JP2006503082A5 - - Google Patents

Download PDF

Info

Publication number
JP2006503082A5
JP2006503082A5 JP2004543863A JP2004543863A JP2006503082A5 JP 2006503082 A5 JP2006503082 A5 JP 2006503082A5 JP 2004543863 A JP2004543863 A JP 2004543863A JP 2004543863 A JP2004543863 A JP 2004543863A JP 2006503082 A5 JP2006503082 A5 JP 2006503082A5
Authority
JP
Japan
Prior art keywords
compound
hydrocarbyl
substituted
substituents
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004543863A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006503082A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/CA2003/001557 external-priority patent/WO2004035525A1/en
Publication of JP2006503082A publication Critical patent/JP2006503082A/ja
Publication of JP2006503082A5 publication Critical patent/JP2006503082A5/ja
Pending legal-status Critical Current

Links

JP2004543863A 2002-10-17 2003-10-16 ヒストンデアセチラーゼの阻害剤 Pending JP2006503082A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41968802P 2002-10-17 2002-10-17
PCT/CA2003/001557 WO2004035525A1 (en) 2002-10-17 2003-10-16 Inhibitors of histone deacetylase

Publications (2)

Publication Number Publication Date
JP2006503082A JP2006503082A (ja) 2006-01-26
JP2006503082A5 true JP2006503082A5 (enExample) 2006-11-30

Family

ID=32108128

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004543863A Pending JP2006503082A (ja) 2002-10-17 2003-10-16 ヒストンデアセチラーゼの阻害剤

Country Status (8)

