JP2006506388A - 医薬組成物および化粧品組成物 - Google Patents
医薬組成物および化粧品組成物 Download PDFInfo
- Publication number
- JP2006506388A JP2006506388A JP2004547507A JP2004547507A JP2006506388A JP 2006506388 A JP2006506388 A JP 2006506388A JP 2004547507 A JP2004547507 A JP 2004547507A JP 2004547507 A JP2004547507 A JP 2004547507A JP 2006506388 A JP2006506388 A JP 2006506388A
- Authority
- JP
- Japan
- Prior art keywords
- silicon dioxide
- aerosil
- highly dispersible
- hydrophobic
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Birds (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
イブプロフェン錠剤中で、Aerosil(登録商標)R972は、親水性の高度に分散性の二酸化ケイ素よりも著しく作用化合物の放出を減少させる(E.M. Samy et al., ; Bull. Pharma. Sci. Assiut University 19 (1996) 19)。
医薬組成物:
粉末状出発物質を前記順序で正確に0.01gまで計量し、ガラス瓶中で手で混合する。この混合物を目開き0.71mmの篩を通して篩別し、ガラス瓶中でターブラミキサー(Turbula mixer)を用いて5分間均質化する。
カプセル充填装置を用いて、71〜78mgの空の質量を有する寸法1の硬質ゼラチンカプセルを、第1表による組成物で充填する。それぞれ60個のカプセルを製造し、平均カプセル質量を測定する。
第1表による組成物を偏心プレス(EKO, Korsch)を用いて同じ圧縮圧力で圧縮し、約600mgの質量を有する錠剤を生じる。錠剤のを硬さをそれぞれ10錠ずつ半自動硬さ試験機により測定する。更に、37℃に昇温された水中での崩壊時間を6錠ずつ測定する(製造業者Erweka, 型ZT 31)。
Avicel PH101 198.0gおよびそれぞれAerosil(登録商標)R 972(Degussa; 突き固め密度約50g/l;比較例)およびAerosil(登録商標)R 972 V(Degussa; 突き固め密度90g/l;本発明による)およびAerosil(登録商標)R 972 W(Nippon Aerosil Corporation; 突き固め密度160g/l)を、1 lの広口瓶中で手で予め混合し、この混合物を目開き0.71mmの篩を通して篩別し、自由落下型ミキサー(Turbula)中で42rpmで10分間混合する。次に、混合物の流速および注入される円錐の高さを測定する。
正確に0.001gまで計量された物質約0.2gを250mlの洋ナシ形の分離漏斗中で水50mlと一緒に1分間強力に振盪させる。次に、この漏斗を1時間放置させる。この間、固体の過半量の部分は、浮遊する。懸濁液を再度振盪させることなく、僅かに曇っていてもよい液体45mlを、滴下形式で排出させ、140℃に乾燥された皿に移し、乾燥器中で冷却する。
Claims (5)
- 疎水性で高度に分散性の二酸化ケイ素を含有する医薬組成物および化粧品組成物において、二酸化ケイ素が70〜400g/lの突き固め密度を有することを特徴とする、医薬組成物および化粧品組成物。
- 疎水性で高度に分散性の二酸化ケイ素のBET表面積が50〜400m2/gである、請求項1記載の組成物。
- 疎水性で高度に分散性の二酸化ケイ素が0.01〜30質量%の程度で組成物中に存在する、請求項1または2記載の組成物。
- 疎水性で高度に分散性の二酸化ケイ素を含有する請求項1または2記載の組成物において、二酸化ケイ素が最大3.0質量%の水湿潤性含量を有することを特徴する、疎水性で高度に分散性の二酸化ケイ素を含有する請求項1または2記載の組成物。
- 疎水性で高度に分散性の二酸化ケイ素を含有する請求項1または2記載の組成物において、二酸化ケイ素がDIN 55943により測定された、70〜400g/lの突き固め密度を有し、最大3.0質量%の水湿潤性含量を有することを特徴する、疎水性で高度に分散性の二酸化ケイ素を含有する請求項1または2記載の組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10250711A DE10250711A1 (de) | 2002-10-31 | 2002-10-31 | Pharmazeutische und kosmetische Zubereitungen |
PCT/EP2003/011054 WO2004039349A1 (en) | 2002-10-31 | 2003-10-07 | Pharmaceutical and cosmetic formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2006506388A true JP2006506388A (ja) | 2006-02-23 |
Family
ID=32115006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004547507A Pending JP2006506388A (ja) | 2002-10-31 | 2003-10-07 | 医薬組成物および化粧品組成物 |
Country Status (10)
Country | Link |
---|---|
US (1) | US20060292192A1 (ja) |
EP (1) | EP1558212B1 (ja) |
JP (1) | JP2006506388A (ja) |
KR (1) | KR100755193B1 (ja) |
CN (1) | CN100488565C (ja) |
AT (1) | ATE476959T1 (ja) |
AU (1) | AU2003276059A1 (ja) |
DE (2) | DE10250711A1 (ja) |
ES (1) | ES2350742T3 (ja) |
WO (1) | WO2004039349A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009524714A (ja) * | 2006-01-25 | 2009-07-02 | エボニック デグサ ゲーエムベーハー | 二酸化ケイ素を含有するゴム混合物の製造方法 |
WO2009113522A1 (ja) | 2008-03-11 | 2009-09-17 | あすか製薬株式会社 | 固体分散体とその医薬組成物、並びにそれらの製造方法 |
JP2013514336A (ja) * | 2009-12-18 | 2013-04-25 | アンドティス、ファルマ | 合成オリゴサッカリドを含有する医薬経口剤形 |
