JP2006502128A - 抗菌性エステル−マクロサイクル - Google Patents

抗菌性エステル−マクロサイクル Download PDF

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Publication number
JP2006502128A
JP2006502128A JP2004525241A JP2004525241A JP2006502128A JP 2006502128 A JP2006502128 A JP 2006502128A JP 2004525241 A JP2004525241 A JP 2004525241A JP 2004525241 A JP2004525241 A JP 2004525241A JP 2006502128 A JP2006502128 A JP 2006502128A
Authority
JP
Japan
Prior art keywords
hydrogen
alkyl
amino
group
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2004525241A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006502128A5 (enExample
Inventor
トーマス・ランペ
イザベル・アデル
ディーター・バイエル
ニーナ・ブルンナー
ライナー・エンダーマン
ケルスティン・エーレルト
ハイン−ペーター・クロール
フランツ・フォン・ヌスバウム
ジークフリート・ラダッツ
ヨアヒム・ルドルフ
ギド・シファー
アンドレアス・シューマッハー
ヨランダ・カンチョ−グランデ
マルティン・ミヒェルス
シュテファン・ヴァイガント
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Publication of JP2006502128A publication Critical patent/JP2006502128A/ja
Publication of JP2006502128A5 publication Critical patent/JP2006502128A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2004525241A 2002-07-29 2003-07-18 抗菌性エステル−マクロサイクル Withdrawn JP2006502128A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10234422A DE10234422A1 (de) 2002-07-29 2002-07-29 Antibakterielle Ester-Makrozyklen
PCT/EP2003/007824 WO2004012816A1 (de) 2002-07-29 2003-07-18 Antibakterielle ester-makrozyklen

Publications (2)

Publication Number Publication Date
JP2006502128A true JP2006502128A (ja) 2006-01-19
JP2006502128A5 JP2006502128A5 (enExample) 2006-08-31

Family

ID=30128472

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004525241A Withdrawn JP2006502128A (ja) 2002-07-29 2003-07-18 抗菌性エステル−マクロサイクル

Country Status (7)

Country Link
US (1) US20060258571A1 (enExample)
EP (1) EP1526896A1 (enExample)
JP (1) JP2006502128A (enExample)
AU (1) AU2003246716A1 (enExample)
CA (1) CA2495479A1 (enExample)
DE (1) DE10234422A1 (enExample)
WO (1) WO2004012816A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019239880A1 (ja) * 2018-06-15 2019-12-19 国立大学法人東京工業大学 アミドの製造方法
WO2019239879A1 (ja) * 2018-06-15 2019-12-19 国立大学法人東京工業大学 アミドの製造方法
WO2020137545A1 (ja) * 2018-12-25 2020-07-02 国立大学法人東京工業大学 アミドの製造方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10226921A1 (de) * 2002-06-17 2003-12-24 Bayer Ag Antibakterielle Amid-Makrozyklen
JP4928261B2 (ja) 2003-06-18 2012-05-09 トランザイム・ファーマ・インコーポレイテッド モチリン受容体の大環状拮抗薬
DE10358824A1 (de) 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102004025731A1 (de) * 2004-05-26 2005-12-15 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen III
DE102005014240A1 (de) * 2004-09-24 2006-03-30 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen IV
DE102005014245A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
DE102005014247A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen VI
DE102005032781A1 (de) * 2005-07-14 2007-01-18 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Markozyklen VII
CN101351451B (zh) * 2005-12-29 2013-02-20 莱西肯医药有限公司 多环氨基酸衍生物及其使用方法
RU2729609C2 (ru) 2015-10-27 2020-08-11 Ф. Хоффманн-Ля Рош Аг Пептидные макроциклы против acinetobacter baumannii
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2801591B1 (fr) * 1999-11-30 2002-03-01 Aventis Pharma Sa Derives macrocycliques de l'acide hydroxamique, leur preparation et les compositions qui les contiennent
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019239880A1 (ja) * 2018-06-15 2019-12-19 国立大学法人東京工業大学 アミドの製造方法
WO2019239879A1 (ja) * 2018-06-15 2019-12-19 国立大学法人東京工業大学 アミドの製造方法
JPWO2019239879A1 (ja) * 2018-06-15 2021-02-12 国立大学法人東京工業大学 アミドの製造方法
JPWO2019239880A1 (ja) * 2018-06-15 2021-02-12 国立大学法人東京工業大学 アミドの製造方法
WO2020137545A1 (ja) * 2018-12-25 2020-07-02 国立大学法人東京工業大学 アミドの製造方法
JPWO2020137545A1 (ja) * 2018-12-25 2021-11-04 国立大学法人東京工業大学 アミドの製造方法

Also Published As

Publication number Publication date
EP1526896A1 (de) 2005-05-04
DE10234422A1 (de) 2004-02-12
WO2004012816A1 (de) 2004-02-12
CA2495479A1 (en) 2004-02-12
US20060258571A1 (en) 2006-11-16
AU2003246716A1 (en) 2004-02-23

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