JP2006503001A5 - - Google Patents
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- Publication number
- JP2006503001A5 JP2006503001A5 JP2004525322A JP2004525322A JP2006503001A5 JP 2006503001 A5 JP2006503001 A5 JP 2006503001A5 JP 2004525322 A JP2004525322 A JP 2004525322A JP 2004525322 A JP2004525322 A JP 2004525322A JP 2006503001 A5 JP2006503001 A5 JP 2006503001A5
- Authority
- JP
- Japan
- Prior art keywords
- erythropoietin
- use according
- epo
- pharmaceutical composition
- progenitor cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 44
- 102000003951 Erythropoietin Human genes 0.000 claims 24
- 108090000394 Erythropoietin Proteins 0.000 claims 24
- 230000003511 endothelial effect Effects 0.000 claims 24
- 229940105423 erythropoietin Drugs 0.000 claims 24
- 108010092408 Eosinophil Peroxidase Proteins 0.000 claims 20
- 102100031939 Erythropoietin Human genes 0.000 claims 20
- 210000000130 stem cell Anatomy 0.000 claims 19
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 230000037396 body weight Effects 0.000 claims 10
- 230000003442 weekly effect Effects 0.000 claims 10
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 8
- 210000001519 tissue Anatomy 0.000 claims 8
- 239000004480 active ingredient Substances 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- 230000000638 stimulation Effects 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 230000004064 dysfunction Effects 0.000 claims 6
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 6
- 230000033115 angiogenesis Effects 0.000 claims 5
- 230000015572 biosynthetic process Effects 0.000 claims 5
- 210000004204 blood vessel Anatomy 0.000 claims 5
- 210000002889 endothelial cell Anatomy 0.000 claims 5
- 201000011461 pre-eclampsia Diseases 0.000 claims 5
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 4
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 4
- 101001001487 Homo sapiens Phosphatidylinositol-glycan biosynthesis class F protein Proteins 0.000 claims 4
- 101000595923 Homo sapiens Placenta growth factor Proteins 0.000 claims 4
- 102100035194 Placenta growth factor Human genes 0.000 claims 4
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 4
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 4
- 208000020832 chronic kidney disease Diseases 0.000 claims 4
- 210000003038 endothelium Anatomy 0.000 claims 4
- 230000001771 impaired effect Effects 0.000 claims 4
- 239000002840 nitric oxide donor Substances 0.000 claims 4
- 210000000056 organ Anatomy 0.000 claims 4
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 3
- 201000001320 Atherosclerosis Diseases 0.000 claims 3
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 3
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims 3
- 229930064664 L-arginine Natural products 0.000 claims 3
- 235000014852 L-arginine Nutrition 0.000 claims 3
- 208000003782 Raynaud disease Diseases 0.000 claims 3
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 3
- 208000033626 Renal failure acute Diseases 0.000 claims 3
- 206010038802 Reticuloendothelial system stimulated Diseases 0.000 claims 3
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims 3
- AJLFOPYRIVGYMJ-UHFFFAOYSA-N SJ000287055 Natural products C12C(OC(=O)C(C)CC)CCC=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 AJLFOPYRIVGYMJ-UHFFFAOYSA-N 0.000 claims 3
- 201000011040 acute kidney failure Diseases 0.000 claims 3
- 208000012998 acute renal failure Diseases 0.000 claims 3
- 229960005370 atorvastatin Drugs 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 208000037976 chronic inflammation Diseases 0.000 claims 3