US20210106531A1 (en) * | 2018-01-29 | 2021-04-15 | Pathelen Health Care Ag | Hydrophilic/hydrophobic pharmaceutical composition and method of its production and use |
Families Citing this family (57)
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US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
EP1175205B1 (en) | 1999-11-12 | 2006-06-14 | Abbott Laboratories | Solid dispersion comprising ritonavir, fenofibrate or griseofulvin |
DE10320196A1 (de) * | 2002-12-20 | 2004-07-08 | Henkel Kg Auf Aktien | Bleichmittelhaltige Wasch- oder Reinigungsmittel |
WO2004104154A2 (en) * | 2003-05-23 | 2004-12-02 | Degussa Ag | Pulverulent mixture comprising hydrogen peroxide and hydrophobized silicon dioxide |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
DE10351448A1 (de) * | 2003-11-04 | 2005-06-09 | Bayer Healthcare Ag | Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften |
JP2007512380A (ja) * | 2003-12-01 | 2007-05-17 | デグサ ゲーエムベーハー | 高い含水量を有する薄塗り可能な化粧用調製物 |
DE102004031785A1 (de) * | 2004-07-01 | 2006-01-26 | Degussa Ag | Polyol enthaltende Siliciumdioxid-Dispersion |
DE102004037044A1 (de) | 2004-07-29 | 2006-03-23 | Degussa Ag | Mittel zur Ausstattung von auf Cellulose und/oder Stärke basierenden Substraten mit Wasser abweisenden und gleichzeitig pilz-, bakterien-, insekten- sowie algenwidrigen Eigenschaften |
DE102004037045A1 (de) | 2004-07-29 | 2006-04-27 | Degussa Ag | Wässrige Silan-Nanokomposite |
ES2322175T3 (es) * | 2004-09-17 | 2009-06-17 | EISAI R&D MANAGEMENT CO., LTD. | Composicion medicinal con estabilidad mejorada y gelificacion reducida. |
DE102004049427A1 (de) | 2004-10-08 | 2006-04-13 | Degussa Ag | Polyetherfunktionelle Siloxane, polyethersiloxanhaltige Zusammensetzungen, Verfahren zu deren Herstellung und deren Verwendung |
US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
DE102004056862A1 (de) * | 2004-11-25 | 2006-06-14 | Degussa Ag | Pulverförmige, kosmetische Zubereitung mit hohem Wassergehalt |
DE102005055226A1 (de) * | 2004-12-24 | 2006-07-13 | Degussa Ag | Lagerung pulverförmiger Stoffe mit hohem Wassergehalt |
DE102005004872A1 (de) | 2005-02-03 | 2006-08-10 | Degussa Ag | Wässrige Emulsionen von funktionellen Alkoxysilanen und deren kondensierten Oligomeren, deren Herstellung und Verwendung zur Oberflächenbehandlung |
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PT2487163T (pt) | 2007-02-23 | 2016-11-21 | Gilead Sciences Inc | Moduladores de propriedades farmacocinéticas de agentes terapêuticos |
ES2725499T3 (es) | 2007-04-20 | 2019-09-24 | Evonik Degussa Gmbh | Mezcla que contiene un compuesto de organosilicio y su uso |
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DE102008007261A1 (de) | 2007-08-28 | 2009-03-05 | Evonik Degussa Gmbh | Wässrige Silansysteme basierend auf Bis(trialkoxysilyalkyl)aminen |
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BR112012032462A2 (pt) | 2010-06-25 | 2016-11-08 | Eisai R&D Man Co Ltd | agente antitumoral empregando compostos que, em combinação, têm efeito inibidor de quinase. |
US8962650B2 (en) | 2011-04-18 | 2015-02-24 | Eisai R&D Management Co., Ltd. | Therapeutic agent for tumor |
EP3444363B1 (en) | 2011-06-03 | 2020-11-25 | Eisai R&D Management Co., Ltd. | Biomarkers for prediciting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
