JP2006503913A - 高眼圧症および緑内障の処置のための方法およびラタノプロスト含有組成物 - Google Patents
高眼圧症および緑内障の処置のための方法およびラタノプロスト含有組成物 Download PDFInfo
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- JP2006503913A JP2006503913A JP2005501572A JP2005501572A JP2006503913A JP 2006503913 A JP2006503913 A JP 2006503913A JP 2005501572 A JP2005501572 A JP 2005501572A JP 2005501572 A JP2005501572 A JP 2005501572A JP 2006503913 A JP2006503913 A JP 2006503913A
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- composition
- benzalkonium chloride
- eye drop
- ophthalmic
- solubilizer
- Prior art date
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229940114926 stearate Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229940127230 sympathomimetic drug Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960002368 travoprost Drugs 0.000 description 1
- MKPLKVHSHYCHOC-AHTXBMBWSA-N travoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COC1=CC=CC(C(F)(F)F)=C1 MKPLKVHSHYCHOC-AHTXBMBWSA-N 0.000 description 1
- 229960004791 tropicamide Drugs 0.000 description 1
- 229950008081 unoprostone isopropyl Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Solid Thermionic Cathode (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42077602P | 2002-10-24 | 2002-10-24 | |
| US42104402P | 2002-10-25 | 2002-10-25 | |
| US10/429,677 US7074827B2 (en) | 2002-10-24 | 2003-05-06 | Method for treating ocular hypertension and glaucoma |
| PCT/JP2003/013452 WO2004037267A1 (en) | 2002-10-24 | 2003-10-22 | Method and composition containing latanoprost for treating ocular hypertension and glaucoma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012125019A Division JP2012162570A (ja) | 2002-10-24 | 2012-05-31 | 高眼圧症および緑内障の処置のための方法およびラタノプロスト含有組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006503913A true JP2006503913A (ja) | 2006-02-02 |
| JP2006503913A5 JP2006503913A5 (enExample) | 2006-12-07 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005501572A Pending JP2006503913A (ja) | 2002-10-24 | 2003-10-22 | 高眼圧症および緑内障の処置のための方法およびラタノプロスト含有組成物 |
| JP2012125019A Pending JP2012162570A (ja) | 2002-10-24 | 2012-05-31 | 高眼圧症および緑内障の処置のための方法およびラタノプロスト含有組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012125019A Pending JP2012162570A (ja) | 2002-10-24 | 2012-05-31 | 高眼圧症および緑内障の処置のための方法およびラタノプロスト含有組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7074827B2 (enExample) |
| EP (2) | EP1553953B1 (enExample) |
| JP (2) | JP2006503913A (enExample) |
| AT (1) | ATE480240T1 (enExample) |
| AU (1) | AU2003274734A1 (enExample) |
| CA (1) | CA2502437C (enExample) |
| DE (1) | DE60334134D1 (enExample) |
| DK (1) | DK1553953T3 (enExample) |
| WO (1) | WO2004037267A1 (enExample) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008096804A1 (ja) * | 2007-02-07 | 2008-08-14 | Teika Pharmaceutical Co., Ltd. | ラタノプロスト含有点眼剤 |
| JP2008247828A (ja) * | 2007-03-30 | 2008-10-16 | Wakamoto Pharmaceut Co Ltd | ラタノプロストを含有する水性医薬組成物。 |
| JP2009040727A (ja) * | 2007-08-09 | 2009-02-26 | Towa Yakuhin Kk | ラタノプロストを有効成分とする安定な点眼液剤 |
