JP2003502282A5 - - Google Patents
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- Publication number
- JP2003502282A5 JP2003502282A5 JP2000609450A JP2000609450A JP2003502282A5 JP 2003502282 A5 JP2003502282 A5 JP 2003502282A5 JP 2000609450 A JP2000609450 A JP 2000609450A JP 2000609450 A JP2000609450 A JP 2000609450A JP 2003502282 A5 JP2003502282 A5 JP 2003502282A5
- Authority
- JP
- Japan
- Prior art keywords
- thymic stromal
- stromal cell
- polypeptide
- cells
- isolate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002992 thymic effect Effects 0.000 description 13
- 210000002536 stromal cell Anatomy 0.000 description 12
- 229920001184 polypeptide Polymers 0.000 description 8
- 108090000765 processed proteins & peptides Proteins 0.000 description 8
- 102000004196 processed proteins & peptides Human genes 0.000 description 8
- 210000002865 immune cell Anatomy 0.000 description 5
- 230000002940 repellent Effects 0.000 description 3
- 239000005871 repellent Substances 0.000 description 3
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 description 2
- 101710082513 C-X-C chemokine receptor type 4 Proteins 0.000 description 2
- 102000006573 Chemokine CXCL12 Human genes 0.000 description 2
- 108010008951 Chemokine CXCL12 Proteins 0.000 description 2
- 108091006027 G proteins Proteins 0.000 description 2
- 102000030782 GTP binding Human genes 0.000 description 2
- 108091000058 GTP-Binding Proteins 0.000 description 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229940045109 genistein Drugs 0.000 description 2
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 description 2
- 235000006539 genistein Nutrition 0.000 description 2
- ZCOLJUOHXJRHDI-CMWLGVBASA-N genistein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- QDLHCMPXEPAAMD-QAIWCSMKSA-N wortmannin Chemical group C1([C@]2(C)C3=C(C4=O)OC=C3C(=O)O[C@@H]2COC)=C4[C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O QDLHCMPXEPAAMD-QAIWCSMKSA-N 0.000 description 2
- QDLHCMPXEPAAMD-UHFFFAOYSA-N wortmannin Natural products COCC1OC(=O)C2=COC(C3=O)=C2C1(C)C1=C3C2CCC(=O)C2(C)CC1OC(C)=O QDLHCMPXEPAAMD-UHFFFAOYSA-N 0.000 description 2
- 101100289894 Caenorhabditis elegans lys-7 gene Proteins 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 108010045306 T134 peptide Proteins 0.000 description 1
- 230000003609 chemorepellent Effects 0.000 description 1
- 239000002838 chemorepellent Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12827299P | 1999-04-08 | 1999-04-08 | |
| US60/128,272 | 1999-04-08 | ||
| US16895299P | 1999-12-03 | 1999-12-03 | |
| US60/168,952 | 1999-12-03 | ||
| PCT/US2000/009678 WO2000059941A1 (en) | 1999-04-08 | 2000-04-07 | Purposeful movement of human migratory cells away from an agent source |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003502282A JP2003502282A (ja) | 2003-01-21 |
| JP2003502282A5 true JP2003502282A5 (https=) | 2007-06-21 |
Family
ID=26826444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000609450A Pending JP2003502282A (ja) | 1999-04-08 | 2000-04-07 | ヒト転移性細胞の作用因子源から離れた意図された移動 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US6448054B1 (https=) |
| EP (1) | EP1169348B1 (https=) |
| JP (1) | JP2003502282A (https=) |
| AU (1) | AU4230900A (https=) |
| CA (1) | CA2367173A1 (https=) |
| WO (1) | WO2000059941A1 (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6746482B2 (en) * | 1994-10-17 | 2004-06-08 | Baxter International Inc. | Method for producing medical devices and devices so produced |
| US6448054B1 (en) | 1999-04-08 | 2002-09-10 | The General Hospital Corporation | Purposeful movement of human migratory cells away from an agent source |
| US20020151515A1 (en) * | 1999-06-18 | 2002-10-17 | Roberts Bruce L. | Preparation and use of superior vaccines |