US9549894B2 (en) * | 2012-06-21 | 2017-01-24 | L'oreal | Water-releasing cosmetic composition including a hydrophobic silica |
MX2015004979A (es) | 2012-12-21 | 2015-07-17 | Eisai R&D Man Co Ltd | Forma amorfa de derivado de quinolina y metodo para su produccion. |
ES2687968T3 (es) | 2013-05-14 | 2018-10-30 | Eisai R&D Management Co., Ltd. | Biomarcadores para pronosticar y evaluar la reactividad de sujetos con cáncer de endometrio a compuestos con lenvatinib |
BR112017002827B1 (pt) | 2014-08-28 | 2023-04-18 | Eisai R&D Management Co., Ltd | Derivado de quinolina altamente puro e método para produção do mesmo |
MX2017010474A (es) | 2015-02-25 | 2017-11-28 | Eisai R&D Man Co Ltd | Metodo para suprimir el amargor de un derivado de quinoleina. |
KR20240064733A (ko) | 2015-03-04 | 2024-05-13 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
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-
2002
- 2002-10-31 DE DE10250711A patent/DE10250711A1/de not_active Ceased
-
2003
- 2003-10-07 US US10/530,326 patent/US20060292192A1/en not_active Abandoned
- 2003-10-07 KR KR1020057007314A patent/KR100755193B1/ko not_active IP Right Cessation
- 2003-10-07 WO PCT/EP2003/011054 patent/WO2004039349A1/en active Application Filing
- 2003-10-07 JP JP2004547507A patent/JP2006506388A/ja active Pending
- 2003-10-07 CN CNB2003801024200A patent/CN100488565C/zh not_active Expired - Fee Related
- 2003-10-07 AT AT03809723T patent/ATE476959T1/de not_active IP Right Cessation
- 2003-10-07 ES ES03809723T patent/ES2350742T3/es not_active Expired - Lifetime
- 2003-10-07 AU AU2003276059A patent/AU2003276059A1/en not_active Abandoned
- 2003-10-07 EP EP03809723A patent/EP1558212B1/en not_active Expired - Lifetime
- 2003-10-07 DE DE60333776T patent/DE60333776D1/de not_active Expired - Lifetime
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009524714A (ja) * | 2006-01-25 | 2009-07-02 | エボニック デグサ ゲーエムベーハー | 二酸化ケイ素を含有するゴム混合物の製造方法 |
WO2009113522A1 (ja) | 2008-03-11 | 2009-09-17 | あすか製薬株式会社 | 固体分散体とその医薬組成物、並びにそれらの製造方法 |
US8722094B2 (en) | 2008-03-11 | 2014-05-13 | Aska Pharmaceutical Co., Ltd. | Solid dispersion and pharmaceutical composition of the same, and production processes thereof |
JP2013514336A (ja) * | 2009-12-18 | 2013-04-25 | アンドティス、ファルマ | 合成オリゴサッカリドを含有する医薬経口剤形 |
JP2016041735A (ja) * | 2009-12-18 | 2016-03-31 | アンドティス、ファルマEndotis Pharma | 合成オリゴサッカリドを含有する医薬経口剤形 |
US20210106531A1 (en) * | 2018-01-29 | 2021-04-15 | Pathelen Health Care Ag | Hydrophilic/hydrophobic pharmaceutical composition and method of its production and use |
Also Published As
Publication number | Publication date |
---|---|
DE10250711A1 (de) | 2004-05-19 |
ES2350742T3 (es) | 2011-01-26 |
KR100755193B1 (ko) | 2007-09-05 |
WO2004039349A1 (en) | 2004-05-13 |
WO2004039349A8 (en) | 2004-06-24 |
KR20050071632A (ko) | 2005-07-07 |
AU2003276059A8 (en) | 2004-05-25 |
DE60333776D1 (de) | 2010-09-23 |
CN100488565C (zh) | 2009-05-20 |
CN1708287A (zh) | 2005-12-14 |
US20060292192A1 (en) | 2006-12-28 |
AU2003276059A1 (en) | 2004-05-25 |
EP1558212B1 (en) | 2010-08-11 |
EP1558212A1 (en) | 2005-08-03 |
ATE476959T1 (de) | 2010-08-15 |
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