BR0315117A - Anticorpos anti-erb-b biespecìficos e seu uso na terapia de tumores - Google Patents

Anticorpos anti-erb-b biespecìficos e seu uso na terapia de tumores

Info

Publication number
BR0315117A
BR0315117A BR0315117-4A BR0315117A BR0315117A BR 0315117 A BR0315117 A BR 0315117A BR 0315117 A BR0315117 A BR 0315117A BR 0315117 A BR0315117 A BR 0315117A
Authority
BR
Brazil
Prior art keywords
antibodies
tumor therapy
erb
unusual
bispecific anti
Prior art date
Application number
BR0315117-4A
Other languages
English (en)
Inventor
Hans-Georg Kreysch
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR0315117A publication Critical patent/BR0315117A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

"ANTICORPOS ANTI-ERB-B BIESPECìFICOS E SEU USO NA TERAPIA DE TUMORES". A presente invenção refere-se a anticorpos biespecíficos inusitados e seu uso na terapia de tumores. Os anticorpos inusitados têm a capacidade de ligar-se a receptores ErbB, de preferência receptores ErbB1, que são superexpressados em muitos tecidos cancerosos. Como as especificidades diferentes dos sítios de ligação de antígenos são direcionadas contra epitopos diferentes dentro do domínio de ligação de receptores ErbB iguais ou diferentes, estes anticorpos são mais eficazes com relação à inibição e infra-regulação do receptor ErbB e da cascata de sinalização correspondente.
BR0315117-4A 2002-10-10 2003-10-09 Anticorpos anti-erb-b biespecìficos e seu uso na terapia de tumores BR0315117A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02022390 2002-10-10
EP02022389 2002-10-10
PCT/EP2003/011165 WO2004032961A1 (en) 2002-10-10 2003-10-09 Bispecific anti-erb-b antibodies and their use in tumor therapy

Publications (1)

Publication Number Publication Date
BR0315117A true BR0315117A (pt) 2005-08-16

Family

ID=32095025

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0315117-4A BR0315117A (pt) 2002-10-10 2003-10-09 Anticorpos anti-erb-b biespecìficos e seu uso na terapia de tumores
BR0315123-9A BR0315123A (pt) 2002-10-10 2003-10-09 Composições farmacêuticas direcionadas a receptores erb-b1

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR0315123-9A BR0315123A (pt) 2002-10-10 2003-10-09 Composições farmacêuticas direcionadas a receptores erb-b1

Country Status (19)

Country Link
US (2) US7638125B2 (pt)
EP (2) EP1549345A1 (pt)
JP (3) JP5179702B2 (pt)
KR (2) KR101088661B1 (pt)
CN (1) CN1703243B (pt)
AU (2) AU2003273964B2 (pt)
BR (2) BR0315117A (pt)
CA (2) CA2501818C (pt)
CY (1) CY1116167T1 (pt)
DK (1) DK1549344T3 (pt)
ES (1) ES2533963T3 (pt)
HK (2) HK1081449A1 (pt)
HU (1) HUE025086T2 (pt)
MX (2) MXPA05003796A (pt)
PL (2) PL210545B1 (pt)
PT (1) PT1549344E (pt)
RU (2) RU2354402C2 (pt)
SI (1) SI1549344T1 (pt)
WO (2) WO2004032960A1 (pt)

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