| ATE285821T1 (de) * | 1999-10-08 | 2005-01-15 | Affinium Pharm Inc | Fab i inhibitoren |
| WO2002036070A2 (en) * | 2000-10-30 | 2002-05-10 | Wayne State University | Novel fish chemokine and methods for use |
| US6709655B2 (en) | 2001-02-28 | 2004-03-23 | Instituto Bioclon, S.A. De C.V. | Pharmaceutical composition of F(ab1)2 antibody fragments and a process for the preparation thereof |
| CA2444597A1 (en) * | 2001-04-06 | 2002-10-06 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
| JP4233092B2 (ja) * | 2001-06-07 | 2009-03-04 | ケモセントリックス， インコーポレイテッド | 細胞移動アッセイ |
| US7468253B2 (en) * | 2001-06-07 | 2008-12-23 | Chemocentryx, Inc. | Method for multiple chemokine receptor screening for antagonists using RAM assay |
| DE10133870A1 (de) * | 2001-07-12 | 2003-02-06 | Chris P Lohmann | Ophthalmisches Mittel, Verwendung von EGF zur Behandlung von Dry Eye-Syndrom und Insert zur Verabreichung von EGF am Auge |
| US20030065382A1 (en) * | 2001-10-02 | 2003-04-03 | Fischell Robert E. | Means and method for the treatment of coronary artery obstructions |
| US20030100009A1 (en) * | 2001-11-23 | 2003-05-29 | George Jackowski | Inter alpha trypsin inhibitor biopolymer markers indicative of insulin resistance |
| US7871619B2 (en) * | 2001-11-30 | 2011-01-18 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
| US7253007B2 (en) * | 2001-11-30 | 2007-08-07 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
| US7442512B2 (en) * | 2001-11-30 | 2008-10-28 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
| US7413866B2 (en) * | 2001-11-30 | 2008-08-19 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
| US20030194421A1 (en) * | 2001-12-28 | 2003-10-16 | Angiotech Pharmaceuticals, Inc. | Treatment of uveitis |
| US20050271639A1 (en) * | 2002-08-22 | 2005-12-08 | Penn Marc S | Genetically engineered cells for therapeutic applications |
| US7335759B2 (en) * | 2002-12-02 | 2008-02-26 | Universidad Nacional Autónoma de Méxica (UNAM) | Recombinant immunogens for the generation of antivenoms to the venom of scorpions of the genus Centruroides |
| CA2509193A1 (en) * | 2002-12-06 | 2004-06-24 | The General Hospital Corporation | Methods and compositions relating to gradient exposed cells |
| EP1575951B1 (en) | 2002-12-06 | 2014-06-25 | Debiopharm International SA | Heterocyclic compounds, methods of making them and their use in therapy |
| ATE427933T1 (de) * | 2002-12-20 | 2009-04-15 | Chemocentryx Inc | Inhibitoren der bindungder chemokine i-tac bzw. sdf-1 an den ccxckr2-rezeptor |
| JP2006517227A (ja) * | 2003-01-30 | 2006-07-20 | ザ・ジェネラル・ホスピタル・コーポレイション | 免疫細胞活性を調節する組成物およびその検出方法 |
| DE602004016831D1 (de) * | 2003-03-17 | 2008-11-13 | Affinium Pharm Inc | Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend |
| US20060210563A1 (en) * | 2003-07-25 | 2006-09-21 | Juan Lopez De Silanes | Administration of anti-cytokine f(ab')2 antibody fragments |
| US20060025335A1 (en) * | 2004-01-30 | 2006-02-02 | Kinane Thomas B | Netrin compositions and methods of using the same |
| EP2848614A3 (en) | 2004-06-04 | 2015-07-29 | Debiopharm International SA | Acrylamide derivatives as antibiotic agents |
| JP2008506703A (ja) | 2004-07-14 | 2008-03-06 | ユニバーシティ オブ ユタ リサーチ ファウンデーション | ネトリン関連化合物および用途 |
| US7351423B2 (en) | 2004-09-01 | 2008-04-01 | Depuy Spine, Inc. | Musculo-skeletal implant having a bioactive gradient |
| US9789171B2 (en) | 2004-11-05 | 2017-10-17 | The General Hospital Corporation | Anti-fugetactic agents for the treatment of ovarian cancer |
| US7381802B2 (en) * | 2005-04-15 | 2008-06-03 | Universidad Nacional Autónoma De México (UNAM) | Human antibodies that specifically recognize the toxin Cn2 from Centruroides noxius scorpion venom |
