JP2006506332A5 - - Google Patents
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- Publication number
- JP2006506332A5 JP2006506332A5 JP2004520457A JP2004520457A JP2006506332A5 JP 2006506332 A5 JP2006506332 A5 JP 2006506332A5 JP 2004520457 A JP2004520457 A JP 2004520457A JP 2004520457 A JP2004520457 A JP 2004520457A JP 2006506332 A5 JP2006506332 A5 JP 2006506332A5
- Authority
- JP
- Japan
- Prior art keywords
- inclusion bodies
- inclusion
- interleukin
- expression product
- lipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000003000 inclusion body Anatomy 0.000 claims 6
- 102000004388 Interleukin-4 Human genes 0.000 claims 2
- 108090000978 Interleukin-4 Proteins 0.000 claims 2
- 229940028885 interleukin-4 Drugs 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 102000008300 Mutant Proteins Human genes 0.000 claims 1
- 108010021466 Mutant Proteins Proteins 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000002421 cell wall Anatomy 0.000 claims 1
- 230000036425 denaturation Effects 0.000 claims 1
- 238000004925 denaturation Methods 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000003259 recombinant expression Methods 0.000 claims 1
- 230000003381 solubilizing effect Effects 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02015589A EP1382614A1 (en) | 2002-07-15 | 2002-07-15 | Process for the purification of interleukin-4 and its muteins |
| PCT/EP2003/007022 WO2004007549A1 (en) | 2002-07-15 | 2003-07-02 | Process for the purification of interleukin-4 and its muteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010288204A Division JP2011088922A (ja) | 2002-07-15 | 2010-12-24 | インターロイキン−４およびその突然変異蛋白質の精製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006506332A JP2006506332A (ja) | 2006-02-23 |
| JP2006506332A5 true JP2006506332A5 (https=) | 2006-07-06 |
Family
ID=29762614
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004520457A Pending JP2006506332A (ja) | 2002-07-15 | 2003-07-02 | インターロイキン−４およびその突然変異蛋白質の精製法 |
| JP2010288204A Pending JP2011088922A (ja) | 2002-07-15 | 2010-12-24 | インターロイキン−４およびその突然変異蛋白質の精製法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010288204A Pending JP2011088922A (ja) | 2002-07-15 | 2010-12-24 | インターロイキン−４およびその突然変異蛋白質の精製法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20060134690A1 (https=) |
| EP (2) | EP1382614A1 (https=) |
| JP (2) | JP2006506332A (https=) |
| AT (1) | ATE352566T1 (https=) |
| AU (1) | AU2003244635A1 (https=) |
| DE (1) | DE60311470T2 (https=) |
| ES (1) | ES2280764T3 (https=) |
| WO (1) | WO2004007549A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1382614A1 (en) * | 2002-07-15 | 2004-01-21 | Bayer HealthCare AG | Process for the purification of interleukin-4 and its muteins |
| US8189621B2 (en) | 2006-05-12 | 2012-05-29 | Microsoft Corporation | Stack signaling to application with lack of requested bandwidth |
| US8144793B2 (en) | 2006-12-12 | 2012-03-27 | Microsoft Corporation | Cognitive multi-user OFDMA |
| US8241697B2 (en) | 2007-12-20 | 2012-08-14 | Abbott Point Of Care Inc. | Formation of immobilized biological layers for sensing |
| US8268604B2 (en) * | 2007-12-20 | 2012-09-18 | Abbott Point Of Care Inc. | Compositions for forming immobilized biological layers for sensing |
| KR101113495B1 (ko) | 2008-01-23 | 2012-02-29 | 한미홀딩스 주식회사 | 인간 인터페론 베타의 정제방법 |
| WO2010105227A1 (en) * | 2009-03-13 | 2010-09-16 | Aerovance, Inc. | Methods of renaturation of recombinant proteins |
| WO2010128141A1 (en) * | 2009-05-07 | 2010-11-11 | Novo Nordisk Health Care Ag | Stable pharmaceutical compositions of peptide derivatized using an oxime linker |
| EP2611419A2 (en) * | 2010-08-30 | 2013-07-10 | F.Hoffmann-La Roche Ag | Method for producing a tetranectin-apolipoprotein a-1 lipid particle, the lipid particle itself and its use |
| CN103068369A (zh) * | 2010-08-30 | 2013-04-24 | 霍夫曼-拉罗奇有限公司 | 产生四连蛋白-载脂蛋白a-i颗粒的方法，由此获得的脂质颗粒及其应用 |
| CN103320447A (zh) * | 2013-05-20 | 2013-09-25 | 深圳市亚太兴实业有限公司 | 重组人白介素4基因、含重组人白介素4基因的工程菌发酵方法 |
| CN108753753B (zh) * | 2018-05-28 | 2022-04-22 | 中国林业科学研究院林业研究所 | Lrr受体激酶-pxy的纯化方法 |
| CN114599665A (zh) | 2019-08-16 | 2022-06-07 | 应用分子转运公司 | 组合物、制剂及白细胞介素产生和纯化 |
| CN116874552B (zh) * | 2023-09-08 | 2023-12-08 | 成都华任康生物科技有限公司 | 一种目标蛋白的纯化方法及其试剂盒和相关应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4137333A1 (de) * | 1991-11-13 | 1993-05-19 | W Prof Dr Sebald | Therapeutische mittel, die antagonisten oder partielle agonisten des humanen interleukin 4 sind oder diese enthalten, hil-4-mutantenproteine sowie vefahren zu deren herstellung |
| CA2155335C (en) * | 1993-02-04 | 2001-06-05 | HANS CHRISTIAN THõGERSEN | Improved method for the refolding of proteins |
| US5563057A (en) * | 1994-10-31 | 1996-10-08 | Wisconsin Alumni Research Foundation | Method for refolding misfolded enzymes with detergent and cyclodextrin |
| JP3344618B2 (ja) * | 1997-06-20 | 2002-11-11 | 株式会社エイチ・エス・ピー研究所 | シャペロン発現プラスミド |
| US5932102A (en) * | 1998-01-12 | 1999-08-03 | Schering Corporation | Immobilized metal, affinity chromatography |
| EP1382614A1 (en) * | 2002-07-15 | 2004-01-21 | Bayer HealthCare AG | Process for the purification of interleukin-4 and its muteins |
-
2002
- 2002-07-15 EP EP02015589A patent/EP1382614A1/en not_active Withdrawn
-
2003
- 2003-07-02 DE DE60311470T patent/DE60311470T2/de not_active Expired - Lifetime
- 2003-07-02 AT AT03738109T patent/ATE352566T1/de not_active IP Right Cessation
- 2003-07-02 US US10/520,883 patent/US20060134690A1/en not_active Abandoned
- 2003-07-02 WO PCT/EP2003/007022 patent/WO2004007549A1/en not_active Ceased
- 2003-07-02 EP EP03738109A patent/EP1523500B1/en not_active Expired - Lifetime
- 2003-07-02 JP JP2004520457A patent/JP2006506332A/ja active Pending
- 2003-07-02 AU AU2003244635A patent/AU2003244635A1/en not_active Abandoned
- 2003-07-02 ES ES03738109T patent/ES2280764T3/es not_active Expired - Lifetime
-
2010
- 2010-11-12 US US12/945,829 patent/US20110060128A1/en not_active Abandoned
- 2010-12-24 JP JP2010288204A patent/JP2011088922A/ja active Pending
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