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 3
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 210000003709 heart valve Anatomy 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 230000000302 ischemic effect Effects 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 claims 3
- 229950009116 mevastatin Drugs 0.000 claims 3
- BOZILQFLQYBIIY-UHFFFAOYSA-N mevastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CCC=C21 BOZILQFLQYBIIY-UHFFFAOYSA-N 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- 229960002855 simvastatin Drugs 0.000 claims 3
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims 3
- 230000029663 wound healing Effects 0.000 claims 3
- 206010070538 Gestational hypertension Diseases 0.000 claims 2
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 230000002491 angiogenic effect Effects 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 208000032467 Aplastic anaemia Diseases 0.000 claims 1
- 238000012270 DNA recombination Methods 0.000 claims 1
- 101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 claims 1
- 101000920686 Homo sapiens Erythropoietin Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 125000002059 L-arginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 230000007910 cell fusion Effects 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 208000028208 end stage renal disease Diseases 0.000 claims 1
- 201000000523 end stage renal failure Diseases 0.000 claims 1
- 102000044890 human EPO Human genes 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 230000007794 irritation Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 230000035935 pregnancy Effects 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 230000007115 recruitment Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 230000009772 tissue formation Effects 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10234192.3 | 2002-07-26 | ||
| DE10234192A DE10234192B4 (de) | 2002-07-26 | 2002-07-26 | Verwendung von Erythropoetin |
| PCT/EP2003/008229 WO2004012759A2 (de) | 2002-07-26 | 2003-07-25 | Erythropoetin zur stimulation endothelialer voläuferzellen |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010157094A Division JP2010280672A (ja) | 2002-07-26 | 2010-07-09 | エリスロポエチンの使用 |
| JP2010157092A Division JP2010280670A (ja) | 2002-07-26 | 2010-07-09 | エリスロポエチンの使用 |
| JP2010157093A Division JP2010280671A (ja) | 2002-07-26 | 2010-07-09 | エリスロポエチンの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006503001A JP2006503001A (ja) | 2006-01-26 |
| JP2006503001A5 true JP2006503001A5 (enExample) | 2006-06-15 |
| JP4727988B2 JP4727988B2 (ja) | 2011-07-20 |
Family
ID=30128436
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004525322A Expired - Fee Related JP4727988B2 (ja) | 2002-07-26 | 2003-07-25 | エリスロポエチンの使用 |
| JP2010157094A Withdrawn JP2010280672A (ja) | 2002-07-26 | 2010-07-09 | エリスロポエチンの使用 |
| JP2010157092A Withdrawn JP2010280670A (ja) | 2002-07-26 | 2010-07-09 | エリスロポエチンの使用 |
| JP2010157093A Withdrawn JP2010280671A (ja) | 2002-07-26 | 2010-07-09 | エリスロポエチンの使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010157094A Withdrawn JP2010280672A (ja) | 2002-07-26 | 2010-07-09 | エリスロポエチンの使用 |
| JP2010157092A Withdrawn JP2010280670A (ja) | 2002-07-26 | 2010-07-09 | エリスロポエチンの使用 |
| JP2010157093A Withdrawn JP2010280671A (ja) | 2002-07-26 | 2010-07-09 | エリスロポエチンの使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US7745387B2 (enExample) |
| EP (3) | EP1779862B1 (enExample) |
| JP (4) | JP4727988B2 (enExample) |
| KR (2) | KR20100077033A (enExample) |
| CN (3) | CN101099860B (enExample) |
| AT (2) | ATE468132T1 (enExample) |