| WO2009028674A1 (ja) * | 2007-08-29 | 2009-03-05 | Wakamoto Pharmaceutical Co., Ltd. | ラタノプロスト含有水性医薬組成物 |
| JP2010275259A (ja) * | 2009-05-29 | 2010-12-09 | Toa Yakuhin Kk | 均一、かつ安定なラタノプロスト点眼液剤組成物 |
| JP2013511494A (ja) * | 2009-11-19 | 2013-04-04 | ノバガリ ファーマ エスエー | 角膜および結膜病変を治癒させるためのプロスタグランジンＦ２αおよび類似体の使用 |
| JP2013522272A (ja) * | 2010-03-17 | 2013-06-13 | ノバリック ゲーエムベーハー | 眼圧上昇の治療のための医薬組成物 |
| JP2013532159A (ja) * | 2010-06-29 | 2013-08-15 | ラボラトワール テア | 防腐剤を含まない非粘性プロスタグランジン系点眼液用のポリマー送達システム |
| WO2015029923A1 (ja) * | 2013-08-26 | 2015-03-05 | ロート製薬株式会社 | 眼科用製剤 |
| US9999593B2 (en) | 2008-05-30 | 2018-06-19 | Santen Pharmaceutical Co., Ltd. | Method and composition for treating ocular hypertension and glaucoma |
| JP2022120120A (ja) * | 2022-06-13 | 2022-08-17 | 東亜薬品株式会社 | 眼科用水性組成物及びプロスタグランジンＦ２α誘導体の含量の低下を抑制する方法 |
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| DE102005035986B4 (de) * | 2005-07-28 | 2009-10-15 | Bausch & Lomb Incorporated | Steriles tropfbares mehrphasiges emulgatorfreies ophthalmisches Präparat |
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| FR2918891B1 (fr) * | 2007-07-20 | 2009-09-25 | Thea Sa Lab | Solution ophtalmique a base de prostaglandines sans conservateur |
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| CN114449999A (zh) | 2019-09-06 | 2022-05-06 | 诺瓦利克有限责任公司 | 用于治疗葡萄膜炎的眼用组合物 |
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| US5578618A (en) * | 1988-09-06 | 1996-11-26 | Pharmacia Aktiebolag | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| JPH10259179A (ja) * | 1996-09-19 | 1998-09-29 | Santen Pharmaceut Co Ltd | 多置換アリールオキシ基を有するプロスタグランジン類およびその用途 |
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| AU665287B2 (en) | 1992-12-21 | 1995-12-21 | Alcon Laboratories, Inc. | Prostaglandin combinations in glaucoma therapy |
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| SE0002211D0 (sv) | 2000-06-13 | 2000-06-13 | Synphora Ab | Methods and compositions for prevention of myopia |
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| PT1321144E (pt) * | 2000-09-13 | 2011-03-10 | Santen Pharmaceutical Co Ltd | Colírio |
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| EP1532981B1 (en) * | 2002-08-23 | 2007-09-26 | Santen Pharmaceutical Co., Ltd. | Stable eye drops containing latanoprost as the active ingredient |
| CA2498233C (en) * | 2002-09-09 | 2012-08-14 | Santen Pharmaceutical Co., Ltd. | Clear ophthalmic solution comprising latanoprost as active ingredient |
-
2003
- 2003-05-06 US US10/429,677 patent/US7074827B2/en not_active Expired - Fee Related
- 2003-10-22 EP EP03758746A patent/EP1553953B1/en not_active Expired - Lifetime
- 2003-10-22 AT AT03758746T patent/ATE480240T1/de active
- 2003-10-22 CA CA2502437A patent/CA2502437C/en not_active Expired - Fee Related
- 2003-10-22 DK DK03758746.6T patent/DK1553953T3/da active
- 2003-10-22 WO PCT/JP2003/013452 patent/WO2004037267A1/en not_active Ceased
- 2003-10-22 AU AU2003274734A patent/AU2003274734A1/en not_active Abandoned
