JP2006502167A5 - - Google Patents
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- Publication number
- JP2006502167A5 JP2006502167A5 JP2004534637A JP2004534637A JP2006502167A5 JP 2006502167 A5 JP2006502167 A5 JP 2006502167A5 JP 2004534637 A JP2004534637 A JP 2004534637A JP 2004534637 A JP2004534637 A JP 2004534637A JP 2006502167 A5 JP2006502167 A5 JP 2006502167A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- tumor cells
- use according
- glucan
- complement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001503 Glucan Polymers 0.000 claims 19
- 210000004881 tumor cell Anatomy 0.000 claims 13
- 239000002245 particle Substances 0.000 claims 12
- 230000000295 complement effect Effects 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 210000005170 neoplastic cell Anatomy 0.000 claims 5
- 230000000259 anti-tumor effect Effects 0.000 claims 4
- 108010078015 Complement C3b Proteins 0.000 claims 3
- 230000003213 activating effect Effects 0.000 claims 3
- 210000001185 bone marrow Anatomy 0.000 claims 2
- 230000035605 chemotaxis Effects 0.000 claims 2
- 230000024203 complement activation Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000002538 fungal effect Effects 0.000 claims 2
- 210000002540 macrophage Anatomy 0.000 claims 2
- 210000000440 neutrophil Anatomy 0.000 claims 2
- 235000001674 Agaricus brunnescens Nutrition 0.000 claims 1
- 240000005979 Hordeum vulgare Species 0.000 claims 1
- 235000007340 Hordeum vulgare Nutrition 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 229940022399 cancer vaccine Drugs 0.000 claims 1
- 238000009566 cancer vaccine Methods 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000008021 deposition Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 108090001082 glucan-binding proteins Proteins 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229960004641 rituximab Drugs 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40812602P | 2002-09-04 | 2002-09-04 | |
| PCT/US2003/027841 WO2004021994A2 (en) | 2002-09-04 | 2003-09-04 | Cancer therapy using whole glucan particles and antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006502167A JP2006502167A (ja) | 2006-01-19 |
| JP2006502167A5 true JP2006502167A5 (https=) | 2006-10-19 |
Family
ID=31978563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004534637A Pending JP2006502167A (ja) | 2002-09-04 | 2003-09-04 | 全グルカン粒子および抗体を用いた癌治療 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8883760B2 (https=) |
| EP (3) | EP2181711A1 (https=) |
| JP (1) | JP2006502167A (https=) |
| CN (3) | CN1939335A (https=) |
| AT (1) | ATE462437T1 (https=) |
| AU (2) | AU2003295326A1 (https=) |
| CA (2) | CA2496508C (https=) |
| DE (1) | DE60331925D1 (https=) |
| WO (2) | WO2004021994A2 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7507724B2 (en) * | 2001-01-16 | 2009-03-24 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| US7906492B2 (en) | 2001-01-16 | 2011-03-15 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| WO2004014320A2 (en) | 2002-08-13 | 2004-02-19 | Biopolymer Engineering, Inc. | Methods of using beta glucan as a radioprotective agent |
| US8883760B2 (en) * | 2002-09-04 | 2014-11-11 | University Of Louisville Research Foundation, Inc. | Cancer therapy using beta glucan and antibodies |
| US20060165700A1 (en) * | 2002-09-04 | 2006-07-27 | Ostroff Gary R | Cancer therapy using whole glucan particles and antibodies |
| EP2070546A1 (en) | 2004-04-09 | 2009-06-17 | Takeda Pharmaceutical Company Limited | Preventives/remedies for cancer |
| US7740861B2 (en) | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
| AU2005284727A1 (en) | 2004-09-17 | 2006-03-23 | University Of Massachusetts | Compositions and their uses for lysosomal enzyme deficiencies |
| US20070059310A1 (en) * | 2005-05-03 | 2007-03-15 | Karel Steven J | Therapeutic combination compositions and methods of using same |
| US8323644B2 (en) * | 2006-01-17 | 2012-12-04 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| US20090053221A1 (en) * | 2006-01-17 | 2009-02-26 | Cheung Nai-Kong V | Immune response enhancing glucan |
| EP1984004A4 (en) * | 2006-01-17 | 2010-03-03 | Sloan Kettering Inst Cancer | THE THERAPY REINFORCING GLUCAN |
| WO2007146440A2 (en) | 2006-06-15 | 2007-12-21 | Biopolymer Engineering, Inc. Dba Biothera, Inc. | Glucan preparations |
| EP2062588A4 (en) * | 2006-08-24 | 2011-06-08 | Kirin Holdings Kk | COMPOSITION FOR TREATING A SKIN CONDITION |
| WO2008027580A2 (en) * | 2006-09-01 | 2008-03-06 | University Of Louisville | PARTICULATE β-GLUCAN COMPOSITIONS FOR REGULATING DENDRITIC CELLS |
| WO2008027581A1 (en) * | 2006-09-01 | 2008-03-06 | University Of Louisville | Mcrp antagonists and their uses |
| US9457047B2 (en) | 2006-11-06 | 2016-10-04 | Whitehead Institute | Immunomodulating compositions and methods of use thereof |
| ES2397186T3 (es) * | 2006-11-06 | 2013-03-05 | Whitehead Institute | Composiciones inmunomoduladoras y métodos para su uso |
| EP2222283A2 (en) | 2007-10-29 | 2010-09-01 | University of Massachusetts | Yeast cell wall protein (ycwp) encapsulated multilayered nanoparticles for nucleic acid delivery (sirna) |
| WO2009103115A1 (en) * | 2008-02-19 | 2009-08-27 | Novogen Research Pty Ltd | Evaluating the therapeutic potential of a glucan |
| US20110053855A1 (en) * | 2008-02-19 | 2011-03-03 | Novogen Research Pty Ltd. | Ex vivo cell stimulation |
| WO2013040027A1 (en) * | 2011-09-12 | 2013-03-21 | Baylor Research Institute | Reprogramming immune environment in breast cancer via dendritic cells |
| EP3363462A1 (en) | 2012-04-30 | 2018-08-22 | Biothera, Inc. | Compositions and methods for beta-glucan immunotherapy |
| BR112014027989A2 (pt) | 2012-05-07 | 2017-07-18 | Algal Scient Corporation | processo multi-etapas para produção de modulador imunológico |
| US9744193B2 (en) | 2012-09-06 | 2017-08-29 | Orbis Health Solutions Llc | Tumor lysate loaded particles |
| JP6372890B2 (ja) * | 2013-03-08 | 2018-08-15 | 学校法人東京理科大学 | 乳酸菌増殖促進剤、制御性ｔ細胞増加剤、乳酸菌増殖促進方法、制御性ｔ細胞を増加させる方法、制御性ｔ細胞増加効果の評価方法、および乳酸菌増殖促進効果の評価方法 |
| EP2832360A1 (en) | 2013-07-30 | 2015-02-04 | Fresenius Kabi Deutschland GmbH | Polysaccharide for use in preventing metastasis formation and/or relapse |
| MX2016007148A (es) * | 2013-12-05 | 2016-12-07 | Biothera Inc | Metodos de ensayo de beta-glucano. |
| US10166195B2 (en) | 2014-03-05 | 2019-01-01 | Orbis Health Solutions, Llc | Vaccine delivery systems using yeast cell wall particles |
| LT6145B (lt) | 2014-04-14 | 2015-04-27 | Uab "Biocentras" | TERAPINĖ ß-GLIUKANŲ KOMPOZICIJA, MODULIUOJANTI ŽMOGAUS IMUNINĘ SISTEMĄ IR INICIJUOJANTI VĖŽINIŲ LĄSTELIŲ ARDYMĄ |
| WO2016007876A1 (en) * | 2014-07-10 | 2016-01-14 | Biothera, Inc. | Beta-glucan in combination with anti-cancer agents affecting the tumor microenvironment |
| EP3215163B1 (en) | 2014-11-06 | 2021-03-10 | Biothera, Inc. | Beta-glucan methods and compositions that affect the tumor microenvironment |
| US20180110853A1 (en) * | 2016-10-21 | 2018-04-26 | Wisconsin Alumni Research Foundation | Vaccine Adjuvant |
| WO2018106645A1 (en) | 2016-12-07 | 2018-06-14 | Innate Biotherapeutics, Llc | β-1,6-GLUCAN THERAPEUTIC ANTIBODY CONJUGATES |
| WO2018106644A1 (en) * | 2016-12-07 | 2018-06-14 | Innate Biotherapeutics, Llc | ß-1,6-GLUCAN TRASTUZUMAB ANTIBODY CONJUGATES |
| WO2018156888A1 (en) | 2017-02-24 | 2018-08-30 | Biothera Pharmaceuticals, Inc. | Beta glucan immunopharmacodynamics |
| CN110582209A (zh) | 2017-04-10 | 2019-12-17 | 基博生物技术公司 | 用于消化系统健康，控制体重，增强免疫力和改善健康的多纤维益生元组合物 |
| MX2020009510A (es) | 2018-03-13 | 2021-08-05 | Hibercell Inc | Inmunoterapia combinada de beta glucano y agonista cd40. |
| WO2021049587A1 (ja) * | 2019-09-11 | 2021-03-18 | 株式会社アウレオ | 抗体医薬の効果増強用組成物 |
| EP3858362A1 (en) | 2020-01-29 | 2021-08-04 | Pleuran, s.r.o. | Beta-glucan for use in enhancement of anti-tumor immunity in remission |
| EP4096685A1 (en) * | 2020-01-29 | 2022-12-07 | Pleuran, s.r.o. | Beta-glucan for use in modulation of an immune response in a remission |
| WO2022251123A1 (en) * | 2021-05-24 | 2022-12-01 | Frank Jordan | Alkaline extraction of beta glucan compounds for use in anti-viral and immune therapies |
| US12433915B2 (en) | 2022-11-23 | 2025-10-07 | Jjr&D, Llc | Cancer cytotoxic exosome formulations and methods for use in treating cancer |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3943247A (en) * | 1972-05-22 | 1976-03-09 | Kaken Kagaku Kabushiki Kaisha | Treatment of bacterial infections with glucan compositions |
| US3903297A (en) | 1973-11-01 | 1975-09-02 | Upjohn Co | Method of treatment and prophylaxis of gastric hypersecretion and gastric and duodenal ulcers using prostaglandin analogs |
| US4138479A (en) * | 1975-11-07 | 1979-02-06 | Bayer Aktiengesellschaft | Process for the preparation of immunopotentiating agents from components of yeast cell wall material |
| JPS5461112A (en) * | 1977-10-24 | 1979-05-17 | Ono Pharmaceut Co Ltd | Oncostatic polysaccharide* its preparation* and oncostatic drugs containing it as an effective component |
| JPS58220989A (ja) * | 1982-06-14 | 1983-12-22 | Diesel Kiki Co Ltd | 可変容量式ベ−ン型圧縮機 |
| SE456911B (sv) * | 1983-12-19 | 1988-11-14 | Olle Larm | Vattenloeslig, aminerad beta-1,3-bunden d-glukan och makrofagstimulerande komposition innehaallande densamma |
| US4810646A (en) * | 1984-11-28 | 1989-03-07 | Massachusetts Institute Of Technology | Glucan compositions and process for preparation thereof |
| US5250436A (en) * | 1984-11-28 | 1993-10-05 | Massachusetts Institute Of Technology | Glucan compositions and process for preparation thereof |
| US5082936A (en) * | 1984-11-28 | 1992-01-21 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US5028703A (en) * | 1988-03-11 | 1991-07-02 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US5037972A (en) * | 1984-11-28 | 1991-08-06 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US4992540A (en) | 1984-11-28 | 1991-02-12 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| CA1340080C (en) * | 1985-03-11 | 1998-10-13 | Dorothee Herlyn | Human tumor therapy |
| US4900722A (en) * | 1985-08-19 | 1990-02-13 | Bioglucans, L.P. | Methods and compositions for prophylactic and therapeutic treatment of infections |
| US4975421A (en) * | 1985-08-19 | 1990-12-04 | Bioglucan, Lp. | Soluble phosphorylated glucan: methods and compositions for wound healing |
| US4739046A (en) | 1985-08-19 | 1988-04-19 | Luzio Nicholas R Di | Soluble phosphorylated glucan |
| US5221616A (en) * | 1988-07-15 | 1993-06-22 | Quidel Corporation | Prevention of spontaneous complement activation in mammalian biological fluids |
| KR0141685B1 (ko) * | 1988-09-01 | 1998-07-01 | 야마따니 와따루 | 참게 아메보사이트 라이세이트 g 인자 활성화 저해제 |
| EP0436597B1 (en) | 1988-09-02 | 1997-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5057503A (en) * | 1989-01-23 | 1991-10-15 | The Brigham And Women's Hospital | Derivativized polysaccharides with biologic activity, method of their isolation, and uses therefor |
| CA2010511A1 (en) * | 1989-03-01 | 1990-09-01 | Roberto L. Ceriani | Method of enhancing cancer therapy by administration of unsaturated fatty acids |
| US4946450A (en) * | 1989-04-18 | 1990-08-07 | Biosource Genetics Corporation | Glucan/collagen therapeutic eye shields |
| US5032401A (en) * | 1989-06-15 | 1991-07-16 | Alpha Beta Technology | Glucan drug delivery system and adjuvant |
| IT1232310B (it) | 1989-09-04 | 1992-01-28 | Consiglio Nazionale Ricerche | Processo per la preparazione di un prodotto contenente glucano a partire da candida albicans bmm-12 |
| US5488040A (en) * | 1989-09-08 | 1996-01-30 | Alpha-Beta Technology, Inc. | Use of neutral soluble glucan preparations to stimulate platelet production |
| JPH05503952A (ja) | 1989-09-08 | 1993-06-24 | アルファ ベータ テクノロジー，インコーポレイティッド | 可溶性グルカン類の製造方法 |
| US5811542A (en) * | 1989-09-08 | 1998-09-22 | Alpha-Beta Technology, Inc. | Method for producing soluble glucans |
| EP0491829B1 (en) | 1989-09-08 | 1997-06-04 | Alpha Beta Technology, Inc. | Composition for immune system activation |
| US5622939A (en) * | 1992-08-21 | 1997-04-22 | Alpha-Beta Technology, Inc. | Glucan preparation |
| US5223491A (en) | 1989-11-09 | 1993-06-29 | Donzis Byron A | Method for revitalizing skin by applying topically water insoluble glucan |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| JP2911554B2 (ja) * | 1990-06-25 | 1999-06-23 | 台糖株式会社 | 抗ウィルス剤 |
| DK0585287T3 (da) | 1990-07-10 | 2000-04-17 | Cambridge Antibody Tech | Fremgangsmåde til fremstilling af specifikke bindingsparelementer |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| JP3122454B2 (ja) * | 1990-09-27 | 2001-01-09 | 生化学工業株式会社 | カブトガニ・アメボサイト・ライセートの調製法 |
| CA2095633C (en) | 1990-12-03 | 2003-02-04 | Lisa J. Garrard | Enrichment method for variant proteins with altered binding properties |
| EP1820858B1 (en) | 1991-03-01 | 2009-08-12 | Dyax Corporation | Chimeric protein comprising micro-protein having two or more disulfide bonds and embodiments thereof |
| ATE414768T1 (de) | 1991-04-10 | 2008-12-15 | Scripps Research Inst | Bibliotheken heterodimerer rezeptoren mittels phagemiden |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| IT1256035B (it) | 1992-08-10 | 1995-11-21 | Consiglio Nazionale Ricerche | Glucani ad attivita' immunostimolante |
| US5453124A (en) * | 1992-12-30 | 1995-09-26 | Texas Instruments Incorporated | Programmable multizone gas injector for single-wafer semiconductor processing equipment |
| US5622940A (en) * | 1994-07-14 | 1997-04-22 | Alpha-Beta Technology | Inhibition of infection-stimulated oral tissue destruction by β(1,3)-glucan |
| GB9420645D0 (en) * | 1994-10-13 | 1994-11-30 | Dow Chemical Co | Non-linear stytrenic polymer compositions and articles prepared therefrom |
| US5576015A (en) | 1995-03-02 | 1996-11-19 | Donzis; Byron A. | Substantially purified beta (1,3) finely ground yeast cell wall glucan composition with dermatological and nutritional uses |
| AUPN166195A0 (en) | 1995-03-13 | 1995-04-06 | Norvet Research Pty Limited | Process for glucan extraction |
| US6036946A (en) * | 1997-12-24 | 2000-03-14 | Shaklee Corporation | Methods for protecting skin from damaging effects of ultraviolet light |
| ES2321892T3 (es) * | 1998-09-14 | 2009-06-12 | Nabi Biopharmaceuticals | Composiciones de beta-glucanos e inmunoglobulinas especificas. |
| US6369216B1 (en) * | 1998-09-25 | 2002-04-09 | Biopolymer Engineering Pharmaceutical, Inc. | Very high molecular weight β-glucans |
| EP1357919B1 (en) * | 2001-01-16 | 2017-04-05 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| US7906492B2 (en) * | 2001-01-16 | 2011-03-15 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| US7507724B2 (en) * | 2001-01-16 | 2009-03-24 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| US7786094B2 (en) * | 2001-10-09 | 2010-08-31 | Biopolymer Engineering, Inc. | Use of beta-glucans against biological warfare weapons and pathogens including anthrax |
| WO2004014320A2 (en) | 2002-08-13 | 2004-02-19 | Biopolymer Engineering, Inc. | Methods of using beta glucan as a radioprotective agent |
| US20060165700A1 (en) * | 2002-09-04 | 2006-07-27 | Ostroff Gary R | Cancer therapy using whole glucan particles and antibodies |
| US8883760B2 (en) | 2002-09-04 | 2014-11-11 | University Of Louisville Research Foundation, Inc. | Cancer therapy using beta glucan and antibodies |
| CN1964722A (zh) | 2004-05-10 | 2007-05-16 | 生物聚合物工程有限公司 | 与抗生素、疫苗和病毒单克隆抗体组合的全葡聚糖颗粒 |
-
2003
- 2003-09-04 US US10/526,185 patent/US8883760B2/en active Active
- 2003-09-04 CN CNA2006101362698A patent/CN1939335A/zh active Pending
- 2003-09-04 DE DE60331925T patent/DE60331925D1/de not_active Expired - Lifetime
- 2003-09-04 CA CA2496508A patent/CA2496508C/en not_active Expired - Lifetime
- 2003-09-04 CA CA2496596A patent/CA2496596C/en not_active Expired - Fee Related
- 2003-09-04 EP EP10001786A patent/EP2181711A1/en not_active Withdrawn
- 2003-09-04 AT AT03749452T patent/ATE462437T1/de not_active IP Right Cessation
- 2003-09-04 WO PCT/US2003/027841 patent/WO2004021994A2/en not_active Ceased
- 2003-09-04 AU AU2003295326A patent/AU2003295326A1/en not_active Abandoned
- 2003-09-04 EP EP03749452.3A patent/EP1536820B2/en not_active Expired - Lifetime
- 2003-09-04 CN CNB038248956A patent/CN100363054C/zh not_active Ceased
- 2003-09-04 JP JP2004534637A patent/JP2006502167A/ja active Pending
- 2003-09-04 CN CN03824893XA patent/CN1694715B/zh not_active Expired - Lifetime
- 2003-09-04 WO PCT/US2003/027975 patent/WO2004030613A2/en not_active Ceased
- 2003-09-04 EP EP03786508A patent/EP1539194A4/en not_active Ceased
- 2003-09-04 AU AU2003268486A patent/AU2003268486A1/en not_active Abandoned
-
2014
- 2014-10-30 US US14/528,900 patent/US9522187B2/en not_active Expired - Fee Related
-
2016
- 2016-11-10 US US15/348,057 patent/US20170056432A1/en not_active Abandoned
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