| AU (2) | AU2003255290B2 (enExample) |
| BR (1) | BR0312981A (enExample) |
| CA (2) | CA2710100A1 (enExample) |
| CY (2) | CY1108052T1 (enExample) |
| DE (3) | DE10234192B4 (enExample) |
| DK (2) | DK1526867T3 (enExample) |
| EA (3) | EA013966B1 (enExample) |
| ES (2) | ES2345673T3 (enExample) |
| HR (3) | HRP20050065A2 (enExample) |
| IL (2) | IL166401A0 (enExample) |
| IS (3) | IS2671B (enExample) |
| MX (1) | MXPA05001120A (enExample) |
| NO (1) | NO20051002L (enExample) |
| PL (2) | PL395151A1 (enExample) |
| PT (2) | PT1779862E (enExample) |
| SG (1) | SG177004A1 (enExample) |
| SI (2) | SI1526867T1 (enExample) |
| UA (2) | UA85997C2 (enExample) |
| WO (1) | WO2004012759A2 (enExample) |
| ZA (1) | ZA200500726B (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7723303B2 (en) | 2000-08-24 | 2010-05-25 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| US7199102B2 (en) * | 2000-08-24 | 2007-04-03 | The Regents Of The University Of California | Orally administered peptides synergize statin activity |
| DE10234192B4 (de) | 2002-07-26 | 2009-11-26 | Epoplus Gmbh Co.Kg | Verwendung von Erythropoetin |
| RU2351357C2 (ru) * | 2003-07-29 | 2009-04-10 | ДОМПЕ ФА.Р.МА. С.п.А. | Фармацевтическая композиция, используемая для мобилизации стволовых клеток |
| ES2346226T3 (es) * | 2003-12-30 | 2010-10-13 | Augustinus Bader | Uso de la eritropoyetina para la regeneracion de tejido hepatico. |
| DE102004004509B4 (de) * | 2004-01-23 | 2010-07-01 | Epoplus Gmbh Co.Kg | Einsatz von niedrig dosiertem Erythropoietin zur Stimulation endothelialer Vorläuferzellen sowie zur Organregeneration und Progressionsverlangsamung von Endorganschäden |
| AU2005314043A1 (en) | 2004-12-06 | 2006-06-15 | The Regents Of The University Of California | Methods for improving the structure and function of arterioles |
| AR053416A1 (es) | 2005-11-10 | 2007-05-09 | Protech Pharma S A | Combinacion de glicoisoformas para el tratamiento o prevencion de la septicemia, linea celular transgenica productora de glicoformas de eritropoyetina, composicion farmaceutica que comprende a dicha combinacion, procedimientos para obtener la linea celular, procedimiento para producir dicha combinac |
| MX2008006626A (es) | 2005-11-23 | 2008-09-24 | Acceleron Pharma Inc | Antagonistas de activin-actriia y usos para promover el crecimiento de huesos. |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| WO2007142288A1 (ja) * | 2006-06-07 | 2007-12-13 | The University Of Tokushima | エリスロポエチンを用いた虚血性疾患の治療 |
| CN101801403A (zh) * | 2006-09-29 | 2010-08-11 | 森托科尔奥索生物科技公司 | 用于防止、治疗葡萄糖耐受不良相关病症的人epo受体激动剂、组合物、方法及应用 |
| CN101589059A (zh) | 2006-10-20 | 2009-11-25 | 株式会社未来创药研究所 | 包含抗hb-egf抗体作为活性成分的药物组合物 |
| US8975374B2 (en) * | 2006-10-20 | 2015-03-10 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition comprising anti-HB-EGF antibody as active ingredient |
| EP3040347A3 (en) * | 2006-10-20 | 2016-09-21 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition comprising anti-hb-egf antibody as active ingredient |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| CN101610782A (zh) * | 2007-01-10 | 2009-12-23 | 爱迪生药物公司 | 使用具有促红细胞生成素或血小板生成素活性的化合物治疗呼吸链紊乱 |
| TWI782836B (zh) | 2007-02-02 | 2022-11-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| AR065613A1 (es) * | 2007-03-09 | 2009-06-17 | Chugai Pharmaceutical Co Ltd | Agentes de proteccion para organos transplantados |
| WO2009022338A2 (en) * | 2007-08-16 | 2009-02-19 | Saher Hamed | Erythropoietin and fibronectin compositions for therapeutic and cosmetic applications |
| EP2303309A2 (en) * | 2008-05-22 | 2011-04-06 | Edison Pharmaceuticals, Inc. | Treatment of mitochondrial diseases with an erythropoietin mimetic |