| WO2006116319A2 (en) * | 2005-04-21 | 2006-11-02 | Chemocentryx, Inc. | Reagents that bind ccx-ckr2 |
| EP1973902A2 (en) * | 2005-12-05 | 2008-10-01 | Affinium Pharmaceuticals, Inc. | 3-heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents |
| EP2687533B1 (en) | 2006-07-20 | 2017-07-19 | Debiopharm International SA | Acrylamide derivatives as FAB I inhibitors |
| WO2008127355A2 (en) * | 2006-10-06 | 2008-10-23 | Celtaxsys, Inc. | Chemorepulsion of cells |
| WO2008098374A1 (en) | 2007-02-16 | 2008-08-21 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab i inhibitors |
| JP2010523496A (ja) | 2007-03-30 | 2010-07-15 | ザ クリーブランド クリニック ファウンデーション | 虚血障害の治療方法 |
| KR101589442B1 (ko) * | 2007-08-06 | 2016-02-01 | 녹손 파르마 아게 | 에스디에프-1 결합형 핵산 및 이의 용도 |
| WO2009079451A2 (en) | 2007-12-14 | 2009-06-25 | The Cleveland Clinic Foundation | Compositions and methods of promoting wound healing |
| WO2010040029A1 (en) * | 2008-10-02 | 2010-04-08 | Celtaxsys, Inc. | Methods of modulating the negative chemotaxis of immune cells |
| US8377914B2 (en) * | 2008-10-10 | 2013-02-19 | Celtaxsys, Inc. | Method of inducing negative chemotaxis |
| CA2772610C (en) | 2009-08-28 | 2018-01-23 | The Cleveland Clinic Foundation | Sdf-1 delivery for treating ischemic tissue |
| US11273250B2 (en) | 2010-08-04 | 2022-03-15 | Georgia Tech Research Corporation | Devices, systems, and methods for excavating cancer cells |
| SI2861608T1 (sl) | 2012-06-19 | 2019-08-30 | Debiopharm International Sa | Derivati predzdravila (E)-N-metil-N-((3-metilbenzofuran-2-IL)metil)- 3-(7-okso-5,6,7,8-tetrahidro-1 ,8-nafthiridin-3-il)akrilamid |
| PL2978839T3 (pl) * | 2013-03-28 | 2019-11-29 | Ge Healthcare Bio Sciences Ab | Sposób hodowli komórek |
| US9775816B2 (en) | 2013-11-07 | 2017-10-03 | The General Hospital Corporation | Eluting matrix and uses thereof |
| EP3288638A1 (en) | 2015-04-25 | 2018-03-07 | The General Hospital Corporation | Anti-fugetactic agent and anti-cancer agent combination therapy and compositions for the treatment of cancer |
| US11890348B2 (en) | 2015-09-18 | 2024-02-06 | The General Hospital Corporation | Localized delivery of anti-fugetactic agent for treatment of cancer |
| WO2017049237A1 (en) * | 2015-09-18 | 2017-03-23 | The General Hospital Corporation Dba Massachusetts General Hospital | Personalized approach to dosage of anti-fugetactic agent for treatment of cancer |
| BR122023021456A2 (pt) | 2016-02-26 | 2024-02-20 | Debiopharm International S.A. | Uso de di-hidrogeno fosfato de {6- [(e)-3-{metil[(3-metil-1-benfofuran-2- iol)metil]amino)-3- oxopro-1-en-1-il]-2-oxo-3,4-di-hidro-1,8-naftiridin-1(2h)- il}metila para tratamento de osteomielite do pé diabético e composição farmacêutica |
| US11453706B2 (en) | 2016-09-09 | 2022-09-27 | The General Hospital Corporation | HSP fusion protein with anti-chemorepellant agent for treatment of infectious disease |
| WO2018049118A1 (en) | 2016-09-09 | 2018-03-15 | The General Hospital Corporation | Hsp fusion protein with anti-chemorepellant agent for treatment of cancer |
| US11364264B2 (en) | 2016-09-09 | 2022-06-21 | The General Hospital Corporation | Ex vivo antigen-presenting cells or activated CD-positive T cells for treatment of cancer |
| WO2018102685A1 (en) * | 2016-12-02 | 2018-06-07 | The General Hospital Corporation | Compositions and methods for reducing transplant rejection |
| EP3692139B1 (en) | 2017-10-03 | 2024-11-06 | SDF BioPharma Inc. | Treating diabetes with genetically modified beta cells |
| US10493233B1 (en) | 2018-06-05 | 2019-12-03 | Duke University | Bi-directional access to tumors |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| LT3923914T (lt) | 2019-02-14 | 2023-07-25 | Debiopharm International S.A. | Afabicino kompozicija, jos gamybos būdas |
| CN113939306B (zh) | 2019-06-14 | 2024-07-19 | 德彪药业国际股份公司 | 用于治疗涉及生物膜的细菌感染的药物及其用途 |
| WO2022130884A1 (ja) * | 2020-12-18 | 2022-06-23 | ソニーグループ株式会社 | 測定装置、測定方法、測定システム |
| CN115323062B (zh) * | 2022-08-19 | 2024-08-16 | 沈阳大学 | 一种预示和鉴定大骨鸡股骨长性状的分子标记方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2557452B1 (fr) | 1983-12-28 | 1986-08-14 | Roussel Uclaf | Nouvelles compositions pour les soins de la peau renfermant de l'huile d'onagre et des traits tissulaires de rate |
| CA1282727C (en) * | 1985-07-11 | 1991-04-09 | Michael R. Buchanan | Chemorepellant compound |
| US5510418A (en) * | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
| US5739107A (en) * | 1991-03-11 | 1998-04-14 | Creative Biomolecules, Inc. | Morphogen treatment of gastrointestinal ulcers |
| US20020032313A1 (en) * | 1991-03-29 | 2002-03-14 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
| US5573934A (en) * | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
| US5514555A (en) | 1993-03-12 | 1996-05-07 | Center For Blood Research, Inc. | Assays and therapeutic methods based on lymphocyte chemoattractants |
| FR2706771A1 (en) | 1993-06-21 | 1994-12-30 | Pelletier Jacques | Formula for the treatment of certain cancers. |
| CA2171761C (en) * | 1993-09-14 | 2011-11-15 | Timothy John Williams | Eotaxin: eosinophil chemotactic cytokine |
| JP3367581B2 (ja) | 1993-10-14 | 2003-01-14 | 小野薬品工業株式会社 | 新規なポリペプチド、その製造方法、そのポリペプチドをコードするｄｎａ、そのｄｎａからなるベクター、そのベクターで形質転換された宿主細胞 |
| US5621671A (en) * | 1995-03-17 | 1997-04-15 | The United States Of America As Represented By The Secretary Of The Navy | Digital simulation of organismal growth |
| US5624957A (en) * | 1995-06-06 | 1997-04-29 | Bristol-Myers Squibb Company | Rary-specific retinobenzoic acid derivatives |
| WO1998009642A2 (en) * | 1996-09-06 | 1998-03-12 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Therapeutic chemokine antagonists |
| US5919776A (en) * | 1996-12-20 | 1999-07-06 | Merck & Co., Inc. | Substituted aminoquinolines as modulators of chemokine receptor activity |
| ATE279461T1 (de) * | 1997-04-03 | 2004-10-15 | Guilford Pharm Inc | Bioabbaubare terephthalat polyester-polyphosphat polymere, zusammensetzungen, gegenstände und verfahren für ihre herstellung und verwendung |
| US5994298A (en) * | 1997-12-18 | 1999-11-30 | Tsai; David | Proteins for cancer cell specific induction of apoptosis and method for isolation thereof |
| EP1101106A4 (en) * | 1998-07-28 | 2006-05-03 | Bd Biosciences Systems And Rea | ARRANGEMENT AND METHOD FOR THE TEST FOR CELL MOBILITY |
| US6262228B1 (en) | 1998-08-17 | 2001-07-17 | Tularik Inc. | IRAK3 polypeptides and methods |
| US6448054B1 (en) * | 1999-04-08 | 2002-09-10 | The General Hospital Corporation | Purposeful movement of human migratory cells away from an agent source |
| US20020131953A1 (en) * | 2001-03-14 | 2002-09-19 | Ut Southwestern Medical Center | In situ langerhans cell vaccine |
-
2000
- 2000-04-07 US US09/546,153 patent/US6448054B1/en not_active Expired - Lifetime
- 2000-04-07 JP JP2000609450A patent/JP2003502282A/ja active Pending
- 2000-04-07 EP EP00922067.4A patent/EP1169348B1/en not_active Expired - Lifetime
- 2000-04-07 AU AU42309/00A patent/AU4230900A/en not_active Abandoned
- 2000-04-07 CA CA002367173A patent/CA2367173A1/en not_active Abandoned
- 2000-04-07 WO PCT/US2000/009678 patent/WO2000059941A1/en not_active Ceased
-
2002
- 2002-07-09 US US10/191,988 patent/US7141363B2/en not_active Expired - Lifetime
-
2006
- 2006-04-20 US US11/407,477 patent/US7775469B2/en not_active Expired - Lifetime
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