Country Link
US (2) US7282608B2 (enExample)
EP (1) EP1551795A1 (enExample)
JP (1) JP2006503082A (enExample)
KR (1) KR20050074487A (enExample)
CN (1) CN100448844C (enExample)
AU (1) AU2003273701A1 (enExample)
CA (1) CA2501265A1 (enExample)
WO (1) WO2004035525A1 (enExample)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US20030129724A1 (en) * 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
US7868204B2 (en) * 2001-09-14 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
US6897220B2 (en) * 2001-09-14 2005-05-24 Methylgene, Inc. Inhibitors of histone deacetylase
MXPA04002397A (es) 2001-09-14 2004-12-02 Methylgene Inc Inhibidores de histona deacetilasa.
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7375228B2 (en) 2003-03-17 2008-05-20 Takeda San Diego, Inc. Histone deacetylase inhibitors
EP1663953A1 (en) * 2003-09-24 2006-06-07 Methylgene, Inc. Inhibitors of histone deacetylase
JP4667384B2 (ja) 2003-10-07 2011-04-13 レノビス, インコーポレイテッド イオンチャネルリガンドとしてのアミド誘導体および薬学的組成物、ならびにこれらを使用する方法
US7253204B2 (en) * 2004-03-26 2007-08-07 Methylgene Inc. Inhibitors of histone deacetylase
WO2005121073A1 (en) * 2004-06-10 2005-12-22 Cancer Research Technology Limited Inhibitors of histone deacetylase
JP2008505970A (ja) * 2004-07-12 2008-02-28 メルク エンド カムパニー インコーポレーテッド ヒストン脱アセチル化酵素阻害剤
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
EA200700243A1 (ru) 2004-07-14 2007-08-31 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способы лечения гепатита с
EP1781289A1 (en) 2004-07-22 2007-05-09 PTC Therapeutics, Inc. Thienopyridines for treating hepatitis c
WO2006066133A2 (en) 2004-12-16 2006-06-22 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
MX2007009381A (es) * 2005-02-28 2007-09-25 Renovis Inc Derivados de amida como ligandos de canales ionicos y composiciones farmaceuticas y metodos para usar los mismos.
SG171690A1 (en) 2005-03-22 2011-06-29 Harvard College Treatment of protein degradation disorders
JP2008540574A (ja) 2005-05-11 2008-11-20 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
BRPI0610322B8 (pt) 2005-05-20 2021-05-25 Methylgene Inc inibidores de sinalização de receptor de vegf e de receptor de hgf e composição farmacêutica
US7732475B2 (en) * 2005-07-14 2010-06-08 Takeda San Diego, Inc. Histone deacetylase inhibitors
CA2633010A1 (en) * 2005-12-19 2007-06-28 Methylgene Inc. Histone deacetylase inhibitors for enhancing activity of antifungal agents
CN100346830C (zh) * 2005-12-28 2007-11-07 上海交通大学医学院附属瑞金医院 一种治疗b细胞淋巴瘤的药物组合物
WO2007084390A2 (en) * 2006-01-13 2007-07-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
JP5441416B2 (ja) 2006-02-14 2014-03-12 プレジデント アンド フェロウズ オブ ハーバード カレッジ 二官能性ヒストンデアセチラーゼインヒビター
US8383855B2 (en) 2006-02-14 2013-02-26 President And Fellows Of Harvard College Histone deacetylase inhibitors
WO2007100657A2 (en) 2006-02-28 2007-09-07 Merck & Co., Inc. Inhibitors of histone deacetylase
CA2654540C (en) * 2006-05-03 2017-01-17 President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
RU2459811C2 (ru) 2006-10-28 2012-08-27 Метилджен Инк. Ингибиторы гистоновой деацетилазы
US8030344B2 (en) 2007-03-13 2011-10-04 Methylgene Inc. Inhibitors of histone deacetylase
CN101646460A (zh) 2007-03-28 2010-02-10 参天制药株式会社 含有具有组蛋白脱乙酰化酶抑制作用的化合物作为有效成分的降眼压剂
EP2170814B1 (en) 2007-06-12 2016-08-17 Achaogen, Inc. Antibacterial agents
EP2003118A1 (de) * 2007-06-13 2008-12-17 Bayer Schering Pharma Aktiengesellschaft Zimtsäurederivate als Modulatoren des EP2-Rezeptors
EP2170076B1 (en) 2007-06-27 2016-05-18 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
WO2009005638A2 (en) 2007-06-27 2009-01-08 Merck & Co., Inc. Pyridyl and pyrimidinyl derivatives as histone deacetylase inhibitors
RU2453536C2 (ru) 2007-10-22 2012-06-20 Оркид Рисерч Лабораториз Лимитед Ингибиторы гистондезацетилазы
WO2009067808A1 (en) * 2007-11-27 2009-06-04 Ottawa Health Research Institute Amplification of cancer-specific oncolytic viral infection by histone deacetylase inhibitors
EP2220066A1 (en) * 2007-12-14 2010-08-25 Gilead Colorado, Inc. Benzofuran anilide histone deacetylase inhibitors
AU2009271019A1 (en) 2008-07-14 2010-01-21 Gilead Sciences, Inc. Fused heterocyclyc inhibitors of histone deacetylase and/or cyclin-dependent kinases
NZ590283A (en) 2008-07-14 2012-11-30 Gilead Sciences Inc Imidazolylpyrimidine compounds as hdac and / or cdk inhibitors
EP2303841A1 (en) 2008-07-14 2011-04-06 Gilead Sciences, Inc. Oxindolyl inhibitor compounds
WO2010011700A2 (en) 2008-07-23 2010-01-28 The Brigham And Women's Hospital, Inc. Treatment of cancers characterized by chromosomal rearrangement of the nut gene
KR101708946B1 (ko) 2008-07-23 2017-02-21 다나-파버 캔서 인스티튜트 인크. 탈아세틸화제 억제제 및 그것의 용도
CA2731323A1 (en) 2008-07-28 2010-02-04 Gilead Sciences, Inc. Cycloalkylidene and heterocycloalkylidene histone deacetylase inhibitor compounds
AU2009289649B2 (en) 2008-09-03 2016-05-05 Biomarin Pharmaceutical Inc. Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
WO2010045095A1 (en) 2008-10-14 2010-04-22 Ning Xi Compounds and methods of use
CA2763167A1 (en) 2009-06-08 2010-12-16 Gilead Sciences, Inc. Cycloalkylcarbamate benzamide aniline hdac inhibitor compounds
EP2440519A1 (en) 2009-06-08 2012-04-18 Gilead Sciences, Inc. Alkanoylamino benzamide aniline hdac inihibitor compounds
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
CA2779497A1 (en) 2009-10-30 2011-05-05 Massachusetts Institute Of Technology The use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disorders
EP2523941B1 (en) * 2010-01-12 2014-10-15 Council of Scientific & Industrial Research Imidazolone-chalcone derivatives as potential anticancer agent and process for the preparation thereof
CN102249958B (zh) * 2010-11-29 2014-06-04 江苏先声药物研究有限公司 苯甲酰氨类组蛋白去乙酰化酶抑制剂
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
WO2012118632A1 (en) 2011-02-28 2012-09-07 Ning Xi Substituted quinoline compounds and methods of use
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
JP6250403B2 (ja) 2011-02-28 2017-12-20 バイオマリン ファーマシューティカル インク ヒストン脱アセチル化酵素阻害剤
CA2839956A1 (en) 2011-06-20 2012-12-27 Emory University Prostaglandin receptor ep2 antagonists, derivatives, compositions, and uses related thereto
WO2013170165A1 (en) 2012-05-10 2013-11-14 Achaogen, Inc. Antibacterial agents
AU2013296897B2 (en) 2012-07-28 2015-09-17 Beijing Findcure Biosciences Ltd. Substituted pyrazolone compounds and methods of use
TWI574962B (zh) 2012-11-14 2017-03-21 加拓科學公司 作爲pi3激酶調節劑的芳雜環化合物及其使用方法和用途
BR112015018318A2 (pt) 2013-02-21 2017-08-22 Sunshine Lake Pharma Co Ltd Composto, composição farmacêutica, uso de um composto ou de uma composição farmacêutica, e, métodos para prevenir, gerenciar, tratar ou diminuir a severidade de um distúrbio proliferativo em um paciente e para inibir ou modular a atividade de uma proteína quinase em uma amostra biológica
JP6503338B2 (ja) 2013-03-15 2019-04-17 バイオマリン ファーマシューティカル インコーポレイテッド Hdac阻害剤
WO2015006875A1 (en) * 2013-07-18 2015-01-22 Methylgene Inc. Process for the preparation of substituted pyrimidines
EP3769757A3 (en) * 2013-10-18 2021-10-06 The General Hospital Corporation Imaging histone deacetylases with a radiotracer using positron emission tomography
US9636298B2 (en) 2014-01-17 2017-05-02 Methylgene Inc. Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs
EP3137074B1 (en) 2014-04-29 2020-08-05 Emory University Prostaglandin receptor ep2 antagonists, derivatives, compositions, and uses related thereto
CN105037194B (zh) * 2015-05-27 2017-06-23 厦门大学 一系列查尔酮、二氢查尔酮和黄酮化合物及其制备方法和用途
EP3365344B1 (en) 2015-10-19 2020-12-09 Sunshine Lake Pharma Co., Ltd. (3-chloro-4-fluoro-phenyl)-(6-((4ar,7as)-3-(hexahydro-(1,4)dioxino(2,3-c)pyrrol-6-yl)-propoxy)-7-methoxy-quinazolin-4-yl)-amine di(methanesulfonic acid) salt and crystalline form of the monohydrate (a egfr inhibitor)
EP3941916B1 (en) 2019-03-20 2025-10-01 Emory University Prostaglandin receptor ep2 antagonists, derivatives, and uses related thereto
CN116768815B (zh) * 2023-06-13 2025-04-18 首都医科大学附属北京安定医院 靛红酸酐类化合物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149797A (en) * 1990-02-15 1992-09-22 The Worcester Foundation For Experimental Biology Method of site-specific alteration of rna and production of encoded polypeptides
US5652355A (en) * 1992-07-23 1997-07-29 Worcester Foundation For Experimental Biology Hybrid oligonucleotide phosphorothioates
DE19510957A1 (de) 1995-03-25 1996-09-26 Huels Chemische Werke Ag Eingedickter Bodenverfestiger, sowie diesen enthaltende verpackte Fertigmischung für Bodenbehandlungen
US6174905B1 (en) * 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
KR101026205B1 (ko) 1999-11-23 2011-03-31 메틸진 인코포레이티드 히스톤 디아세틸라제의 억제제
CA2404002A1 (en) 2000-03-24 2001-09-27 Methylgene, Inc. Inhibitors of histone deacetylase

