2004043359A2 (en) | 2004-05-27 |
| CA2504496C (en) | 2010-05-04 |
| US20040087556A1 (en) | 2004-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |