JP2006502747A5 - - Google Patents

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JP2006502747A5
JP2006502747A5 JP2005501484A JP2005501484A JP2006502747A5 JP 2006502747 A5 JP2006502747 A5 JP 2006502747A5 JP 2005501484 A JP2005501484 A JP 2005501484A JP 2005501484 A JP2005501484 A JP 2005501484A JP 2006502747 A5 JP2006502747 A5 JP 2006502747A5
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Japan
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sequence
probe
complementary
target
wnv
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JP2005501484A
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JP2006502747A (ja
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Priority claimed from PCT/US2003/033639 external-priority patent/WO2004036190A2/en
Publication of JP2006502747A publication Critical patent/JP2006502747A/ja
Publication of JP2006502747A5 publication Critical patent/JP2006502747A5/ja
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JP2005501484A 2002-10-16 2003-10-16 西ナイルウィルスを検出するための、組成物および方法 Withdrawn JP2006502747A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41889102P 2002-10-16 2002-10-16
US42900602P 2002-11-25 2002-11-25
US44981003P 2003-02-24 2003-02-24
PCT/US2003/033639 WO2004036190A2 (en) 2002-10-16 2003-10-16 Compositions and methods for detecting west nile virus

Related Child Applications (1)

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JP2010174042A Division JP5568403B2 (ja) 2002-10-16 2010-08-02 西ナイルウィルスを検出するための、組成物および方法

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JP2006502747A JP2006502747A (ja) 2006-01-26
JP2006502747A5 true JP2006502747A5 (https=) 2006-11-24

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JP2005501484A Withdrawn JP2006502747A (ja) 2002-10-16 2003-10-16 西ナイルウィルスを検出するための、組成物および方法
JP2010174042A Expired - Fee Related JP5568403B2 (ja) 2002-10-16 2010-08-02 西ナイルウィルスを検出するための、組成物および方法

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JP2010174042A Expired - Fee Related JP5568403B2 (ja) 2002-10-16 2010-08-02 西ナイルウィルスを検出するための、組成物および方法

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US (2) US7115374B2 (https=)
EP (4) EP3241915B1 (https=)
JP (2) JP2006502747A (https=)
AU (1) AU2003298605B2 (https=)
CA (4) CA3081071A1 (https=)
ES (1) ES2890882T3 (https=)
WO (1) WO2004036190A2 (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030224353A1 (en) * 2001-10-16 2003-12-04 Stein David A. Antisense antiviral agent and method for treating ssRNA viral infection
US7927840B2 (en) * 2006-09-11 2011-04-19 Gen Probe Incorporated Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region
US7132233B2 (en) 2002-12-12 2006-11-07 Novartis Vaccines And Diagnostics, Inc. Identification of oligonucleotides for the capture, detection and quantitation of West Nile virus
EP1611254B1 (en) * 2003-03-31 2014-09-10 Roche Diagnostics GmbH Compositions and methods for detecting certain flaviviruses, including members of the japanese encephalitis virus serogroup
US20080311556A1 (en) * 2003-08-07 2008-12-18 Iversen Patrick L Sense Antiviral Compound and Method for Treating Ssrna Viral Infection
US20050222068A1 (en) * 2003-10-23 2005-10-06 Mourich Dan V Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells
US8129352B2 (en) * 2004-09-16 2012-03-06 Avi Biopharma, Inc. Antisense antiviral compound and method for treating ssRNA viral infection
US8357664B2 (en) 2004-10-26 2013-01-22 Avi Biopharma, Inc. Antisense antiviral compound and method for treating influenza viral infection
US7524829B2 (en) * 2004-11-01 2009-04-28 Avi Biopharma, Inc. Antisense antiviral compounds and methods for treating a filovirus infection
WO2006137939A2 (en) 2004-11-09 2006-12-28 Gen-Probe Incorporated Compositions and methods for detecting group a streptococci
EP1930730B1 (en) 2005-03-10 2019-08-14 Gen-Probe Incorporated Systems and methods to perform assays for detecting or quantifying analytes
US7964413B2 (en) 2005-03-10 2011-06-21 Gen-Probe Incorporated Method for continuous mode processing of multiple reaction receptacles in a real-time amplification assay
US20060240032A1 (en) * 2005-03-31 2006-10-26 Hinrichs David J Immunomodulating compositions and methods for use in the treatment of human autoimmune diseases
US8067571B2 (en) 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
WO2007030576A2 (en) * 2005-09-08 2007-03-15 Avi Biopharma, Inc. Antisense antiviral compound and method for treating picornavirus infection
US8524676B2 (en) * 2005-09-08 2013-09-03 Sarepta Therapeutics, Inc. Method for treating enterovirus or rhinovirus infection using antisense antiviral compounds
US8501704B2 (en) 2005-11-08 2013-08-06 Sarepta Therapeutics, Inc. Immunosuppression compound and treatment method
PL2735568T3 (pl) * 2006-05-10 2018-02-28 Sarepta Therapeutics, Inc. Analogi oligonukleotydowe mające kationowe połączenia pomiędzy podjednostkami
US8785407B2 (en) * 2006-05-10 2014-07-22 Sarepta Therapeutics, Inc. Antisense antiviral agent and method for treating ssRNA viral infection
WO2009012387A2 (en) * 2007-07-18 2009-01-22 Gen-Probe Incorporated Compositions and methods to detect tmprss2/erg transcript variants in prostate cancer
JP5624892B2 (ja) * 2008-01-04 2014-11-12 セントラル アデレード ローカル ヘルス ネットワーク インコーポレイテッド Efmr(女性に限られた癲癇及び精神遅滞)の診断方法及び治療方法
EP3957754B1 (en) * 2008-04-21 2026-01-28 Gen-Probe Incorporated Method for detecting chikungunya virus
EP2376633A1 (en) * 2008-12-17 2011-10-19 AVI BioPharma, Inc. Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis
WO2010101947A2 (en) * 2009-03-02 2010-09-10 Cooperative Diagnostics, Llc Rapid oligo probes
EP2499248B1 (en) 2009-11-13 2017-01-04 Sarepta Therapeutics, Inc. Antisense antiviral compound and method for treating influenza viral infection
ES2364833B1 (es) * 2010-01-29 2012-09-13 Instituto De Salud Carlos Iii Método de amplificación genómica del virus west nile.
KR20200133284A (ko) 2010-05-28 2020-11-26 사렙타 쎄러퓨틱스, 인코퍼레이티드 변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체
US8198429B2 (en) 2010-08-09 2012-06-12 Avi Biopharma, Inc. Antisense antiviral compounds and methods for treating a filovirus infection
US10017763B2 (en) 2010-09-03 2018-07-10 Sarepta Therapeutics, Inc. dsRNA molecules comprising oligonucleotide analogs having modified intersubunit linkages and/or terminal groups
AU2012222178B2 (en) 2011-02-24 2014-12-18 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
HK1201514A1 (en) 2011-11-18 2015-09-04 Sarepta Therapeutics, Inc. Functionally-modified oligonucleotides and subunits thereof
EP2836501B1 (en) * 2012-04-10 2018-03-07 City of Hope Rna aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells
AU2013202804A1 (en) 2012-06-14 2014-01-16 Gen-Probe Incorporated Use of a fluorescent material to detect failure or deteriorated performance of a fluorometer
AU2013202808B2 (en) 2012-07-31 2014-11-13 Gen-Probe Incorporated System and method for performing multiplex thermal melt analysis
US11020417B2 (en) 2015-06-04 2021-06-01 Sarepta Therapeutics, Inc Methods and compounds for treatment of lymphocyte-related diseases and conditions
EP3764079B1 (en) 2015-12-31 2023-08-09 Gen-Probe Incorporated System and method for monitoring the performance of an optical signal detector

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422956A1 (fr) 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4868105A (en) 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
WO1988001302A1 (en) 1986-08-11 1988-02-25 Siska Diagnostics, Inc. Nucleic acid probe assay methods and compositions
US5541308A (en) 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
WO1989001050A1 (en) 1987-07-31 1989-02-09 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
US5283174A (en) 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US5639604A (en) 1987-09-21 1997-06-17 Gen-Probe Incorporated Homogeneous protection assay
US5585481A (en) 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
JPH02500880A (ja) 1987-11-18 1990-03-29 カイロン コーポレイション Nanbvの診断用薬およびワクチン
US4895650A (en) 1988-02-25 1990-01-23 Gen-Probe Incorporated Magnetic separation rack for diagnostic assays
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
JP3276955B2 (ja) 1988-09-30 2002-04-22 ジーン−トラック・システムス Rnaの鋳型の末端に結合したプローブ構造およびその使用方法
US5118801A (en) 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
KR0185373B1 (ko) 1989-03-17 1999-05-01 로버트 피. 블랙버언 Hcv 폴리단백질에서 유래되는 hcv 아미노산 서열 부분을 포함하는 폴리펩티드 및 그 사용
US5656207A (en) 1989-06-24 1997-08-12 Gen Probe Incorporated Detecting or quantifying multiple analytes using labelling techniques
CA2020958C (en) * 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US6087331A (en) 1990-01-19 2000-07-11 The Blood Center Of Southeastern Wisconsin Therapeutic use of platelet-endothelial cell adhesion molecule-1 compositions
US6172039B1 (en) 1990-04-16 2001-01-09 Apex Bioscience, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
US5472841A (en) 1990-06-11 1995-12-05 Nexstar Pharmaceuticals, Inc. Methods for identifying nucleic acid ligands of human neutrophil elastase
CA2094938A1 (en) 1991-01-04 1992-07-05 Grant R. Sutherland Dna sequences related to isolated fragile x syndrome
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
ATE257860T1 (de) 1991-08-02 2004-01-15 Biomerieux Bv Quantifikation von nukleinsäuren
JP3131222B2 (ja) 1991-12-24 2001-01-31 アイシス・ファーマシューティカルス・インコーポレーテッド ギャップを有する2′修飾オリゴヌクレオチド
HUT67943A (en) 1992-02-06 1995-05-29 Schering Corp Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5
US5837447A (en) 1992-04-15 1998-11-17 Blood Center Research Foundation, Inc., The Monitoring an immune response by analysis of amplified immunoglobulin or T-cell-receptor nucleic acid
KR100249110B1 (ko) 1992-05-06 2000-04-01 다니엘 엘. 캐시앙 핵산 서열 증폭 방법, 이에 이용되는 조성물 및 키트
CA2141430C (en) 1992-08-04 2009-05-12 Sherrol H. Mcdonough Nucleic acid sequence amplification
US5770356A (en) 1992-09-04 1998-06-23 The Scripps Research Institute Phagemids coexpressing a surface receptor and a surface heterologous protein
US6042828A (en) 1992-09-07 2000-03-28 Kyowa Hakko Kogyo Co., Ltd. Humanized antibodies to ganglioside GM2
US6337070B1 (en) 1993-04-29 2002-01-08 Takara Shuzo Co., Ltd. Polypeptides for use in generating anti-human influenza virus antibodies
US5339491A (en) * 1992-11-06 1994-08-23 United Technologies Automotive, Inc. Sealed retainer grommet
WO1995003430A1 (en) 1993-07-23 1995-02-02 Gen-Probe Incorporated Methods for enhancing nucleic acid amplification
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US5591578A (en) 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US5709998A (en) * 1993-12-15 1998-01-20 The Johns Hopkins University Molecular diagnosis of familial adenomatous polyposis
US5962332A (en) 1994-03-17 1999-10-05 University Of Massachusetts Detection of trinucleotide repeats by in situ hybridization
JPH10500310A (ja) 1994-05-19 1998-01-13 ダコ アクティーゼルスカブ 淋菌及びトラコーマ クラミジアの検出のためのpna プローブ
US7074904B2 (en) 1994-07-29 2006-07-11 Altor Bioscience Corporation MHC complexes and uses thereof
US6056957A (en) 1994-08-04 2000-05-02 Schering Corporation Humanized monoclonal antibodies against human interleukin-5
DE69535240T2 (de) 1994-10-28 2007-06-06 Gen-Probe Inc., San Diego Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen
US5731148A (en) 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
US6127116A (en) 1995-08-29 2000-10-03 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
US5869270A (en) 1996-01-31 1999-02-09 Sunol Molecular Corporation Single chain MHC complexes and uses thereof
JP4117027B2 (ja) 1996-04-19 2008-07-09 コルパン メチン パルボウイルス感染のための核酸予防接種
SE506700C2 (sv) * 1996-05-31 1998-02-02 Mikael Kubista Sond och förfaranden för analys av nukleinsyra
US6312892B1 (en) 1996-07-19 2001-11-06 Cornell Research Foundation, Inc. High fidelity detection of nucleic acid differences by ligase detection reaction
GB9703681D0 (en) 1997-02-21 1997-04-09 Gene Shears Pty Ltd Protein complemention
FR2760367B1 (fr) 1997-03-06 1999-04-30 Pasteur Merieux Serums Vacc Composition vaccinale destinee a la prevention ou au traitement des hepatites c
CA2225189C (en) 1997-03-06 2010-05-25 Queen's University At Kingston Canine factor viii gene, protein and methods of use
US5939254A (en) * 1997-04-28 1999-08-17 University Of Massachusetts Methods and reagents for rapid diagnosis of dengue virus infection
EP0975807B1 (en) 1997-05-02 2006-09-27 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
CN1183253C (zh) 1997-06-26 2005-01-05 宝生物工程株式会社 Dna聚合酶相关因子
US6448003B1 (en) 1998-06-10 2002-09-10 Dna Sciences Laboratories, Inc. Genotyping the human phenol sulfotransferbase 2 gene STP2
AU762728B2 (en) 1998-07-02 2003-07-03 Gen-Probe Incorporated Molecular torches
FR2792837B1 (fr) 1999-04-29 2001-07-13 Centre Nat Rech Scient Medicaments utiles pour le traitement des troubles de la regulation de la masse adipeuse et des maladies associees aux troubles de la production de leptine
WO2000075338A2 (en) 1999-06-04 2000-12-14 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services CLONED GENONE OF INFECTIOUS HEPATITIS C VIRUS OF GENOTYPE 2a AND USES THEREOF
US6316200B1 (en) 2000-06-08 2001-11-13 Becton, Dickinson And Company Probes and methods for detection of nucleic acids
US6846656B1 (en) 1999-08-30 2005-01-25 Kyowa Hakko Kogyo Co., Ltd. Process for producing N-acetylneuraminic acid
AU7602800A (en) 1999-09-23 2001-04-24 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Hepatitis c virus envelope two protein (e2) which lacks all or part of the hypervariable region one (hvr1), corresponding nucleic acids, chimeric viruses and uses thereof
RU2002112751A (ru) 1999-11-12 2004-02-27 Файброджен, Инк. (Us) Рекомбинантные желатины
EP1232182B1 (en) 1999-11-12 2007-10-03 Fibrogen, Inc. Bovine collagen and method for producing recombinant gelatin
WO2001038360A2 (en) 1999-11-24 2001-05-31 Chiron Corporation Novel hcv non-structural polypeptide
CA2393045A1 (en) 1999-12-07 2001-06-14 Sumitomo Chemical Co., Ltd. Mutant er.alpha. and test systems for transactivation
US6251607B1 (en) 1999-12-09 2001-06-26 National Science Council Of Republic Of China PCR primers for the rapid and specific detection of Salmonella typhimurium
EP1282726A2 (en) 1999-12-27 2003-02-12 Curagen Corporation Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
CA2395240A1 (en) 2000-01-13 2001-07-19 Genset S.A. Biallelic markers derived from genomic regions carrying genes involved in central nervous system disorders
US20030087847A1 (en) 2000-02-03 2003-05-08 Onyx Pharmaceuticals, Inc. Method and reagent for the inhibition of checkpoint kinase-1 (Chk1) enzyme
AU2001239470A1 (en) 2000-02-24 2001-09-03 Philogen S.R.L. Compositions and methods for treatment of angiogenesis in pathological lesions
BR0017215A (pt) * 2000-04-14 2004-02-10 Us Army Med Res Mat Command Detecção de flavivìrus e análises de quantificação
JP4927290B2 (ja) 2000-04-14 2012-05-09 ウィスコンシン アルムニ リサーチ ファンデイション 変異イオンチャンネルタンパク質を含んで成るウイルス
WO2001083816A2 (en) 2000-05-04 2001-11-08 Philogen S.R.L. Method for detecting tumors
JP2004521606A (ja) 2000-05-24 2004-07-22 サード・ウェーブ・テクノロジーズ・インク Rnaの検出法
US6586229B1 (en) 2000-06-01 2003-07-01 North Carolina State University Method for the production of ρ-Hydroxybenzoate in species of pseudomonas and agrobacterium
AU2001268233A1 (en) 2000-06-08 2001-12-17 Chiron Corporation Compositions and methods for treating neoplastic disease using inhibitors of laminin5beta3
WO2002002599A2 (en) 2000-06-30 2002-01-10 Ingenium Pharmaceuticals Ag HUMAN G PROTEIN-COUPLED RECEPTOR IGPcR17, AND USES THEROF
IL153833A0 (en) 2000-07-18 2003-07-31 Novartis Ag Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches
EP1178116A1 (en) 2000-08-03 2002-02-06 Hybrigenics S.A. Sid nucleic acids and polypeptides selected from a pathogenic strain of hepatitis C virus and applications thereof
US20030096239A1 (en) 2000-08-25 2003-05-22 Kevin Gunderson Probes and decoder oligonucleotides
WO2002068637A2 (en) * 2000-10-20 2002-09-06 Ribozyme Pharmaceuticals, Inc. Nucleic acid-based treatment of diseases or conditions related to west nile virus infection
US20030188326A1 (en) 2000-11-03 2003-10-02 Dana Farber Cancer Institute Methods and compositions for the diagnosis of cancer susceptibilities and defective DNA repair mechanisms and treatment thereof
WO2002036761A2 (en) 2000-11-03 2002-05-10 Dana Farber Cancer Institute Compositions and methods for the diagnosis of cancer
US20030101476A1 (en) 2000-12-12 2003-05-29 Short Jay M. Recombinant phytases and uses thereof
AU2002309133A1 (en) 2001-04-17 2002-10-28 Institut Pasteur Recombinant segmented negative strand virus with a duplicated 3' noncoding flanking sequence, and therapeutic compositions containing the same
EP2345665A3 (en) 2001-12-04 2012-02-15 Bavarian Nordic A/S Flavivirus NS1 subunit vaccine
DE60330795D1 (de) 2002-11-08 2010-02-11 Crucell Holland Bv Impfstoff gegen west nile virus
US7132233B2 (en) 2002-12-12 2006-11-07 Novartis Vaccines And Diagnostics, Inc. Identification of oligonucleotides for the capture, detection and quantitation of West Nile virus
EP1611254B1 (en) 2003-03-31 2014-09-10 Roche Diagnostics GmbH Compositions and methods for detecting certain flaviviruses, including members of the japanese encephalitis virus serogroup

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