- 2003-10-22 DE DE60334134T patent/DE60334134D1/de not_active Expired - Lifetime
- 2003-10-22 EP EP10171708A patent/EP2253322A1/en not_active Withdrawn
- 2003-10-22 JP JP2005501572A patent/JP2006503913A/ja active Pending
-
2006
- 2006-05-23 US US11/438,290 patent/US8673973B2/en not_active Expired - Fee Related
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2012
- 2012-05-31 JP JP2012125019A patent/JP2012162570A/ja active Pending
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Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013189450A (ja) * | 2007-02-07 | 2013-09-26 | Teika Seiyaku Kk | ラタノプロスト含有点眼液組成物 |
| WO2008096804A1 (ja) * | 2007-02-07 | 2008-08-14 | Teika Pharmaceutical Co., Ltd. | ラタノプロスト含有点眼剤 |
| JPWO2008096804A1 (ja) * | 2007-02-07 | 2010-05-27 | テイカ製薬株式会社 | ラタノプロスト含有点眼剤 |
| JP2008247828A (ja) * | 2007-03-30 | 2008-10-16 | Wakamoto Pharmaceut Co Ltd | ラタノプロストを含有する水性医薬組成物。 |
| JP2009040727A (ja) * | 2007-08-09 | 2009-02-26 | Towa Yakuhin Kk | ラタノプロストを有効成分とする安定な点眼液剤 |
| US9456980B2 (en) | 2007-08-29 | 2016-10-04 | Wakamoto Pharmaceutical Co., Ltd. | Latanoprost-containing aqueous pharmaceutical composition |
| WO2009028674A1 (ja) * | 2007-08-29 | 2009-03-05 | Wakamoto Pharmaceutical Co., Ltd. | ラタノプロスト含有水性医薬組成物 |
| US9999593B2 (en) | 2008-05-30 | 2018-06-19 | Santen Pharmaceutical Co., Ltd. | Method and composition for treating ocular hypertension and glaucoma |
| US10864159B2 (en) | 2008-05-30 | 2020-12-15 | Santen Pharmaceutical Co., Ltd. | Method and composition for treating ocular hypertension and glaucoma |
| JP2010275259A (ja) * | 2009-05-29 | 2010-12-09 | Toa Yakuhin Kk | 均一、かつ安定なラタノプロスト点眼液剤組成物 |
| JP2013511494A (ja) * | 2009-11-19 | 2013-04-04 | ノバガリ ファーマ エスエー | 角膜および結膜病変を治癒させるためのプロスタグランジンＦ２αおよび類似体の使用 |
| JP2013522272A (ja) * | 2010-03-17 | 2013-06-13 | ノバリック ゲーエムベーハー | 眼圧上昇の治療のための医薬組成物 |
| JP2013532159A (ja) * | 2010-06-29 | 2013-08-15 | ラボラトワール テア | 防腐剤を含まない非粘性プロスタグランジン系点眼液用のポリマー送達システム |
| JP2015038099A (ja) * | 2010-06-29 | 2015-02-26 | ラボラトワール テアＬａｂｏｒａｔｏｉｒｅｓ Ｔｈｅａ | 防腐剤を含まない非粘性プロスタグランジン系点眼液用のポリマー送達システム |
| KR101809713B1 (ko) * | 2010-06-29 | 2017-12-15 | 라보라토이레스 테아 | 방부제 없는 프로스타글란딘계 비점성 용액의 고분자 전달 시스템 |
| WO2015029923A1 (ja) * | 2013-08-26 | 2015-03-05 | ロート製薬株式会社 | 眼科用製剤 |
| JP2022120120A (ja) * | 2022-06-13 | 2022-08-17 | 東亜薬品株式会社 | 眼科用水性組成物及びプロスタグランジンＦ２α誘導体の含量の低下を抑制する方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2253322A1 (en) | 2010-11-24 |
| EP1553953A1 (en) | 2005-07-20 |
| US8673973B2 (en) | 2014-03-18 |
| US20060205725A1 (en) | 2006-09-14 |
| DK1553953T3 (da) | 2010-10-25 |
| ATE480240T1 (de) | 2010-09-15 |
| AU2003274734A1 (en) | 2004-05-13 |
| US7074827B2 (en) | 2006-07-11 |
| JP2012162570A (ja) | 2012-08-30 |
| WO2004037267A1 (en) | 2004-05-06 |
| EP1553953B1 (en) | 2010-09-08 |
| DE60334134D1 (de) | 2010-10-21 |
| CA2502437C (en) | 2012-07-17 |
| CA2502437A1 (en) | 2004-05-06 |
| US20040082660A1 (en) | 2004-04-29 |
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