Similar Documents

Publication Publication Date Title
JP2006503082A5 (enExample)
RU2376287C2 (ru) Производные бензамида, способ их получения и их применение, фармацевтическая композиция и способ обеспечения ингибирующего действия по отношению к hdac
CA2474738A1 (en) N-phenyl-2-pyrimidine-amine derivatives
JP6227707B2 (ja) Mcl‐1を調節する小分子、並びに細胞死、細胞分裂、細胞分化を調節する方法、及び疾患を治療する方法。
ES2274642T3 (es) Derivados de quinazolina como medicamentos.
JP2005537300A5 (enExample)
CA2653941A1 (en) Substituted amino purine derivatives and uses thereof
JP2007517807A5 (enExample)
JP2008510770A5 (enExample)
JP2004516314A5 (enExample)
JP2010509356A5 (enExample)
JP2017507122A5 (enExample)
JP2009534455A5 (enExample)
JP2014516360A5 (enExample)
JP2017528498A5 (enExample)
JP2008506644A5 (enExample)
JP2014503574A5 (enExample)
RU2006137716A (ru) Ингибиторы гистондеацетилазы
JP2004513168A5 (enExample)
JP2004525174A5 (enExample)
JP2010501478A5 (enExample)
JP2006507355A5 (enExample)
JP2005513020A5 (enExample)
JP2006520761A5 (enExample)
JP2005526794A5 (ja) ベンズイミダゾールおよびマイトジェン活性化およびrhoキナーゼ阻害剤としてのその使用