JP2006506435A5 - - Google Patents
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- Publication number
- JP2006506435A5 JP2006506435A5 JP2004553487A JP2004553487A JP2006506435A5 JP 2006506435 A5 JP2006506435 A5 JP 2006506435A5 JP 2004553487 A JP2004553487 A JP 2004553487A JP 2004553487 A JP2004553487 A JP 2004553487A JP 2006506435 A5 JP2006506435 A5 JP 2006506435A5
- Authority
- JP
- Japan
- Prior art keywords
- albumin
- solution
- crystals
- product according
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000009027 Albumins Human genes 0.000 claims 82
- 108010088751 Albumins Proteins 0.000 claims 82
- 239000013078 crystal Substances 0.000 claims 56
- 238000000034 method Methods 0.000 claims 46
- 239000000047 product Substances 0.000 claims 42
- 238000002425 crystallisation Methods 0.000 claims 37
- 230000008025 crystallization Effects 0.000 claims 37
- 102000008100 Human Serum Albumin Human genes 0.000 claims 31
- 108091006905 Human Serum Albumin Proteins 0.000 claims 31
- 239000000126 substance Substances 0.000 claims 26
- 229910019142 PO4 Inorganic materials 0.000 claims 24
- 239000000203 mixture Substances 0.000 claims 24
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 24
- 239000010452 phosphate Substances 0.000 claims 24
- 239000000725 suspension Substances 0.000 claims 20
- 239000003607 modifier Substances 0.000 claims 17
- 238000000926 separation method Methods 0.000 claims 13
- 238000001914 filtration Methods 0.000 claims 12
- 230000009261 transgenic effect Effects 0.000 claims 10
- 238000001816 cooling Methods 0.000 claims 9
- 239000012535 impurity Substances 0.000 claims 8
- 210000004748 cultured cell Anatomy 0.000 claims 7
- 239000000706 filtrate Substances 0.000 claims 7
- 239000007788 liquid Substances 0.000 claims 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical group CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 6
- 239000002202 Polyethylene glycol Substances 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- 238000000746 purification Methods 0.000 claims 5
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical group [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 4
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 4
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 4
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 4
- 210000001124 body fluid Anatomy 0.000 claims 4
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical group CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 claims 4
- 238000010438 heat treatment Methods 0.000 claims 4
- 235000013336 milk Nutrition 0.000 claims 4
- 239000008267 milk Substances 0.000 claims 4
- 210000004080 milk Anatomy 0.000 claims 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical group CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 4
- 159000000001 potassium salts Chemical class 0.000 claims 4
- 229910052708 sodium Inorganic materials 0.000 claims 4
- 239000011734 sodium Substances 0.000 claims 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims 4
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 4
- 239000010839 body fluid Substances 0.000 claims 3
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims 2
- 241000238631 Hexapoda Species 0.000 claims 2
- 208000003623 Hypoalbuminemia Diseases 0.000 claims 2
- 208000034767 Hypoproteinaemia Diseases 0.000 claims 2
- 102000014171 Milk Proteins Human genes 0.000 claims 2
- 108010011756 Milk Proteins Proteins 0.000 claims 2
- 206010029164 Nephrotic syndrome Diseases 0.000 claims 2
- 206010030113 Oedema Diseases 0.000 claims 2
- 206010033645 Pancreatitis Diseases 0.000 claims 2
- 206010033647 Pancreatitis acute Diseases 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 201000003229 acute pancreatitis Diseases 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 230000002612 cardiopulmonary effect Effects 0.000 claims 2
- 238000005119 centrifugation Methods 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000012141 concentrate Substances 0.000 claims 2
- 239000012228 culture supernatant Substances 0.000 claims 2
- 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 230000005484 gravity Effects 0.000 claims 2
- 230000002949 hemolytic effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 235000021239 milk protein Nutrition 0.000 claims 2
- 208000009928 nephrosis Diseases 0.000 claims 2
- 231100001027 nephrosis Toxicity 0.000 claims 2
- 229960002446 octanoic acid Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 239000001103 potassium chloride Substances 0.000 claims 2
- 235000011164 potassium chloride Nutrition 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical group N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 claims 1
- 239000005695 Ammonium acetate Substances 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 229940043376 ammonium acetate Drugs 0.000 claims 1
