JP2006505545A5 - - Google Patents
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- JP2006505545A5 JP2006505545A5 JP2004542465A JP2004542465A JP2006505545A5 JP 2006505545 A5 JP2006505545 A5 JP 2006505545A5 JP 2004542465 A JP2004542465 A JP 2004542465A JP 2004542465 A JP2004542465 A JP 2004542465A JP 2006505545 A5 JP2006505545 A5 JP 2006505545A5
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- JP
- Japan
- Prior art keywords
- immune
- fragments
- iii
- mab425
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000012634 fragment Substances 0.000 description 8
- 108090000695 Cytokines Proteins 0.000 description 7
- 102000004127 Cytokines Human genes 0.000 description 7
- 108060006698 EGF receptor Proteins 0.000 description 3
- 102000001301 EGF receptor Human genes 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 2
- AMLYAMJWYAIXIA-VWNVYAMZSA-N cilengitide Chemical compound N1C(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CC1=CC=CC=C1 AMLYAMJWYAIXIA-VWNVYAMZSA-N 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical class NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 description 1
- 102000005685 Cyclic AMP-Dependent Protein Kinase Type I Human genes 0.000 description 1
- 108010084920 Cyclic AMP-Dependent Protein Kinase Type I Proteins 0.000 description 1
- 102000001189 Cyclic Peptides Human genes 0.000 description 1
- 108010069514 Cyclic Peptides Proteins 0.000 description 1
- 229940091518 ErbB antagonist Drugs 0.000 description 1
- BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 description 1
- 108010069236 Goserelin Proteins 0.000 description 1
- 102100026720 Interferon beta Human genes 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010047761 Interferon-alpha Proteins 0.000 description 1
- 102000006992 Interferon-alpha Human genes 0.000 description 1
- 108090000467 Interferon-beta Proteins 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 102000000588 Interleukin-2 Human genes 0.000 description 1
- 239000005411 L01XE02 - Gefitinib Substances 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 description 1
- 101710100963 Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
- 239000004037 angiogenesis inhibitor Substances 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 239000013059 antihormonal agent Substances 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000000074 antisense oligonucleotide Substances 0.000 description 1
- 238000012230 antisense oligonucleotides Methods 0.000 description 1
- 108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229950009003 cilengitide Drugs 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 description 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 1
- 229960005277 gemcitabine Drugs 0.000 description 1
- 229960002913 goserelin Drugs 0.000 description 1
- 229940022353 herceptin Drugs 0.000 description 1
- 229940127121 immunoconjugate Drugs 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 229940084651 iressa Drugs 0.000 description 1
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 229960001603 tamoxifen Drugs 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 description 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02022389 | 2002-10-10 | ||
| EP02022389.7 | 2002-10-10 | ||
| EP02022390.5 | 2002-10-10 | ||
| EP02022390 | 2002-10-10 | ||
| PCT/EP2003/011164 WO2004032960A1 (en) | 2002-10-10 | 2003-10-09 | Pharmaceutical compositions directed to erb-b1 receptors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010211122A Division JP2010280727A (ja) | 2002-10-10 | 2010-09-21 | 受容体Ｅｒｂ−Ｂ１に対する医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006505545A JP2006505545A (ja) | 2006-02-16 |
| JP2006505545A5 true JP2006505545A5 (cg-RX-API-DMAC7.html) | 2006-11-24 |
| JP5179702B2 JP5179702B2 (ja) | 2013-04-10 |
Family
ID=32095025
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004542466A Pending JP2006505546A (ja) | 2002-10-10 | 2003-10-09 | 二重特異性抗ＥｒｂＢ抗体および腫瘍治療でのその使用 |
| JP2004542465A Expired - Fee Related JP5179702B2 (ja) | 2002-10-10 | 2003-10-09 | 受容体Ｅｒｂ−Ｂ１に対する医薬組成物 |
| JP2010211122A Pending JP2010280727A (ja) | 2002-10-10 | 2010-09-21 | 受容体Ｅｒｂ−Ｂ１に対する医薬組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004542466A Pending JP2006505546A (ja) | 2002-10-10 | 2003-10-09 | 二重特異性抗ＥｒｂＢ抗体および腫瘍治療でのその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010211122A Pending JP2010280727A (ja) | 2002-10-10 | 2010-09-21 | 受容体Ｅｒｂ−Ｂ１に対する医薬組成物 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7226592B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP1549344B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP2006505546A (cg-RX-API-DMAC7.html) |
| KR (2) | KR101088661B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1703243B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2003276084B2 (cg-RX-API-DMAC7.html) |
| BR (2) | BR0315123A (cg-RX-API-DMAC7.html) |
| CA (2) | CA2501818C (cg-RX-API-DMAC7.html) |
| CY (1) | CY1116167T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1549344T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2533963T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE025086T2 (cg-RX-API-DMAC7.html) |
| MX (2) | MXPA05003796A (cg-RX-API-DMAC7.html) |
| PL (2) | PL374586A1 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1549344E (cg-RX-API-DMAC7.html) |
| RU (2) | RU2349340C2 (cg-RX-API-DMAC7.html) |
| SI (1) | SI1549344T1 (cg-RX-API-DMAC7.html) |
| WO (2) | WO2004032961A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
| US20030224001A1 (en) * | 1998-03-19 | 2003-12-04 | Goldstein Neil I. | Antibody and antibody fragments for inhibiting the growth of tumors |
| ZA200007412B (en) * | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
| EE200100603A (et) * | 1999-05-14 | 2003-02-17 | Imclone Systems Incorporated | Inimese refraktaarsete kasvajate ravi epidermaalse kasvufaktori retseptori antagonistidega |
| AU2001295002B2 (en) * | 2000-08-09 | 2007-05-31 | Imclone Systems Incorporated | Treatment of hyperproliferative diseases with epidermal growth factor receptor antagonists |
| CA2436326C (en) * | 2001-01-09 | 2012-08-14 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Combination therapy using receptor tyrosine kinase inhibitors and angiogenesis inhibitors |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20080008704A1 (en) * | 2001-03-16 | 2008-01-10 | Mark Rubin | Methods of treating colorectal cancer with anti-epidermal growth factor antibodies |
| DK1392359T4 (da) | 2001-05-11 | 2013-06-10 | Ludwig Inst For Cancer Res Ltd | Specifikke bindingsproteiner og deres anvendelser. |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| US7332585B2 (en) * | 2002-04-05 | 2008-02-19 | The Regents Of The California University | Bispecific single chain Fv antibody molecules and methods of use thereof |
| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US7696320B2 (en) * | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| JP2006505546A (ja) * | 2002-10-10 | 2006-02-16 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 二重特異性抗ＥｒｂＢ抗体および腫瘍治療でのその使用 |
| US8505468B2 (en) * | 2002-11-19 | 2013-08-13 | Sharp Kabushiki Kaisha | Substrate accommodating tray |
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| ES2387809T3 (es) * | 2004-03-19 | 2012-10-02 | Imclone Llc | Anticuerpo frente al receptor del factor de crecimiento epidérmico humano |
| US8921528B2 (en) | 2004-06-01 | 2014-12-30 | Domantis Limited | Bispecific fusion antibodies with enhanced serum half-life |
| AU2006272555B2 (en) | 2005-07-25 | 2012-03-08 | Aptevo Research And Development Llc | B-cell reduction using CD37-specific and CD20-specific binding molecules |
| US20100021473A1 (en) * | 2005-12-06 | 2010-01-28 | Domantis Limited | Bispecific Ligands With Binding Specificity to Cell Surface Targets and Methods of Use Therefor |
| WO2007076923A1 (en) * | 2006-01-04 | 2007-07-12 | Merck Patent Gmbh | Combination therapy using anti-egfr and anti-her2 antibodies |
| US20110165150A1 (en) * | 2006-01-18 | 2011-07-07 | Merck Patent Gmbh | Isolated organ perfusion combination therapy of cancer |
| US7498142B2 (en) * | 2006-01-31 | 2009-03-03 | Yeda Research And Development Co., Ltd. | Methods of identifying combinations of antibodies with an improved anti-tumor activity and compositions and methods using the antibodies |
| EP2010911A4 (en) | 2006-03-31 | 2009-05-13 | Massachusetts Inst Technology | TREATMENT OF EGF RECEPTOR MUTANTS EXPRESSING TUMORS |
| US20080045589A1 (en) * | 2006-05-26 | 2008-02-21 | Susan Kelley | Drug Combinations with Substituted Diaryl Ureas for the Treatment of Cancer |
| CN105837690A (zh) | 2006-06-12 | 2016-08-10 | 新兴产品开发西雅图有限公司 | 具有效应功能的单链多价结合蛋白 |
| AU2007353412A1 (en) | 2006-11-21 | 2008-11-20 | Fox Chase Cancer Center | Anti-EGFR family antibodies, bispecific anti-EGFR family antibodies and methods of use thereof |
| US9090693B2 (en) | 2007-01-25 | 2015-07-28 | Dana-Farber Cancer Institute | Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease |
| BRPI0808551B1 (pt) | 2007-03-01 | 2022-04-05 | Symphogen A/S | Composições de anticorpo para o receptor do fator de crescimento antiepidérmico recombinante, molécula de ligação bi-específica e composição farmacêutica que os compreende |
| AU2013200209B9 (en) * | 2007-03-01 | 2015-07-09 | Symphogen A/S | Recombinant anti-epidermal growth factor receptor antibody compositions |
| JP5618549B2 (ja) | 2007-03-15 | 2014-11-05 | ルードヴィッヒ インスティテュート フォー キャンサーリサーチ リミテッド | Ｅｇｆｒ抗体及びｓｒｃ阻害剤を用いる治療方法及び関連製剤 |
| JP5532486B2 (ja) | 2007-08-14 | 2014-06-25 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | Ｅｇｆ受容体を標的とするモノクローナル抗体１７５ならびにその誘導体および用途 |
| WO2009030239A1 (en) * | 2007-09-06 | 2009-03-12 | Genmab A/S | Novel methods and antibodies for treating cancer |
| EP2193149A1 (en) * | 2007-10-02 | 2010-06-09 | Merck Patent GmbH | Crystalline egfr - matuzumab complex and matuzumab mimetics obtained thereof |
| WO2009070753A2 (en) * | 2007-11-28 | 2009-06-04 | The Scripps Research Institute | Bivalent single chain fv antibody compositions that specifically bind to integrin receptor on a metastatic cell in a mammalian subject |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US8574577B2 (en) | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| US8557242B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
| EA021967B1 (ru) | 2008-01-03 | 2015-10-30 | Дзе Скриппс Рисерч Инститьют | Доставка антител посредством модульного домена распознавания |
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| DK2714738T3 (en) | 2011-05-24 | 2019-01-28 | Zyngenia Inc | MULTIVALENT AND MONOVALENT MULTISPECIFIC COMPLEXES AND THEIR APPLICATIONS |
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| WO2014064682A1 (en) * | 2012-10-24 | 2014-05-01 | Yeda Research And Development Co. Ltd. | Combinations of epidermal growth factor receptor targeting antibodies for treating cancer |
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| US5705157A (en) * | 1989-07-27 | 1998-01-06 | The Trustees Of The University Of Pennsylvania | Methods of treating cancerous cells with anti-receptor antibodies |
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2003
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- 2003-10-09 WO PCT/EP2003/011165 patent/WO2004032961A1/en not_active Ceased
- 2003-10-09 RU RU2005114482A patent/RU2349340C2/ru active
- 2003-10-09 CA CA2501818A patent/CA2501818C/en not_active Expired - Fee Related
- 2003-10-09 RU RU2005114480A patent/RU2354402C2/ru active
- 2003-10-09 AU AU2003276084A patent/AU2003276084B2/en not_active Ceased
- 2003-10-09 HU HUE03757931A patent/HUE025086T2/en unknown
- 2003-10-09 KR KR1020057006262A patent/KR101088661B1/ko not_active Expired - Fee Related
- 2003-10-09 PL PL37458603A patent/PL374586A1/xx not_active Application Discontinuation
- 2003-10-09 PL PL374587A patent/PL210545B1/pl unknown
- 2003-10-09 DK DK03757931.5T patent/DK1549344T3/en active
- 2003-10-09 ES ES03757931.5T patent/ES2533963T3/es not_active Expired - Lifetime
- 2003-10-09 PT PT37579315T patent/PT1549344E/pt unknown
- 2003-10-09 BR BR0315123-9A patent/BR0315123A/pt not_active IP Right Cessation
- 2003-10-09 CN CN2003801010871A patent/CN1703243B/zh not_active Expired - Fee Related
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- 2003-10-09 JP JP2004542465A patent/JP5179702B2/ja not_active Expired - Fee Related
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- 2003-10-09 AU AU2003273964A patent/AU2003273964B2/en not_active Ceased
- 2003-10-09 WO PCT/EP2003/011164 patent/WO2004032960A1/en not_active Ceased
- 2003-10-09 MX MXPA05003795A patent/MXPA05003795A/es active IP Right Grant
- 2003-10-09 EP EP03807851A patent/EP1549345A1/en not_active Withdrawn
- 2003-10-09 US US10/530,871 patent/US7638125B2/en not_active Expired - Lifetime
- 2003-10-09 KR KR1020057006038A patent/KR20050057631A/ko not_active Ceased
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