| HRP20191109T1 (hr) | 2008-08-14 | 2019-09-20 | Acceleron Pharma Inc. | Gdf klopke za uporabu u liječenju anemije |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| AU2010258931B2 (en) | 2009-06-08 | 2015-04-23 | Acceleron Pharma Inc. | Methods for increasing thermogenic adipocytes |
| CN107267520A (zh) | 2009-06-12 | 2017-10-20 | 阿塞勒隆制药公司 | 截短的actriib‑fc融合蛋白 |
| KR101882521B1 (ko) * | 2009-08-13 | 2018-07-27 | 악셀레론 파마 인코포레이티드 | 적혈구 수준을 증가시키기 위한 ｇｄｆ 트랩과 에리트로포이에틴 수용체 활성인자의 병용 |
| CA2781152A1 (en) | 2009-11-17 | 2011-05-26 | Acceleron Pharma Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| EP2590666B1 (en) | 2010-07-06 | 2017-04-26 | Augustinus Bader | Topical application of erythropoietin for use in the treatment of injuries of the cornea |
| WO2012148200A2 (ko) * | 2011-04-26 | 2012-11-01 | 아주대학교 산학협력단 | 허혈성 혈관 질환 치료시술 보조용 조성물 |
| ES2884095T3 (es) | 2012-11-02 | 2021-12-10 | Celgene Corp | Antagonistas de activina-actrii y usos para el tratamiento de trastornos óseos y otros trastornos |
| US8992951B2 (en) | 2013-01-09 | 2015-03-31 | Sapna Life Sciences Corporation | Formulations, procedures, methods and combinations thereof for reducing or preventing the development, or the risk of development, of neuropathology as a result of trauma |
| EP3060174B1 (en) * | 2013-10-22 | 2020-05-27 | Concievalve LLC | Methods for inhibiting stenosis, obstruction, or calcification of a stented heart valve or bioprosthesis |
| MA40008A (fr) | 2014-06-13 | 2021-05-05 | Acceleron Pharma Inc | Antagoniste actrii pour le traitement et la prevention d'un ulcere cutane chez un sujet ayant l'anemie |
| CA2976376A1 (en) * | 2015-02-13 | 2016-08-18 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| CN105233256A (zh) * | 2015-10-28 | 2016-01-13 | 中国人民解放军第三军医大学 | 促红细胞生成素及其衍生物在制备治疗疾病中促进凋亡细胞清除的药物中的应用 |
| US11534466B2 (en) * | 2016-03-09 | 2022-12-27 | Aal Scientifics, Inc. | Pancreatic stem cells and uses thereof |
| GB2550114A (en) * | 2016-05-03 | 2017-11-15 | Kymab Ltd | Methods, regimens, combinations & antagonists |
| AU2017312113B2 (en) | 2016-08-17 | 2023-05-25 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| CN108114282B (zh) * | 2016-11-28 | 2021-03-02 | 北京大学第三医院 | 他汀类化合物治疗缺血性疾病的用途 |
| JP7185884B2 (ja) | 2017-05-02 | 2022-12-08 | 国立研究開発法人国立精神・神経医療研究センター | Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法 |
| WO2019078344A1 (ja) * | 2017-10-20 | 2019-04-25 | 学校法人兵庫医科大学 | 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物 |
| RU2695334C1 (ru) * | 2018-09-25 | 2019-07-23 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Способ профилактики нарушений функций почек карбамилированным дарбэпоэтином в эксперименте |
| RU2678768C1 (ru) * | 2018-09-25 | 2019-02-01 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Способ профилактики ишемически-реперфузионных повреждений почек карбамилированным дарбэпоэтином в эксперименте |
| EP3997059A4 (en) | 2019-07-03 | 2023-12-13 | Factor Bioscience Inc. | CATIONIC LIPIDS AND THEIR USES |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| CN119080909A (zh) * | 2024-08-29 | 2024-12-06 | 深圳赛保尔生物药业有限公司 | 负载peg-epo及间充质干细胞的组合物、药物及其制备方法 |
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| NZ210501A (en) | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| IL77081A (en) | 1984-12-04 | 1999-10-28 | Genetics Inst | Dna sequence encoding human erythropoietin process for the preparation thereof and a pharmaceutical composition of human erythropoietin |
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2002
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