- 235000019257 ammonium acetate Nutrition 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 claims 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical group O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- 238000001953 recrystallisation Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/300,233 US7087719B2 (en) | 2002-11-19 | 2002-11-19 | Method for the crystallization of human serum albumin |
| PCT/US2003/034205 WO2004046311A2 (en) | 2002-11-19 | 2003-10-28 | A method for the crystallization of human serum albumin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006506435A JP2006506435A (ja) | 2006-02-23 |
| JP2006506435A5 true JP2006506435A5 (enExample) | 2006-12-21 |
Family
ID=32297870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004553487A Abandoned JP2006506435A (ja) | 2002-11-19 | 2003-10-28 | ヒト血清アルブミンの結晶化の方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7087719B2 (enExample) |
| EP (1) | EP1562991A4 (enExample) |
| JP (1) | JP2006506435A (enExample) |
| CN (2) | CN101560253A (enExample) |
| AU (1) | AU2003285055A1 (enExample) |
| CA (1) | CA2506594A1 (enExample) |
| NZ (1) | NZ540149A (enExample) |
| WO (1) | WO2004046311A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050181482A1 (en) * | 2004-02-12 | 2005-08-18 | Meade Harry M. | Method for the production of an erythropoietin analog-human IgG fusion proteins in transgenic mammal milk |
| CA2330527A1 (en) * | 1998-06-15 | 1999-12-23 | Genzyme Transgenics Corporation | Erythropoietin analog-human serum albumin fusion |
| US7087719B2 (en) * | 2002-11-19 | 2006-08-08 | Gtc Biotherapeutics, Inc. | Method for the crystallization of human serum albumin |
| DE602004023338D1 (de) * | 2004-12-21 | 2009-11-05 | Ericsson Telefon Ab L M | Anordnung und verfahren in bezug auf den fluss von paketen in kommunikationssystemen |
| WO2012090067A1 (en) | 2010-12-30 | 2012-07-05 | Lfb Biotechnologies | Glycols as pathogen inactivating agents |
| CN102492027A (zh) * | 2011-12-09 | 2012-06-13 | 福建省农业科学院农业生物资源研究所 | 一种提取Bt杀虫蛋白晶体的方法 |
| BR112014027994A2 (pt) * | 2012-05-11 | 2017-06-27 | Novartis Ag | métodos de cristalização para purificação de anticorpos monoclonais |
| CN103012581B (zh) * | 2012-11-28 | 2015-11-25 | 李英俊 | 制备白蛋白的方法 |
| EP3594230A1 (en) | 2013-02-13 | 2020-01-15 | Laboratoire Français du Fractionnement et des Biotechnologies | Highly galactosylated anti-tnf-alpha antibodies and uses thereof |
| WO2014140927A2 (en) | 2013-02-13 | 2014-09-18 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Proteins with modified glycosylation and methods of production thereof |
| ES2793176T3 (es) | 2013-07-05 | 2020-11-13 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies Sa | Matriz de cromografía de afinidad |
| CN104758924A (zh) * | 2014-01-06 | 2015-07-08 | 河南省医药科学研究院 | 包含白蛋白的药物组合物及其用途 |
| GB201409451D0 (en) | 2014-05-28 | 2014-07-09 | Ipabc Ltd | Antimicrobial preparations, methods for preparing the same and uses thereof to combat microorganisms |
| FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| CN105582883B (zh) * | 2015-12-25 | 2017-12-15 | 北海开元生物科技有限公司 | 一种活化硅藻土及在血液制品生产中的应用 |
| US20210284958A1 (en) * | 2018-06-15 | 2021-09-16 | Fuso Pharmaceutical Industries, Ltd. | Culture medium for assisted reproductive technology |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4833233A (en) | 1987-08-20 | 1989-05-23 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Human serum albumin crystals and method of preparation |
| SE9101149D0 (sv) * | 1991-04-17 | 1991-04-17 | Pharmacia Lkb Biotech | Beads for down stream processing |
| US5585466A (en) | 1994-12-06 | 1996-12-17 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Crystals of serum albumin for use in genetic engineering and rational drug design |
| CA2448432A1 (en) | 2001-06-13 | 2002-12-19 | Taurus Hsa Llc | Purification of human serum albumin |
| US7087719B2 (en) * | 2002-11-19 | 2006-08-08 | Gtc Biotherapeutics, Inc. | Method for the crystallization of human serum albumin |
-
2002
- 2002-11-19 US US10/300,233 patent/US7087719B2/en not_active Expired - Fee Related
-
2003
- 2003-10-28 NZ NZ540149A patent/NZ540149A/en unknown
- 2003-10-28 JP JP2004553487A patent/JP2006506435A/ja not_active Abandoned
- 2003-10-28 WO PCT/US2003/034205 patent/WO2004046311A2/en not_active Ceased
- 2003-10-28 CA CA002506594A patent/CA2506594A1/en not_active Abandoned
- 2003-10-28 EP EP03779369A patent/EP1562991A4/en not_active Withdrawn
- 2003-10-28 CN CNA2009100046254A patent/CN101560253A/zh active Pending
- 2003-10-28 CN CNA2003801078639A patent/CN1732185A/zh active Pending
- 2003-10-28 AU AU2003285055A patent/AU2003285055A1/en not_active Abandoned
-
2006
- 2006-03-17 US US11/378,727 patent/US20060178309A1/en not_active Abandoned
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